Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

PLoS Genetics

Volumn 4, Issue 8, 2008, Pages

  O'Hagan, Heather M ^a   Mohammad, Helai P ^a   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DMNT3B PROTEIN; DNA; DNA METHYLTRANSFERASE 1; EZH2 PROTEIN; PROTEIN; SIRTUIN 1; UNCLASSIFIED DRUG; UVOMORULIN; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNMT3B PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; SIRTUIN;

ARTICLE; CHROMATIN; CONTROLLED STUDY; CPG ISLAND; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EPIGENETICS; GENE SILENCING; HUMAN; HUMAN CELL; NEOPLASM; PROMOTER REGION; TRANSCRIPTION REGULATION; GENETICS; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMATIN; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA BREAKS, DOUBLE-STRANDED; DNA METHYLATION; GENE SILENCING; HUMANS; PROMOTER REGIONS (GENETICS); SIRTUINS;

EID: 50849104569     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000155     Document Type: Article

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