Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5529-5538

  Zefirova, Olga N ^a,b   Nurieva, Evgeniya V ^a   Shishov, Dmitrii V ^a   Baskin, Igor I ^a   Fuchs, Fabian ^c   Lemcke, Heiko ^c   Schröder, Fabian ^c   Weiss, Dieter G ^c   Zefirov, Nikolay S ^a,b   Kuznetsov, Sergei A ^c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Adamantane derivatives; Colchicine derivatives; Cytotoxicity; Hybrid molecules; Microtubule depolymerization; Tubulin clustering

Indexed keywords

ADAMANTANE; COLCHICINE; N (5 ADAMANT 2 YLOXY 5 OXOPENTANOYL) N DEACTYLCOLCHICINE; N (6 ADAMANT 2 YLOXY 6 OXOHEXANOYL) N DEACTYLCOLCHICINE; N (7 ADAMANT 1 YLOXY 7 OXOHEPTANOYL) N DEACTYLCOLCHICINE; N (7 ADAMANT 2 YLOXY 7 OXOHEPTANOYL) N DEACTYLCOLCHICINE; N (7 CYCLOHEXYLOXYLOXY 7 OXOHEPTANOYL) N DEACTYLCOLCHICINE; N (7 ISOPROPYLOXY 7 OXOHEPTANOYL) N DEACTYLCOLCHICINE; N (7 METHOXY 7 OXOHEPTANOYL) N DEACTYLCOLCHICINE; N (7 PHENYLOXY 7 OXOHEPTANOYL) N DEACTYLCOLCHICINE; N (8 ADAMANT 2 YLOXY 8 OXOOCTANOYL) N DEACTYLCOLCHICINE; N (9 ADAMANT 1 YLOXY 9 OXONONANOYL) N DEACTYLCOLCHICINE; N (9 ADAMANT 2 YLOXY 9 OXONONANOYL) N DEACTYLCOLCHICINE; N (TERT BUTOXYCARBONYL)PHENYLISOSERINE 12 OXO 12 (N DEACETYLCOLCHICIN 7 N YL)DODECYL ESTER; N [[(TERT BUTOXYCARBONYL)PHENYLISOSERINYL]OXY] 4 ADAMANTYL 5 OXO 5 (N DEACETYLCOLCHICINO)PENTAPNOATE; N [[(TERT BUTOXYCARBONYL)PHENYLISOSERINYL]OXY] 4 ADAMANTYL 8 OXO 8 (N DEACETYLCOLCHICIN 7 N YL)OCTANOATE; N TERT BUTOXYCARBONYLPHENYLISOSERINE; TUBULIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DEPOLYMERIZATION; DRUG ACTIVITY; DRUG BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CARCINOMA; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXICITY TESTING;

ADAMANTANE; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PACLITAXEL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 80052566973     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.040     Document Type: Article

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