IDH mutation impairs histone demethylation and results in a block to cell differentiation

Nature

Volumn 483, Issue 7390, 2012, Pages 474-478

  Lu, Chao ^a,b   Ward, Patrick S ^a,b   Kapoor, Gurpreet S ^b   Rohle, Dan ^a,c   Turcan, Sevin ^a   Abdel Wahab, Omar ^a   Edwards, Christopher R ^b   Khanin, Raya ^a   Figueroa, Maria E ^c   Melnick, Ari ^c   Wellen, Kathryn E ^b   Oĝrourke, Donald M ^b   Berger, Shelley L ^b   Chan, Timothy A ^a   Levine, Ross L ^a   Mellinghoff, Ingo K ^a,c   Thompson, Craig B ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; H3K9 DEMETHYLASE; HISTONE H3; ISOCITRATE DEHYDROGENASE; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

BIOCHEMISTRY; BLOOD SYSTEM DISORDER; CANCER; CYTOLOGY; DNA; ENZYME ACTIVITY; GENE EXPRESSION; METHYLATION; MUTATION; NERVOUS SYSTEM DISORDER; PHYSIOLOGY; PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; DEMETHYLATION; DNA METHYLATION; GENE EXPRESSION; GLIOMA; HISTONE METHYLATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; STEM CELL;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ASTROCYTES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL LINEAGE; DNA METHYLATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GLIOMA; GLUTARATES; HEK293 CELLS; HISTONES; HUMANS; ISOCITRATE DEHYDROGENASE; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; METHYLATION; MICE; MUTATION; NEURAL STEM CELLS; PROMOTER REGIONS, GENETIC;

EID: 84858796262     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10860     Document Type: Article

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