Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice

Journal of Lipid Research

Volumn 42, Issue 3, 2001, Pages 328-337

  Patel, Dilip D ^a   Knight, Brian L ^a   Wiggins, David ^b   Humphreys, Sandy M ^b   Gibbons, Geoffrey F ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cholesterol; Diurnal cycle; Element binding protein; Fatty acids; Liver; Peroxisome proliferator activated receptor; Plasma; Sterol regulatory

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CHOLESTEROL; FATTY ACID; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL INTAKE; CHOLESTEROL SYNTHESIS; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; FOOD INTAKE; GENE EXPRESSION; GENE EXPRESSION REGULATION; LIPID LIVER LEVEL; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0035065450     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0022-2275(20)31655-2     Document Type: Article

References (50)

1. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
2. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
3. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm
4. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids
5. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
6. A critical role for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
7. A circadian rhythm in lipid mobilization which is altered in IDDM
8. Regulation of lipogenic enzyme gene expression by nutrients and hormones
9. Regulation of the mevalonate pathway
10. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membranebound transcription factor
11. Insulin and glucagon modulate hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by affecting immunoreactive protein levels
12. Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes
13. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
14. Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle
15. Diurnal variations of lipogenic enzymes, their substrate and effector levels, and lipogenesis from tritiated water in rat liver
16. Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states
17. Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freezeclamping. Effects of high fat diets
18. Physiological control of HMG CoA reductase activity
19. Regulation of cholesterol biosynthesis
20. Mevalonic acid in human plasma: Relationship of concentration and circadian rhythm to cholesterol synthesis rates in man
21. Sterol regulation of acetyl coenzyme A carboxylase: A mechanism for coordinate control of cellular lipid
22. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
23. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
24. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
25. Single-step method of RNA isolation by acid guanidininm thiocyanate-phenol-chloroform extraction
26. A relationship between the activities of hepatic lanosterol 14 alpha-demethylase and 3-hydroxy-3-methylglutaryl-CoA reductase
27. Increased rates of hepatic cholesterogenesis and lipogenesis in septic rats in vivo. Evidence for the possible involvement of insulin
28. Postprandial substrate deposition in human forearm and adipose tissues in vivo
29. Metabolic characteristics of human adipose tissue in vivo
30. Micromethod for measurement of sub-nanomole amounts of triacylglycerol
31. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor
32. A simple method for the isolation and purification of total lipids from animal tissues
33. The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A:Cholesterol acyltransferase activity in membranes from cultured human fibroblasts
34. Circadian rhythm in hepatic low-density-lipoprotein (LDL)-receptor expression and plasma LDL levels
35. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
36. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
37. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)
38. Diurnal variations of lipogenic enzyme mRNA quantities in rat liver
39. Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein
40. Diurnal and dietary induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase
41. Nutritional and hormonal regulation of lipogenicenzyme gene expression in rat liver
42. Peroxisome proliferator-activated receptors: Structures and function
43. Dietary polyunsaturated fatty acid regulation of gene transcription
44. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
45. Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels
46. Regulation of cholesterol biosynthesis in HeLa S3G cells by serum lipoproteins: Dexamethasone-mediated interference with suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase
47. The role of substrate supply in the regulation of cholesterol biosynthesis in rat hepatocytes
48. Evidence that changes in hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity are required partly to maintain a constant rate of sterol synthesis
49. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha