메뉴 건너뛰기




Volumn 107, Issue 20, 2010, Pages 9216-9221

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

Author keywords

catenin; Breast cancer; Cambinol; Colon cancer; Sirtuin 2

Indexed keywords

DISHEVELLED 1; DISHEVELLED 2; DISHEVELLED 3; DISHEVELLED PROTEIN; HYDROLASE INHIBITOR; SIRTUIN 1; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 77952714326     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911325107     Document Type: Article
Times cited : (102)

References (54)
  • 1
    • 34347338702 scopus 로고    scopus 로고
    • Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
    • DOI 10.1128/MCB.02279-06
    • Qiang L, Wang H, Farmer SR (2007) Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L α. Mol Cell Biol 27: 4698-4707. (Pubitemid 47016124)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.13 , pp. 4698-4707
    • Qiang, L.1    Wang, H.2    Farmer, S.R.3
  • 4
    • 27544434763 scopus 로고    scopus 로고
    • Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    • Chen WY, et al. (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123:437-448.
    • (2005) Cell , vol.123 , pp. 437-448
    • Chen, W.Y.1
  • 5
    • 47249154705 scopus 로고    scopus 로고
    • A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
    • Kojima K, et al. (2008) A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun 373:423-428.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 423-428
    • Kojima, K.1
  • 6
    • 53349091778 scopus 로고    scopus 로고
    • SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
    • Liang XJ, et al. (2008) SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res 6:1499-1506.
    • (2008) Mol Cancer Res , vol.6 , pp. 1499-1506
    • Liang, X.J.1
  • 7
    • 67650691722 scopus 로고    scopus 로고
    • SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • Nosho K, et al. (2009) SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 22: 922-932.
    • (2009) Mod Pathol , vol.22 , pp. 922-932
    • Nosho, K.1
  • 8
    • 37349110355 scopus 로고    scopus 로고
    • Metabolic adaptations through the PGC-1alpha and SIRT1 pathways
    • DOI 10.1016/j.febslet.2007.11.034, PII S0014579307011787
    • Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P (2008) Metabolic adaptations through the PGC-1 α and SIRT1 pathways. FEBS Lett 582:46-53. (Pubitemid 350297246)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 46-53
    • Rodgers, J.T.1    Lerin, C.2    Gerhart-Hines, Z.3    Puigserver, P.4
  • 10
    • 45349084772 scopus 로고    scopus 로고
    • Sirt1 deficiency attenuates spermatogenesis and germ cell function
    • DOI 10.1371/journal.pone.0001571
    • Coussens M, Maresh JG, Yanagimachi R, Maeda G, Allsopp R (2008) Sirt1 deficiency attenuates spermatogenesis and germ cell function. PLoS One 3:e1571. (Pubitemid 351843811)
    • (2008) PLoS ONE , vol.3 , Issue.2
    • Coussens, M.1    Maresh, J.G.2    Yanagimachi, R.3    Maeda, G.4    Allsopp, R.5
  • 11
    • 0037207475 scopus 로고    scopus 로고
    • The mammalian SIR2α protein has a role in embryogenesis and gametogenesis
    • McBurney MW, et al. (2003) The mammalian SIR2α protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23:38-54.
    • (2003) Mol Cell Biol , vol.23 , pp. 38-54
    • McBurney, M.W.1
  • 12
    • 36849010732 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in adipogenesis and metabolism
    • Prestwich TC, Macdougald OA (2007) Wnt/β-catenin signaling in adipogenesis and metabolism. Curr Opin Cell Biol 19:612-617.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 612-617
    • Prestwich, T.C.1    Macdougald, O.A.2
  • 13
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • DOI 10.1038/nrd2154, PII NRD2154
    • Barker N, Clevers H (2006) Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 5:997-1014. (Pubitemid 44835127)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 14
    • 33646463574 scopus 로고    scopus 로고
    • Stage-dependent Dishevelled-1 expression during mouse spermatogenesis suggests a role in regulating spermatid morphological changes
    • Ma P, et al. (2006) Stage-dependent Dishevelled-1 expression during mouse spermatogenesis suggests a role in regulating spermatid morphological changes. Mol Reprod Dev 73:774-783.
