Regulation of energy metabolism by long-chain fatty acids

Progress in Lipid Research

Volumn 53, Issue 1, 2014, Pages 124-144

  Nakamura, Manabu T ^a   Yudell, Barbara E ^a   Loor, Juan J ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Adiponectin; Exercise; Fasting; FGF21; PPAR

Indexed keywords

ADIPONECTIN; CADHERIN; CERAMIDE; FIBROBLAST GROWTH FACTOR 21; HEPATOCYTE NUCLEAR FACTOR 4; LIVER X RECEPTOR; LONG CHAIN FATTY ACID; MYOCYTE ENHANCER FACTOR 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN CHREBP; RETINOID X RECEPTOR; SKIN LIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADAPTATION; ADIPOCYTE; ADIPOSE TISSUE; AMINO ACID METABOLISM; BINDING KINETICS; COMPLEX FORMATION; DIET RESTRICTION; DOWN REGULATION; ENDURANCE TRAINING; ENERGY EXPENDITURE; ENERGY METABOLISM; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID OXIDATION; GENE INDUCTION; GENE MUTATION; GENE TARGETING; GLUCOSE METABOLISM; HUMAN; INSULIN SENSITIVITY; KERATINOCYTE; KETOGENESIS; KNOCKOUT MOUSE; LIGAND BINDING; LIVER MITOCHONDRION; METABOLIC REGULATION; METABOLIC SYNDROME X; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REVIEW; SKELETAL MUSCLE; SKIN CONDUCTANCE; SPECIES DIFFERENCE; STARVATION;

3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE 2; 3-OXOACYL-COA THIOLASE; 6-PHOSPHOFURCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3; ACAA2; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATION FUNCTION 1,2; ADIPONECTIN; ADIPONECTIN RECEPTOR; ADIPOR; ADIPOSE TRIGLYCERIDE LIPASE; AF1,2; AMP-ACTIVATED PROTEIN KINASE; AMPK; ATF4; ATGL; CALCIUM/CALMODULIN-DEPENDENT KINASE; CAMK; CAMP RESPONSIVE ELEMENT BINDING PROTEIN 1; CARNITINE PALMITOYLTRANSFERASE 1A (LIVER TYPE); CARNITINE PALMITOYLTRANSFERASE 1B (MUSCLE TYPE); CD36; CPT1A; CPT1B; CREB; D6D; DBD; DELTA-6 DESATURASE (ALSO CALLED FADS2); DGAT; DIACYLGLYCEROL ACYLTRANSFERASE; DISSOCIATION CONSTANT; DNA BINDING DOMAIN; EFA; ELECTRON-TRANSFERRING FLAVOPROTEIN DEHYDROGENASE; ELONGATION OF VERY-LONG CHAIN; ELOVL; ESSENTIAL FATTY ACID; ETFDH; EXERCISE; FABP; FARNESOID-X RECEPTOR; FAS; FASTING; FATP; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; FATTY ACID TRANSFER PROTEIN; FATTY ACID TRANSLOCASE; FFAR; FGF21; FIBROBLAST GROWTH FACTOR 21; FORKHEAD BOX O1; FOXO1; FREE FATTY ACID RECEPTOR; FXR; G PROTEIN-COUPLED RECEPTOR; G3P; GENE KNOCKOUT; GH; GK; GLUCOKINASE; GLUCOSE TRANSPORTER 4; GLUT4; GLYCEROL-3-PHOSPHATE; GPR; GROWTH HORMONE; HADHA; HEPATOCYTE NUCLEAR FACTOR 4; HIGH MOLECULAR WEIGHT ADIPONECTIN (UP TO 18MER); HMGCS2; HMW ADIPONECTIN; HNF4; HORMONE SENSITIVE LIPASE; HSL; IGF1; IGF1 BINDING PROTEIN; IGF1BP; INSULIN-LIKE GROWTH FACTOR 1; KD; KO; LACS; LBD; LCAD; LCFA; LIGAND BINDING DOMAIN; LIPOPROTEIN LIPASE; LIVER-X RECEPTOR; LONG CHAIN ACYL-COA DEHYDROGENASE; LONG CHAIN ACYL-COA SYNTHASE; LONG CHAIN FATTY ACID (C=14-20); LPL; LXR; MALONYL-COA DECARBOXYLASE; MCDC; MEF2; MYOCYTE ENHANCER FACTOR 2; PDH; PDK; PEPCK; PEROXISOME PROLIFERATOR RESPONSE ELEMENT; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1Α; PFK; PFKFB3; PGC1Α; PHOSPHOENOLPYRUVATE CARBOXYKINASE; PHOSPHOFRUCTOKINASE; PKA; POLYUNSATURATED FATTY ACID; PPAR; PPRE; PROTEIN KINASE A; PUFA; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; RAR; RETINOIC ACID RECEPTOR; RETINOID-X RECEPTOR; RXR; SCD1; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5; SOCS2; STAT5; STEAROYL-COA DESATURASE 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; THIAZOLIDINEDIONE; THYROID HORMONE RECEPTOR; TNFΑ; TR; TRB3; TRIBBLES HOMOLOG 3; TRIFUNCTIONAL PROTEIN Α SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; TZD; UCP; UNCOUPLING PROTEIN; VDR; VERY LONG CHAIN ACYL-COA DEHYDROGENASE; VERY LOW DENSITY LIPOPROTEIN; VITAMIN D RECEPTOR; VLCAD; VLDL;

ANIMALS; ENERGY METABOLISM; FASTING; FATTY ACIDS; HUMANS; LIGANDS; ORGAN SPECIFICITY; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84892144705     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2013.12.001     Document Type: Review

References (266)

1. M.T. Nakamura, Y. Cheon, Y. Li, and T.Y. Nara Mechanisms of regulation of gene expression by fatty acids Lipids 39 2004 1077 1083 (Pubitemid 40129050)
2. M.T. Nakamura, and T.Y. Nara Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases Annu Rev Nutr 24 2004 345 376
3. D.B. Jump N-3 polyunsaturated fatty acid regulation of hepatic gene transcription Curr Opin Lipidol 19 2008 242 247 (Pubitemid 351653561)
4. I. Issemann, and S. Green Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 1990 645 650
5. C. Dreyer, G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli Control of the peroxisomal [beta]-oxidation pathway by a novel family of nuclear hormone receptors Cell 68 1992 879 887
6. A. Schmidt, N. Endo, S.J. Rutledge, R. Vogel, D. Shinar, and G.A. Rodan Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids Mol Endocrinol 6 1992 1634 1641
7. S.A. Kliewer, B.M. Forman, B. Blumberg, E.S. Ong, U. Borgmeyer, and D.J. Mangelsdorf et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors Proc Natl Acad Sci USA 91 1994 7355 7359 (Pubitemid 24226862)
8. I. Takada, R.T. Yu, H.E. Xu, M.H. Lambert, V.G. Montana, and S.A. Kliewer et al. Alteration of a single amino acid in peroxisome proliferator-activated receptor-{alpha} (PPAR{alpha}) generates a PPAR{delta} phenotype Mol Endocrinol 14 2000 733 740 (Pubitemid 32260515)
9. S.L. Marcus, K.S. Miyata, B. Zhang, S. Subramani, R.A. Rachubinski, and J.P. Capone Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression Proc Natl Acad Sci USA 90 1993 5723 5727 (Pubitemid 23176234)
10. C. Juge-Aubry, A. Pernin, T. Favez, A.G. Burger, W. Wahli, and C.A. Meier et al. DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region J Biol Chem 272 1997 25252 25259 (Pubitemid 27415714)
11. H. Nakshatri, and P. Bhat-Nakshatri Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements Nucl Acids Res 26 1998 2491 2499 (Pubitemid 28297354)
12. O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat Endocrinology 137 1996 354 366 (Pubitemid 26005011)
13. D. Auboeuf, J. Rieusset, L. Fajas, P. Vallier, V. Frering, and J.P. Riou et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients Diabetes 46 1997 1319 1327 (Pubitemid 27315281)
14. F.J. Gonzalez, and Y.M. Shah PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators Toxicology 246 2008 2 8
15. M. Lehrke, and M.A. Lazar The many faces of PPAR[gamma] Cell 123 2005 993 999
