-
1
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403: 795-800
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
2
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 2000; 273: 793-798
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
3
-
-
84874108083
-
Seven sirtuins for seven deadly diseases of aging
-
Morris BJ. Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med 2012; 56: 133-171
-
(2012)
Free Radic Biol Med
, vol.56
, pp. 133-171
-
-
Morris, B.J.1
-
4
-
-
81055122671
-
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
-
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, et al. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 2011; 334: 806-809
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
Zhou, Y.2
Su, X.3
Yu, J.J.4
Khan, S.5
Jiang, H.6
-
5
-
-
34249083199
-
Sirtuins in mammals: Insights into their biological function
-
Michan S, Sinclair D. Sirtuins in mammals: Insights into their biological function. Biochem J 2007; 404: 1-13
-
(2007)
Biochem J
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
6
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001; 410: 227-230
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
7
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999; 13: 2570-2580
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
8
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 2004; 101: 15998-16003
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
9
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-196
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
-
10
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004; 430: 686-689
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
-
11
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndrome-Associated cancer
-
Herranz D, Munoz-Martin M, Canamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-Associated cancer. Nat Commun 2010; 1: 3
-
(2010)
Nat Commun
, vol.1
, pp. 3
-
-
Herranz, D.1
Munoz-Martin, M.2
Canamero, M.3
Mulero, F.4
Martinez-Pastor, B.5
Fernandez-Capetillo, O.6
-
12
-
-
80053168829
-
Absence of effects of sir2 overexpression on lifespan in c elegans and drosophila
-
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011; 477: 482-485
-
(2011)
Nature
, vol.477
, pp. 482-485
-
-
Burnett, C.1
Valentini, S.2
Cabreiro, F.3
Goss, M.4
Somogyvari, M.5
Piper, M.D.6
-
13
-
-
78649482634
-
Sirt1: Recent lessons from mouse models
-
Herranz D, Serrano M. SIRT1: Recent lessons from mouse models. Nat Rev Cancer 2010; 10: 819-823
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 819-823
-
-
Herranz, D.1
Serrano, M.2
-
14
-
-
84858000209
-
The sirtuin sirt6 regulates lifespan in male mice
-
Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012; 483: 218-221
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
Naiman, S.2
Amir, G.3
Peshti, V.4
Zinman, G.5
Nahum, L.6
-
15
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144: 646-674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
17
-
-
4944245398
-
Human sirt1 interacts with histone h1 and promotes formation of facultative heterochromatin
-
Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 2004; 16: 93-105
-
(2004)
Mol Cell
, vol.16
, pp. 93-105
-
-
Vaquero, A.1
Scher, M.2
Lee, D.3
Erdjument-Bromage, H.4
Tempst, P.5
Reinberg, D.6
-
18
-
-
70349138701
-
The conserved role of sirtuins in chromatin regulation
-
Vaquero A. The conserved role of sirtuins in chromatin regulation. Int J Dev Biol 2009; 53: 303-322
-
(2009)
Int J Dev Biol
, vol.53
, pp. 303-322
-
-
Vaquero, A.1
-
19
-
-
0034193776
-
Sir2 links chromatin silencing, metabolism, and aging
-
Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 2000; 14: 1021-1026
-
(2000)
Genes Dev
, vol.14
, pp. 1021-1026
-
-
Guarente, L.1
-
20
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005; 37: 391-400
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
-
22
-
-
34547875773
-
Sirtuins: Critical regulators at the crossroads between cancer and aging
-
Saunders LR, Verdin E. Sirtuins: Critical regulators at the crossroads between cancer and aging. Oncogene 2007; 26: 5489-5504
-
(2007)
Oncogene
, vol.26
, pp. 5489-5504
-
-
Saunders, L.R.1
Verdin, E.2
-
23
-
-
0037207475
-
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
-
McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003; 23: 38-54
-
(2003)
Mol Cell Biol
, vol.23
, pp. 38-54
-
-
McBurney, M.W.1
Yang, X.2
Jardine, K.3
Hixon, M.4
Boekelheide, K.5
Webb, J.R.6
-
24
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 2003; 100: 10794-10799
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
-
25
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008; 14: 312-323
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
Xiao, C.6
-
26
-
-
56749156405
-
Sirt1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008; 135: 907-918
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
McVay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
-
27
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, et al. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 2008; 3: E2020
-
(2008)
PLoS One
, vol.3
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
Oberdoerffer, P.4
Ogino, S.5
Campbell, J.6
-
28
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23: P 2369-2380
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
-
29
-
-
70350764831
-
NF-kappaB signaling pathway, inflammation and colorectal cancer
-
Wang S, Liu Z, Wang L, Zhang X. NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol 2009; 6: 327-334
-
(2009)
Cell Mol Immunol
, vol.6
, pp. 327-334
-
-
Wang, S.1
Liu, Z.2
Wang, L.3
Zhang, X.4
-
30
-
-
53149144656
-
Interplay among brca1 sirt1, and survivin during brca1-Associated tumorigenesis
-
Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, et al. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated tumorigenesis. Mol Cell 2008; 32: 11-20
-
(2008)
Mol Cell
, vol.32
, pp. 11-20
-
-
Wang, R.H.1
Zheng, Y.2
Kim, H.S.3
Xu, X.4
Cao, L.5
Luhasen, T.6
-
31
-
-
84866386083
-
Sirt1 and c-myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
-
Jang KY, Noh SJ, Lehwald N, Tao GZ, Bellovin DI, Park HS, et al. SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. PLoS One 2012; 7: E45119
-
(2012)
PLoS One
, vol.7
-
-
Jang, K.Y.1
Noh, S.J.2
Lehwald, N.3
Tao, G.Z.4
Bellovin, D.I.5
Park, H.S.6
-
32
-
-
79960391940
-
MiR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
-
Eades G, Yao Y, Yang M, Zhang Y, Chumsri S, Zhou Q. miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem 2011; 286: 25992-26002
-
(2011)
J Biol Chem
, vol.286
, pp. 25992-26002
-
-
Eades, G.1
Yao, Y.2
Yang, M.3
Zhang, Y.4
Chumsri, S.5
Zhou, Q.6
-
33
-
-
67650348173
-
Expression of dbc1 and sirt1 is associated with poor prognosis of gastric carcinoma
-
Cha EJ, Noh SJ, Kwon KS, Kim CY, Park BH, Park HS, et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 2009; 15: 4453-4459
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4453-4459
-
-
Cha, E.J.1
Noh, S.J.2
Kwon, K.S.3
Kim, C.Y.4
Park, B.H.5
Park, H.S.6
-
34
-
-
34547100073
-
Sirt1 is significantly elevated in mouse and human prostate cancer
-
Huffman DM, Grizzle WE, Bamman MM, Kim JS, Eltoum IA, Elgavish A, et al. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 2007; 67: 6612-6618
-
(2007)
Cancer Res
, vol.67
, pp. 6612-6618
-
-
Huffman, D.M.1
Grizzle, W.E.2
Bamman, M.M.3
Kim, J.S.4
Eltoum, I.A.5
Elgavish, A.6
-
35
-
-
63649125404
-
Role of sirtuin histone deacetylase sirt1 in prostate cancer a target for prostate cancer management via its inhibition
