-
1
-
-
34548354859
-
Recent advances in targeted therapy for renal cell carcinoma
-
Clark, P.E. (2007) Recent advances in targeted therapy for renal cell carcinoma. Curr. Opin. Urol., 17, 331-336.
-
(2007)
Curr. Opin. Urol.
, vol.17
, pp. 331-336
-
-
Clark, P.E.1
-
2
-
-
33746268329
-
Parathyroid hormone-related protein in human renal cell carcinoma
-
Sourbier, C. et al. (2006) Parathyroid hormone-related protein in human renal cell carcinoma. Cancer Lett., 240, 170-182.
-
(2006)
Cancer Lett
, vol.240
, pp. 170-182
-
-
Sourbier, C.1
-
3
-
-
0033978220
-
Systemic therapy for renal cell carcinoma
-
Motzer, R.J. et al. (2000) Systemic therapy for renal cell carcinoma. J. Urol., 163, 408-417.
-
(2000)
J. Urol.
, vol.163
, pp. 408-417
-
-
Motzer, R.J.1
-
4
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier, B. et al. (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med., 356, 125-134.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 125-134
-
-
Escudier, B.1
-
5
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renalcell carcinoma
-
Motzer, R.J. et al. (2007) Sunitinib versus interferon alfa in metastatic renalcell carcinoma. N. Engl. J. Med., 356, 115-124.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
-
6
-
-
0033569787
-
Von Hippel-Lindau syndrome. A pleomorphic condition
-
Friedrich, C.A. (1999) Von Hippel-Lindau syndrome. A pleomorphic condition. Cancer, 86, 2478-2482.
-
(1999)
Cancer
, vol.86
, pp. 2478-2482
-
-
Friedrich, C.A.1
-
7
-
-
39749132878
-
The von hippel-lindau tumor suppressor protein: An update
-
Kaelin, W.G.Jr (2007) The von hippel-lindau tumor suppressor protein: An update. Methods Enzymol., 435, 371-383.
-
(2007)
Methods Enzymol
, vol.435
, pp. 371-383
-
-
Kaelin W.G., Jr.1
-
8
-
-
34547651351
-
Posttranscriptional orchestration of an antiapoptotic program by HuR
-
Abdelmohsen, K. et al. (2007) Posttranscriptional orchestration of an antiapoptotic program by HuR. Cell Cycle, 6, 1288-1292.
-
(2007)
Cell Cycle
, vol.6
, pp. 1288-1292
-
-
Abdelmohsen, K.1
-
9
-
-
27744520451
-
HuR: Post-transcriptional paths to malignancy
-
Lopez de Silanes, I. et al. (2005) HuR: Post-transcriptional paths to malignancy. RNA Biol., 2, 11-13.
-
(2005)
RNA Biol
, vol.2
, pp. 11-13
-
-
Lopez de Silanes, I.1
-
10
-
-
0038185346
-
Post-transcriptional regulation of gene expression by degradation of messenger RNAs
-
Bevilacqua, A. et al. (2003) Post-transcriptional regulation of gene expression by degradation of messenger RNAs. J. Cell Physiol., 195, 356-372.
-
(2003)
J. Cell Physiol.
, vol.195
, pp. 356-372
-
-
Bevilacqua, A.1
-
11
-
-
33947699785
-
Modulation of mRNA stability as a novel therapeutic approach
-
Eberhardt, W. et al. (2007) Modulation of mRNA stability as a novel therapeutic approach. Pharmacol. Ther., 114, 56-73.
-
(2007)
Pharmacol. Ther.
, vol.114
, pp. 56-73
-
-
Eberhardt, W.1
-
13
-
-
37549037125
-
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
-
Galban, S. et al. (2008) RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol. Cell. Biol., 28, 93-107.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 93-107
-
-
Galban, S.1
-
14
-
-
62349134194
-
von Hippel-Lindau tumor suppressor genedependent mRNA stabilization of the survival factor parathyroid hormonerelated protein in human renal cell carcinoma by the RNA-binding protein HuR
-
Danilin, S. et al. (2009) von Hippel-Lindau tumor suppressor genedependent mRNA stabilization of the survival factor parathyroid hormonerelated protein in human renal cell carcinoma by the RNA-binding protein HuR. Carcinogenesis, 30, 387-396.
-
(2009)
Carcinogenesis
, vol.30
, pp. 387-396
-
-
Danilin, S.1
-
15
-
-
0033933196
-
Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue
-
Blaxall, B.C. et al. (2000) Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue. Mol. Carcinog., 28, 76-83.
-
(2000)
Mol. Carcinog.
, vol.28
, pp. 76-83
-
-
Blaxall, B.C.1
-
16
-
-
33747601610
-
Expression of the ELAV-like protein HuR in human colon cancer: Association with tumor stage and cyclooxygenase-2
-
Denkert, C. et al. (2006) Expression of the ELAV-like protein HuR in human colon cancer: Association with tumor stage and cyclooxygenase-2. Mod. Pathol., 19, 1261-1269.