16. G.D. Barish, V.A. Narkar, and R.M. Evans PPAR{delta}: a dagger in the heart of the metabolic syndrome J Clin Invest 116 2006 590 597 (Pubitemid 43326863)
17. B.M. Forman, J. Chen, and R.M. Evans Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta Proc Natl Acad Sci USA 94 1997 4312 4317 (Pubitemid 27194238)
18. S.A. Kliewer, S.S. Sundseth, S.A. Jones, P.J. Brown, G.B. Wisely, and C.S. Koble et al. Fatty acids and eicosanoids regulate gene expression through direct interaction with peroxisome proliferator-activated receptors alpha and gamma Proc Natl Acad Sci USA 94 1997 4318 4323 (Pubitemid 27194239)
19. J.S. Nichols, D.J. Parks, T.G. Consler, and S.G. Blanchard Development of a scintillation proximity assay for peroxisome proliferator-activated receptor gamma ligand binding domain Anal Biochem 257 1998 112 119 (Pubitemid 28128972)
20. H.E. Xu, M.H. Lambert, V.G. Montana, D.J. Parks, S.G. Blanchard, and P.J. Brown et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors Mol Cell 3 1999 397 403 (Pubitemid 29290680)
21. Q. Lin, S.E. Ruuska, N.S. Shaw, D. Dong, and N. Noy Ligand selectivity of the peroxisome proliferator-activated receptor alpha Biochemistry 38 1999 185 190 (Pubitemid 29035685)
22. L.A. Cowart, S. Wei, M. Hsu, E.F. Johnson, M.U. Krishna, and J.R. Falck et al. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands J Biol Chem 277 2002 35105 35112
23. W.S. He, T.Y. Nara, and M.T. Nakamura Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator Biochem Biophys Res Commun 299 2002 832 838 (Pubitemid 36040365)
24. Y. Li, T.Y. Nara, and M.T. Nakamura Peroxisome proliferator activated receptor-alpha is required for feedback regulation of highly unsaturated fatty acid synthesis J Lipid Res 46 2005 2432 2440 (Pubitemid 41532531)
25. J. Storch, and A.E.A. Thumser The fatty acid transport function of fatty acid-binding proteins Biochim Biophys Acta (BBA) - Mol Cell Biol Lipids 1486 2000 28 44 (Pubitemid 30336790)
26. R.K. Ockner, J.A. Manning, and J.P. Kane Fatty acid binding protein. Isolation from rat liver, characterization, and immunochemical quantification J Biol Chem 257 1982 7872 7878
27. C.G. Guglielmo, N.H. Haunerland, and T.D. Williams Fatty acid binding protein, a major protein in the flight muscle of migrating western sandpipers Comp Biochem Physiol 119 1998 549 555 (Pubitemid 28345085)
28. B. Rolf, E. Oudenampsen-Kruger, T. Borchers, N.J. Faergeman, J. Knudsen, and A. Lezius et al. Analysis of the ligand binding properties of recombinant bovine liver-type fatty acid binding protein Biochim Biophys Acta 1259 1995 245 253 (Pubitemid 26014979)
29. G.V. Richieri, R.T. Ogata, and A.M. Kleinfeld Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB J Biol Chem 269 1994 23918 23930
30. J.P. Kampf, and A.M. Kleinfeld Fatty acid transport in adipocytes monitored by imaging intracellular free fatty acid levels J Biol Chem 279 2004 35775 35780 (Pubitemid 39100583)
31. L. Makowski, K.C. Brittingham, J.M. Reynolds, J. Suttles, and G.S. Hotamisligil The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities J Biol Chem 280 2005 12888 12895
32. M.V. Chakravarthy, I.J. Lodhi, L. Yin, R.R. Malapaka, H.E. Xu, and J. Turk et al. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver Cell 138 2009 476 488
33. B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr Rev 20 1999 649 688 (Pubitemid 30650602)
34. R.T. Gampe Jr, V.G. Montana, M.H. Lambert, A.B. Miller, R.K. Bledsoe, and M.V. Milburn et al. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors Mol Cell 5 2000 545 555
35. H.E. Xu, T.B. Stanley, V.G. Montana, M.H. Lambert, B.G. Shearer, and J.E. Cobb et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha Nature 415 2002 813 817 (Pubitemid 34150506)
36. P. Dowell, J.E. Ishmael, D. Avram, V.J. Peterson, D.J. Nevrivy, and M. Leid Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein J Biol Chem 274 1999 15901 15907
37. A.M. Krogsdam, C.A. Nielsen, S. Neve, D. Holst, T. Helledie, and B. Thomsen et al. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation Biochem J 363 2002 157 165 (Pubitemid 34280622)
38. M.L. Privalsky The role of corepressors in transcriptional regulation by nuclear hormone receptors Annu Rev Physiol 66 2004 315 360 (Pubitemid 40614447)
39. S. Yu, and J.K. Reddy Transcription coactivators for peroxisome proliferator-activated receptors Biochim Biophys Acta 1771 2007 936 951 (Pubitemid 47198542)
40. J. Uppenberg, C. Svensson, M. Jaki, G. Bertilsson, L. Jendeberg, and A. Berkenstam Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma J Biol Chem 273 1998 31108 31112 (Pubitemid 28533120)
41. R.T. Nolte, G.B. Wisely, S. Westin, J.E. Cobb, M.H. Lambert, and R. Kurokawa et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma Nature 395 1998 137 143 (Pubitemid 28425645)
42. H.E. Xu, M.H. Lambert, V.G. Montana, K.D. Plunket, L.B. Moore, and J.L. Collins et al. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors Proc Natl Acad Sci USA 98 2001 13919 13924 (Pubitemid 33115999)
43. D.J. Mangelsdorf, and R.M. Evans The RXR heterodimers and orphan receptors Cell 83 1995 841 850 (Pubitemid 26006526)
44. G. Wolf Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor? Nutr Rev 64 2006 532 538 (Pubitemid 46057720)
45. J. Lengqvist, A. Mata De Urquiza, A.C. Bergman, T.M. Willson, J. Sjovall, and T. Perlmann et al. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain Mol Cell Proteomics 3 2004 692 703 (Pubitemid 39077000)
46. A.A. Bogan, Q. Dallas-Yang, M.D. Ruse Jr, Y. Maeda, G. Jiang, and L. Nepomuceno et al. Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha J Mol Biol 302 2000 831 851
47. G.B. Wisely, A.B. Miller, R.G. Davis, A.D. Thornquest Jr., R. Johnson, and T. Spitzer et al. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids Structure (Camb) 10 2002 1225 1234 (Pubitemid 35254011)
48. S. Dhe-Paganon, K. Duda, M. Iwamoto, Y.I. Chi, and S.E. Shoelson Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand J Biol Chem 277 2002 37973 37976 (Pubitemid 35154647)
49. K. Duda, Y.I. Chi, and S.E. Shoelson Structural basis for HNF-4alpha activation by ligand and coactivator binding J Biol Chem 279 2004 23311 23316 (Pubitemid 38685640)
50. D.T. Odom, N. Zizlsperger, D.B. Gordon, G.W. Bell, N.J. Rinaldi, and H.L. Murray et al. Control of pancreas and liver gene expression by HNF transcription factors Science 303 2004 1378 1381 (Pubitemid 38269432)
51. A.W. Adamson, G. Suchankova, C. Rufo, M.T. Nakamura, M. Teran-Garcia, and S.D. Clarke et al. Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase Biochem J 399 2006 285 295 (Pubitemid 44570291)