-
Jung-Hynes B, Nihal M, Zhong W, Ahmad N. Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem 2009; 284: 3823-3832
-
(2009)
J Biol Chem
, vol.284
, pp. 3823-3832
-
-
Jung-Hynes, B.1
Nihal, M.2
Zhong, W.3
Ahmad, N.4
-
36
-
-
84865535247
-
High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells
-
Kozako T, Aikawa A, Shoji T, Fujimoto T, Yoshimitsu M, Shirasawa S, et al. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. Int J Cancer 2012; 131: 2044-2055
-
(2012)
Int J Cancer
, vol.131
, pp. 2044-2055
-
-
Kozako, T.1
Aikawa, A.2
Shoji, T.3
Fujimoto, T.4
Yoshimitsu, M.5
Shirasawa, S.6
-
37
-
-
84862804268
-
Histone deacetylase in chronic lymphocytic leukemia
-
Wang JC, Kafeel MI, Avezbakiyev B, Chen C, Sun Y, Rathnasabapathy C, et al. Histone deacetylase in chronic lymphocytic leukemia. Oncology 2011; 81: 325-329
-
(2011)
Oncology
, vol.81
, pp. 325-329
-
-
Wang, J.C.1
Kafeel, M.I.2
Avezbakiyev, B.3
Chen, C.4
Sun, Y.5
Rathnasabapathy, C.6
-
38
-
-
53449083751
-
Sirt1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
-
Jang KY, Hwang SH, Kwon KS, Kim KR, Choi HN, Lee NR, et al. SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. Am J Surg Pathol 2008; 32: 1523-1531
-
(2008)
Am J Surg Pathol
, vol.32
, pp. 1523-1531
-
-
Jang, K.Y.1
Hwang, S.H.2
Kwon, K.S.3
Kim, K.R.4
Choi, H.N.5
Lee, N.R.6
-
39
-
-
84863116364
-
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
-
Yuan H, Wang Z, Li L, Zhang H, Modi H, Horne D, et al. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 2012; 119: 1904-1914
-
(2012)
Blood
, vol.119
, pp. 1904-1914
-
-
Yuan, H.1
Wang, Z.2
Li, L.3
Zhang, H.4
Modi, H.5
Horne, D.6
-
40
-
-
84863011183
-
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
-
Li L, Wang L, Li L, Wang Z, Ho Y, McDonald T, et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell 2012; 21: 266-281
-
(2012)
Cancer Cell
, vol.21
, pp. 266-281
-
-
Li, L.1
Wang, L.2
Li, L.3
Wang, Z.4
Ho, Y.5
McDonald, T.6
-
41
-
-
27144475816
-
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
-
Bradbury CA, Khanim FL, Hayden R, Bunce CM, White DA, Drayson MT, et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 2005; 19: 1751-1759
-
(2005)
Leukemia
, vol.19
, pp. 1751-1759
-
-
Bradbury, C.A.1
Khanim, F.L.2
Hayden, R.3
Bunce, C.M.4
White, D.A.5
Drayson, M.T.6
-
42
-
-
67650563916
-
Sirt1 is an inhibitor of proliferation and tumor formation in colon cancer
-
Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, et al. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem 2009; 284: 18210-18217
-
(2009)
J Biol Chem
, vol.284
, pp. 18210-18217
-
-
Kabra, N.1
Li, Z.2
Chen, L.3
Li, B.4
Zhang, X.5
Wang, C.6
-
43
-
-
67650691722
-
Sirt1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
-
Nosho K, Shima K, Irahara N, Kure S, Firestein R, Baba Y, et al. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 2009; 22: 922-932
-
(2009)
Mod Pathol
, vol.22
, pp. 922-932
-
-
Nosho, K.1
Shima, K.2
Irahara, N.3
Kure, S.4
Firestein, R.5
Baba, Y.6
-
44
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 2005; 123: 437-448
-
(2005)
Cell
, vol.123
, pp. 437-448
-
-
Chen, W.Y.1
Wang, D.H.2
Yen, R.C.3
Luo, J.4
Gu, W.5
Baylin, S.B.6
-
45
-
-
13844315463
-
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
-
Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci USA 2005; 102: 1859-1864
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1859-1864
-
-
Kuzmichev, A.1
Margueron, R.2
Vaquero, A.3
Preissner, T.S.4
Scher, M.5
Kirmizis, A.6
-
46
-
-
0037312934
-
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
-
Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, et al. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet 2003; 33: 197-202
-
(2003)
Nat Genet
, vol.33
, pp. 197-202
-
-
Chen, W.Y.1
Zeng, X.2
Carter, M.G.3
Morrell, C.N.4
Chiu Yen, R.W.5
Esteller, M.6
-
47
-
-
5444259434
-
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis
-
Chen WY, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, et al. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell 2004; 6: 387-398
-
(2004)
Cancer Cell
, vol.6
, pp. 387-398
-
-
Chen, W.Y.1
Cooper, T.K.2
Zahnow, C.A.3
Overholtzer, M.4
Zhao, Z.5
Ladanyi, M.6
-
48
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
-
Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 2004; 306: 2105-2108
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
49
-
-
41149149301
-
Interpretation of cytokine signaling through the transcription factors stat5a and stat5b
-
Hennighausen L, Robinson GW. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev 2008; 22: 711-721
-
(2008)
Genes Dev
, vol.22
, pp. 711-721
-
-
Hennighausen, L.1
Robinson, G.W.2
-
50
-
-
0029810923
-
Constitutive activation of stat5 by the bcr-Abl oncogene in chronic myelogenous leukemia
-
Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996; 13: 247-254
-
(1996)
Oncogene
, vol.13
, pp. 247-254
-
-
Shuai, K.1
Halpern, J.2
Ten Hoeve, J.3
Rao, X.4
Sawyers, C.L.5
-
51
-
-
0000506439
-
P210 and p190(bcr/abl) induce the tyrosine phosphorylation and dna binding activity of multiple specific stat family members
-
Ilaria Jr. RL, Van Etten RA. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 1996; 271: 31704-31710
-
(1996)
J Biol Chem
, vol.271
, pp. 31704-31710
-
-
Ilaria Jr., R.L.1
Van Etten, R.A.2
-
52
-
-
84856384698
-
The c-myc oncoprotein, the nampt enzyme, the sirt1-inhibitor dbc1, and the sirt1 deacetylase form a positive feedback loop
-
Menssen A, Hydbring P, Kapelle K, Vervoorts J, Diebold J, Luscher B, et al. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci USA 2012; 109: E187-E196
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Menssen, A.1
Hydbring, P.2
Kapelle, K.3
Vervoorts, J.4
Diebold, J.5
Luscher, B.6
-
53
-
-
65349096174
-
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
-
Yuan J, Minter-Dykhouse K, Lou Z. A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol 2009; 185: 203-211
-
(2009)
J Cell Biol
, vol.185
, pp. 203-211
-
-
Yuan, J.1
Minter-Dykhouse, K.2
Lou, Z.3
-
54
-
-
79959837062
-
Sirt1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
-
Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, et al. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet 2011; 7: E1002135
-
(2011)
PLoS Genet
, vol.7
-
-
Marshall, G.M.1
Liu, P.Y.2
Gherardi, S.3
Scarlett, C.J.4
Bedalov, A.5
Xu, N.6
-
55
-
-
80053377582
-
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
-
Mao B, Zhao G, Lv X, Chen HZ, Xue Z, Yang B, et al. Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. Int J Biochem Cell Biol 2011; 43: 1573-1581
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 1573-1581
-
-
Mao, B.1
Zhao, G.2
Lv, X.3
Chen, H.Z.4
Xue, Z.5
Yang, B.6
-
56
-
-
33748200050
-
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
-
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, et al. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol 2006; 8: 1025-1031
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1025-1031
-
-
Wang, C.1
Chen, L.2
Hou, X.3
Li, Z.4
Kabra, N.5
Ma, Y.6
-
57
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
59
-
-
34249812122
-
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
-
Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 2007; 26: 5017-5022
-
(2007)
Oncogene
, vol.26
, pp. 5017-5022
-
-
Welch, C.1
Chen, Y.2
Stallings, R.L.3
-
60
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007; 26: 745-752
-
(2007)
Mol Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
-
61
-
-
79957819926
-
MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes
-
Lages E, Guttin A, El Atifi M, Ramus C, Ipas H, Dupre I, et al. MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes. PLoS One 2011; 6: E20600
-
(2011)
PLoS One
, vol.6
-
-
Lages, E.1
Guttin, A.2
El Atifi, M.3
Ramus, C.4
Ipas, H.5
Dupre, I.6
-
62
-
-
33847035824
-
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
-
Abdelmohsen K, Pullmann Jr. R, Lal A, Kim HH, Galban S, Yang X, et al. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 2007; 25: 543-557
-
(2007)
Mol Cell
, vol.25
, pp. 543-557
-
-
Abdelmohsen, K.1
Pullmann Jr., R.2
Lal, A.3
Kim, H.H.4
Galban, S.5
Yang, X.6
-
63
-
-
77953921408
-
Role of the RNA-binding protein HuR in human renal cell carcinoma
-
Danilin S, Sourbier C, Thomas L, Lindner V, Rothhut S, Dormoy V, et al. Role of the RNA-binding protein HuR in human renal cell carcinoma. Carcinogenesis 2010; 31: 1018-1026
-
(2010)
Carcinogenesis
, vol.31
, pp. 1018-1026
-
-
Danilin, S.1
Sourbier, C.2
Thomas, L.3
Lindner, V.4
Rothhut, S.5
Dormoy, V.6
-
64
-
-
77957774913
-
Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model
-
Nowotarski SL, Shantz LM. Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model. J Biol Chem 2010; 285: 31885-31894
-
(2010)
J Biol Chem
, vol.285
, pp. 31885-31894
-
-
Nowotarski, S.L.1
Shantz, L.M.2
-
65
-
-
79959957496
-
Role of RNA binding protein HuR in ductal carcinoma in situ of the breast
-
Heinonen M, Hemmes A, Salmenkivi K, Abdelmohsen K, Vilen ST, Laakso M, et al. Role of RNA binding protein HuR in ductal carcinoma in situ of the breast. J Pathol 2011; 224: 529-539
-
(2011)
J Pathol
, vol.224
, pp. 529-539
-
-
Heinonen, M.1
Hemmes, A.2
Salmenkivi, K.3
Abdelmohsen, K.4
Vilen, S.T.5
Laakso, M.6
-
66
-
-
58149202185
-
Phosphorylation regulates SIRT1 function
-
Sasaki T, Maier B, Koclega KD, Chruszcz M, Gluba W, Stukenberg PT, et al. Phosphorylation regulates SIRT1 function. PLoS One 2008; 3: E4020
-
(2008)
PLoS One
, vol.3
-
-
Sasaki, T.1
Maier, B.2
Koclega, K.D.3
Chruszcz, M.4
Gluba, W.5
Stukenberg, P.T.6
-
67
-
-
77951225449
-
Dyrk1a and dyrk3 promote cell survival through phosphorylation and activation of sirt1
-
Guo X, Williams JG, Schug TT, Li X. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem 2010; 285: 13223-13232
-
(2010)
J Biol Chem
, vol.285
, pp. 13223-13232
-
-
Guo, X.1
Williams, J.G.2
Schug, T.T.3
Li, X.4
-
68
-
-
53649100104
-
JNK2-dependent regulation of SIRT1 protein stability
-
Ford J, Ahmed S, Allison S, Jiang M, Milner J. JNK2-dependent regulation of SIRT1 protein stability. Cell Cycle 2008; 7: 3091-3097
-
(2008)
Cell Cycle
, vol.7
, pp. 3091-3097
-
-
Ford, J.1
Ahmed, S.2
Allison, S.3
Jiang, M.4
Milner, J.5
-
69
-
-
79959355078
-
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-Terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
-
Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-Terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem 2011; 286: 22227-22234
-
(2011)
J Biol Chem
, vol.286
, pp. 22227-22234
-
-
Gao, Z.1
Zhang, J.2
Kheterpal, I.3
Kennedy, N.4
Davis, R.J.5
Ye, J.6
-
70
-
-
35748962613
-
Sirt1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
-
Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, et al. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol 2007; 9: 1253-1262
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1253-1262
-
-
Yang, Y.1
Fu, W.2
Chen, J.3
Olashaw, N.4
Zhang, X.5
Nicosia, S.V.6
-
71
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 2008; 451: 587-590
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
-
72
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 2008; 451: 583-586
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
73
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim EJ, Kho JH, Kang MR, Um SJ. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell 2007; 28: 277-290
-
(2007)
Mol Cell
, vol.28
, pp. 277-290
-
-
Kim, E.J.1
Kho, J.H.2
Kang, M.R.3
Um, S.J.4
-
74
-
-
79952007931
-
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
-
Wang B, Hasan MK, Alvarado E, Yuan H, Wu H, Chen WY. NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene 2011; 30: 907-921
-
(2011)
Oncogene
, vol.30
, pp. 907-921
-
-
Wang, B.1
Hasan, M.K.2
Alvarado, E.3
Yuan, H.4
Wu, H.5
Chen, W.Y.6
-
75
-
-
84883177488
-
Sirt1 promotes thyroid carcinogenesis driven by PTEN deficiency
-
Herranz D, Maraver A, Cañamero M, Gómez-López G, Inglada-Pérez L, Robledo M, et al. SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. Oncogene 2013; 32: 4052-4056
-
(2013)
Oncogene
, vol.32
, pp. 4052-4056
-
-
Herranz, D.1
Maraver, A.2
Cañamero, M.3
Gómez-López, G.4
Inglada-Pérez, L.5
Robledo, M.6
-
76
-
-
84873408603
-
Sirt1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
-
Wang Z, Yuan H, Roth M, Stark JM, Bhatia R, Chen WY. SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells. Oncogene 2013; 32: 589-598
-
(2013)
Oncogene
, vol.32
, pp. 589-598
-
-
Wang, Z.1
Yuan, H.2
Roth, M.3
Stark, J.M.4
Bhatia, R.5
Chen, W.Y.6
-
77
-
-
50849104569
-
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
-
O'Hagan HM, Mohammad HP, Baylin SB. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet 2008; 4: E1000155
-
(2008)
PLoS Genet
, vol.4
-
-
O'Hagan, H.M.1
Mohammad, H.P.2
Baylin, S.B.3
-
78
-
-
81255162523
-
Oxidative damage targets complexes containing dna methyltransferases sirt1, and polycomb members to promoter cpg islands
-
O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell 2011; 20: 606-619
-
(2011)
Cancer Cell
, vol.20
, pp. 606-619
-
-
O'Hagan, H.M.1
Wang, W.2
Sen, S.3
Destefano Shields, C.4
Lee, S.S.5
Zhang, Y.W.6
-
79
-
-
77952737658
-
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
-
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci USA 2010; 107: 8788-8793
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 8788-8793
-
-
Weinberg, F.1
Hamanaka, R.2
Wheaton, W.W.3
Weinberg, S.4
Joseph, J.5
Lopez, M.6
-
80
-
-
33745608455
-
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
-
Koptyra M, Falinski R, Nowicki MO, Stoklosa T, Majsterek I, Nieborowska-Skorska M, et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 2006; 108: 319-327
-
(2006)
Blood
, vol.108
, pp. 319-327
-
-
Koptyra, M.1
Falinski, R.2
Nowicki, M.O.3
Stoklosa, T.4
Majsterek, I.5
Nieborowska-Skorska, M.6
-
81
-
-
9444264703
-
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen speciesdependent DNA double-strand breaks
-
Nowicki MO, Falinski R, Koptyra M, Slupianek A, Stoklosa T, Gloc E, et al. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen speciesdependent DNA double-strand breaks. Blood 2004; 104: 3746-3753
-
(2004)
Blood
, vol.104
, pp. 3746-3753
-
-
Nowicki, M.O.1
Falinski, R.2
Koptyra, M.3
Slupianek, A.4
Stoklosa, T.5
Gloc, E.6
-
82
-
-
30344461008
-
BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
-
Slupianek A, Nowicki MO, Koptyra M, Skorski T. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst) 2006; 5: 243-250
-
(2006)
DNA Repair (Amst
, vol.5
, pp. 243-250
-
-
Slupianek, A.1
Nowicki, M.O.2
Koptyra, M.3
Skorski, T.4
-
83
-
-
84867152993
-
Accelerating cancer evolution: A dark side of SIRT1 in genome maintenance
-
Chen WY. Accelerating cancer evolution: A dark side of SIRT1 in genome maintenance. Oncotarget 2012; 3: 363-364
-
(2012)
Oncotarget
, vol.3
, pp. 363-364
-
-
Chen, W.Y.1
-
84
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128: 683-692
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
85
-
-
83255186739
-
Sirt1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
-
Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, et al. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol 2011; 31: 4720-4734
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4720-4734
-
-
Peng, L.1
Yuan, Z.2
Ling, H.3
Fukasawa, K.4
Robertson, K.5
Olashaw, N.6
-
86
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
Widschwendter M, Fiegl H, Egle D, Mueller-Holzner E, Spizzo G, Marth C, et al. Epigenetic stem cell signature in cancer. Nat Genet 2007; 39: 157-158
-
(2007)
Nat Genet
, vol.39
, pp. 157-158
-
-
Widschwendter, M.1
Fiegl, H.2
Egle, D.3
Mueller-Holzner, E.4
Spizzo, G.5
Marth, C.6
-
87
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
-
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007; 39: 237-242
-
(2007)
Nat Genet
, vol.39
, pp. 237-242
-
-
Ohm, J.E.1
McGarvey, K.M.2
Yu, X.3
Cheng, L.4
Schuebel, K.E.5
Cope, L.6
-
88
-
-
0036830642
-
Role of histone H3 lysine 27 methylation in Polycomb-group silencing
-
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039-1043
-
(2002)
Science
, vol.298
, pp. 1039-1043
-
-
Cao, R.1
Wang, L.2
Wang, H.3
Xia, L.4
Erdjument-Bromage, H.5
Tempst, P.6
-
89
-
-
79955513100
-
Aberrations of EZH2 in cancer
-
Chase A, Cross NC. Aberrations of EZH2 in cancer. Clin Cancer Res 2011; 17: 2613-2618
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2613-2618
-
-
Chase, A.1
Cross, N.C.2
-
90
-
-
6944253702
-
SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex
-
Furuyama T, Banerjee R, Breen TR, Harte PJ. SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex. Curr Biol 2004; 14: 1812-1821
-
(2004)
Curr Biol
, vol.14
, pp. 1812-1821
-
-
Furuyama, T.1
Banerjee, R.2
Breen, T.R.3
Harte, P.J.4
-
91
-
-
33645768490
-
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
-
Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2006; 2: E40
-
(2006)
PLoS Genet
, vol.2
-
-
Pruitt, K.1
Zinn, R.L.2
Ohm, J.E.3
McGarvey, K.M.4
Kang, S.H.5
Watkins, D.N.6
-
92
-
-
36248954501
-
Sirt1 regulates the histone methyl-Transferase SUV39H1 during heterochromatin formation
-
Vaquero A, Scher M, Erdjument-Bromage H, Tempst P, Serrano L, Reinberg D. SIRT1 regulates the histone methyl-Transferase SUV39H1 during heterochromatin formation. Nature 2007; 450: 440-444
-
(2007)
Nature
, vol.450
, pp. 440-444
-
-
Vaquero, A.1
Scher, M.2
Erdjument-Bromage, H.3
Tempst, P.4
Serrano, L.5
Reinberg, D.6
-
93
-
-
43049169926
-
Epigenetic control of rDNA loci in response to intracellular energy status
-
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, et al. Epigenetic control of rDNA loci in response to intracellular energy status. Cell 2008; 133: 627-639
-
(2008)
Cell
, vol.133
, pp. 627-639
-
-
Murayama, A.1
Ohmori, K.2
Fujimura, A.3
Minami, H.4
Yasuzawa-Tanaka, K.5
Kuroda, T.6
-
94
-
-
0035913903
-
Hsir2(sirt1) functions as an nad-dependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001; 107: 149-159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
-
95
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001; 107: 137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
-
96
-
-
33845396682
-
Sirt1 interacts with p73 and suppresses p73-dependent transcriptional activity
-
Dai JM, Wang ZY, Sun DC, Lin RX, Wang SQ. SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J Cell Physiol 2007; 210: 161-166
-
(2007)
J Cell Physiol
, vol.210
, pp. 161-166
-
-
Dai, J.M.1
Wang, Z.Y.2
Sun, D.C.3
Lin, R.X.4
Wang, S.Q.5
-
97
-
-
64849113485
-
Control of mitochondrial apoptosis by the bcl-2 family
-
Brunelle JK, Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 2009; 122(Pt 4): 437-441
-
(2009)
J Cell Sci
, vol.122
, Issue.PART 4
, pp. 437-441
-
-
Brunelle, J.K.1
Letai, A.2
-
98
-
-
0037385609
-
Ku70 suppresses the apoptotic translocation of bax to mitochondria
-
Sawada M, Sun W, Hayes P, Leskov K, Boothman DA, Matsuyama S. Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol 2003; 5: 320-329
-
(2003)
Nat Cell Biol
, vol.5
, pp. 320-329
-
-
Sawada, M.1
Sun, W.2
Hayes, P.3
Leskov, K.4
Boothman, D.A.5
Matsuyama, S.6
-
99
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004; 305: 390-392
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
-
100
-
-
0036898253
-
Acetylation inactivates the transcriptional repressor BCL6
-
Bereshchenko OR, Gu W, Dalla-Favera R. Acetylation inactivates the transcriptional repressor BCL6. Nat Genet 2002; 32: 606-613
-
(2002)
Nat Genet
, vol.32
, pp. 606-613
-
-
Bereshchenko, O.R.1
Gu, W.2
Dalla-Favera, R.3
-
101
-
-
0033680860
-
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
-
Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000; 13: 199-212
-
(2000)
Immunity
, vol.13
, pp. 199-212
-
-
Shaffer, A.L.1
Yu, X.2
He, Y.3
Boldrick, J.4
Chan, E.P.5
Staudt, L.M.6
-
102
-
-
0027495491
-
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
-
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993; 262: 747-750
-
(1993)
Science
, vol.262
, pp. 747-750
-
-
Ye, B.H.1
Lista, F.2
Lo Coco, F.3
Knowles, D.M.4
Offit, K.5
Chaganti, R.S.6
-
103
-
-
0027306091
-
C BastardLAZ3 a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas
-
Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G. and C. BastardLAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat Genet 1993; 5: 66-70
-
(1993)
Nat Genet
, vol.5
, pp. 66-70
-
-
Kerckaert, J.P.1
Deweindt, C.2
Tilly, H.3
Quief, S.4
Lecocq, G.5
-
104
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 2006; 66: 4368-4377
-
(2006)
Cancer Res
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
Gatbonton, T.2
Schuler, A.D.3
Posakony, J.4
Li, H.5
Goehle, S.6
-
105
-
-
28544451205
-
Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1
-
Chu F, Chou PM, Zheng X, Mirkin BL, Rebbaa A. Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. Cancer Res 2005; 65: 10183-10187
-
(2005)
Cancer Res
, vol.65
, pp. 10183-10187
-
-
Chu, F.1
Chou, P.M.2
Zheng, X.3
Mirkin, B.L.4
Rebbaa, A.5
-
106
-
-
77958126835
-
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
-
Oh WK, Cho KB, Hien TT, Kim TH, Kim HS, Dao TT, et al. Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol Pharmacol 2010; 78: 855-864
-
(2010)
Mol Pharmacol
, vol.78
, pp. 855-864
-
-
Oh, W.K.1
Cho, K.B.2
Hien, T.T.3
Kim, T.H.4
Kim, H.S.5
Dao, T.T.6
-
107
-
-
77952714326
-
Sirt1 regulates dishevelled proteins and promotes transient and constitutive Wnt signaling
-
Holloway KR, Calhoun TN, Saxena M, Metoyer CF, Kandler EF, Rivera CA, et al. SIRT1 regulates dishevelled proteins and promotes transient and constitutive Wnt signaling. Proc Natl Acad Sci USA 2010; 107: 9216-9221
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 9216-9221
-
-
Holloway, K.R.1
Calhoun, T.N.2
Saxena, M.3
Metoyer, C.F.4
Kandler, E.F.5
Rivera, C.A.6
-
108
-
-
84872781106
-
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
-
Kriegl L, Vieth M, Kirchner T, Menssen A. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. Oncotarget 2012; 3: 1182-1193
-
(2012)
Oncotarget
, vol.3
, pp. 1182-1193
-
-
Kriegl, L.1
Vieth, M.2
Kirchner, T.3
Menssen, A.4
-
109
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
-
110
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004; 116: 551-563
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
-
111
-
-
3142742707
-
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1
-
Van Der Horst A, Tertoolen LG, De Vries-Smits LM, Frye RA, Medema RH, Burgering BM. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 2004; 279: 28873-28879
-
(2004)
J Biol Chem
, vol.279
, pp. 28873-28879
-
-
Van Der Horst, A.1
Tertoolen, L.G.2
