Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) α. PPARα fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression

Journal of Biological Chemistry

Volumn 276, Issue 34, 2001, Pages 31521-31527

  Lawrence, Jeffrey W ^a   Li, Ying ^a   Chen, Shiying ^a   DeLuca, John G ^a   Berger, Joel P ^a   Umbenhauer, Diane R ^a   Moller, David E ^a   Zhou, Gaochao ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; GENES; ORGANIC ACIDS; RNA;

HEPATOCYTES;

BIOCHEMISTRY;

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A DEHYDROGENASE; APOLIPOPROTEIN C3; CARNITINE PALMITOYLTRANSFERASE; CIS ACTING ELEMENT; ENOYL COENZYME A HYDRATASE; FENOFIBRIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MESSENGER RNA; PEROXISOMAL MEMBRANE PROTEIN 70; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANS ACTING FACTOR; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCD3 PROTEIN, HUMAN; ABCD3 PROTEIN, RAT; APOLIPOPROTEIN C; CELL RECEPTOR; ISOMERASE; MEMBRANE PROTEIN; MULTIENZYME COMPLEX; PEROXISOMAL BIFUNCTIONAL ENZYME; PEROXISOMAL-BIFUNCTIONAL ENZYME; PRIMER DNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; TRANSACTIVATION; ANIMAL; COMPARATIVE STUDY; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PEROXISOME; PHYSIOLOGY; RAT; ULTRASTRUCTURE;

ANIMALIA; RODENTIA;

3-HYDROXYACYL COA DEHYDROGENASES; ACETYL-COA C-ACYLTRANSFERASE; ANIMALS; APOLIPOPROTEIN C-III; APOLIPOPROTEINS C; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; DNA PRIMERS; ENOYL-COA HYDRATASE; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; ISOMERASES; MEMBRANE PROTEINS; MULTIENZYME COMPLEXES; PEROXISOMES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0035943681     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103306200     Document Type: Article

References (37)