52. R. Hertz, J. Magenheim, I. Berman, and J. Bar-Tana Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4 alpha Nature 392 1998 512 516 (Pubitemid 28168984)
53. A.D. Petrescu, R. Hertz, J. Bar-Tana, F. Schroeder, and A.B. Kier Ligand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha) J Biol Chem 277 2002 23988 23999 (Pubitemid 34951910)
54. F. Rajas, A. Gautier, I. Bady, S. Montano, and G. Mithieux Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha J Biol Chem 277 2002 15736 15744 (Pubitemid 34967848)
55. J.J. Repa, and D.J. Mangelsdorf The liver X receptor gene team: potential new players in atherosclerosis Nat Med 8 2002 1243 1248 (Pubitemid 35373555)
56. J.J. Repa, G. Liang, J. Ou, Y. Bashmakov, J.M. Lobaccaro, and I. Shimomura et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Genes Develop 14 2000 2819 2830
57. J. Ou, H. Tu, B. Shan, A. Luk, R.A. DeBose-Boyd, and Y. Bashmakov et al. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR Proc Natl Acad Sci USA 98 2001 6027 6032 (Pubitemid 32488187)
58. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 2002 1125 1131 (Pubitemid 34496588)
59. J. Xu, M. Teran-Garcia, J.H. Park, M.T. Nakamura, and S.D. Clarke Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay J Biol Chem 276 2001 9800 9807
60. J. Xu, M.T. Nakamura, H.P. Cho, and S.D. Clarke Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids: a mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats J Biol Chem 274 1999 23577 23583
61. R. Dentin, F. Benhamed, J.P. Pegorier, F. Foufelle, B. Viollet, and S. Vaulont et al. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation J Clin Invest 115 2005 2843 2854 (Pubitemid 41434411)
62. J. Xu, B. Christian, and D.B. Jump Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist J Biol Chem 281 2006 18351 18362 (Pubitemid 44035492)
63. T. Kawaguchi, K. Osatomi, H. Yamashita, T. Kabashima, and K. Uyeda Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase J Biol Chem 277 2002 3829 3835 (Pubitemid 34968632)
64. S. Talukdar, J.M. Olefsky, and O. Osborn Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases Trends Pharmacol Sci 32 2011 543 550
65. C.P. Briscoe, M. Tadayyon, J.L. Andrews, W.G. Benson, J.K. Chambers, and M.M. Eilert et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids J Biol Chem 278 2003 11303 11311 (Pubitemid 36792687)
66. Y. Itoh, Y. Kawamata, M. Harada, M. Kobayashi, R. Fujii, and S. Fukusumi et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 2003 173 176 (Pubitemid 36362750)
67. A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, and M. Yamada et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat Med 11 2005 90 94 (Pubitemid 40215843)
68. A.J. Brown, S.M. Goldsworthy, A.A. Barnes, M.M. Eilert, L. Tcheang, and D. Daniels et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids J Biol Chem 278 2003 11312 11319 (Pubitemid 36792688)
69. S. Edfalk, P. Steneberg, and H. Edlund Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion Diabetes 57 2008 2280 2287
70. C. Cartoni, K. Yasumatsu, T. Ohkuri, N. Shigemura, R. Yoshida, and N. Godinot et al. Taste preference for fatty acids is mediated by GPR40 and GPR120 J Neurosci 30 2010 8376 8382
71. M.K. Nohr, M.H. Pedersen, A. Gille, K.L. Egerod, M.S. Engelstoft, and A.S. Husted et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes Endocrinology 154 2013 3552 3564
72. S. Kersten, J. Seydoux, J.M. Peters, F.J. Gonzalez, B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting J Clin Invest 103 1999 1489 1498
73. T.C. Leone, C.J. Weinheimer, and D.P. Kelly A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders Proc Natl Acad Sci USA 96 1999 7473 7478 (Pubitemid 29299686)
74. T. Hashimoto, W.S. Cook, C. Qi, A.V. Yeldandi, J.K. Reddy, and M.S. Rao Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting J Biol Chem 275 2000 28918 28928
75. C. Le May, T. Pineau, K. Bigot, C. Kohl, J. Girard, and J.P. Pegorier Reduced hepatic fatty acid oxidation in fasting PPARalpha null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression FEBS Lett 475 2000 163 166 (Pubitemid 30408445)
76. S.S.T. Lee, W. Chan, C.K.C. Lo, D.C.C. Wan, D.S.C. Tsang, and W. Cheung Requirement of PPAR{alpha} in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation J Lipid Res 45 2004 2025 2037 (Pubitemid 40990897)
77. G.Y. Lee, N.H. Kim, Z.S. Zhao, B.S. Cha, and Y.S. Kim Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level Biochem J 378 2004 983 990 (Pubitemid 38406876)
78. K. Motojima, and T. Hirai Peroxisome proliferator-activated receptor α plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors FEBS J 273 2006 292 300
79. P.R. Devchand, H. Keller, J.M. Peters, M. Vazquez, F.J. Gonzalez, and W. Wahli The PPAR alpha-leucotriene B4 pathway to inflammation control Nature 384 1996 39 43 (Pubitemid 26374579)
80. T.Y. Nara, W.S. He, C. Tang, S.D. Clarke, and M.T. Nakamura The E-box like sterol regulatory element mediates the suppression of human delta-6 desaturase gene by highly unsaturated fatty acids Biochem Biophys Res Commun 296 2002 111 117 (Pubitemid 35002063)
81. M. Cherkaoui-Malki, K. Meyer, W.Q. Cao, N. Latruffe, A.V. Yeldandi, and M.S. Rao et al. Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis Gene Expression 9 2001 291 304 (Pubitemid 33096400)
82. J.A. Kramer, E.A. Blomme, R.T. Bunch, J.C. Davila, C.J. Jackson, and P.F. Jones et al. Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate Toxicol Pathol 31 2003 417 431 (Pubitemid 36897238)
83. Y. Cheon, T.Y. Nara, M.R. Band, J.E. Beever, M.A. Wallig, and M.T. Nakamura Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species Am J Physiol Regul Integr Comp Physiol 288 2005 R1525 R1535
84. M. Bauer, A.C. Hamm, M. Bonaus, A. Jacob, J. Jaekel, and H. Schorle et al. Starvation response in mouse liver shows strong correlation with life-span-prolonging processes Physiol Genomics 17 2004 230 244 (Pubitemid 38924168)
85. J.F. Louet, F. Chatelain, J.F. Decaux, E.A. Park, C. Kohl, and T. Pineau et al. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway Biochem J 354 2001 189 197 (Pubitemid 32183459)
86. F.M. Campbell, R. Kozak, A. Wagner, J.Y. Altarejos, J.R.B. Dyck, and D.D. Belke et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels. Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking pparalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase J Biol Chem 277 2002 4098 4103 (Pubitemid 34968667)