De Vries-Smits, L.M.3
Frye, R.A.4
Medema, R.H.5
Burgering, B.M.6
-
112
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 2004; 101: 10042-10047
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
Aratani, S.4
Ohshima, T.5
Miyagishi, M.6
-
113
-
-
41849108086
-
Many forks in the path: Cycling with foxo
-
Ho KK, Myatt SS, Lam EW. Many forks in the path: Cycling with FoxO. Oncogene 2008; 27: 2300-2311
-
(2008)
Oncogene
, vol.27
, pp. 2300-2311
-
-
Ho, K.K.1
Myatt, S.S.2
Lam, E.W.3
-
114
-
-
49849093007
-
Unravelling the tumor-suppressive functions of FOXO proteins
-
Dansen TB, Burgering BM. Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol 2008; 18: 421-429
-
(2008)
Trends Cell Biol
, vol.18
, pp. 421-429
-
-
Dansen, T.B.1
Burgering, B.M.2
-
115
-
-
84858795617
-
Deacetylation of foxo3 by sirt1 or sirt2 leads to skp2-mediated foxo3 ubiquitination and degradation
-
Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene 2012; 31: 1546-1557
-
(2012)
Oncogene
, vol.31
, pp. 1546-1557
-
-
Wang, F.1
Chan, C.H.2
Chen, K.3
Guan, X.4
Lin, H.K.5
Tong, Q.6
-
116
-
-
79955926985
-
Acetylation-dependent regulation of endothelial notch signalling by the SIRT1 deacetylase
-
Guarani V, Deflorian G, Franco CA, Kruger M, Phng LK, Bentley K, et al. Acetylation-dependent regulation of endothelial notch signalling by the SIRT1 deacetylase. Nature 2011; 473: 234-238
-
(2011)
Nature
, vol.473
, pp. 234-238
-
-
Guarani, V.1
Deflorian, G.2
Franco, C.A.3
Kruger, M.4
Phng, L.K.5
Bentley, K.6
-
117
-
-
35348980724
-
Sirt1 controls endothelial angiogenic functions during vascular growth
-
Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, et al. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 2007; 21: 2644-2658
-
(2007)
Genes Dev
, vol.21
, pp. 2644-2658
-
-
Potente, M.1
Ghaeni, L.2
Baldessari, D.3
Mostoslavsky, R.4
Rossig, L.5
Dequiedt, F.6
-
118
-
-
84866523750
-
Sirt1 regulates endothelial notch signaling in lung cancer
-
Xie M, Liu M, He CS. SIRT1 regulates endothelial notch signaling in lung cancer. PLoS One 2012; 7: E45331
-
(2012)
PLoS One
, vol.7
-
-
Xie, M.1
Liu, M.2
He, C.S.3
-
119
-
-
35549008884
-
Sirt1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, et al. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 2007; 104: 14855-14860
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14855-14860
-
-
Mattagajasingh, I.1
Kim, C.S.2
Naqvi, A.3
Yamamori, T.4
Hoffman, T.A.5
Jung, S.B.6
-
120
-
-
84867901275
-
Sirt1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
-
Byles V, Zhu L, Lovaas JD, Chmilewski LK, Wang J, Faller DV, et al. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene 2012; 31: 4619-4629
-
(2012)
Oncogene
, vol.31
, pp. 4619-4629
-
-
Byles, V.1
Zhu, L.2
Lovaas, J.D.3
Chmilewski, L.K.4
Wang, J.5
Faller, D.V.6
-
121
-
-
78650878686
-
HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention
-
Monti E, Gariboldi MB. HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention. Curr Mol Pharmacol 2011; 4: 62-77
-
(2011)
Curr Mol Pharmacol
, vol.4
, pp. 62-77
-
-
Monti, E.1
Gariboldi, M.B.2
-
122
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 2001; 292: 464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
-
123
-
-
0035917808
-
Targeting of hif-Alpha to the von hippel-lindau ubiquitylation complex by o2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, et al. Targeting of HIF-Alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001; 292: 468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
-
124
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
-
Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 2010; 38: 864-878
-
(2010)
Mol Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
Lee, Y.M.2
Chun, Y.S.3
Chen, J.4
Kim, J.E.5
Park, J.W.6
-
125
-
-
84859113488
-
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1alpha protein under hypoxic conditions
-
Laemmle A, Lechleiter A, Roh V, Schwarz C, Portmann S, Furer C, et al. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1alpha protein under hypoxic conditions. PLoS One 2012; 7: E33433
-
(2012)
PLoS One
, vol.7
-
-
Laemmle, A.1
Lechleiter, A.2
Roh, V.3
Schwarz, C.4
Portmann, S.5
Furer, C.6
-
126
-
-
66749129781
-
Regulation of hypoxia-inducible factor 2 alpha signaling by the stress-responsive deacetylase sirtuin 1
-
Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, et al. Regulation of hypoxia-inducible factor 2 alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 2009; 324: 1289-1293
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
Chen, R.2
Alexander, M.S.3
Zhang, Q.4
Hogg, R.T.5
Gerard, R.D.6
-
127
-
-
77952896646
-
TGFbeta signalling: A complex web in cancer progression
-
Ikushima H, Miyazono K. TGFbeta signalling: A complex web in cancer progression. Nat Rev Cancer 2010; 10: 415-424
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 415-424
-
-
Ikushima, H.1
Miyazono, K.2
-
128
-
-
0032480226
-
DNA hypomethylation leads to elevated mutation rates
-
Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R. DNA hypomethylation leads to elevated mutation rates. Nature 1998; 395: 89-93
-
(1998)
Nature
, vol.395
, pp. 89-93
-
-
Chen, R.Z.1
Pettersson, U.2
Beard, C.3
Jackson-Grusby, L.4
Jaenisch, R.5
-
129
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003; 300: 455
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
130
-
-
33646550204
-
Sirt2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
-
Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, et al. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev 2006; 20: 1256-1261
-
(2006)
Genes Dev
, vol.20
, pp. 1256-1261
-
-
Vaquero, A.1
Scher, M.B.2
Lee, D.H.3
Sutton, A.4
Cheng, H.L.5
Alt, F.W.6
-
131
-
-
39149122568
-
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
-
North BJ, Verdin E. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One 2007; 2: E784
-
(2007)
PLoS One
, vol.2
-
-
North, B.J.1
Verdin, E.2
-
132
-
-
65549113750
-
CBP/p300-mediated acetylation of histone H3 on lysine 56
-
Das C, Lucia MS, Hansen KC, Tyler JK. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 2009; 459: 113-117
-
(2009)
Nature
, vol.459
, pp. 113-117
-
-
Das, C.1
Lucia, M.S.2
Hansen, K.C.3
Tyler, J.K.4
-
133
-
-
0037291214
-
The human Sir2 ortholog, SIRT2, is an NAD.-dependent tubulin deacetylase
-
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD.-dependent tubulin deacetylase. Mol Cell 2003; 11: 437-444
-
(2003)
Mol Cell
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
134
-
-
34547397081
-
Sirt2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
-
Jing E, Gesta S, Kahn CR. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 2007; 6: 105-114
-
(2007)
Cell Metab
, vol.6
, pp. 105-114
-
-
Jing, E.1
Gesta, S.2
Kahn, C.R.3
-
135
-
-
77954225200
-
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
-
Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol 2010; 12: 665-675
-
(2010)
Nat Cell Biol
, vol.12
, pp. 665-675
-
-
Zhao, Y.1
Yang, J.2
Liao, W.3
Liu, X.4
Zhang, H.5
Wang, S.6
-
136
-
-
34447626095
-
Sirt2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
-
Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007; 6: 505-514
-
(2007)
Aging Cell
, vol.6
, pp. 505-514
-
-
Wang, F.1
Nguyen, M.2
Qin, F.X.3
Tong, Q.4
-
137
-
-
39749143163
-
Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53
-
Jin YH, Kim YJ, Kim DW, Baek KH, Kang BY, Yeo CY, et al. Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun 2008; 368: 690-695
-
(2008)
Biochem Biophys Res Commun
, vol.368
, pp. 690-695
-
-
Jin, Y.H.1
