Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 21, 2009, Pages 7585-7592

  Solomon, V Raja ^a,b   Hu, Changkun ^a   Lee, Hoyun ^a,b  

^a SUDBURY REGIONAL HOSPITAL   (Canada)

^b LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Anticancer activity; Benzothiazole; Breast cancer cells; Hybrid pharmacophore; Isatin; Schiff base

Indexed keywords

4 BROMO 1 DIETHYLAMINOMETHYL 1H INDOLE 2,3 DIONE; 4 CHLORO 1 DIMETHYLAMINOMETHYL 3 (6 METHYL BENZOTHIAZOL 2 YLIMINO) 1,3 DIHYDRO INDOL 2 ONE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; ISATIN; UNCLASSIFIED DRUG; 4-BROMO-1-DIETHYLAMINOMETHYL-1H-INDOLE-2,3-DIONE; 4-CHLORO-1-DIMETHYLAMINOMETHYL-3-(6-METHYL-BENZOTHIAZOL-2-YLIMINO)-1,3-DIHYDRO-INDOL-2-ONE; BENZOTHIAZOLE; INDOLE DERIVATIVE; THIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER CONTROL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYBRID; PHARMACOPHORE; BREAST TUMOR; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; FEMALE; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; BREAST NEOPLASMS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDOLES; ISATIN; THIAZOLES;

EID: 73949084441     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.068     Document Type: Article

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