87. R.K. Olsen, S.E. Olpin, B.S. Andresen, Z.H. Miedzybrodzka, M. Pourfarzam, and B. Merinero et al. ETFDH mutations as a major cause of riboflavin- responsive multiple acyl-CoA dehydrogenation deficiency Brain 130 2007 2045 2054 (Pubitemid 47236622)
88. R.J. Pollitt Disorders of mitochondrial long-chain fatty acid oxidation J Inherited Metab Dis 18 1995 473 490
89. J.C. Rodriguez, G. Gil-Gomez, F.G. Hegardt, and D. Haro Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids J Biol Chem 269 1994 18767 18772 (Pubitemid 24226186)
90. J.K. Reddy, and T. Hashimoto Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system Annu Rev Nutr 21 2001 193 230 (Pubitemid 32695270)
91. J.D. Tugwood, I. Issemann, R.G. Anderson, K.R. Bundell, W.L. McPheat, and S. Green The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene EMBO J 11 1992 433 439
92. R.A. Harris, M.M. Bowker-Kinley, B. Huang, and P. Wu Regulation of the activity of the pyruvate dehydrogenase complex Adv Enzyme Regul 42 2002 249 259 (Pubitemid 35033542)
93. K. Motojima, and K. Seto Fibrates and statins rapidly and synergistically induce pyruvate dehydrogenase kinase 4 mRNA in the liver and muscles of mice Biol Pharm Bull 26 2003 954 958 (Pubitemid 41685418)
94. B. Huang, P. Wu, M.M. Bowker-Kinley, and R.A. Harris Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin Diabetes 51 2002 276 283 (Pubitemid 34764781)
95. D. Wei, R. Tao, Y. Zhang, M.F. White, and X.C. Dong Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1 Am J Physiol Endocrinol Metab 300 2011 E312 E320
96. P. Wu, P.V. Blair, J. Sato, J. Jaskiewicz, K.M. Popov, and R.A. Harris Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues Arch Biochem Biophys 381 2000 1 7
97. R. Li, Q. Zhang, Z. Liu, J. Qiao, S. Zhao, and L. Shao et al. Effect of short-term and long-term fasting on transcriptional regulation of metabolic genes in rat tissues Biochem Biophys Res Commun 344 2006 562 570
98. M.C. Sugden, K. Bulmer, G.F. Gibbons, B.L. Knight, and M.J. Holness Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin Biochem J 364 2002 361 368 (Pubitemid 34620795)
99. N.H. Jeoung, P. Wu, M.A. Joshi, J. Jaskiewicz, C.B. Bock, and A.A. Depaoli-Roach et al. Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation Biochem J 397 2006 417 425 (Pubitemid 44187500)
100. T. Inagaki, P. Dutchak, G. Zhao, X. Ding, L. Gautron, and V. Parameswara et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21 Cell Metab 5 2007 415 425 (Pubitemid 46825496)
101. M.J. Potthoff, T. Inagaki, S. Satapati, X. Ding, T. He, and R. Goetz et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response Proc Natl Acad Sci USA 106 2009 10853 10858
102. T. Inagaki, V.Y. Lin, R. Goetz, M. Mohammadi, D.J. Mangelsdorf, and S.A. Kliewer Inhibition of growth hormone signaling by the fasting-induced hormone FGF21 Cell Metab 8 2008 77 83
103. M.G. Holloway, Y. Cui, E.V. Laz, A. Hosui, L. Hennighausen, and D.J. Waxman Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus Endocrinology 148 2007 1977 1986 (Pubitemid 46997034)
104. T.J. Zhao, G. Liang, R.L. Li, X. Xie, M.W. Sleeman, and A.J. Murphy et al. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice Proc Natl Acad Sci USA 107 2010 7467 7472
105. S.A. Rogers, I.E. Karl, and M.R. Hammerman Growth hormone directly stimulates gluconeogenesis in canine renal proximal tubule Am J Physiol 257 1989 E751 E756
106. Y.D. Kim, T. Li, S.W. Ahn, D.K. Kim, J.M. Lee, and S.L. Hwang et al. Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation J Biol Chem 287 2012 37098 37108
107. L.A. Gustafson, F. Kuipers, C. Wiegman, H.P. Sauerwein, J.A. Romijn, and A.J. Meijer Clofibrate improves glucose tolerance in fat-fed rats but decreases hepatic glucose consumption capacity J Hepatol 37 2002 425 431
108. C.J. Chou, M. Haluzik, C. Gregory, K.R. Dietz, C. Vinson, and O. Gavrilova et al. WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice J Biol Chem 277 2002 24484 24489 (Pubitemid 34951973)
109. W.L. Holland, A.C. Adams, J.T. Brozinick, H.H. Bui, Y. Miyauchi, and C.M. Kusminski et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice Cell Metab 17 2013 790 797
110. Z. Lin, H. Tian, K.S. Lam, S. Lin, R.C. Hoo, and M. Konishi et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice Cell Metab 17 2013 779 789
111. T. Aoyama, J.M. Peters, N. Iritani, T. Nakajima, K. Furihata, and T. Hashimoto et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) J Biol Chem 273 1998 5678 5684 (Pubitemid 28124039)
112. M. Bunger, H.M. van den Bosch, J. van der Meijde, S. Kersten, G.J. Hooiveld, and M. Muller Genome-wide analysis of PPARalpha activation in murine small intestine Physiol Genomics 30 2007 192 204 (Pubitemid 47173282)
113. J. Xu, G. Xiao, C. Trujillo, V. Chang, L. Blanco, and S.B. Joseph et al. Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production J Biol Chem 277 2002 50237 50244 (Pubitemid 36042171)
114. M.S. Kilberg, J. Shan, and N. Su ATF4-dependent transcription mediates signaling of amino acid limitation Trends Endocrinol Metab 20 2009 436 443
115. K. Du, S. Herzig, R.N. Kulkarni, and M. Montminy TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Science 300 2003 1574 1577 (Pubitemid 36682889)
116. D.D. Patel, B.L. Knight, D. Wiggins, S.M. Humphreys, and G.F. Gibbons Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice J Lipid Res 42 2001 328 337 (Pubitemid 32270055)
117. F.J. Gonzalez The peroxisome proliferator-activated receptor alpha (PPAR alpha): role in hepatocarcinogenesis Mol Cell Endocrinol 193 2002 71 79 (Pubitemid 34823609)
118. J.W. Lawrence, Y. Li, S. Chen, J.G. DeLuca, J.P. Berger, and D.R. Umbenhauer et al. Differential gene regulation in human vs rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha}: PPAR{alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression J Biol Chem 276 2001 31521 31527
119. C. Cheung, T.E. Akiyama, J.M. Ward, C.J. Nicol, L. Feigenbaum, and C. Vinson et al. Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha Cancer Res 64 2004 3849 3854 (Pubitemid 38697295)
120. Y.M. Shah, K. Morimura, Q. Yang, T. Tanabe, M. Takagi, and F.J. Gonzalez Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation Mol Cell Biol 27 2007 4238 4247 (Pubitemid 46906549)
121. P.A. Tesch Skeletal muscle adaptations consequent to long-term heavy resistance exercise Med Sci Sports Exercise 20 1988 S132 S134
122. J.O. Holloszy, and F.W. Booth Biochemical adaptations to endurance exercise in muscle Annu Rev Physiol 38 1976 273 291
