Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4589-4600

  Kamal, Ahmed ^a   Suresh, Paidakula ^a   Janaki Ramaiah, M ^a   Mallareddy, Adla ^a   Kumar, Banala Ashwini ^a   Raju, Paidakula ^a   Vinay Gopal, J ^a   Pushpavalli, S N C V L ^a   Lavanya, A ^a   Sarma, Pranjal ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

H2AX staining; Anticancer activity; Cell cycle analysis; Comet assay; DNA strand breaks; Etoposide; Podophyllotoxin

Indexed keywords

2 (2 METHOXYPHENYL) 3 (2 NITROPHENYL)ACRYLIC ACID; 2 (2 METHOXYPHENYL) 3 (4 NITROPHENYL)ACRYLIC ACID; 3 (2 FLUORO 4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (2 FLUORO 5 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (3 ACETOXY 4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (3 FLUORO 4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (3 HYDROXY 4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (3 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (3 NITROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 ACETOXY 3 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 ACETOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 FLUORO 3 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 HYDROXY 3 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 HYDROXY 3 NITROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 HYDROXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 METHOXY 3 NITROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 3 (4 NITROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID; 4 BETA 3 (2 FLUORO 4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDO PODOPHYLLOTOXIN; 4 BETA 3 (2 FLUORO 5 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDO PODOPHYLLOTOXIN; 4 BETA 3 (3 FLUORO 4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDO PODOPHYLLOTOXIN; 4 BETA 3 (4 FLUORO 3 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDO PODOPHYLLOTOXIN; 4 BETA 3 (4 HYDROXY 3 NITROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDO PODOPHYLLOTOXIN; 4 BETA 3 (4 METHOXY 3 NITROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDO PODOPHYLLOTOXIN; 4 BETA ACRYLAMIDOPODOPHYLLOTOXIN DERIVATIVE; COMBRETASTATIN A4; ETOPOSIDE; PODOPHYLLOTOXIN DERIVATIVE; TENIPOSIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; COLON CANCER; COMET ASSAY; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; LUNG CANCER; MOUTH CANCER; OVARY CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE STRANDED DNA BREAK; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; COMET ASSAY; DNA; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; HUMANS; NEOPLASMS; PODOPHYLLOTOXIN;

PUFFINUS AURICULARIS;

EID: 79960561101     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.017     Document Type: Article

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