1. Lawrence, J. W., and Eacho, P. (1998) in Toxicology of the Liver (Plaa, G. L., and Hewitt, W. R., eds) pp. 125-157, Taylor & Francis, Washington, D. C
2. Foxworthy, P. S., White, S. L., Hoover, D. M., and Eacho, P. I. (1990) Toxicol. Appl. Pharmacol. 104, 386-394
3. Eacho, P. I., Foxworthy, P. S., Johnson, W. D., Hoover, D. M., and White, S. L. (1986) Toxicol. Appl. Pharmacol. 83, 430-437
4. Lake, B. G., Evans, J. G., Gray, T. J., Korosi, S. A., and North, C. J. (1989) Toxicol. Appl. Pharmacol. 99, 148-160
5. Staels, B., VuDac, N., Kosykh, V. A., Saladin, R., Fruchart, J. C., Dallongeville, J., and Auwerx, J. (1995) J. Clin. Invest. 95, 705-712
6. Rodriguez, J. C., Gilgomez, G., Hegardt, F. G., and Haro, D. (1994) J. Biol. Chem. 269, 18767-18772
7. Gonzalez, F. J., Peters, J. M., and Cattley, R. C. (1998) J. Natl. Cancer Inst. 90, 1702-1709
8. Tugwood, J. D., Aldridge, T. C., Lambe, K. G., Macdonald, N., and Woodyatt, N. J. (1996) Ann. N. Y. Acad. Sci. 804, 252-265
9. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7355-7359
10. Tugwood, J. D., Holden, P. R., James, N. H, Prince, R. A., and Roberts, R. A. (1998) Arch. Toxicol. 72, 169-177
11. Palmer, C. A., Hsu, M. H., Griffin, K. J., Raucy, J. L., and Johnson, E. F. (1998) Mol. Pharmacol. 53, 14-22
12. Woodyatt, N. J., Lambe, K. G., Myers, K. A., Tugwood, J. D., and Roberts, R. A. (1999) Carcinogenesis 20, 369-372
13. Lambe, K. G., Woodyatt, N. J., Macdonald, N., Chevalier, S., and Roberts, R. A. (1999) Toxicol. Lett. 110, 119-127
14. Foxworthy, P. S., and Eacho, P. I. (1986) Toxicol. Lett. 30, 189-196
15. Lowry, O. H., Roseborough, N. J., Carr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
16. Zhou, G., Cummings, R., Li, Y., Mitra, S., Wilkinson, H. A., Elbrecht, A., Hermes, J. D., Schaeffer, J. M., Smith, R. G., and Moller, D. E. (1998) Mol. Endocrinol. 12, 1594-1604
17. Berger, J., Leibowitz, M. D., Doebber, T. W., Elbrecht, A., Zhang, B., Zhou, G. C., Biswas, C., Cullinan, C. A., Hayes, N. S., Li, Y., Tanen, M., Ventre, J., Wu, M. S., Berger, G. D., Mosley, R., Marquis, R., Santini, C., Sahoo, S. P., Tolman, R. L., Smith, R. G., and Moller, D. E. (1999) J. Biol. Chem. 274, 6718-6725
18. Shu, H., Wong, B., Zhou, G., Li, Y., Berger, J., Woods, J. W., Wright, S. D., and Cai, T. Q. (2000) Biochem. Biophys. Res. Commun. 267, 345-349
19. Poosch, M. S., and Yamazaki, R. K. (1986) Biochim. Biophys. Acta 884, 585-593
20. Haddad, I. A., Ordovas, J. M., Fitzpatrick, T., and Karathanasis, S. K. (1986) J. Biol. Chem. 261, 13268-13277
21. Sharpe, C. R., Sidoli, A., Shelley, C. S., Lucero, M. A., Shoulders, C. C., and Baralle, F. E. (1984) Nucleic Acids Res. 12, 3917-3932
22. Mukherjee, R., Jow, L., Noonan, D., and McDonnell, D. P. (1994) J. Steroid Biochem. Mol. Biol. 51, 157-166
23. Blaauboer, B. J., Van Holstein, C. W. M., Bleumink, R., Mennes, W. C., Van Pelt, F. N. A. M., Yap, S. H., Van Pelt, J. F., Van Iersel, A. A. J., Timmerman, A., and Schmid, B. P. (1990) Biochem. Pharmacol. 40, 521-528
24. Elcombe, C. R., and Mitchell, A. M. (1986) Environ. Health Perspect. 70, 211-219
25. Brandt, J. M., Djouadi, F., and Kelly, D. P. (1998) J. Biol. Chem. 273, 23786-23792
26. Yu, G. S., Lu, Y. C., and Gulick, T. (1998) J. Biol. Chem. 273, 32901-32909
27. Wanders, R. J., Van, R. C., Griffioen, M., and Cohen, L. (1991) Biochim. Biophys. Acta 1115, 54-59
28. Stier, H., Fahimi, H. D., Van, V. P., Mannaerts, G. P., Volkl, A., and Baumgart, E. (1998) Differentiation 64, 55-66
29. Hertz, R., and Bar, T. J. (1998) Toxicol. Lett. 102-103, 85-90
30. Holden, P. R., and Tugwood, J. D. (1999) J. Mol. Endocrinol. 22, 1-8
31. Roberts, R. A., James, N. H., Hasmall, S. C., Holden, P. R., Lambe, K., Macdonald, N., West, D., Woodyatt, N. J., and Whitecome, D. (2000) Toxicol. Lett. 112, 49-57
32. Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez, S. P., Westphal, H., and Gonzalez, F. J. (1995) Mol. Cell. Biol. 15, 3012-3022
33. Peters, J. M., Cattley, R. C., and Gonzalez, F. J. (1997) Carcinogenesis 18, 2029-2033
34. Roberts, R. A. (1999) Arch. Toxicol. 73, 413-418
35. Macdonald, N., Holden, P. R., and Roberts, R. A. (1999) Cancer Res. 59, 4776-4780
36. Gervois, P., Torra, I. P., Chinetti, G., Grotzinger, T., Dubois, G., Fruchart, J. C., Fruchart, N. J., Leitersdorf, E., and Staels, B. (1999) Mol. Endocrinol. 13, 1535-1549
37. Hasmall, S. C., James, N. H., Macdonald, N., Soames, A. R., and Roberts, R. A. (2000) Arch. Toxicol. 74, 85-91