-
1
-
-
0345184913
-
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
-
Sawyers, C. L. Opportunities and challenges in the development of kinase inhibitor therapy for cancer. Genes Dev. 17, 2998-3010 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 2998-3010
-
-
Sawyers, C.L.1
-
2
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
3
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella, R., Bell, D. W., Haber, D. A. & Settleman, J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305, 1163-1167 (2004).
-
(2004)
Science
, vol.305
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
Settleman, J.4
-
4
-
-
4944232647
-
Lung cancer: Intragenic ERBB 2 kinase mutations in tumours
-
Stephens, P. et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 431, 525-526 (2004).
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
-
5
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
-
6
-
-
0038670241
-
Mutational analysis of the tyrosine kinome in colorectal cancers
-
Bardelli, A. et al. Mutational analysis of the tyrosine kinome in colorectal cancers. Science 300, 949-950 (2003).
-
(2003)
Science
, vol.300
, pp. 949-950
-
-
Bardelli, A.1
-
7
-
-
11144358645
-
High frequency of mutations of the PTK 3CA gene in human cancers
-
Samuels, Y. et al. High frequency of mutations of the PTK3CA gene in human cancers. Science 304, 554 (2004).
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
-
8
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIPILI genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools, J. et al. A tyrosine kinase created by fusion of the PDGFRA and FIPILI genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348, 1201-1214 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
-
9
-
-
0036727124
-
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
-
Rubin, B. P. et al. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J. Clin. Oncol. 20,3586-3591 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3586-3591
-
-
Rubin, B.P.1
-
10
-
-
4043095240
-
Phase I clinical results with MLN518, a novel FLT3 antagonist: Tolerability, pharmacokinetics, and pharmacodynamics
-
Abstr. 219
-
De Angelo, D. J. et al. Phase I clinical results with MLN518, a novel FLT3 antagonist: tolerability, pharmacokinetics, and pharmacodynamics. Blood 102 (65a), Abstr. 219 (2003).
-
(2003)
Blood
, vol.102
, Issue.65 A
-
-
De Angelo, D.J.1
-
11
-
-
3042772932
-
Oral PKC 412 has activity in patients (pts) with mutant FLT3 acute myeloid leukemia (AML): A phase II trial
-
Stone, R. M. et al. Oral PKC 412 has activity in patients (pts) with mutant FLT3 acute myeloid leukemia (AML): a phase II trial. Proc. Am. Soc. Clin. Oncol. Abstr. 22, 563 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol. Abstr.
, vol.22
, pp. 563
-
-
Stone, R.M.1
-
12
-
-
0141542147
-
Single agent CEP-701, a novel FLT3 inhibitor, shows initial response in patients with refractory acute myeloid leukemia
-
Smith, B. D. et al, Single agent CEP-701, a novel FLT3 inhibitor, shows initial response in patients with refractory acute myeloid leukemia. Proc. Am. Soc. Clin. Oncol. Abstr. 22, 194 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol. Abstr.
, vol.22
, pp. 194
-
-
Smith, B.D.1
-
13
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre, M. E. et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880 (2001).
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
-
14
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah, N. P. et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2, 117-125 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
-
15
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford, S. et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99, 3472-3475 (2002).
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
-
16
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah, N. P. et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305, 399-401 (2004).
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
-
17
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptcl(-/-)p53(-/-) mice
-
Romer, J. T. et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptcl(-/-)p53(-/-) mice. Cancer Cell 6, 229-240 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 229-240
-
-
Romer, J.T.1
-
18
-
-
0028978274
-
A p16INK4a-insensitive CDK 4 mutant targeted by cytolytic T lymphocytes in a human melanoma
-
Wolfel, T. et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269, 1281-1284 (1995).
-
(1995)
Science
, vol.269
, pp. 1281-1284
-
-
Wolfel, T.1
-
19
-
-
0027380330
-
Chromosome t(11;14)(q13;q32) breakpoints in centrocytic lymphoma are highly localized at the bcl-1 major translocation cluster
-
Williams, M. E., Swerdlow, S. H. & Meeker, T. C. Chromosome t(11;14)(q13;q32) breakpoints in centrocytic lymphoma are highly localized at the bcl-1 major translocation cluster. Leukemia 7, 1437-1440 (1993).
-
(1993)
Leukemia
, vol.7
, pp. 1437-1440
-
-
Williams, M.E.1
Swerdlow, S.H.2
Meeker, T.C.3
-
20
-
-
0344063370
-
Will mTOR inhibitors make it as cancer drugs?
-
Sawyers, C. L. Will mTOR inhibitors make it as cancer drugs? Cancer Cell 4, 343-348 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 343-348
-
-
Sawyers, C.L.1
-
21
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
-
Hughes, T. P. et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N. Engl. J. Med. 349, 1423-1432 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1423-1432
-
-
Hughes, T.P.1
-
22
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST 1571 in vitro
-
Graham, S. M. et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro. Blood 99, 319-325 (2002).
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
-
23
-
-
0038454621
-
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
-
Bhatia, R. et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101, 4701-4707 (2003).
-
(2003)
Blood
, vol.101
, pp. 4701-4707
-
-
Bhatia, R.1
-
24
-
-
14944367962
-
Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatimb mesylate treatment
-
published online 2 September (doi: 10.1182/blood-2004-03- 1114)
-
Chu, S. et al. Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatimb mesylate treatment. Blood published online 2 September 2004 (doi: 10.1182/blood-2004-03-1114).
-
(2004)
Blood
-
-
Chu, S.1
-
25
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz, H. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335-2342 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
-
26
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang, J. C. et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl J. Med. 349, 427-434 (2003).
-
(2003)
N. Engl J. Med.
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
-
27
-
-
9244232694
-
ASCO annual meeting proceedings
-
post-meeting edn
-
Ratain et al. ASCO annual meeting proceedings (post-meeting edn). J. Clin. Oncol. 22, (no. 14 suppl.) 4501 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.SUPPL.
, pp. 4501
-
-
Ratain1
-
28
-
-
9744226669
-
ASCO annual meeting proceedings
-
post-meeting edn
-
Motzer et al. ASCO annual meeting proceedings (post-meeting edn). J. Clin. Oncol. 22, (no. 14 suppl.) 4500 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.SUPPL.
, pp. 4500
-
-
Motzer1
-
29
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin, W. G., Jr Molecular basis of the VHL hereditary cancer syndrome. Nature Rev. Cancer 2, 673-682 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
30
-
-
0842288323
-
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick, N. A. et al. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303, 848-851 (2004).
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
-
31
-
-
0033215242
-
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
-
Olumi, A. F. et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002-5011 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 5002-5011
-
-
Olumi, A.F.1
|