Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities - Development of highly efficacious cytotoxic agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 4968-4982

  Singh, Palwinder ^a   Kaur, Matinder ^a   Holzer, Wolfgang ^b  

^a GURU NANAK DEV UNIVERSITY   (India)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cancer; Hybrid molecules; Tumor growth inhibition

Indexed keywords

1 (2,6 DICHLOROPHENYL) 3 (3 PHENYLALLYLIDENE)INDOLIN 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 [(1 CINNAMYL 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 [(1-TOSYL 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 [(4 OXO 4H CHROMEN 3 YL)METHYLENE]INDOLIN 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 [(PYRIDIN 2 YL)METHYLENE)INDOLIN 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 [[1 (PROP 2 YNYL) 1H INDOL 3 YL]METHYLENE]INDOLIN 2 ONE; 1 (3 CHLOROPHENYL) 3 METHYL 4 [(1 (PROP 2 YNYL) 1H INDOL 3 YL)METHYLENE] 1H PYRAZOL 5(4H) ONE; 1 (3 CHLOROPHENYL) 3 METHYL 4 [(4OXO 4H CHROMEN 3 YL)METHYLENE) 1H PYRAZOL 5(4H) ONE; 1 (3 CHLOROPHENYL) 4 [(1 CINNAMYL 1H INDOL 3 YL)METHYLENE] 3 METHYL 1H PYRAZOL 5(4H) ONE; 1 (PROP 2 YNYL) 3 [(1 (PROP 2 YNYL) 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 1 3 [(1 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 1,3 DIBENZYL 5 [(1 BENZYL 1H INDOL 3 YL)METHYLENE]PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 1,3 DIMETHYL 5 [(4 OXO 4H CHROMEN 3 YL)METHYLENE]PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 3 [(1 1H INDOL 3 YL)METHYLENE] 1 (2,6 DICHLOROPHENYL)INDOLIN 2 ONE; 3 [(1 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1 BENZYL 1H INDOL 3 YL)METHYLENE] 1 (2,6 DICHLOROPHENYL)INDOLIN 2 ONE; 3 [(1 CINNAMYL 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1 TOSYL 1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1H INDOL 3 YL)METHYLENE] 1 (2,6 DICHLOROPHENYL)INDOLIN 2 ONE; 3 [(1H INDOL 3 YL)METHYLENE]INDOLIN 2 ONE; 3 [[1 (PROP 2 YNYL) 1H INDOL 3 YL]METHYLENE]INDOLIN 2 ONE; 4 [(1 1H INDOL 3 YL)METHYLENE] 1 (3 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 5(4H) ONE; 4 [(1 BENZYL 1H INDOL 3 YL)METHYLENE] 1 (3 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 5(4H) ONE; 5 [(4 OXO 4H CHROMEN 3 YL)METHYLENE]PYRIMIDINE 2,4,6 (1H,3H,5H) TRIONE; ANTINEOPLASTIC AGENT; CHROMONE DERIVATIVE; CYTOTOXIC AGENT; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER INHIBITION; CHEMICAL INTERACTION; COLON CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; KIDNEY CANCER; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MELANOMA; MOUSE; NONHUMAN; OVARY CANCER; PROSTATE CANCER; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; PYRAZOLES; PYRIMIDINES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 77957844566     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.08.004     Document Type: Article

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