Chromosomal instability and tumors promoted by DNA hypomethylation

Science

Volumn 300, Issue 5618, 2003, Pages 455-

  Eden, Amir ^a   Gaudet, François ^a,c   Waghmare, Alpana ^a,b   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA METHYLTRANSFERASE;

CHROMOSOME; DNA;

ANIMAL CELL; ANIMAL MODEL; CARCINOGENESIS; CENTROMERE; CHROMATIN STRUCTURE; DNA METHYLATION; DNA STRUCTURE; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SOFT TISSUE SARCOMA;

ANIMALS; CHROMOSOMES, MAMMALIAN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FIBROBLASTS; GENES, NEUROFIBROMATOSIS 1; GENES, P53; HUMANS; LOSS OF HETEROZYGOSITY; MICE; MUTATION; NEOPLASMS; RECOMBINATION, GENETIC; SARCOMA; SOFT TISSUE NEOPLASMS;

ANIMALIA;

EID: 0242584454     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083557     Document Type: Short Survey

References (8)

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8. We thank T. Jacks and K. Reilly for NPcis mice and V. Carey for advice on biostatistics. Supported by an EMBO fellowship ALTF 43-1999 (A.E.), by Boehringer Ingelheim (A.E.), and by an NIH grant CA87869 (R.J.).