    • (2006) Mol Reprod Dev , vol.73 , pp. 774-783
    • Ma, P.1
  • 15
    • 34547107319 scopus 로고    scopus 로고
    • WNT signaling pathway and stem cell signaling network
    • DOI 10.1158/1078-0432.CCR-06-2316
    • Katoh M, Katoh M (2007) WNT signaling pathway and stem cell signaling network. Clin Cancer Res 13:4042-4045. (Pubitemid 47105963)
    • (2007) Clinical Cancer Research , vol.13 , Issue.14 , pp. 4042-4045
    • Katoh, M.1    Katoh, M.2
  • 16
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Angers S, Moon RT (2009) Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 10:468-477.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 17
    • 0037229938 scopus 로고    scopus 로고
    • Runnin' with the Dvl: Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    • Wharton KA, Jr (2003) Runnin' with the Dvl: Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 253:1-17.
    • (2003) Dev Biol , vol.253 , pp. 1-17
    • Wharton Jr., K.A.1
  • 18
    • 12144286381 scopus 로고    scopus 로고
    • NEDL1, a novel ubiquitin-protein isopeptide ligase for Dishevelled-1, targets mutant superoxide dismutase-1
    • Miyazaki K, et al. (2004) NEDL1, a novel ubiquitin-protein isopeptide ligase for Dishevelled-1, targets mutant superoxide dismutase-1. J Biol Chem 279:11327-11335.
    • (2004) J Biol Chem , vol.279 , pp. 11327-11335
    • Miyazaki, K.1
  • 19
    • 13244255645 scopus 로고    scopus 로고
    • PR72, a novel regulator of Wnt signaling required for Naked cuticle function
    • Creyghton MP, et al. (2005) PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev 19:376-386.
    • (2005) Genes Dev , vol.19 , pp. 376-386
    • Creyghton, M.P.1
  • 20
    • 33645714061 scopus 로고    scopus 로고
    • The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting Dishevelled for degradation
    • Angers S, et al. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 8: 348-357.
    • (2006) Nat Cell Biol , vol.8 , pp. 348-357
    • Angers, S.1
  • 21
    • 33846990139 scopus 로고    scopus 로고
    • Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling
    • DOI 10.1186/jbiol20
    • Itoh K, Brott BK, Bae GU, Ratcliffe MJ, Sokol SY (2005) Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling. J Biol 4:3. (Pubitemid 46257033)
    • (2005) Journal of Biology , vol.4 , pp. 3
    • Itoh, K.1    Brott, B.K.2    Bae, G.-U.3    Ratcliffe, M.J.4    Sokol, S.Y.5
  • 22
    • 33744791463 scopus 로고    scopus 로고
    • Wnt signaling: Is the party in the nucleus?
    • Willert K, Jones KA (2006) Wnt signaling: Is the party in the nucleus? Genes Dev 20: 1394-1404.
    • (2006) Genes Dev , vol.20 , pp. 1394-1404
    • Willert, K.1    Jones, K.A.2
  • 23
    • 33645768490 scopus 로고    scopus 로고
    • Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
    • Pruitt K, et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2:e40.
    • (2006) PLoS Genet , vol.2
    • Pruitt, K.1
  • 24
    • 65949116604 scopus 로고    scopus 로고
    • Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells
    • Hussain M, et al. (2009) Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. Cancer Res 69:3570-3578.
    • (2009) Cancer Res , vol.69 , pp. 3570-3578
    • Hussain, M.1
  • 25
    • 41549133557 scopus 로고    scopus 로고
    • Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabilization of β-catenin-TCF interaction
    • Gan XQ, et al. (2008) Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabilization of β-catenin-TCF interaction. J Cell Biol 180:1087-1100.
    • (2008) J Cell Biol , vol.180 , pp. 1087-1100
    • Gan, X.Q.1
  • 26
    • 41549152176 scopus 로고    scopus 로고
    • Wnt signaling pathway in invasive ductal carcinoma of the breast: Relationship between beta-catenin, disheveled and cyclin D1 expression
    • DOI 10.1159/000120999
    • Prasad CP, Gupta SD, Rath G, Ralhan R (2007) Wnt signaling pathway in invasive ductal carcinoma of the breast: Relationship between β-catenin, dishevelled and cyclin D1 expression. Oncology 73:112-117. (Pubitemid 351465609)
    • (2007) Oncology , vol.73 , Issue.1-2 , pp. 112-117
    • Prasad, C.P.1    Gupta, S.D.2    Rath, G.3    Ralhan, R.4
  • 27
