Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal Kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22227-22234

  Gao, Zhanguo ^a   Zhang, Jin ^a   Kheterpal, Indu ^a   Kennedy, Norm ^b   Davis, Roger J ^b   Ye, Jianping ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-JUN N-TERMINAL KINASE; HEPATIC STEATOSIS; HEPATOCYTES; IN-VIVO; MOLECULAR MECHANISM; OBESE MICE; PROTEASOMES; PROTEIN DEGRADATION; SIRTUIN; UBIQUITINATION;

AMINO ACIDS; ENZYME ACTIVITY; MAMMALS; NUTRITION; PHOSPHORYLATION; PROTEINS;

DEGRADATION;

ALANINE; HISTONE DEACETYLASE; PROTEASOME; SERINE; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; FATTY LIVER; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

ANIMALS; CELL LINE; DIETARY FATS; ENZYME ACTIVATION; FATTY LIVER; GENE KNOCKOUT TECHNIQUES; HISTONE DEACETYLASES; HUMANS; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 8; OBESITY; PHOSPHORYLATION; RATS; SIRTUIN 1; UBIQUITINATION;

MUS;

EID: 79959355078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.228874     Document Type: Article

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