Kim, Y.J.2
Kim, D.W.3
Baek, K.H.4
Kang, B.Y.5
Yeo, C.Y.6
-
138
-
-
78650638268
-
Sirt2 down-regulation in hela can induce p53 accumulation via p38 mapk activationdependent p300 decrease, eventually leading to apoptosis
-
Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A, et al. SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activationdependent p300 decrease, eventually leading to apoptosis. Genes Cells 2011; 16: 34-45
-
(2011)
Genes Cells
, vol.16
, pp. 34-45
-
-
Li, Y.1
Matsumori, H.2
Nakayama, Y.3
Osaki, M.4
Kojima, H.5
Kurimasa, A.6
-
139
-
-
77950835404
-
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
-
Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther 2010; 9: 844-855
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 844-855
-
-
Peck, B.1
Chen, C.Y.2
Ho, K.K.3
Di Fruscia, P.4
Myatt, S.S.5
Coombes, R.C.6
-
140
-
-
84870999850
-
The naddependent deacetylase sirt2 is required for programmed necrosis
-
Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, et al. The NADdependent deacetylase SIRT2 is required for programmed necrosis. Nature 2012; 492: 199-204
-
(2012)
Nature
, vol.492
, pp. 199-204
-
-
Narayan, N.1
Lee, I.H.2
Borenstein, R.3
Sun, J.4
Wong, R.5
Tong, G.6
-
141
-
-
34248151365
-
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation
-
Inoue T, Hiratsuka M, Osaki M, Oshimura M. The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 2007; 6: 1011-1018
-
(2007)
Cell Cycle
, vol.6
, pp. 1011-1018
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Oshimura, M.4
-
142
-
-
80054769188
-
Sirt2 maintains genome integrity and suppresses tumorigenesis through regulating apc/c activity
-
Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 2011; 20: 487-499
-
(2011)
Cancer Cell
, vol.20
, pp. 487-499
-
-
Kim, H.S.1
Vassilopoulos, A.2
Wang, R.H.3
Lahusen, T.4
Xiao, Z.5
Xu, X.6
-
143
-
-
84856628731
-
Dietary obesity-Associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD. System
-
Krishnan J, Danzer C, Simka T, Ukropec J, Walter KM, Kumpf S, et al. Dietary obesity-Associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD. system. Genes Dev 2012; 26: 259-270
-
(2012)
Genes Dev
, vol.26
, pp. 259-270
-
-
Krishnan, J.1
Danzer, C.2
Simka, T.3
Ukropec, J.4
Walter, K.M.5
Kumpf, S.6
-
144
-
-
34547920351
-
Mutations in sirt2 deacetylase which regulate enzymatic activity but not its interaction with hdac6 and tubulin
-
Nahhas F, Dryden SC, Abrams J, Tainsky MA. Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin. Mol Cell Biochem 2007; 303: 221-230
-
(2007)
Mol Cell Biochem
, vol.303
, pp. 221-230
-
-
Nahhas, F.1
Dryden, S.C.2
Abrams, J.3
Tainsky, M.A.4
-
145
-
-
0041829415
-
Proteomics-based identification of differentially expressed genes in human gliomas: Down-regulation of SIRT2 gene
-
Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, et al. Proteomics-based identification of differentially expressed genes in human gliomas: Down-regulation of SIRT2 gene. Biochem Biophys Res Commun 2003; 309: 558-566
-
(2003)
Biochem Biophys Res Commun
, vol.309
, pp. 558-566
-
-
Hiratsuka, M.1
Inoue, T.2
Toda, T.3
Kimura, N.4
Shirayoshi, Y.5
Kamitani, H.6
-
146
-
-
27644534576
-
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
-
Lennerz V, Fatho M, Gentilini C, Frye RA, Lifke A, Ferel D, et al. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Proc Natl Acad Sci USA 2005; 102: 16013-16018
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16013-16018
-
-
Lennerz, V.1
Fatho, M.2
Gentilini, C.3
Frye, R.A.4
Lifke, A.5
Ferel, D.6
-
147
-
-
78649704141
-
A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
-
Peters CJ, Rees JR, Hardwick RH, Hardwick JS, Vowler SL, Ong CA, et al. A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Gastroenterology 2010; 139: 1995-2004
-
(2010)
Gastroenterology
, vol.139
, pp. 1995-2004
-
-
Peters, C.J.1
Rees, J.R.2
Hardwick, R.H.3
Hardwick, J.S.4
Vowler, S.L.5
Ong, C.A.6
-
148
-
-
33847053144
-
Sirt2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
-
Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S, et al. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene 2007; 26: 945-957
-
(2007)
Oncogene
, vol.26
, pp. 945-957
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Yamada, H.4
Kishimoto, I.5
Yamaguchi, S.6
-
149
-
-
34547098165
-
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
-
North BJ, Verdin E. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem 2007; 282: 19546-19555
-
(2007)
J Biol Chem
, vol.282
, pp. 19546-19555
-
-
North, B.J.1
Verdin, E.2
-
150
-
-
84859447698
-
The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
-
Dan L, Klimenkova O, Klimiankou M, Klusman JH, Van Den Heuvel-Eibrink MM, Reinhardt D, et al. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica 2012; 97: 551-559
-
(2012)
Haematologica
, vol.97
, pp. 551-559
-
-
Dan, L.1
Klimenkova, O.2
Klimiankou, M.3
Klusman, J.H.4
Van Den Heuvel-Eibrink, M.M.5
Reinhardt, D.6
-
151
-
-
84870063661
-
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ
-
Hou H, Chen W, Zhao L, Zuo Q, Zhang G, Zhang X, et al. Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ. J Clin Pathol 2012; 65: 1088-1096
-
(2012)
J Clin Pathol
, vol.65
, pp. 1088-1096
-
-
Hou, H.1
Chen, W.2
Zhao, L.3
Zuo, Q.4
Zhang, G.5
Zhang, X.6
-
152
-
-
84873736861
-
The histone deacetylase SIRT2 stabilizes Myc oncoproteins
-
Liu PY, Xu N, Malyukova A, Scarlett CJ, Sun YT, Zhang XD, et al. The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death Differ 2012; 20: 503-514
-
(2012)
Cell Death Differ
, vol.20
, pp. 503-514
-
-
Liu, P.Y.1
Xu, N.2
Malyukova, A.3
Scarlett, C.J.4
Sun, Y.T.5
Zhang, X.D.6
-
153
-
-
57649119787
-
Aurora A is essential for early embryonic development and tumor suppression
-
Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, et al. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem 2008; 283: 31785-31790
-
(2008)
J Biol Chem
, vol.283
, pp. 31785-31790
-
-
Lu, L.Y.1
Wood, J.L.2
Ye, L.3
Minter-Dykhouse, K.4
Saunders, T.L.5
Yu, X.6
-
154
-
-
33751085368
-
Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
-
Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T, et al. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 2006; 25: 7148-7158
-
(2006)
Oncogene
, vol.25
, pp. 7148-7158
-
-
Wang, X.1
Zhou, Y.X.2
Qiao, W.3
Tominaga, Y.4
Ouchi, M.5
Ouchi, T.6
-
155
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 2007; 27: 8807-8814
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
Alt, F.W.2
Cheng, H.L.3
Bunkenborg, J.4
Streeper, R.S.5
Mostoslavsky, R.6
-
156
-
-
34247271282
-
Sirt3 is a nuclear NAD.-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
-
Scher MB, Vaquero A, Reinberg D. SirT3 is a nuclear NAD.-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev 2007; 21: 920-928
-
(2007)
Genes Dev
, vol.21
, pp. 920-928
-
-
Scher, M.B.1
Vaquero, A.2
Reinberg, D.3
-
157
-
-
63749099484
-
A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein
-
Cooper HM, Huang JY, Verdin E, Spelbrink JN. A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One 2009; 4: E4986
-
(2009)
PLoS One
, vol.4
-
-
Cooper, H.M.1
Huang, J.Y.2
Verdin, E.3
Spelbrink, J.N.4
-
158
-
-
0037135972
-
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
-
Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 2002; 158: 647-657
-
(2002)
J Cell Biol
, vol.158
, pp. 647-657
-
-
Schwer, B.1
North, B.J.2
Frye, R.A.3
Ott, M.4
Verdin, E.5
-
159
-
-
77953287165
-
Mitochondrial sirtuins
-
Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochim Biophys Acta 2010; 1804: 1645-1651
