Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation

Oncogene

Volumn 25, Issue 54, 2006, Pages 7148-7158

  Wang, X ^a   Zhou, Y X ^a   Qiao, W ^a   Tominaga, Y ^a   Ouchi, M ^b   Ouchi, T ^b   Deng, C X ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Centrosome; Chromosome tetraploidization; Cyclin D1; mTOR; Premature sister chromatid segregation

Indexed keywords

AURORA A KINASE; CYCLIN D1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST EPITHELIUM; CANCER INCIDENCE; CELL DEATH; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; FEMALE; GENE AMPLIFICATION; GENE DISRUPTION; GENE INDUCTION; GENE OVEREXPRESSION; HETEROZYGOSITY; HUMAN; INDUCED MUTATION; MALIGNANT TRANSFORMATION; MORPHOGENESIS; MOUSE; MOUSE STRAIN; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SISTER CHROMATID; TETRAPLOIDY; TRANSGENE;

ANIMALS; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; EPITHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; MUTATION; ONCOGENE PROTEIN V-AKT; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MAMMALIA; MOUSE MAMMARY TUMOR VIRUS;

EID: 33751085368     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209707     Document Type: Article

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