Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 11, 2001, Pages 6494-6499

  Tansey, J T ^a   Sztalryd, C ^a   Gruia Gray, J ^a   Roush, D L ^a   Zee, J V ^a   Gavrilova, O ^a   Reitman, M L ^a   Deng, C X ^a   Li, C ^a   Kimmel, A R ^a   Londos, C ^a,b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; LIPID;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; GLUCOSE INTOLERANCE; IN VIVO STUDY; INSULIN RESISTANCE; LIPID DIET; LIPID METABOLISM; LIPOLYSIS; METABOLIC RATE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CHOLESTEROL ESTERASE; DIETARY FATS; FEMALE; LEPTIN; LIPOLYSIS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; OXYGEN CONSUMPTION; PEPTIDES; PHOSPHOPROTEINS; THINNESS; TRIGLYCERIDES;

ANIMALIA;

EID: 14344268795     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.101042998     Document Type: Article

References (24)

1. Servetnick, D. A., Brasaemle, D. L., Gruia-Gray, J., Kimmel, A. R., Wolff, J. & Londos, C. (1995) J. Biol. Chem. 270, 16970-16973.
2. Greenberg, A. S., Egan, J. J., Wek, S. A., Moos, M. C., Jr., Londos, C. & Kimmel, A. R. (1993) Proc. Natl. Acad. Sci. USA 90, 12035-12039.
3. Londos, C., Brasaemle, D. L., Schultz, C. J., Segrest, J. P. & Kimmel, A. R. (1999) Semin. Cell Dev. Biol. 10, 51-58.
4. Brasaemle, D. L., Rubin, B., Harten, I. A., Gruia-Gray, J., Kimmel, A. R. & Londos, C. (2000) J. Biol. Chem. 275, 38486-38493.
5. Souza, S. C., de Vargas, L. M., Yamamoto, M. T., Lien, P., Franciosa, M. D., Moss, L. G. & Greenberg, A. S. (1998) J. Biol. Chem. 273, 24665-24669.
6. Martinez-Botas, J., Anderson, J. B., Tessier, D., Lapillone, A., Chang, B. H. J., Quast, M. J., Forenstein, D., Chen, K. H. & Chan, L. (2000) Nat. Genet. 26, 474-479.
7. Rodbell, M. (1964) J. Biol. Chem. 239, 375-380.
8. Honnor, R. C., Dhillon, G. S. & Londos, C. (1985) J. Biol. Chem. 260, 15122-15129.
9. Bradley, D. C. & Kaslow, H. R. (1989) Anal. Biochem. 131, 547.
10. Brasaemle, D. L., Levin, D. M., Adler-Wailes, D. C. & Londos, C. (1999) Biochim. Biophys. Acta 1483, 251-262.
11. Fine, J. B. & Di Girolamo, M. (1997) Int. J. Obesity Relat. Metab. Disord. 21, 764-768.
12. Brasaemle, D. L., Barber, T., Wolins, N. E., Serrero, G., Blanchette-Mackie, E. J. & Londos, C. (1997) J. Lipid Res. 38, 2249-2263.
13. Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L. & Brown, M. S. (1998) Genes Dev. 12, 3182-3194.
14. Egan, J. J., Greenberg, A. S., Chang, M. K., Wek, S. A., Moos, M. C., Jr., & Londos, C. (1992) Proc. Natl. Acad. Sci. USA 89, 8537-8541.
15. Honnor, R. C., Dhillon, G. S. & Londos, C. (1985) J. Biol. Chem. 260, 15130-15138.
16. Bergman, R. N. & Mittelman, S. D. (1998) J. Basic Clin. Physiol. Pharmacol. 9, 205-221.
17. Kleiber, R. E. (1975) in The Fire of Life (Krieger, Huntington, NY), pp. 179-222.
18. West, G. B., Brown, J. H. & Enquist, B. J. (1999) Science 284, 1677-1679.
19. Gavrilova, O., Leon, L. R., Marcus-Samuels, B., Mason, M. M., Castle, A. L., Refetoff, S., Vinson, C. & Reitman, M. L. (1999) Proc Natl. Acad. Sci. USA 96, 14623-14628.
20. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J.& Bauer, T. L. (1996) N. Engl. J. Med. 334, 292-295.
21. Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S. & Goldstein, J. L. (1999) Nature (London) 401, 73-76.
22. Gavrilova, O., Marcus-Samuels, B., Leon, L. R., Vinson, C. & Reitman, M. L. (2000) Nature (London) 403, 850-851.
23. Holm, C., Osterlund, T., Laurell, H. & Contreras, J. A. (2000)Annu. Rev. Nutr. 20, 365-393.
24. Gavrilova, O., Marcus-Samuels, B. & Reitman, M. L. (2000) Diabetes 49, 1910-1916.