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Volumn 20, Issue 3, 2013, Pages 503-514

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

Author keywords

histone deacetylase; N Myc; NEDD4; neuroblastoma; pancreatic cancer; SIRT2

Indexed keywords

AURORA A KINASE; MYC PROTEIN; SIRTUIN 2; UBIQUITIN PROTEIN LIGASE NEDD4;

EID: 84873736861     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.147     Document Type: Article
Times cited : (184)

References (47)
  • 1
    • 77749279644 scopus 로고    scopus 로고
    • Myc proteins as therapeutic targets
    • Gustafson WC, Weiss WA. Myc proteins as therapeutic targets. Oncogene 2010; 29: 1249-1259.
    • (2010) Oncogene , vol.29 , pp. 1249-1259
    • Gustafson, W.C.1    Weiss, W.A.2
  • 2
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM. Neuroblastoma: Biological insights into a clinical enigma. Nat Rev Cancer 2003; 3: 203-216.
    • (2003) Nat Rev Cancer , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 3
    • 0033034390 scopus 로고    scopus 로고
    • Molecular biology of neuroblastoma
    • Maris JM, Matthay KK. Molecular biology of neuroblastoma. J Clin Oncol 1999; 17: 2264-2279.
    • (1999) J Clin Oncol , vol.17 , pp. 2264-2279
    • Maris, J.M.1    Matthay, K.K.2
  • 5
    • 0036229486 scopus 로고    scopus 로고
    • C-myc activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance
    • Schleger C, Verbeke C, Hildenbrand R, Zentgraf H, Bleyl U. C-myc activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance. Mod Pathol 2002; 15: 462-469.
    • (2002) Mod Pathol , vol.15 , pp. 462-469
    • Schleger, C.1    Verbeke, C.2    Hildenbrand, R.3    Zentgraf, H.4    Bleyl, U.5
  • 6
    • 78149468828 scopus 로고    scopus 로고
    • Transcriptional upregulation of histone deacetylase 2 promotes myc-induced oncogenic effects
    • Marshall GM, Gherardi S, Xu N, Neiron Z, Trahair T, Scarlett CJ et al. Transcriptional upregulation of histone deacetylase 2 promotes myc-induced oncogenic effects. Oncogene 2010; 29: 5957-5968.
    • (2010) Oncogene , vol.29 , pp. 5957-5968
    • Marshall, G.M.1    Gherardi, S.2    Xu, N.3    Neiron, Z.4    Trahair, T.5    Scarlett, C.J.6
  • 7
    • 0034306997 scopus 로고    scopus 로고
    • Multiple ras-dependent phosphorylation pathways regulate myc protein stability
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple ras-dependent phosphorylation pathways regulate myc protein stability. Genes Dev 2000; 14: 2501-2514.
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 8
    • 57849107571 scopus 로고    scopus 로고
    • Stabilization of n-myc is a critical function of aurora a in human neuroblastoma
    • Otto T, Horn S, Brockmann M, Eilers U, Schuttrumpf L, Popov N et al. Stabilization of n-myc is a critical function of aurora a in human neuroblastoma. Cancer Cell 2009; 15: 67-78.
    • (2009) Cancer Cell , vol.15 , pp. 67-78
    • Otto, T.1    Horn, S.2    Brockmann, M.3    Eilers, U.4    Schuttrumpf, L.5    Popov, N.6
  • 9
    • 2942693567 scopus 로고    scopus 로고
    • Myc degradation: Dancing with ubiquitin ligases
    • Amati B. Myc degradation: Dancing with ubiquitin ligases. Proc Natl Acad Sci USA 2004; 101: 8843-8844.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8843-8844
    • Amati, B.1
  • 12
    • 0036781812 scopus 로고    scopus 로고
    • C-myc: More than just a matter of life and death
    • Pelengaris S, Khan M, Evan G. C-myc: More than just a matter of life and death. Nat Rev Cancer 2002; 2: 764-776.
    • (2002) Nat Rev Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 13
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers M, Eisenman RN. Myc's broad reach. Genes Dev 2008; 22: 2755-2766.
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 14
    • 77949920493 scopus 로고    scopus 로고
    • Myc as a regulator of ribosome biogenesis and protein synthesis
    • van Riggelen J, Yetil A, Felsher DW. Myc as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 2010; 10: 301-309.
    • (2010) Nat Rev Cancer , vol.10 , pp. 301-309
    • Van Riggelen, J.1    Yetil, A.2    Felsher, D.W.3
  • 15
    • 52449101436 scopus 로고    scopus 로고
    • Transcription-independent functions of myc: Regulation of translation and DNA replication