123. J. Henriksson The possible role of skeletal muscle in the adaptation to periods of energy deficiency Eur J Clin Nutr 44 Suppl 1 1990 55 64
124. M. Miyazaki, and K.A. Esser Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals J Appl Physiol 106 2009 1367 1373
125. R. Bassel-Duby, and E.N. Olson Signaling pathways in skeletal muscle remodeling Annu Rev Biochem 75 2006 19 37 (Pubitemid 44118024)
126. J.M. Peters, S.S. Lee, W. Li, J.M. Ward, O. Gavrilova, and C. Everett et al. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta) Mol Cell Biol 20 2000 5119 5128 (Pubitemid 30431565)
127. Y. Barak, D. Liao, W. He, E.S. Ong, M.C. Nelson, and J.M. Olefsky et al. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer Proc Natl Acad Sci USA 99 2002 303 308 (Pubitemid 34060358)
128. L. Michalik, B. Desvergne, N.S. Tan, S. Basu-Modak, P. Escher, and J. Rieusset et al. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice J Cell Biol 154 2001 799 814 (Pubitemid 34292961)
129. C. Lee, K. Kang, I.R. Mehl, R. Nofsinger, W.A. Alaynick, and L. Chong et al. Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage Proc Natl Acad Sci USA 103 2006 2434 2439 (Pubitemid 43271687)
130. K.D. Wagner, and N. Wagner Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) acts as regulator of metabolism linked to multiple cellular functions Pharmacol Ther 125 2010 423 435
131. D.M. Muoio, P.S. MacLean, D.B. Lang, S. Li, J.A. Houmard, and J.M. Way et al. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPARdelta J Biol Chem 277 2002
132. Y.X. Wang, C.L. Zhang, R.T. Yu, H.K. Cho, M.C. Nelson, and C.R. Bayuga-Ocampo et al. Regulation of muscle fiber type and running endurance by PPARdelta PLoS Biol 2 2004 e294
133. T. Tanaka, J. Yamamoto, S. Iwasaki, H. Asaba, H. Hamura, and Y. Ikeda et al. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome Proc Natl Acad Sci USA 100 2003 15924 15929 (Pubitemid 38021091)
134. V.A. Narkar, M. Downes, R.T. Yu, E. Embler, Y.X. Wang, and E. Banayo et al. AMPK and PPARdelta agonists are exercise mimetics Cell 134 2008 405 415
135. M.J. Holness, K. Bulmer, G.F. Gibbons, and M.C. Sugden Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha) Biochem J 366 2002 839 846
136. M. Schuler, F. Ali, C. Chambon, D. Duteil, J.M. Bornert, and A. Tardivel et al. PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes Cell Metab 4 2006 407 414 (Pubitemid 44645068)
137. D. Holst, S. Luquet, V. Nogueira, K. Kristiansen, X. Leverve, and P.A. Grimaldi Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle Biochim Biophys Acta 1633 2003 43 50 (Pubitemid 36773945)
138. T. Furuyama, K. Kitayama, H. Yamashita, and N. Mori Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation Biochem J 375 2003 365 371 (Pubitemid 37315444)
139. Z. Nahle, M. Hsieh, T. Pietka, C.T. Coburn, P.A. Grimaldi, and M.Q. Zhang et al. CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress J Biol Chem 283 2008 14317 14326
140. P.K. Vogt, H. Jiang, and M. Aoki Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins Cell Cycle 4 2005 908 913 (Pubitemid 41359756)
141. J. Nakae, B.C. Park, and D. Accili Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway J Biol Chem 274 1999 15982 15985
142. H.S. Kwon, and R.A. Harris Mechanisms responsible for regulation of pyruvate dehydrogenase kinase 4 gene expression Adv Enzyme Regul 44 2004 109 121 (Pubitemid 39568168)
143. P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 1998 829 839 (Pubitemid 28155321)
144. Y.X. Wang, C.H. Lee, S. Tiep, R.T. Yu, J. Ham, and H. Kang et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity Cell 113 2003 159 170 (Pubitemid 36514968)
145. P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, and F. Oriente et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction Nature 423 2003 550 555 (Pubitemid 36648580)
146. J. Lin, C. Handschin, and B.M. Spiegelman Metabolic control through the PGC-1 family of transcription coactivators Cell Metab 1 2005 361 370 (Pubitemid 43960626)
147. H. Daitoku, K. Yamagata, H. Matsuzaki, M. Hatta, and A. Fukamizu Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR Diabetes 52 2003 642 649 (Pubitemid 36323569)
148. R.J. Southgate, C.R. Bruce, A.L. Carey, G.R. Steinberg, K. Walder, and R. Monks et al. PGC-1alpha gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle FASEB J 19 2005 2072 2074 (Pubitemid 41759769)
149. H. Pilegaard, T. Osada, L.T. Andersen, J.W. Helge, B. Saltin, and P.D. Neufer Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise Metabolism 54 2005 1048 1055 (Pubitemid 41033106)
150. S.S. Eivers, B.A. McGivney, J. Gu, D.E. MacHugh, L.M. Katz, and E.W. Hill PGC-1alpha encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise Anim Genet 43 2012 153 162
151. L. Wang, and K. Sahlin The effect of continuous and interval exercise on PGC-1alpha and PDK4 mRNA in type I and type II fibres of human skeletal muscle Acta Physiol (Oxf) 204 2012 525 532
152. K. Kannisto, A. Chibalin, B. Glinghammar, J.R. Zierath, A. Hamsten, and E. Ehrenborg Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise Int J Mol Med 17 2006 45 52
153. S. Luquet, J. Lopez-Soriano, D. Holst, A. Fredenrich, J. Melki, and M. Rassoulzadegan et al. Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability FASEB J 17 2003 2299 2301 (Pubitemid 39561472)
154. J.Y. Chan, M. Kwong, R. Lu, J. Chang, B. Wang, and T.S. Yen et al. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice EMBO J 17 1998 1779 1787 (Pubitemid 28119131)
155. L. Huo, and R.C. Scarpulla Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice Mol Cell Biol 21 2001 644 654 (Pubitemid 32037382)
156. N. Gleyzer, K. Vercauteren, and R.C. Scarpulla Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators Mol Cell Biol 25 2005 1354 1366 (Pubitemid 40204913)
157. J.A. Villena, and A. Kralli ERRalpha: a metabolic function for the oldest orphan Trends Endocrinol Metab 19 2008 269 276
158. J.M. Huss, K. Imahashi, C.R. Dufour, C.J. Weinheimer, M. Courtois, and A. Kovacs et al. The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload Cell Metab 6 2007 25 37 (Pubitemid 46995780)
159. S.N. Schreiber, R. Emter, M.B. Hock, D. Knutti, J. Cardenas, and M. Podvinec et al. The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis Proc Natl Acad Sci USA 101 2004 6472 6477 (Pubitemid 38585998)
160. P. Puigserver, G. Adelmant, Z. Wu, M. Fan, J. Xu, and B. O'Malley et al. Activation of PPARgamma coactivator-1 through transcription factor docking Science 286 1999 1368 1371
161. Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, and V. Mootha et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Cell 98 1999 115 124 (Pubitemid 29331201)
162. M.V. Thai, S. Guruswamy, K.T. Cao, J.E. Pessin, and A.L. Olson Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes J Biol Chem 273 1998 14285 14292 (Pubitemid 28319143)
163. H. Wu, F.J. Naya, T.A. McKinsey, B. Mercer, J.M. Shelton, and E.R. Chin et al. MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type EMBO J 19 2000 1963 1973 (Pubitemid 30237572)
164. M.P. Czubryt, J. McAnally, G.I. Fishman, and E.N. Olson Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5 Proc Natl Acad Sci USA 100 2003 1711 1716 (Pubitemid 36254513)
165. C. Handschin, J. Rhee, J. Lin, P.T. Tarr, and B.M. Spiegelman An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle Proc Natl Acad Sci USA 100 2003 7111 7116 (Pubitemid 36706401)
166. B.L. Black, and E.N. Olson Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins Annu Rev Cell Develop Biol 14 1998 167 196 (Pubitemid 29001453)
167. M.J. Potthoff, and E.N. Olson MEF2: a central regulator of diverse developmental programs Development 134 2007 4131 4140
168. L.F. Michael, Z. Wu, R.B. Cheatham, P. Puigserver, G. Adelmant, and J.J. Lehman et al. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1 Proc Natl Acad Sci USA 98 2001 3820 3825 (Pubitemid 32249855)
169. J. Lin, H. Wu, P.T. Tarr, C.Y. Zhang, Z. Wu, and O. Boss et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres Nature 418 2002 797 801
170. C. Handschin, S. Chin, P. Li, F. Liu, E. Maratos-Flier, and N.K. Lebrasseur et al. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals J Biol Chem 282 2007 30014 30021 (Pubitemid 350035265)
171. E.D. Rosen, and O.A. MacDougald Adipocyte differentiation from the inside out Nat Rev Mol Cell Biol 7 2006 885 896 (Pubitemid 44871415)
172. T. Imai, R. Takakuwa, S. Marchand, E. Dentz, J.M. Bornert, and N. Messaddeq et al. Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse Proc Natl Acad Sci USA 101 2004 4543 4547 (Pubitemid 38437447)
173. K. Schoonjans, J. Peinado-Onsurbe, A.M. Lefebvre, R.A. Heyman, M. Briggs, and S. Deeb et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene EMBO J 15 1996 5336 5348 (Pubitemid 26336216)
174. Y. Ikeda, A. Takagi, and A. Yamamoto Purification and characterization of lipoprotein lipase and hepatic triglyceride lipase from human postheparin plasma: production of monospecific antibody to the individual lipase Biochim Biophys Acta 1003 1989 254 269 (Pubitemid 19150997)
175. L.K. Summers, B.A. Fielding, S.L. Herd, V. Ilic, M.L. Clark, and P.T. Quinlan et al. Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat J Lipid Res 40 1999 1890 1898 (Pubitemid 29477260)
176. K. Motojima, P. Passilly, J.M. Peters, F.J. Gonzalez, and N. Latruffe Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner J Biol Chem 273 1998 16710 16714 (Pubitemid 28311694)
177. B.I. Frohnert, T.Y. Hui, and D.A. Bernlohr Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene J Biol Chem 274 1999 3970 3977
178. O. Sato, C. Kuriki, Y. Fukui, and K. Motojima Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands J Biol Chem 277 2002 15703 15711 (Pubitemid 34967844)
179. P. Tontonoz, E. Hu, R.A. Graves, A.I. Budavari, and B.M. Spiegelman MPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer Genes Develop 8 1994 1224 1234
180. K.T. Dalen, K. Schoonjans, S.M. Ulven, M.S. Weedon-Fekjaer, T.G. Bentzen, and H. Koutnikova et al. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma Diabetes 53 2004 1243 1252 (Pubitemid 38569010)
181. N. Arimura, T. Horiba, M. Imagawa, M. Shimizu, and R. Sato The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes J Biol Chem 279 2004 10070 10076 (Pubitemid 38372610)
182. A.S. Greenberg, J.J. Egan, S.A. Wek, M.C. Moos Jr, C. Londos, and A.R. Kimmel Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes Proc Natl Acad Sci USA 90 1993 12035 12039 (Pubitemid 24008775)
183. J.T. Tansey, C. Sztalryd, J. Gruia-Gray, D.L. Roush, J.V. Zee, and O. Gavrilova et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity Proc Natl Acad Sci USA 98 2001 6494 6499 (Pubitemid 32488265)
184. S.C. Souza, K.V. Muliro, L. Liscum, P. Lien, M.T. Yamamoto, and J.E. Schaffer et al. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system J Biol Chem 277 2002 8267 8272 (Pubitemid 34968285)
185. C. Sztalryd, G. Xu, H. Dorward, J.T. Tansey, J.A. Contreras, and A.R. Kimmel et al. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation J Cell Biol 161 2003 1093 1103 (Pubitemid 36870171)
186. H. Miyoshi, J.W. Perfield 2nd, S.C. Souza, W.J. Shen, H.H. Zhang, and Z.S. Stancheva et al. Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes J Biol Chem 282 2007 996 1002 (Pubitemid 47076543)
187. J.H. Devine, D.W. Eubank, D.E. Clouthier, P. Tontonoz, B.M. Spiegelman, and R.E. Hammer et al. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo J Biol Chem 274 1999 13604 13612
188. D.D. Sears, A. Hsiao, J.M. Ofrecio, J. Chapman, W. He, and J.M. Olefsky Selective modulation of promoter recruitment and transcriptional activity of PPARgamma Biochem Biophys Res Commun 364 2007 515 521 (Pubitemid 350026497)
189. H.P. Guan, Y. Li, M.V. Jensen, C.B. Newgard, C.M. Steppan, and M.A. Lazar A futile metabolic cycle activated in adipocytes by antidiabetic agents Nat Med 8 2002 1122 1128 (Pubitemid 35175967)
190. X. Guo, K. Xu, J. Zhang, H. Li, W. Zhang, and H. Wang et al. Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of peroxisome proliferator-activated receptor gamma activation in mice J Biol Chem 285 2010 23711 23720
191. A. Aarsland, D. Chinkes, and R.R. Wolfe Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding Am J Clin Nutr 65 1997 1774 1782 (Pubitemid 27240693)
192. J.B. Kim, P. Sarraf, M. Wright, K.M. Yao, E. Mueller, and G. Solanes et al. Nutritional and insulin regulation of fatty acid synthase and leptin gene expression through ADD1/SREBP1 J Clin Invest 101 1998 1 9 (Pubitemid 28058896)
193. C. Rufo, M. Teran-Garcia, M.T. Nakamura, S.H. Koo, H.C. Towle, and S.D. Clarke Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription J Biol Chem 276 2001 21969 21975
194. M. Iwaki, M. Matsuda, N. Maeda, T. Funahashi, Y. Matsuzawa, and M. Makishima et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors Diabetes 52 2003 1655 1663 (Pubitemid 36792453)