-
(2010)
Biochim Biophys Acta
, vol.1804
, pp. 1645-1651
-
-
Huang, J.Y.1
Hirschey, M.D.2
Shimazu, T.3
Ho, L.4
Verdin, E.5
-
160
-
-
78649328799
-
Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling
-
Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling. Trends Biochem Sci 2010; 35: 669-675
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 669-675
-
-
Verdin, E.1
Hirschey, M.D.2
Finley, L.W.3
Haigis, M.C.4
-
161
-
-
77950806433
-
Sirt3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation. Nature 2010; 464: 121-125
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
-
162
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, et al. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 2008; 105: 14447-14452
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
-
163
-
-
77954675024
-
Involvement of oxidatively damaged DNA and repair in cancer development and aging
-
Tudek B, Winczura A, Janik J, Siomek A, Foksinski M, Olinski R. Involvement of oxidatively damaged DNA and repair in cancer development and aging. Am J Transl Res 2010; 2: 254-284
-
(2010)
Am J Transl Res
, vol.2
, pp. 254-284
-
-
Tudek, B.1
Winczura, A.2
Janik, J.3
Siomek, A.4
Foksinski, M.5
Olinski, R.6
-
164
-
-
74049094817
-
Sirt3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
-
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010; 17: 41-52
-
(2010)
Cancer Cell
, vol.17
, pp. 41-52
-
-
Kim, H.S.1
Patel, K.2
Muldoon-Jacobs, K.3
Bisht, K.S.4
Aykin-Burns, N.5
Pennington, J.D.6
-
165
-
-
79959819034
-
Sirt3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production
-
Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Oncogene 2011; 30: 2986-2996
-
(2011)
Oncogene
, vol.30
, pp. 2986-2996
-
-
Bell, E.L.1
Emerling, B.M.2
Ricoult, S.J.3
Guarente, L.4
-
166
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 2010; 40: 893-904
-
(2010)
Mol Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
Coleman, M.C.2
Pennington, J.D.3
Ozden, O.4
Park, S.H.5
Jiang, H.6
-
167
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662-667
-
(2010)
Cell Metab
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
168
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010; 143: 802-812
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
Yu, W.2
Hallows, W.C.3
Xu, J.4
Vann, J.M.5
Leeuwenburgh, C.6
-
169
-
-
70349208608
-
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3adependent antioxidant defense mechanisms in mice
-
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3adependent antioxidant defense mechanisms in mice. J Clin Invest 2009; 119: 2758-2771
-
(2009)
J Clin Invest
, vol.119
, pp. 2758-2771
-
-
Sundaresan, N.R.1
Gupta, M.2
Kim, G.3
Rajamohan, S.B.4
Isbatan, A.5
Gupta, M.P.6
-
170
-
-
79952501323
-
Sirt3 opposes reprogramming of cancer cell metabolism through hif1alpha destabilization
-
Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, et al. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization. Cancer Cell 2011; 19: 416-428
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
Carracedo, A.2
Lee, J.3
Souza, A.4
Egia, A.5
Zhang, J.6
-
171
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
172
-
-
84861161546
-
Sirt3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ros, the warburg effect, and carcinogenesis
-
Haigis MC, Deng CX, Finley LW, Kim HS, Gius D. SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res 2010; 72: 2468-2472
-
(2010)
Cancer Res
, vol.72
, pp. 2468-2472
-
-
Haigis, M.C.1
Deng, C.X.2
Finley, L.W.3
Kim, H.S.4
Gius, D.5
-
173
-
-
84863618431
-
Acetylationdependent regulation of Skp2 function
-
Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, et al. Acetylationdependent regulation of Skp2 function. Cell 2012; 150: 179-193
-
(2012)
Cell
, vol.150
, pp. 179-193
-
-
Inuzuka, H.1
Gao, D.2
Finley, L.W.3
Yang, W.4
Wan, L.5
Fukushima, H.6
-
174
-
-
44349122993
-
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: Tipping the scales of cancer
-
Frescas D, Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: Tipping the scales of cancer. Nat Rev Cancer 2008; 8: 438-449
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 438-449
-
-
Frescas, D.1
Pagano, M.2
-
176
-
-
79953799195
-
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer
-
Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, et al. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer 2011; 117: 1670-1678
-
(2011)
Cancer
, vol.117
, pp. 1670-1678
-
-
Alhazzazi, T.Y.1
Kamarajan, P.2
Joo, N.3
Huang, J.Y.4
Verdin, E.5
D'Silva, N.J.6
-
177
-
-
77956295588
-
P53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase
-
Li S, Banck M, Mujtaba S, Zhou MM, Sugrue MM, Walsh MJ. p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One 2010; 5: E10486
-
(2010)
PLoS One
, vol.5
-
-
Li, S.1
Banck, M.2
Mujtaba, S.3
Zhou, M.M.4
Sugrue, M.M.5
Walsh, M.J.6
-
178
-
-
53549105529
-
Sirt3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
-
Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol 2008; 28: 6384-6401
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6384-6401
-
-
Sundaresan, N.R.1
Samant, S.A.2
Pillai, V.B.3
Rajamohan, S.B.4
Gupta, M.P.5
-
179
-
-
33748316536
-
Sirt4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
-
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006; 126: 941-954
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
Fahie, K.4
Christodoulou, D.C.5
Murphy, A.J.6
-
180
-
-
0035872934
-
Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria
-
Herrero-Yraola A, Bakhit SM, Franke P, Weise C, Schweiger M, Jorcke D, et al. Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria. Embo J 2001; 20: 2404-2412
-
(2001)
Embo J
, vol.20
, pp. 2404-2412
-
-
Herrero-Yraola, A.1
Bakhit, S.M.2
Franke, P.3
Weise, C.4
Schweiger, M.5
Jorcke, D.6
-
181
-
-
34548627517
-
Nutrient-sensitive mitochondrial NAD. Levels dictate cell survival
-
Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, et al. Nutrient-sensitive mitochondrial NAD. levels dictate cell survival. Cell 2007; 130: 1095-1107
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.1
Yang, T.2
Baur, J.A.3
Perez, E.4
Matsui, T.5
Carmona, J.J.6
-
182
-
-
84862632865
-
Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, et al. Inhibition of
-
(2012)
Genes Dev
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
Ma, S.4
Lin, H.5
Zhu, H.6
-
183
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011; 19: 17-30
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
-
184
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010; 18: 553-567
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
185
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012; 483: 474-478
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Turcan, S.5
Abdel-Wahab, O.6
-
186
-
-
77249128352
-
Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1
-
Ogura M, Nakamura Y, Tanaka D, Zhuang X, Fujita Y, Obara A, et al. Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1. Biochem Biophys Res Commun 2010; 393: 73-78
-
(2010)
Biochem Biophys Res Commun
, vol.393
, pp. 73-78
-
-
Ogura, M.1
Nakamura, Y.2
Tanaka, D.3
Zhuang, X.4
Fujita, Y.5
Obara, A.6
-
187
-
-
65249087389
-
Sirt5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009; 137: 560-570
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
188
-
-
84871107379
-
Mitochondrial protein acylation and intermediary metabolism: Regulation by sirtuins and implications for metabolic disease
-