-
(2006)
Mod. Pathol.
, vol.19
, pp. 1261-1269
-
-
Denkert, C.1
-
17
-
-
0345707583
-
Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma
-
Erkinheimo, T.L. et al. (2003) Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res., 63, 7591-7594.
-
(2003)
Cancer Res
, vol.63
, pp. 7591-7594
-
-
Erkinheimo, T.L.1
-
18
-
-
20144389216
-
Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma
-
Heinonen, M. et al. (2005) Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res., 65, 2157-2161.
-
(2005)
Cancer Res
, vol.65
, pp. 2157-2161
-
-
Heinonen, M.1
-
19
-
-
16744361844
-
Role of the RNA-binding protein HuR in colon carcinogenesis
-
Lopez de Silanes, I. et al. (2003) Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene, 22, 7146-7154.
-
(2003)
Oncogene
, vol.22
, pp. 7146-7154
-
-
Lopez de Silanes, I.1
-
20
-
-
6044269455
-
Androgens regulate the binding of endogenous HuR to the AU-rich 3#UTRs of HIF-1alpha and EGF mRNA
-
Sheflin, L.G. et al. (2004) Androgens regulate the binding of endogenous HuR to the AU-rich 3#UTRs of HIF-1alpha and EGF mRNA. Biochem. Biophys. Res. Commun., 322, 644-651.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.322
, pp. 644-651
-
-
Sheflin, L.G.1
-
21
-
-
28344435137
-
Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma
-
Datta, K. et al. (2005) Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. Oncogene, 24, 7850-7858.
-
(2005)
Oncogene
, vol.24
, pp. 7850-7858
-
-
Datta, K.1
-
22
-
-
9144230617
-
Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
-
Massfelder, T. et al. (2004) Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene. Cancer Res., 64, 180-188.
-
(2004)
Cancer Res
, vol.64
, pp. 180-188
-
-
Massfelder, T.1
-
23
-
-
34848886113
-
Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: Evidence for a critical role for integrin-linked kinase and nuclear factor kappa B
-
Agouni, A. et al. (2007) Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: Evidence for a critical role for integrin-linked kinase and nuclear factor kappa B. Carcinogenesis, 28, 1893-1901.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1893-1901
-
-
Agouni, A.1
-
24
-
-
37549051213
-
Targeting the nuclear factor-kappaB rescue pathway has promising future in human renal cell carcinoma therapy
-
Sourbier, C. et al. (2007) Targeting the nuclear factor-kappaB rescue pathway has promising future in human renal cell carcinoma therapy. Cancer Res., 67, 11668-11676.
-
(2007)
Cancer Res
, vol.67
, pp. 11668-11676
-
-
Sourbier, C.1
-
25
-
-
33744902875
-
The phosphoinositide 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy
-
Sourbier, C. et al. (2006) The phosphoinositide 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Res., 66, 5130-5142.
-
(2006)
Cancer Res
, vol.66
, pp. 5130-5142
-
-
Sourbier, C.1
-
26
-
-
29744461227
-
Antitumor effect of parathyroid hormone-related protein neutralizing antibody in human renal cell carcinoma in vitro and in vivo
-
Talon, I. et al. (2006) Antitumor effect of parathyroid hormone-related protein neutralizing antibody in human renal cell carcinoma in vitro and in vivo. Carcinogenesis, 27, 73-83.
-
(2006)
Carcinogenesis
, vol.27
, pp. 73-83
-
-
Talon, I.1
-
27
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
Lowry, O.H. et al. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
-
28
-
-
39149099155
-
Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo
-
Huang, D. et al. (2008) Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Cancer Res., 68, 81-88.
-
(2008)
Cancer Res
, vol.68
, pp. 81-88
-
-
Huang, D.1
-
29
-
-
0032431026
-
HNS, a nuclear-cytoplasmic shuttling sequence in HuR
-
Fan, X.C. et al. (1998) HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc. Natl Acad. Sci. USA, 95, 15293-15298.
-
(1998)
Proc. Natl Acad. Sci. USA.
, vol.95
, pp. 15293-15298
-
-
Fan, X.C.1
-
30
-
-
34250362729
-
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: Implications for posttranscriptional regulation of cyclooxygenase-2
-
Doller, A. et al. (2007) Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: Implications for posttranscriptional regulation of cyclooxygenase-2. Mol. Biol. Cell, 18, 2137-2148.
-
(2007)
Mol. Biol. Cell.
, vol.18
, pp. 2137-2148
-
-
Doller, A.1
-
31
-
-
0034907223
-
Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogenactivated protein kinase
-
Ming, X.F. et al. (2001) Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogenactivated protein kinase. Mol. Cell. Biol., 21, 5778-5789.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5778-5789
-
-
Ming, X.F.1
-
32
-
-
24744459025
-
Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway
-
Pascale, A. et al. (2005) Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway. Proc. Natl Acad. Sci. USA, 102, 12065-12070.