195. A.R. Nawrocki, M.W. Rajala, E. Tomas, U.B. Pajvani, A.K. Saha, and M.E. Trumbauer et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists J Biol Chem 281 2006 2654 2660 (Pubitemid 43845727)
196. K. Maeda, K. Okubo, I. Shimomura, T. Funahashi, Y. Matsuzawa, and K. Matsubara CDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1) Biochem Biophys Res Commun 221 1996 286 289 (Pubitemid 26136463)
197. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes J Biol Chem 270 1995 26746 26749
198. E. Hu, P. Liang, and B.M. Spiegelman AdipoQ is a novel adipose-specific gene dysregulated in obesity J Biol Chem 271 1996 10697 10703 (Pubitemid 26145805)
199. M.P. Krause, Y. Liu, V. Vu, L. Chan, A. Xu, and M.C. Riddell et al. Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function Am J Physiol Cell Physiol 295 2008 C203 C212
200. R. Natarajan, F.N. Salloum, B.J. Fisher, R.C. Kukreja, and A.A. Fowler 3rd Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury J Cardiovasc Pharmacol 51 2008 178 187 (Pubitemid 351301479)
201. T.S. Tsao, E. Tomas, H.E. Murrey, C. Hug, D.H. Lee, and N.B. Ruderman et al. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways J Biol Chem 278 2003 50810 50817 (Pubitemid 37548930)
202. J. Fruebis, T.S. Tsao, S. Javorschi, D. Ebbets-Reed, M.R. Erickson, and F.T. Yen et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice Proc Natl Acad Sci USA 98 2001 2005 2010 (Pubitemid 32165613)
203. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, and J. Miyagawa et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1999 79 83 (Pubitemid 29299050)
204. T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, and K. Tobe Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J Clin Invest 116 2006 1784 1792 (Pubitemid 44033298)
205. B. Ranscht, and M.T. Dours-Zimmermann T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region Neuron 7 1991 391 402
206. C. Hug, J. Wang, N.S. Ahmad, J.S. Bogan, T.S. Tsao, and H.F. Lodish T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin Proc Natl Acad Sci USA 101 2004 10308 10313 (Pubitemid 38924921)
207. E. Kudrjashova, P. Bashtrikov, V. Bochkov, Y. Parfyonova, V. Tkachuk, and J. Antropova et al. Expression of adhesion molecule T-cadherin is increased during neointima formation in experimental restenosis Histochem Cell Biol 118 2002 281 290 (Pubitemid 35216471)
208. Y. Okamoto, Y. Arita, M. Nishida, M. Muraguchi, N. Ouchi, and M. Takahashi et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls Horm Metab Res 32 2000 47 50 (Pubitemid 30143606)
209. S. Landskroner-Eiger, B. Qian, E.S. Muise, A.R. Nawrocki, J.P. Berger, and E.J. Fine et al. Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo Clin Cancer Res 15 2009 3265 3276
210. M.S. Denzel, L.W. Hebbard, G. Shostak, L. Shapiro, R.D. Cardiff, and B. Ranscht Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer Clin Cancer Res 15 2009 3256 3264
211. L.W. Hebbard, M. Garlatti, L.J. Young, R.D. Cardiff, R.G. Oshima, and B. Ranscht T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model Cancer Res 68 2008 1407 1416 (Pubitemid 351346848)
212. N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, and H. Nagaretani et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 Nat Med 8 2002 731 737 (Pubitemid 34778727)
213. T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, and S. Uchida et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med 8 2002 1288 1295 (Pubitemid 35373562)
214. E. Tomas, T.S. Tsao, A.K. Saha, H.E. Murrey, C.Cc. Zhang, and S.I. Itani et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation Proc Natl Acad Sci USA 99 2002 16309 16313 (Pubitemid 35462791)
215. T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo, and S. Kita et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 2003 762 769 (Pubitemid 36735700)
216. Y. Hada, T. Yamauchi, H. Waki, A. Tsuchida, K. Hara, and H. Yago et al. Selective purification and characterization of adiponectin multimer species from human plasma Biochem Biophys Res Commun 356 2007 487 493 (Pubitemid 46454397)
217. Y. Hattori, Y. Nakano, S. Hattori, A. Tomizawa, K. Inukai, and K. Kasai High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells FEBS Lett 582 2008 1719 1724
218. K. Ma, A. Cabrero, P.K. Saha, H. Kojima, L. Li, and B.H. Chang et al. Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin J Biol Chem 277 2002 34658 34661
219. N. Kubota, Y. Terauchi, T. Yamauchi, T. Kubota, M. Moroi, and J. Matsui et al. Disruption of adiponectin causes insulin resistance and neointimal formation J Biol Chem 277 2002 25863 25866 (Pubitemid 34967064)
220. T. Yamauchi, Y. Nio, T. Maki, M. Kobayashi, T. Takazawa, and M. Iwabu et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13 2007 332 339 (Pubitemid 46376688)
221. G.W. Wong, J. Wang, C. Hug, T.S. Tsao, and H.F. Lodish A family of Acrp30/adiponectin structural and functional paralogs Proc Natl Acad Sci USA 101 2004 10302 10307 (Pubitemid 38924920)
222. G.W. Wong, S.A. Krawczyk, C. Kitidis-Mitrokostas, G. Ge, E. Spooner, and C. Hug et al. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin FASEB J 23 2009 241 258
223. M.L. Delporte, S.M. Brichard, M.P. Hermans, C. Beguin, and M. Lambert Hyperadiponectinaemia in anorexia nervosa Clin Endocrinol (Oxf) 58 2003 22 29 (Pubitemid 36098844)
224. I. Dostalova, K. Smitka, H. Papezova, H. Kvasnickova, and J. Nedvidkova Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines Physiol Res 56 2007 587 594
225. P.A. Dutchak, T. Katafuchi, A.L. Bookout, J.H. Choi, R.T. Yu, and D.J. Mangelsdorf et al. Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones Cell 148 2012 556 567
226. A.C. Adams, T. Coskun, C.C. Cheng, L.S. O Farrell, S.L. Dubois, and A. Kharitonenkov Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones Mol Metab 2 2013 205 214
227. Y. Hotta, H. Nakamura, M. Konishi, Y. Murata, H. Takagi, and S. Matsumura et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver Endocrinology 150 2009 4625 4633
228. M.K. Badman, A. Koester, J.S. Flier, A. Kharitonenkov, and E. Maratos-Flier Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis Endocrinology 150 2009 4931 4940
229. V. Golozoubova, H. Gullberg, A. Matthias, B. Cannon, B. Vennstrom, and J. Nedergaard Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors Mol Endocrinol 18 2004 384 401 (Pubitemid 38183937)
230. K.C. Madison Barrier function of the skin: "la raison d'etre" of the epidermis J Invest Dermatol 121 2003 231 241 (Pubitemid 36969895)
