ERRα: a metabolic function for the oldest orphan

Trends in Endocrinology and Metabolism

Volumn 19, Issue 8, 2008, Pages 269-276

  Villena, Josep A ^a   Kralli, Anastasia ^b  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; ESTROGEN RECEPTOR ALPHA; ERRALPHA ESTROGEN RELATED RECEPTOR; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; PPARGC1A PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

CELL FUNCTION; COLD EXPOSURE; ENERGY METABOLISM; GENE TARGETING; HEART VENTRICLE OVERLOAD; HORMONE METABOLISM; HUMAN; INFECTION; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; MULTIGENE FAMILY; PHYSIOLOGY;

ANIMALS; ENERGY METABOLISM; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MULTIGENE FAMILY; RECEPTORS, ESTROGEN; TRANS-ACTIVATORS;

EID: 52249090234     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2008.07.005     Document Type: Review

References (66)

1. Mangelsdorf D.J., et al. The nuclear receptor superfamily: the second decade. Cell 83 (1995) 835-839
2. O'Malley B. The steroid receptor superfamily: more excitement predicted for the future. Mol. Endocrinol. 4 (1990) 363-369
3. Giguere V., et al. Identification of a new class of steroid hormone receptors. Nature 331 (1988) 91-94
4. Kliewer S.A., et al. Orphan nuclear receptors: shifting endocrinology into reverse. Science 284 (1999) 757-760
5. Chawla A., et al. Nuclear receptors and lipid physiology: opening the X-files. Science 294 (2001) 1866-1870
6. Giguere V. To ERR in the estrogen pathway. Trends Endocrinol. Metab. 13 (2002) 220-225
7. Bonnelye E., and Aubin J.E. Estrogen receptor-related receptor alpha: a mediator of estrogen response in bone. J. Clin. Endocrinol. Metab. 90 (2005) 3115-3121
8. Bardet P.L., et al. Studying non-mammalian models? Not a fool's ERRand!. Trends Endocrinol. Metab. 17 (2006) 166-171
9. Ariazi E.A., and Jordan V.C. Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr. Top. Med. Chem. 6 (2006) 203-215
10. Stein R.A., and McDonnell D.P. Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr. Relat. Cancer 13 Suppl. 1 (2006) S25-S32
11. Greschik H., et al. Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Mol. Cell 9 (2002) 303-313
12. Horard B., and Vanacker J.M. Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. J. Mol. Endocrinol. 31 (2003) 349-357
13. Kallen J., et al. Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha. J. Biol. Chem. 279 (2004) 49330-49337
14. Busch B.B., et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J. Med. Chem. 47 (2004) 5593-5596
15. Willy P.J., et al. Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 8912-8917
16. Hyatt S.M., et al. On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. J. Med. Chem. 50 (2007) 6722-6724
17. Kallen J., et al. Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J. Biol. Chem. 282 (2007) 23231-23239
18. Finck B.N., and Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116 (2006) 615-622
19. Handschin C., and Spiegelman B.M. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27 (2006) 728-735
20. Vega R.B., et al. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20 (2000) 1868-1876
21. Tcherepanova I., et al. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J. Biol. Chem. 275 (2000) 16302-16308
22. Knutti D., et al. Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9713-9718
23. Huss J.M., et al. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J. Biol. Chem. 277 (2002) 40265-40274
24. Schreiber S.N., et al. The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J. Biol. Chem. 278 (2003) 9013-9018
25. Gaillard S., et al. Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. Mol. Endocrinol. 21 (2007) 62-76
26. Schreiber S.N., et al. The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6472-6477
27. Kamei Y., et al. PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12378-12383
28. Laganiere J., et al. A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression. J. Biol. Chem. 279 (2004) 18504-18510
29. Mootha V.K., et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6570-6575
30. Liu D., et al. Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element. J. Mol. Endocrinol. 34 (2005) 473-487
31. Sladek R., et al. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol. Cell. Biol. 17 (1997) 5400-5409
32. Vega R.B., and Kelly D.P. A role for estrogen-related receptor alpha in the control of mitochondrial fatty acid beta-oxidation during brown adipocyte differentiation. J. Biol. Chem. 272 (1997) 31693-31699
33. Kressler D., et al. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 277 (2002) 13918-13925
34. Ichida M., et al. Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha). J. Biol. Chem. 277 (2002) 50991-50995
35. Cartoni R., et al. Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J. Physiol. 567 (2005) 349-358
36. Barry J.B., and Giguere V. Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha. Cancer Res. 65 (2005) 6120-6129
37. Ariazi E.A., et al. Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway. Mol. Cancer Res. 5 (2007) 71-85
38. Vu E.H., et al. Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1. Biochemistry 46 (2007) 9795-9804
39. Tremblay A.M., et al. Phosphorylation-Dependent Sumoylation Regulates Estrogen-Related Receptor-{alpha} and -{gamma} Transcriptional Activity through a Synergy Control Motif. Mol. Endocrinol. 22 (2008) 570-584
40. Castet A., et al. Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol. Endocrinol. 20 (2006) 1035-1047
41. Gaillard S., et al. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Mol. Cell 24 (2006) 797-803
42. Huss J.M., et al. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol. Cell. Biol. 24 (2004) 9079-9091
43. Carrier J.C., et al. Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine. J. Biol. Chem. 279 (2004) 52052-52058
44. Villena J.A., et al. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 1418-1423
45. Rangwala S.M., et al. Estrogen-related receptor alpha is essential for the expression of antioxidant protection genes and mitochondrial function. Biochem. Biophys. Res. Commun. 357 (2007) 231-236
46. Sonoda J., et al. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 21 (2007) 1909-1920
47. Soriano F.X., et al. Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes 55 (2006) 1783-1791
48. Wende A.R., et al. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol. Cell. Biol. 25 (2005) 10684-10694
49. Dufour C.R., et al. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab. 5 (2007) 345-356
50. Araki M., and Motojima K. Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle. FEBS J. 273 (2006) 1669-1680
51. Zhang Y., et al. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J. Biol. Chem. 281 (2006) 39897-39906
52. Huss J.M., et al. The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab. 6 (2007) 25-37
53. Johnston S.D., et al. Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol. Endocrinol. 11 (1997) 342-352
54. Powelka A.M., et al. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J. Clin. Invest. 116 (2006) 125-136
55. Christian M., et al. Metabolic regulation by the nuclear receptor corepressor RIP140. Trends Endocrinol. Metab. 17 (2006) 243-250
56. Herzog B., et al. Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J. Biol. Chem. 281 (2006) 99-106
57. Barry J.B., et al. A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters. Mol. Endocrinol. 20 (2006) 302-310
58. Luo J., et al. Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol. Cell. Biol. 23 (2003) 7947-7956
59. Kelly D.P., and Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18 (2004) 357-368
60. Ijichi N., et al. Estrogen-related receptor alpha modulates the expression of adipogenesis-related genes during adipocyte differentiation. Biochem. Biophys. Res. Commun. 358 (2007) 813-818
61. Mootha V.K., et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34 (2003) 267-273
62. Patti M.E., et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 8466-8471
63. Chan D.C. Mitochondria: dynamic organelles in disease, aging, and development. Cell 125 (2006) 1241-1252
64. Lin M.T., and Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443 (2006) 787-795
65. McGill J.K., and Beal M.F. PGC-1alpha, a new therapeutic target in Huntington's disease?. Cell 127 (2006) 465-468
66. Nichol D., et al. RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis. J. Biol. Chem. 281 (2006) 32140-32147