메뉴 건너뛰기




Volumn 116, Issue 3, 2006, Pages 590-597

PPARδ: A dagger in the heart of the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CARBACYCLIN; CELL NUCLEUS RECEPTOR; EZETIMIBE; FATTY ACID; FIBRIC ACID DERIVATIVE; GLITAZONE DERIVATIVE; GW 0742; GW 501516; ILOPROST; INSULIN SENSITIZING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

EID: 33644645013     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI27955     Document Type: Review
Times cited : (584)

References (88)
  • 1
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal, K.M., Carroll, M.D., Ogden, C.L., and Johnson, C.L. 2002. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 288:1723-1727.
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 2
    • 21544462572 scopus 로고    scopus 로고
    • Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of the evidence
    • Ford, E.S. 2005. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care. 28:1769-1778.
    • (2005) Diabetes Care , vol.28 , pp. 1769-1778
    • Ford, E.S.1
  • 3
    • 20144363712 scopus 로고    scopus 로고
    • A potential decline in life expectancy in the United States in the 21st century
    • Olshansky, S.J., et al. 2005. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 352:1138-1145.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1138-1145
    • Olshansky, S.J.1
  • 4
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Eckel, R.H., Grundy, S.M., and Zimmet, P.Z. 2005. The metabolic syndrome. Lancet. 365:1415-1428.
    • (2005) Lancet , vol.365 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 5
    • 23044447258 scopus 로고    scopus 로고
    • Point: The metabolic syndrome still lives
    • Grundy, S.M. 2005. Point: the metabolic syndrome still lives. Clin. Chem. 51:1352-1354.
    • (2005) Clin. Chem. , vol.51 , pp. 1352-1354
    • Grundy, S.M.1
  • 6
    • 0032764784 scopus 로고    scopus 로고
    • Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • Perseghin, G., et al. 1999. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 48:1600-1606.
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1
  • 8
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis: The road ahead
    • Glass, C.K., and Witztum, J.L. 2001. Atherosclerosis: the road ahead. Cell. 104:503-516.
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 9
    • 27444443876 scopus 로고    scopus 로고
    • Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement: Executive Summary
    • Grundy, S.M., et al. 2005. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement: Executive Summary. Circulation. 112:e285-e290.
    • (2005) Circulation , vol.112
    • Grundy, S.M.1
  • 11
    • 0037084392 scopus 로고    scopus 로고
    • Biological roles and mechanistic actions of co-repressor complexes
    • Jepsen, K., and Rosenfeld, M.G. 2002. Biological roles and mechanistic actions of co-repressor complexes. J. Cell Sci. 115:689-698.
    • (2002) J. Cell Sci. , vol.115 , pp. 689-698
    • Jepsen, K.1    Rosenfeld, M.G.2
  • 12
    • 2342573009 scopus 로고    scopus 로고
    • The role of corepressors in transcriptional regulation by nuclear hormone receptors
    • Privalsky, M.L. 2004. The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu. Rev. Physiol. 66:315-360.
    • (2004) Annu. Rev. Physiol. , vol.66 , pp. 315-360
    • Privalsky, M.L.1
  • 13
    • 0142116239 scopus 로고    scopus 로고
    • Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta
    • Lee, C.H., et al. 2003. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 302:453-457.
    • (2003) Science , vol.302 , pp. 453-457
    • Lee, C.H.1
  • 14
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    • Pascual, G., et al. 2005. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature. 437:759-763.
    • (2005) Nature , vol.437 , pp. 759-763
    • Pascual, G.1
  • 15
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and Green, S. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347:645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 16
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann, J.M., et al. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 270:12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1
  • 17
    • 0028972025 scopus 로고
    • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
    • Forman, B.M., et al. 1995. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 83:803-812.
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1
  • 18
    • 0026785388 scopus 로고
    • Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
    • Schmidt, A., et al. 1992. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6:1634-1641.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1634-1641
    • Schmidt, A.1
  • 19
    • 0026517010 scopus 로고
    • Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
    • Dreyer, C., et al. 1992. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell. 68:879-887.
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1
  • 20
    • 0028321529 scopus 로고
    • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    • Kliewer, S.A., et al. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. U. S. A. 91:7355-7359.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 7355-7359
    • Kliewer, S.A.1
  • 21
    • 0037039374 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer
    • Barak, Y., et al. 2002. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc. Natl. Acad. Sci. U. S. A. 99:303-308.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 303-308
    • Barak, Y.1
  • 22
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
    • Peters, J.M., et al. 2000. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator- activated receptor beta(delta). Mol. Cell. Biol. 20:5119-5128.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5119-5128
    • Peters, J.M.1
  • 23
    • 0035893364 scopus 로고    scopus 로고
    • Critical roles of PPAR beta/delta in keratinocyte response to inflammation
    • Tan, N.S., et al. 2001. Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev. 15:3263-3277.
    • (2001) Genes Dev. , vol.15 , pp. 3263-3277
    • Tan, N.S.1
  • 24
    • 0033105510 scopus 로고    scopus 로고
    • Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
    • Xu, H.E., et al. 1999. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell. 3:397-403.
