Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

Cancer

Volumn 117, Issue 8, 2011, Pages 1670-1678

  Alhazzazi, Turki Y ^a   Kamarajan, Pachiyappan ^a   Joo, Nam ^a   Huang, Jing Yi ^b   Verdin, Eric ^b   D'Silva, Nisha J ^a,c   Kapila, Yvonne L ^a  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

carcinogenesis; oral cancer; SIRT3; sirtuins; squamous cell carcinoma

Indexed keywords

CISPLATIN; NICOTINAMIDE; SIRTINOL; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHEMOSENSITIVITY; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; DRUG TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MOUSE; MOUTH CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; TISSUE MICROARRAY; TUMOR VOLUME;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MICE; MICE, NUDE; MOLECULAR TARGETED THERAPY; MOUTH NEOPLASMS; RADIATION TOLERANCE; SIRTUIN 3; UP-REGULATION;

EID: 79953799195     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25676     Document Type: Article

References (40)

1. Bsoul SA, Huber MA, Terezhalmy GT., Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J Contemp Dent Pract. 2005; 6: 1-16. (Pubitemid 41810916)
2. National Cancer Institute; Surveillance, Epidemiology, and End Results (SEER) Program. SEER Stat Fact Sheets: Oral Cavity and Pharynx. Bethesda: Md: National Cancer Institute; 2009. Accessed January 7, 2010.
3. Taylor DM, Maxwell MM, Luthi-Carter R, Kazantsev AG., Biological and potential therapeutic roles of sirtuin deacetylases. Cell Mol Life Sci. 2008; 65: 4000-4018.
4. Saunders LR, Verdin E., Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene. 2007; 26: 5489-5504. (Pubitemid 47255930)
5. Haigis MC, Guarente LP., Mammalian sirtuinsâemerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006; 20: 2913-2921. (Pubitemid 44771725)
6. Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004; 303: 2011-2015. (Pubitemid 38393275)
7. Fu M, Liu M, Sauve AA, et al. Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol. 2006; 26: 8122-8135. (Pubitemid 44631010)
8. Wang RH, Sengupta K, Li C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008; 14: 312-323.
9. Bellizzi D, Dato S, Cavalcante P, et al. Characterization of a bidirectional promoter shared between 2 human genes related to aging: SIRT3 and PSMD13. Genomics. 2007; 89: 143-150. (Pubitemid 44856231)
10. Bellizzi D, Rose G, Cavalcante P, et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics. 2005; 85: 258-263. (Pubitemid 40164791)
11. Rose G, Dato S, Altomare K, et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol. 2003; 38: 1065-1070. (Pubitemid 37324417)
12. Cooper HM, Spelbrink JN., The human SIRT3 protein deacetylase is exclusively mitochondrial. Biochem J. 2008; 411: 279-285. (Pubitemid 351580180)
13. Schwer B, North BJ, Frye RA, Ott M, Verdin E., The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002; 158: 647-657. (Pubitemid 34920104)
14. Chen XJ, Clark-Walker GD., Sir2 mutants of Kluyveromyces lactis are hypersensitive to DNA-targeting drugs. Mol Cell Biol. 1994; 14: 4501-4508.
15. Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I., Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005; 16: 4623-4635. (Pubitemid 41416446)
16. Shi T, Wang F, Stieren E, Tong Q., SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem. 2005; 280: 13560-13567. (Pubitemid 40517248)
17. Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP., SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A. 2002; 99: 13653-13658. (Pubitemid 35215436)
18. Lombard DB, Alt FW, Cheng HL, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007; 27: 8807-8814.
19. Ashraf N, Zino S, Macintyre A, et al. Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer. 2006; 95: 1056-1061. (Pubitemid 44606833)
20. Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP., SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol. 2008; 28: 6384-6401.
21. Yang H, Yang T, Baur JA, et al. Nutrient-sensitive mitochondrial NAD(+) levels dictate cell survival. Cell. 2007; 130: 1095-1107. (Pubitemid 47410271)
22. Li S, Banck M, Mujtaba S, Zhou MM, Sugrue MM, Walsh MJ., p53-Induced growth arrest is regulated by the mitochondrial SirT3 deacetylase [serial online]. PLoS One. 2010; 5: e10486.
23. Henson B, Li F, Coatney DD, et al. An orthotopic floor-of-mouth model for locoregional growth and spread of human squamous cell carcinoma. J Oral Pathol Med. 2007; 36: 363-370. (Pubitemid 46889879)
24. Ota H, Tokunaga E, Chang K, et al. Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene. 2006; 25: 176-185. (Pubitemid 43083679)
25. Luo J, Nikolaev AY, Imai S, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 2001; 107: 137-148. (Pubitemid 33035941)
26. Bauer JA, Trask DK, Kumar B, et al. Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. Mol Cancer Ther. 2005; 4: 1096-1104. (Pubitemid 41079103)
27. Wolter KG, Wang SJ, Henson BS, et al. (-)-Gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia. 2006; 8: 163-172. (Pubitemid 43671231)
28. Marfe G, Tafani M, Indelicato M, et al. Kaempferol induces apoptosis in 2 different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. J Cell Biochem. 2009; 106: 643-650.
29. Allison SJ, Milner J., SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways. Cell Cycle. 2007; 6: 2669-2677. (Pubitemid 350224051)
30. Schild D., Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity. Genetics. 1995; 140: 115-127.
31. Benigni A, Corna D, Zoja C, et al. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest. 2009; 119: 524-530.
32. Scher MB, Vaquero A, Reinberg D., SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev. 2007; 21: 920-928. (Pubitemid 46625641)
33. Nakamura Y, Ogura M, Tanaka D, Inagaki N., Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem Biophys Res Commun. 2008; 366: 174-179. (Pubitemid 50010675)
34. Stunkel W, Peh BK, Tan YC, et al. Function of the SIRT1 protein deacetylase in cancer. Biotechnol J. 2007; 2: 1360-1368. (Pubitemid 350176266)
35. Pillai VB, Sundaresan NR, Kim G, et al. Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. J Biol Chem. 2010; 285: 3133-3144.
36. Kim HS, Patel K, Muldoon-Jacobs K, et al. SIRT3 is a mitochondria- localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010; 17: 41-52.
37. Grenman R, Burk D, Virolainen E, Wagner JG, Lichter AS, Carey TE., Radiosensitivity of head and neck cancer cells in vitro. A 96-well plate clonogenic cell assay for squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 1988; 114: 427-431.
38. Carey TE, Van Dyke DL, Worsham MJ, et al. Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B. Cancer Res. 1989; 49: 6098-6107. (Pubitemid 19274176)
39. Sequeira J, Boily G, Bazinet S, et al. SIRT1-null mice develop an autoimmune-like condition. Exp Cell Res. 2008; 314: 3069-3074.
40. Lombard DB, Schwer B, Alt FW, Mostoslavsky R., SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008; 263: 128-141.