Newman JC, He W, Verdin E. Mitochondrial protein acylation and intermediary metabolism: Regulation by sirtuins and implications for metabolic disease. J Biol Chem 2012; 287: 42436-42443
-
(2012)
J Biol Chem
, vol.287
, pp. 42436-42443
-
-
Newman, J.C.1
He, W.2
Verdin, E.3
-
189
-
-
20444409132
-
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
-
Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem 2005; 280: 21313-21320
-
(2005)
J Biol Chem
, vol.280
, pp. 21313-21320
-
-
Liszt, G.1
Ford, E.2
Kurtev, M.3
Guarente, L.4
-
190
-
-
41349090663
-
Sirt6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008; 452: 492-496
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
-
191
-
-
69249221533
-
Cell cycledependent deacetylation of telomeric histone h3 lysine k56 by human sirt6
-
Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, et al. Cell cycledependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle 2009; 8: 2664-2666
-
(2009)
Cell Cycle
, vol.8
, pp. 2664-2666
-
-
Michishita, E.1
McCord, R.A.2
Boxer, L.D.3
Barber, M.F.4
Hong, T.5
Gozani, O.6
-
192
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124: 315-329
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
-
193
-
-
77956550868
-
Human sirt6 promotes dna end resection through ctip deacetylation
-
Kaidi A, Weinert BT, Choudhary C, Jackson SP. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010; 329: 1348-1353
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
194
-
-
84863974838
-
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
-
Mao Z, X. Tian M, Meter Van, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci USA 2012; 109: 11800-11805
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 11800-11805
-
-
Mao, Z.1
Tian, M.X.2
Meter Van Ke, Z.3
Gorbunova, V.4
Seluanov, A.5
-
195
-
-
66049150672
-
Sirt6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
-
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, et al. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) 2009; 1: 109-121
-
(2009)
Aging (Albany NY
, vol.1
, pp. 109-121
-
-
McCord, R.A.1
Michishita, E.2
Hong, T.3
Berber, E.4
Boxer, L.D.5
Kusumoto, R.6
-
196
-
-
79959363092
-
Sirt6 promotes DNA repair under stress by activating PARP1
-
Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, et al. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011; 332: 1443-1446
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
Hine, C.2
Tian, X.3
Van Meter, M.4
Au, M.5
Vaidya, A.6
-
197
-
-
58149090925
-
Sirt6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
-
Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009; 136: 62-74
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.1
Michishita, E.2
Adler, A.S.3
Damian, M.4
Berber, E.5
Lin, M.6
-
198
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
-
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010; 140: 280-293
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
D'Urso, A.2
Toiber, D.3
Sebastian, C.4
Henry, R.E.5
Vadysirisack, D.D.6
-
199
-
-
80052908853
-
Sirt6 overexpression induces massive apoptosis in cancer cells but not in normal cells
-
Van Meter M, Mao Z, Gorbunova V, Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 2011; 10: 3153-3158
-
(2011)
Cell Cycle
, vol.10
, pp. 3153-3158
-
-
Van Meter, M.1
Mao, Z.2
Gorbunova, V.3
Seluanov, A.4
-
200
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151: 1185-1199
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastian, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
-
201
-
-
33744466971
-
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
-
Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 2006; 20: 1075-1080
-
(2006)
Genes Dev
, vol.20
, pp. 1075-1080
-
-
Ford, E.1
Voit, R.2
Liszt, G.3
Magin, C.4
Grummt, I.5
Guarente, L.6
-
202
-
-
84863453769
-
Sirt7 links H3K18 deacetylation to maintenance of oncogenic transformation
-
Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, et al. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012; 487: 114-118
-
(2012)
Nature
, vol.487
, pp. 114-118
-
-
Barber, M.F.1
Michishita-Kioi, E.2
Xi, Y.3
Tasselli, L.4
Kioi, M.5
Moqtaderi, Z.6
-
203
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, et al. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 2008; 102: 703-710
-
(2008)
Circ Res
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
Kubin, T.6
-
204
-
-
33750212896
-
Altered sirtuin expression is associated with node-positive breast cancer
-
Ashraf N, Zino S, Macintyre A, Kingsmore D, Payne AP, George WD, et al. Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer 2006; 95: 1056-1061
-
(2006)
Br J Cancer
, vol.95
, pp. 1056-1061
-
-
Ashraf, N.1
Zino, S.2
Macintyre, A.3
Kingsmore, D.4
Payne, A.P.5
George, W.D.6
-
205
-
-
0037128690
-
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
-
De Nigris F, Cerutti J, Morelli C, Califano D, Chiariotti L, Viglietto G, et al. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. Br J Cancer 2002; 86: 917-923
-
(2002)
Br J Cancer
, vol.86
, pp. 917-923
-
-
De Nigris, F.1
Cerutti, J.2
Morelli, C.3
Califano, D.4
Chiariotti, L.5
Viglietto, G.6
-
206
-
-
84874487252
-
Sirt7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b
-
Kim JK, Noh JH, Jung KH, Eun JW, Bae HJ, Kim MG, et al. SIRT7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b. Hepatology 2012; 57: 1055-1067
-
(2012)
Hepatology
, vol.57
, pp. 1055-1067
-
-
Kim, J.K.1
Noh, J.H.2
Jung, K.H.3
Eun, J.W.4
Bae, H.J.5
Kim, M.G.6
-
207
-
-
21744457108
-
Global histone modification patterns predict risk of prostate cancer recurrence
-
Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, et al. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 2005; 435: 1262-1266
-
(2005)
Nature
, vol.435
, pp. 1262-1266
-
-
Seligson, D.B.1
Horvath, S.2
Shi, T.3
Yu, H.4
Tze, S.5
Grunstein, M.6
-
208
-
-
65649142216
-
Global levels of histone modifications predict prognosis in different cancers
-
Seligson DB, Horvath S, McBrian MA, Mah V, Yu H, Tze S, et al. Global levels of histone modifications predict prognosis in different cancers. Am J Pathol 2009; 174: 1619-1628
-
(2009)
Am J Pathol
, vol.174
, pp. 1619-1628
-
-
Seligson, D.B.1
Horvath, S.2
McBrian, M.A.3
Mah, V.4
Yu, H.5
Tze, S.6
-
209
-
-
50149109481
-
Epigenetic reprogramming by adenovirus e1a
-
Ferrari R, Pellegrini M, Horwitz GA, Xie W, Berk AJ, Kurdistani SK. Epigenetic reprogramming by adenovirus e1a. Science 2008; 321: 1086-1088
-
(2008)
Science
, vol.321
, pp. 1086-1088
-
-
Ferrari, R.1
Pellegrini, M.2
Horwitz, G.A.3
Xie, W.4
Berk, A.J.5
Kurdistani, S.K.6
-
210
-
-
50149094330
-
Adenovirus small e1a alters global patterns of histone modification
-
Horwitz GA, Zhang K, McBrian MA, Grunstein M, Kurdistani SK, Berk AJ. Adenovirus small e1a alters global patterns of histone modification. Science 2008; 321: 1084-1085
-
(2008)
Science
, vol.321
, pp. 1084-1085
-
-
Horwitz, G.A.1
Zhang, K.2
McBrian, M.A.3
Grunstein, M.4
Kurdistani, S.K.5
Berk, A.J.6
-
211
-
-
53249121556
-
Sirtuins: Novel therapeutic targets to treat age-Associated diseases
-
Lavu S, Boss O, Elliott PJ, Lambert PD. Sirtuins: Novel therapeutic targets to treat age-Associated diseases. Nat Rev Drug Discov 2008; 7: 841-853
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 841-853
-
-
Lavu, S.1
Boss, O.2
Elliott, P.J.3
Lambert, P.D.4
-
212
-
-
42949114938
-
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
-
Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 2008; 13: 454-463.
-
(2008)
Cancer Cell
, vol.13
, pp. 454-463
-
-
Lain, S.1
Hollick, J.J.2
Campbell, J.3
Staples, O.D.4
Higgins, M.5
Aoubala, M.6
|