    • 60649114313 scopus 로고    scopus 로고
    • Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and β-catenin stabilization
    • Wang L, et al. (2009) Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and β-catenin stabilization. Cancer Cell 15:207-219.
    • (2009) Cancer Cell , vol.15 , pp. 207-219
    • Wang, L.1
  • 28
    • 33646254136 scopus 로고    scopus 로고
    • Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    • Heltweg B, et al. (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66:4368-4377.
    • (2006) Cancer Res , vol.66 , pp. 4368-4377
    • Heltweg, B.1
  • 29
    • 37549056198 scopus 로고    scopus 로고
    • Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3
    • Lee YN, Gao Y, Wang HY (2008) Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal 20:443-452.
    • (2008) Cell Signal , vol.20 , pp. 443-452
    • Lee, Y.N.1    Gao, Y.2    Wang, H.Y.3
  • 30
    • 33947514003 scopus 로고    scopus 로고
    • Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3′-end processing
    • DOI 10.1074/jbc.M609745200
    • Shimazu T, Horinouchi S, Yoshida M (2007) Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3′-end processing. J Biol Chem282:4470-4478. (Pubitemid 47100930)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.7 , pp. 4470-4478
    • Shimazu, T.1    Horinouchi, S.2    Yoshida, M.3
  • 31
    • 1342282917 scopus 로고    scopus 로고
    • Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled
    • DOI 10.1128/MCB.24.5.2000-2011.2004
    • Cong F, Schweizer L, Varmus H (2004) Casein kinase Iε modulates the signaling specificities of Dishevelled. Mol Cell Biol 24:2000-2011. (Pubitemid 38248940)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.5 , pp. 2000-2011
    • Cong, F.1    Schweizer, L.2    Varmus, H.3
  • 33
    • 33750946790 scopus 로고    scopus 로고
    • CK2 Controls the Recruitment of Wnt Regulators to Target Genes in Vivo
    • DOI 10.1016/j.cub.2006.09.034, PII S0960982206022597
    • Wang S, Jones KA (2006) CK2 controls the recruitment of Wnt regulators to target genes in vivo. Curr Biol 16:2239-2244. (Pubitemid 44739279)
    • (2006) Current Biology , vol.16 , Issue.22 , pp. 2239-2244
    • Wang, S.1    Jones, K.A.2
  • 34
    • 62049084424 scopus 로고    scopus 로고
    • Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
    • Zschoernig B, Mahlknecht U (2009) Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. Biochem Biophys Res Commun 381:372-377.
    • (2009) Biochem Biophys Res Commun , vol.381 , pp. 372-377
    • Zschoernig, B.1    Mahlknecht, U.2
  • 35
    • 69949138641 scopus 로고    scopus 로고
    • CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    • Kang H, Jung JW, Kim MK, Chung JH (2009) CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS ONE 4:e6611.
    • (2009) PLoS ONE , vol.4
    • Kang, H.1    Jung, J.W.2    Kim, M.K.3    Chung, J.H.4
  • 36
    • 0037093072 scopus 로고    scopus 로고
    • Oncogenic β-catenin is required for bone morphogenetic protein 4 expression in human cancer cells
    • Kim JS, et al. (2002) Oncogenic β-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res 62:2744-2748.
    • (2002) Cancer Res , vol.62 , pp. 2744-2748
    • Kim, J.S.1
  • 37
    • 0033119801 scopus 로고    scopus 로고
    • β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
    • DOI 10.1038/18884
    • Tetsu O, McCormick F (1999) β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422-426. (Pubitemid 29180374)
    • (1999) Nature , vol.398 , Issue.6726 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 39
    • 56749176944 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
    • Colorectal Cancer Association Study Consortium; CoRGI Consortium; International Colorectal Cancer Genetic Association Consortium
    • Houlston RS, et al.; Colorectal Cancer Association Study Consortium; CoRGI Consortium; International Colorectal Cancer Genetic Association Consortium (2008) Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 40:1426-1435.
    • (2008) Nat Genet , vol.40 , pp. 1426-1435
    • Houlston, R.S.1
  • 40
    • 33847017335 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells
    • DOI 10.1016/j.yexcr.2006.12.020, PII S0014482707000043