231. P.W. Wertz, and D.T. Downing Ceramides of pig epidermis: structure determination J Lipid Res 24 1983 759 765
232. N. Nicolaides Skin lipids: their biochemical uniqueness Science 186 1974 19 26
233. Y. Zheng, K.J. Eilertsen, L. Ge, L. Zhang, J.P. Sundberg, and S.M. Prouty et al. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse Nat Genet 23 1999 268 270 (Pubitemid 29526420)
234. L. Ge, J.S. Gordon, C. Hsuan, K. Stenn, and S.M. Prouty Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity J Invest Dermatol 120 2003 707 714 (Pubitemid 36529068)
235. M. Miyazaki, F.E. Gomez, and J.M. Ntambi Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse J Lipid Res 43 2002 2146 2154 (Pubitemid 35471083)
236. H. Guillou, V. Rioux, D. Catheline, J.N. Thibault, M. Bouriel, and S. Jan et al. Conversion of hexadecanoic acid to hexadecenoic acid by rat delta6-desaturase J Lipid Res 44 2003 450 454 (Pubitemid 37279691)
237. G.O. Burr, and M.M. Burr On the nature and role of the fatty acids essential in nutrition J Biol Chem 86 1930 587 621
238. C.D. Funk Prostaglandins and leukotrienes: advances in eicosanoid biology Science 294 2001 1871 1875 (Pubitemid 33101574)
239. P.W. Wertz, E.S. Cho, and D.T. Downing Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat Biochim Biophys Acta 753 1983 350 355 (Pubitemid 14233563)
240. H.S. Hansen, and B. Jensen Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate Biochim Biophys Acta 834 1985 357 363 (Pubitemid 15025244)
241. G. Imokawa, Y. Yada, K. Higuchi, M. Okuda, Y. Ohashi, and A. Kawamata Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia J Clin Invest 94 1994 89 96 (Pubitemid 24218080)
242. C.K. Stroud, T.Y. Nara, M. Roqueta-Rivera, E.C. Radlowski, P. Lawrence, and Y. Zhang et al. Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration J Lipid Res 50 2009 1870 1880
243. S.D. Phinney, S.D. Clarke, R.S. Odin, L.L. Moldawer, G.L. Blackburn, and B.R. Bistrian Thermogenesis secondary to transdermal water loss causes growth retardation in essential fatty acid-deficient rats Metab: Clin Exp 42 1993 1022 1026 (Pubitemid 23230435)
244. M.P. Agbaga, R.S. Brush, M.N. Mandal, K. Henry, M.H. Elliott, and R.E. Anderson Role of stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids Proc Natl Acad Sci USA 105 2008 12843 12848
245. M.N. Mandal, R. Ambasudhan, P.W. Wong, P.J. Gage, P.A. Sieving, and R. Ayyagari Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression Genomics 83 2004 626 635 (Pubitemid 38340804)
246. V. Vasireddy, Y. Uchida, N. Salem Jr, S.Y. Kim, M.N. Mandal, and G.B. Reddy et al. Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death Hum Mol Genet 16 2007 471 482 (Pubitemid 46522611)
247. A. McMahon, I.A. Butovich, N.L. Mata, M. Klein, R. Ritter 3rd, and J. Richardson Retinal pathology and skin barrier defect in mice carrying a stargardt disease-3 mutation in elongase of very long chain fatty acids-4 Mol Vision 13 2007 258 272 (Pubitemid 46323316)
248. D.J. Cameron, Z. Tong, Z. Yang, J. Kaminoh, S. Kamiyah, and H. Chen et al. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival Int J Biol Sci 3 2007 111 119 (Pubitemid 46238637)
249. W. Li, R. Sandhoff, M. Kono, P. Zerfas, V. Hoffmann, and B.C. Ding et al. Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice Int J Biol Sci 3 2007 120 128 (Pubitemid 46232773)
250. R. Westerberg, P. Tvrdik, A.B. Unden, J.E. Mansson, L. Norlen, and A. Jakobsson et al. Role for ELOVL3 and fatty acid chain length in development of hair and skin function J Biol Chem 279 2004 5621 5629 (Pubitemid 38220589)
251. P. Tvrdik, A. Asadi, L.P. Kozak, J. Nedergaard, B. Cannon, and A. Jacobsson Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue J Biol Chem 272 1997 31738 31746 (Pubitemid 28013323)
252. R. Westerberg, J.E. Mansson, V. Golozoubova, I.G. Shabalina, E.C. Backlund, and P. Tvrdik et al. ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue J Biol Chem 281 2006 4958 4968 (Pubitemid 43847758)
253. J.M. Ntambi, and M. Miyazaki Recent insights into stearoyl-CoA desaturase-1 Curr Opin Lipidol 14 2003 255 261 (Pubitemid 36688204)
254. A.H. Gates, and M. Karasek Hereditary absence of sebaceous glands in the mouse Science 148 1965 1471 1473
255. J.W. Fluhr, M. Mao-Qiang, B.E. Brown, P.W. Wertz, D. Crumrine, and J.P. Sundberg et al. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice J Invest Dermatol 120 2003 728 737 (Pubitemid 36529070)
256. M. Miyazaki, W.C. Man, and J.M. Ntambi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid J Nutr 131 2001 2260 2268 (Pubitemid 32851866)
257. J.M. Ntambi, M. Miyazaki, J.P. Stoehr, H. Lan, C.M. Kendziorski, and B.S. Yandell et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity Proc Natl Acad Sci USA 99 2002 11482 11486 (Pubitemid 34920951)
258. S.H. Lee, A. Dobrzyn, P. Dobrzyn, S.M. Rahman, M. Miyazaki, and J.M. Ntambi Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment J Lipid Res 45 2004 1674 1682 (Pubitemid 39296207)
259. H. Sampath, M.T. Flowers, X. Liu, C.M. Paton, R. Sullivan, and K. Chu et al. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity J Biol Chem 284 2009 19961 19973
260. D.E. Williard, J.O. Nwankwo, T.L. Kaduce, S.D. Harmon, M. Irons, and H.W. Moser et al. Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts J Lipid Res 42 2001 501 508 (Pubitemid 32366992)
261. S.J. Smith, S. Cases, D.R. Jensen, H.C. Chen, E. Sande, and B. Tow et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat Nat Genet 25 2000 87 90 (Pubitemid 30257043)
262. K.K. Buhman, S.J. Smith, S.J. Stone, J.J. Repa, J.S. Wong, and F.F. Knapp Jr et al. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis J Biol Chem 277 2002 25474 25479 (Pubitemid 34951861)
263. H.C. Chen, S.J. Smith, B. Tow, P.M. Elias, and R.V. Farese Jr. Leptin modulates the effects of acyl CoA: diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands J Clin Invest 109 2002 175 181 (Pubitemid 34083737)
264. C.L. Yen, M. Monetti, B.J. Burri, and R.V. Farese Jr. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters J Lipid Res 46 2005 1502 1511 (Pubitemid 43109815)
265. H.C. Chen, Z. Ladha, S.J. Smith, and R.V. Farese Jr. Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1 Am J Physiol Endocrinol Metab 284 2003 E213 E218
266. S.J. Stone, H.M. Myers, S.M. Watkins, B.E. Brown, K.R. Feingold, and P.M. Elias et al. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice J Biol Chem 279 2004 11767 11776 (Pubitemid 38401682)