-
(2005)
Proc. Natl Acad. Sci. USA.
, vol.102
, pp. 12065-12070
-
-
Pascale, A.1
-
33
-
-
0036238675
-
AMP-activated kinase regulates cytoplasmic HuR
-
Wang, W. et al. (2002) AMP-activated kinase regulates cytoplasmic HuR. Mol. Cell. Biol., 22, 3425-3436.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3425-3436
-
-
Wang, W.1
-
34
-
-
9144266386
-
AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: Involvement in the nuclear import of RNA-binding protein HuR
-
Wang, W. et al. (2004) AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: Involvement in the nuclear import of RNA-binding protein HuR. J. Biol. Chem., 279, 48376-48388.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48376-48388
-
-
Wang, W.1
-
35
-
-
0033568608
-
The p38 MAP kinase pathway signals for cytokineinduced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
-
Winzen, R. et al. (1999) The p38 MAP kinase pathway signals for cytokineinduced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J., 18, 4969-4980.
-
(1999)
EMBO J
, vol.18
, pp. 4969-4980
-
-
Winzen, R.1
-
36
-
-
0344874067
-
Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)
-
Brenner, W. et al. (2003) Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). Anticancer Res., 23, 4001-4006.
-
(2003)
Anticancer Res
, vol.23
, pp. 4001-4006
-
-
Brenner, W.1
-
37
-
-
0031060705
-
Localization of the human HuR gene to chromosome
-
19p13.2
-
Ma, W.J. et al. (1997) Localization of the human HuR gene to chromosome 19p13.2. Hum. Genet., 99, 32-33.
-
(1997)
Hum. Genet.
, vol.99
, pp. 32-33
-
-
Ma, W.J.1
-
38
-
-
37249049985
-
Renal response to metabolic acidosis: Role of mRNA stabilization
-
Ibrahim, H. et al. (2008) Renal response to metabolic acidosis: Role of mRNA stabilization. Kidney Int., 73, 11-18.
-
(2008)
Kidney Int
, vol.73
, pp. 11-18
-
-
Ibrahim, H.1
-
39
-
-
33845361790
-
Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells
-
Jeyaraj, S.C. et al. (2006) Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells. Am. J. Physiol. Renal Physiol., 291, F1255-F1263.
-
(2006)
Am. J. Physiol. Renal Physiol.
, vol.291
-
-
Jeyaraj, S.C.1
-
40
-
-
0141864381
-
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells
-
Galban, S. et al. (2003) Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol. Cell. Biol., 23, 7083-7095.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7083-7095
-
-
Galban, S.1
-
41
-
-
0038153919
-
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
-
Mazan-Mamczarz, K. et al. (2003) RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc. Natl Acad. Sci. USA, 100, 8354-8359.
-
(2003)
Proc. Natl Acad. Sci. USA.
, vol.100
, pp. 8354-8359
-
-
Mazan-Mamczarz, K.1
-
42
-
-
33846657255
-
The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light
-
Al-Mohanna, M.A. et al. (2007) The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res., 35, 223-233.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 223-233
-
-
Al-Mohanna, M.A.1
-
43
-
-
33947114796
-
Stabilization of Snail by HuR in the process of hydrogen peroxide induced cell migration
-
Dong, R. et al. (2007) Stabilization of Snail by HuR in the process of hydrogen peroxide induced cell migration. Biochem. Biophys. Res. Commun., 356, 318-321.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.356
, pp. 318-321
-
-
Dong, R.1
-
44
-
-
34547235597
-
The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a Urich-element-dependent manner
-
Dormoy-Raclet, V. et al. (2007) The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a Urich-element-dependent manner. Mol. Cell. Biol., 27, 5365-5380.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 5365-5380
-
-
Dormoy-Raclet, V.1
-
45
-
-
33748078455
-
HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells
-
Guo, X. et al. (2006) HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells. Cancer Res., 66, 7948-7956.
-
(2006)
Cancer Res
, vol.66
, pp. 7948-7956
-
-
Guo, X.1
-
46
-
-
20044366611
-
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha
-
Lal, A. et al. (2005) Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J., 24, 1852-1862.
-
(2005)
EMBO J
, vol.24
, pp. 1852-1862
-
-
Lal, A.1
-
47
-
-
33745685879
-
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway
-
Carroll, V.A. et al. (2006) Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway. Cancer Res., 66, 6264-6270.
-
(2006)
Cancer Res
, vol.66
, pp. 6264-6270
-
-
Carroll, V.A.1
-
48
-
-
34447532192
-
Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
-
Meisner, N.C. et al. (2007) Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat. Chem. Biol., 3, 508-515.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 508-515
-
-
Meisner, N.C.1
|