Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Journal of Clinical Investigation

Volumn 119, Issue 9, 2009, Pages 2758-2771

  Sundaresan, Nagalingam R ^a   Gupta, Madhu ^b,c   Kim, Gene ^a   Rajamohan, Senthilkumar B ^a   Isbatan, Ayman ^a   Gupta, Mahesh P ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c ADVOCATE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; INITIATION FACTOR 4E; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; S6 KINASE; SIRTUIN 3; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION REGULATION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART PROTECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

ANIMALS; ANTIOXIDANTS; BASE SEQUENCE; CARDIOMEGALY; CATALASE; CELLS, CULTURED; DNA PRIMERS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; RNA, MESSENGER; SIRTUIN 3; SIRTUINS; SUPEROXIDE DISMUTASE;

EID: 70349208608     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI39162     Document Type: Article

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