Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and α-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2844-2848

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Carrion, Maria Dora ^a   Cruz Lopez, Olga ^a   Preti, Delia ^a   Tabrizi, Mojgan Aghazadeh ^a   Fruttarolo, Francesca ^a   Heilmann, Jörg ^b   Bermejo, Jaime ^c   Estévez, Francisco ^d  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^d UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

Antiproliferative activity; Apoptosis; Hybrid; Leukaemia

Indexed keywords

ACRYLAMIDE DERIVATIVE; ALPHA BROMOACRYLOYLAMIDE; BENZ[4,5]IMIDAZO[1,2 D][1,2,4]THIADIAZOLE; BENZOFURAN DERIVATIVE; BENZOTHIOPHENE; CASPASE 3; DNA FRAGMENT; INDOLE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRAIN U937; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MORPHOLOGY; MYELOID LEUKEMIA; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA FRAGMENTATION; HL-60 CELLS; HUMANS; IMIDAZOLES; LEUKEMIA, MYELOID; THIADIAZOLES; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 34247537137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.048     Document Type: Article

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