    • Deng H, et al. (2007) Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. Exp Cell Res 313:1033-1044. (Pubitemid 46273448)
    • (2007) Experimental Cell Research , vol.313 , Issue.5 , pp. 1033-1044
    • Deng, H.1    Makizumi, R.2    Ravikumar, T.S.3    Dong, H.4    Yang, W.5    Yang, W.-L.6
  • 41
    • 34247187543 scopus 로고    scopus 로고
    • Myc deletion rescues Apc deficiency in the small intestine
    • Sansom OJ, et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446:676-679.
    • (2007) Nature , vol.446 , pp. 676-679
    • Sansom, O.J.1
  • 42
    • 34047269793 scopus 로고    scopus 로고
    • Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells
    • DOI 10.1158/0008-5472.CAN-06-2843
    • Esufali S, Charames GS, Pethe VV, Buongiorno P, Bapat B (2007) Activation of tumor-specific splice variant Rac1b by Dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. Cancer Res 67:2469-2479. (Pubitemid 46548931)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2469-2479
    • Esufali, S.1    Charames, G.S.2    Pethe, V.V.3    Buongiorno, P.4    Bapat, B.5
  • 43
    • 67650076196 scopus 로고    scopus 로고
    • Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways
    • Samarzija I, Sini P, Schlange T, Macdonald G, Hynes NE (2009) Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways. Biochem Biophys Res Commun 386:449-454.
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 449-454
    • Samarzija, I.1    Sini, P.2    Schlange, T.3    Macdonald, G.4    Hynes, N.E.5
  • 44
    • 59649126261 scopus 로고    scopus 로고
    • Deacetylation of cortactin by SIRT1 promotes cell migration
    • Zhang Y, et al. (2009) Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene 28:445-460.
    • (2009) Oncogene , vol.28 , pp. 445-460
    • Zhang, Y.1
  • 45
    • 70949096837 scopus 로고    scopus 로고
    • A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer
    • Najdi R, et al. (2009) A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer. Oncogene 28:4133-4146.
    • (2009) Oncogene , vol.28 , pp. 4133-4146
    • Najdi, R.1
  • 47
    • 34548471739 scopus 로고    scopus 로고
    • Cytoplasm-localized SIRT1 enhances apoptosis
    • Jin Q, et al. (2007) Cytoplasm-localized SIRT1 enhances apoptosis. J Cell Physiol 213: 88-97.
    • (2007) J Cell Physiol , vol.213 , pp. 88-97
    • Jin, Q.1
  • 48
    • 0034637103 scopus 로고    scopus 로고
    • Inhibition of adipogenesis by Wnt signaling
    • Ross SE, et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-953.
    • (2000) Science , vol.289 , pp. 950-953
    • Ross, S.E.1
  • 49
    • 34547100073 scopus 로고    scopus 로고
    • SIRT1 is significantly elevated in mouse and human prostate cancer
    • Huffman DM, et al. (2007) SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67:6612-6618.
    • (2007) Cancer Res , vol.67 , pp. 6612-6618
    • Huffman, D.M.1
  • 50
    • 44849096876 scopus 로고    scopus 로고
    • The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    • Firestein R, et al. (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3:e2020.
    • (2008) PLoS One , vol.3
    • Firestein, R.1
  • 51
    • 59049101982 scopus 로고    scopus 로고
    • Activated Wnt/β-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    • Chien AJ, et al. (2009) Activated Wnt/β-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci USA 106:1193-1198.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1193-1198
    • Chien, A.J.1
  • 52
    • 3442894128 scopus 로고    scopus 로고
    • An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth
    • You L, et al. (2004) An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res 64:5385-5389.
    • (2004) Cancer Res , vol.64 , pp. 5385-5389
    • You, L.1
  • 53
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression
    • DOI 10.1038/sj.onc.1206817
    • Uematsu K, et al. (2003) Activation of the Wnt pathway in non small cell lung cancer: Evidence of Dishevelled overexpression. Oncogene 22:7218-7221. (Pubitemid 37378553)
    • (2003) Oncogene , vol.22 , Issue.46 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3    Xu, Z.4    McCormick, F.5    Jablons, D.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.