    • Cole MD, Cowling VH. Transcription-independent functions of myc: Regulation of translation and DNA replication. Nat Rev Mol Cell Biol 2008; 9: 810-815.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 810-815
    • Cole, M.D.1    Cowling, V.H.2
  • 17
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at lys16 and trimethylation at lys20 of histone h4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G et al. Loss of acetylation at lys16 and trimethylation at lys20 of histone h4 is a common hallmark of human cancer. Nat Genet 2005; 37: 391-400.
    • (2005) Nat Genet , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3    Boix-Chornet, M.4    Espada, J.5    Schotta, G.6
  • 18
    • 33646550204 scopus 로고    scopus 로고
    • Sirt2 is a histone deacetylase with preference for histone h4 lys 16 during mitosis
    • Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW et al. Sirt2 is a histone deacetylase with preference for histone h4 lys 16 during mitosis. Genes Dev 2006; 20: 1256-1261.
    • (2006) Genes Dev , vol.20 , pp. 1256-1261
    • Vaquero, A.1    Scher, M.B.2    Lee, D.H.3    Sutton, A.4    Cheng, H.L.5    Alt, F.W.6
  • 19
    • 79958261783 scopus 로고    scopus 로고
    • Simplification of the tetracyclic sirt1-selective inhibitor mc2141: Coumarin- and pyrimidinebased sirt1/2 inhibitors with different selectivity profile
    • Rotili D, Carafa V, Tarantino D, Botta G, Nebbioso A, Altucci L et al. Simplification of the tetracyclic sirt1-selective inhibitor mc2141: Coumarin- and pyrimidinebased sirt1/2 inhibitors with different selectivity profile. Bioorg Med Chem 2011; 19: 3659-3668.
    • (2011) Bioorg Med Chem , vol.19 , pp. 3659-3668
    • Rotili, D.1    Carafa, V.2    Tarantino, D.3    Botta, G.4    Nebbioso, A.5    Altucci, L.6
  • 20
    • 67650444786 scopus 로고    scopus 로고
    • Identification of a small molecule sirt2 inhibitor with selective tumor cytotoxicity
    • Zhang Y, Au Q, Zhang M, Barber JR, Ng SC, Zhang B. Identification of a small molecule sirt2 inhibitor with selective tumor cytotoxicity. Biochem Biophys Res Commun 2009; 386: 729-733.
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 729-733
    • Zhang, Y.1    Au, Q.2    Zhang, M.3    Barber, J.R.4    Ng, S.C.5    Zhang, B.6
  • 22
    • 79959837062 scopus 로고    scopus 로고
    • Sirt1 promotes n-myc oncogenesis through a positive feedback loop involving the effects of mkp3 and erk on n-myc protein stability
    • Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N et al. Sirt1 promotes n-myc oncogenesis through a positive feedback loop involving the effects of mkp3 and erk on n-myc protein stability. PLoS Genet 2011; 7: e1002135.
    • (2011) PLoS Genet , vol.7
    • Marshall, G.M.1    Liu, P.Y.2    Gherardi, S.3    Scarlett, C.J.4    Bedalov, A.5    Xu, N.6
  • 23
    • 0347695988 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization
    • Gregory MA, Qi Y, Hann SR. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J Biol Chem 2003; 278: 51606-51612.
    • (2003) J Biol Chem , vol.278 , pp. 51606-51612
    • Gregory, M.A.1    Qi, Y.2    Hann, S.R.3
  • 24
    • 36749069011 scopus 로고    scopus 로고
    • Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for myc oncogenesis
    • Liu T, Tee AE, Porro A, Smith SA, Dwarte T, Liu PY et al. Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for myc oncogenesis. Proc Natl Acad Sci USA 2007; 104: 18682-18687.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18682-18687
    • Liu, T.1    Tee, A.E.2    Porro, A.3    Smith, S.A.4    Dwarte, T.5    Liu, P.Y.6
  • 25
    • 77449124047 scopus 로고    scopus 로고
    • Nedd4 and nedd4-2: Closely related ubiquitin-protein ligases with distinct physiological functions
    • Yang B, Kumar S. Nedd4 and nedd4-2: Closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ 2010; 17: 68-77.
    • (2010) Cell Death Differ , vol.17 , pp. 68-77
    • Yang, B.1    Kumar, S.2
  • 26
    • 67349132223 scopus 로고    scopus 로고
    • Physiological functions of the hect family of ubiquitin ligases
    • Rotin D, Kumar S. Physiological functions of the hect family of ubiquitin ligases. Nat Rev Mol Cell Biol 2009; 10: 398-409.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 398-409
    • Rotin, D.1    Kumar, S.2
  • 27
    • 0037088688 scopus 로고    scopus 로고
    • N4wbp5, a potential target for ubiquitination by the nedd4 family of proteins, is a novel golgi-associated protein
    • Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S. N4wbp5, a potential target for ubiquitination by the nedd4 family of proteins, is a novel golgi-associated protein. J Biol Chem 2002; 277: 9307-9317.
    • (2002) J Biol Chem , vol.277 , pp. 9307-9317
    • Harvey, K.F.1    Shearwin-Whyatt, L.M.2    Fotia, A.3    Parton, R.G.4    Kumar, S.5
  • 28
    • 0035854796 scopus 로고    scopus 로고
    • Nuclear import/export of hrpf1/nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates
    • Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP. Nuclear import/export of hrpf1/nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem 2001; 276: 26324-26331.
    • (2001) J Biol Chem , vol.276 , pp. 26324-26331
    • Hamilton, M.H.1    Tcherepanova, I.2    Huibregtse, J.M.3    McDonnell, D.P.4
  • 29
    • 80054769188 scopus 로고    scopus 로고
    • Sirt2 maintains genome integrity and suppresses tumorigenesis through regulating apc/c activity
    • Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X et al. Sirt2 maintains genome integrity and suppresses tumorigenesis through regulating apc/c activity. Cancer Cell 2011; 20: 487-499.
    • (2011) Cancer Cell , vol.20 , pp. 487-499
    • Kim, H.S.1    Vassilopoulos, A.2    Wang, R.H.3    Lahusen, T.4    Xiao, Z.5    Xu, X.6
  • 30
    • 78650638268 scopus 로고    scopus 로고
    • Sirt2 downregulation in hela can induce p53 accumulation via p38 mapk activation-dependent p300 decrease, eventually leading to apoptosis
    • Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A et al. Sirt2 downregulation in hela can induce p53 accumulation via p38 mapk activation-dependent p300 decrease, eventually leading to apoptosis. Genes Cells 2011; 16: 34-45.
    • (2011) Genes Cells , vol.16 , pp. 34-45
    • Li, Y.1    Matsumori, H.2    Nakayama, Y.3    Osaki, M.4    Kojima, H.5    Kurimasa, A.6
  • 31
    • 2942650133 scopus 로고    scopus 로고
    • The fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-myc protein degradation
    • Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN et al. The fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-myc protein degradation. Proc Natl Acad Sci USA 2004; 101: 9085-9090.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9085-9090
    • Welcker, M.1    Orian, A.2    Jin, J.3    Grim, J.E.4    Harper, J.W.5    Eisenman, R.N.6
  • 33
    • 12444264823 scopus 로고    scopus 로고
    • The f-box protein skp2 participates in c-myc proteosomal degradation and acts as a cofactor for c-myc-regulated transcription
    • von der Lehr N, Johansson S, Wu S, Bahram F, Castell A, Cetinkaya C et al. The f-box protein skp2 participates in c-myc proteosomal degradation and acts as a cofactor for c-myc-regulated transcription. Mol Cell 2003; 11: 1189-1200.
    • (2003) Mol Cell , vol.11 , pp. 1189-1200
    • Von Der Lehr, N.1    Johansson, S.2    Wu, S.3    Bahram, F.4    Castell, A.5    Cetinkaya, C.6
  • 34
    • 44649201561 scopus 로고    scopus 로고
    • The hectdomain ubiquitin ligase huwe1 controls neural differentiation and proliferation by destabilizing the n-myc oncoprotein
    • Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F et al. The hectdomain ubiquitin ligase huwe1 controls neural differentiation and proliferation by destabilizing the n-myc oncoprotein. Nat Cell Biol 2008; 10: 643-653.
    • (2008) Nat Cell Biol , vol.10 , pp. 643-653
    • Zhao, X.1    Heng, J.I.2    Guardavaccaro, D.3    Jiang, R.4    Pagano, M.5    Guillemot, F.6
  • 35
    • 33847053144 scopus 로고    scopus 로고
    • Sirt2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
    • Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S et al. Sirt2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene 2007; 26: 945-957.
    • (2007) Oncogene , vol.26 , pp. 945-957
    • Inoue, T.1    Hiratsuka, M.2    Osaki, M.3    Yamada, H.4    Kishimoto, I.5    Yamaguchi, S.6
  • 37
    • 84859447698 scopus 로고    scopus 로고
    • The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
    • Dan L, Klimenkova O, Klimiankou M, Klusmann JH, van den Heuvel-Eibrink MM, Reinhardt D et al. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica 2012; 97: 551-519.
    • (2012) Haematologica , vol.97 , pp. 551-519
    • Dan, L.1    Klimenkova, O.2    Klimiankou, M.3    Klusmann, J.H.4    Van Den Heuvel-Eibrink, M.M.5    Reinhardt, D.6
