A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

Nature Genetics

Volumn 39, Issue 2, 2007, Pages 237-242

  Ohm, Joyce E ^a   McGarvey, Kelly M ^a   Yu, Xiaobing ^a   Cheng, Linzhao ^a   Schuebel, Kornel E ^a   Cope, Leslie ^a   Mohammad, Helai P ^a   Chen, Wei ^a   Daniel, Vincent C ^a   Yu, Wayne ^a   Berman, David M ^a   Jenuwein, Thomas ^b   Pruitt, Kevin ^a   Sharkis, Saul J ^a   Watkins, D Neil ^a   Herman, James G ^a   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYONIC ECTODERM DEVELOPMENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER SUSCEPTIBILITY; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; EMBRYO CELL; EMBRYONIC STEM CELL; GENE REPRESSION; GENE SILENCING; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; HEREDITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; TERATOCARCINOMA; TERATOMA; TUMOR SUPPRESSOR GENE;

ADULT; CELL PROLIFERATION; CHROMATIN; DNA METHYLATION; EMBRYONIC STEM CELLS; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HISTONES; HUMANS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; STEM CELLS; TUMOR CELLS, CULTURED;

EID: 33846569960     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1972     Document Type: Article

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