  • 38
    • 15944365507 scopus 로고    scopus 로고
    • Role of naddependent deacetylases sirt1 and sirt2 in radiation and cisplatin-induced cell death in vertebrate cells
    • Matsushita N, Takami Y, Kimura M, Tachiiri S, Ishiai M, Nakayama T et al. Role of naddependent deacetylases sirt1 and sirt2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 2005; 10: 321-332.
    • (2005) Genes Cells , vol.10 , pp. 321-332
    • Matsushita, N.1    Takami, Y.2    Kimura, M.3    Tachiiri, S.4    Ishiai, M.5    Nakayama, T.6
  • 39
    • 77954225200 scopus 로고    scopus 로고
    • Cytosolic foxo1 is essential for the induction of autophagy and tumour suppressor activity
    • Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S et al. Cytosolic foxo1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol 2011; 12: 665-675.
    • (2011) Nat Cell Biol , vol.12 , pp. 665-675
    • Zhao, Y.1    Yang, J.2    Liao, W.3    Liu, X.4    Zhang, H.5    Wang, S.6
  • 40
    • 79955827893 scopus 로고    scopus 로고
    • Nicotinamide inhibits growth of carcinogen induced mouse bladder tumor and human bladder tumor xenograft through upregulation of runx3 and p300
    • Kim WJ, Lee JW, Quan C, Youn HJ, Kim HM, Bae SC. Nicotinamide inhibits growth of carcinogen induced mouse bladder tumor and human bladder tumor xenograft through upregulation of runx3 and p300. J Urol 2011; 185: 2366-2375.
    • (2011) J Urol , vol.185 , pp. 2366-2375
    • Kim, W.J.1    Lee, J.W.2    Quan, C.3    Youn, H.J.4    Kim, H.M.5    Bae, S.C.6
  • 41
    • 33846122993 scopus 로고    scopus 로고
    • Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
    • Marks PA, Breslow R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 2007; 25: 84-90.
    • (2007) Nat Biotechnol , vol.25 , pp. 84-90
    • Marks, P.A.1    Breslow, R.2
  • 42
    • 33646254136 scopus 로고    scopus 로고
    • Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    • Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 2006; 66: 4368-4377.
    • (2006) Cancer Res , vol.66 , pp. 4368-4377
    • Heltweg, B.1    Gatbonton, T.2    Schuler, A.D.3    Posakony, J.4    Li, H.5    Goehle, S.6
  • 43
    • 42949114938 scopus 로고    scopus 로고
    • Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
    • Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 2008; 13: 454-463.
    • (2008) Cancer Cell , vol.13 , pp. 454-463
    • Lain, S.1    Hollick, J.J.2    Campbell, J.3    Staples, O.D.4    Higgins, M.5    Aoubala, M.6
  • 44
    • 84863011183 scopus 로고    scopus 로고
    • Activation of p53 by sirt1 inhibition enhances elimination of cml leukemia stem cells in combination with imatinib
    • Li L, Wang L, Wang Z, Ho Y, McDonald T, Holyoake TL et al. Activation of p53 by sirt1 inhibition enhances elimination of cml leukemia stem cells in combination with imatinib. Cancer Cell 2012; 21: 266-281.
    • (2012) Cancer Cell , vol.21 , pp. 266-281
    • Li, L.1    Wang, L.2    Wang, Z.3    Ho, Y.4    McDonald, T.5    Holyoake, T.L.6
  • 45
    • 84863116364 scopus 로고    scopus 로고
    • Activation of stress response gene sirt1 by bcr-abl promotes leukemogenesis
    • Yuan H, Wang Z, Li L, Zhang H, Modi H, Horne D et al. Activation of stress response gene sirt1 by bcr-abl promotes leukemogenesis. Blood 2012; 119: 1904-1914.
    • (2012) Blood , vol.119 , pp. 1904-1914
    • Yuan, H.1    Wang, Z.2    Li, L.3    Zhang, H.4    Modi, H.5    Horne, D.6
  • 46
    • 77950468903 scopus 로고    scopus 로고
    • Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation
    • Tee AE, Marshall GM, Liu PY, Xu N, Haber M, Norris MD et al. Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation. J Biol Chem 2010; 285: 3561-3567.
    • (2010) J Biol Chem , vol.285 , pp. 3561-3567
    • Tee, A.E.1    Marshall, G.M.2    Liu, P.Y.3    Xu, N.4    Haber, M.5    Norris, M.D.6
  • 47
    • 66949123885 scopus 로고    scopus 로고
    • Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors
    • Liu T, Liu PY, Tee AE, Haber M, Norris MD, Gleave ME et al. Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors. Eur J Cancer 2009; 45: 1846-1854.
    • (2009) Eur J Cancer , vol.45 , pp. 1846-1854
    • Liu, T.1    Liu, P.Y.2    Tee, A.E.3    Haber, M.4    Norris, M.D.5    Gleave, M.E.6


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