    • (1999) Mol. Cell. , vol.3 , pp. 397-403
    • Xu, H.E.1
  • 25
    • 0034465517 scopus 로고    scopus 로고
    • Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype
    • Takada, I., et al. 2000. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Mol. Endocrinol. 14:733-740.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 733-740
    • Takada, I.1
  • 26
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman, B.M., Chen, J., and Evans, R.M. 1997. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. U. S. A. 94:4312-4317.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 27
    • 0028802627 scopus 로고
    • Differential activation of peroxisome proliferator-activated receptors by eicosanoids
    • Yu, K., et al. 1995. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J. Biol. Chem. 270:23975-23983.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23975-23983
    • Yu, K.1
  • 28
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey, G., et al. 1997. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11:779-791.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 779-791
    • Krey, G.1
  • 29
    • 0037417726 scopus 로고    scopus 로고
    • PPARdelta is a very low-density lipoprotein sensor in macrophages
    • Chawla, A., et al. 2003. PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc. Natl. Acad. Sci. U. S. A. 100:1268-1273.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 1268-1273
    • Chawla, A.1
  • 30
    • 0017614773 scopus 로고
    • The Tromso heart-study. High-density lipoprotein and coronary heart-disease: A prospective case-control study
    • Miller, N.E., Thelle, D.S., Forde, O.H., and Mjos, O.D. 1977. The Tromso heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lancet. 1:965-968.
    • (1977) Lancet , vol.1 , pp. 965-968
    • Miller, N.E.1    Thelle, D.S.2    Forde, O.H.3    Mjos, O.D.4
  • 31
    • 0024230807 scopus 로고
    • High density lipoprotein cholesterol and mortality. the Framingham Heart Study
    • Wilson, P.W., Abbott, R.D., and Castelli, W.P. 1988. High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis. 8:737-741.
    • (1988) Arteriosclerosis , vol.8 , pp. 737-741
    • Wilson, P.W.1    Abbott, R.D.2    Castelli, W.P.3
  • 32
    • 0033547789 scopus 로고    scopus 로고
    • Somatic gene transfer of human ApoA-I inhibits atherosclerosis progression in mouse models
    • Benoit, P., et al. 1999. Somatic gene transfer of human ApoA-I inhibits atherosclerosis progression in mouse models. Circulation. 99:105-110.
    • (1999) Circulation , vol.99 , pp. 105-110
    • Benoit, P.1
  • 33
    • 0035942162 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
    • Oliver, W.R., Jr., et al. 2001. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc. Natl. Acad. Sci. U. S. A. 98:5306-5311.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5306-5311
    • Oliver Jr., W.R.1
  • 34
    • 0034685589 scopus 로고    scopus 로고
    • Activation of PPARdelta alters lipid metabolism in db/db mice
    • Leibowitz, M.D., et al. 2000. Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett. 473:333-336.
    • (2000) FEBS Lett. , vol.473 , pp. 333-336
    • Leibowitz, M.D.1
  • 35
    • 22344449773 scopus 로고    scopus 로고
    • Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1
    • van der Veen, J.N., et al. 2005. Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J. Lipid Res. 46:526-534.
    • (2005) J. Lipid Res. , vol.46 , pp. 526-534
    • Van Der Veen, J.N.1
  • 36
    • 3242795814 scopus 로고    scopus 로고
    • Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    • Carr, D.B., et al. 2004. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 53:2087-2094.
    • (2004) Diabetes , vol.53 , pp. 2087-2094
    • Carr, D.B.1
  • 37
    • 0032162184 scopus 로고    scopus 로고
    • Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report
    • National Institutes of Health
    • [Anonymous]. 1998. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. National Institutes of Health. Obes. Res. 6(Suppl. 2):51S-209S.
    • (1998) Obes. Res. , vol.6 , Issue.2 SUPPL.
  • 39
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
    • Wang, Y.X., et al. 2003. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 113:159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1
  • 40
    • 9144271149 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
    • Tanaka, T., et al. 2003. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc. Natl. Acad. Sci. U. S. A. 100:15924-15929.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15924-15929
    • Tanaka, T.1
  • 41
    • 0034665188 scopus 로고    scopus 로고
    • Myosin isoforms, muscle fiber types, and transitions
    • Pette, D., and Staron, R.S. 2000. Myosin isoforms, muscle fiber types, and transitions. Microsc. Res. Tech. 50:500-509.
    • (2000) Microsc. Res. Tech. , vol.50 , pp. 500-509
    • Pette, D.1    Staron, R.S.2
  • 42
    • 0035083645 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
    • He, J., Watkins, S., and Kelley, D.E. 2001. Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes. 50:817-823.
    • (2001) Diabetes , vol.50 , pp. 817-823
    • He, J.1    Watkins, S.2    Kelley, D.E.3
  • 43
    • 0033504141 scopus 로고    scopus 로고
    • Muscle plasticity and metabolism: Effects of exercise and chronic diseases
    • Mercier, J., Perez-Martin, A., Bigard, X., and Ventura, R. 1999. Muscle plasticity and metabolism: effects of exercise and chronic diseases. Mol. Aspects Med. 20:319-373.
    • (1999) Mol. Aspects Med. , vol.20 , pp. 319-373
    • Mercier, J.1    Perez-Martin, A.2    Bigard, X.3    Ventura, R.4
  • 44
    • 3242727456 scopus 로고    scopus 로고
    • NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching
    • McCullagh, K.J., et al. 2004. NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching. Proc. Natl. Acad. Sci. U. S. A. 101:10590-10595.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10590-10595
    • McCullagh, K.J.1
  • 45
    • 4544358547 scopus 로고    scopus 로고
    • Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    • Kamei, Y., et al. 2004. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J. Biol. Chem. 279:41114-41123.
    • (2004) J. Biol. Chem. , vol.279 , pp. 41114-41123
    • Kamei, Y.1
  • 46
    • 0033519274 scopus 로고    scopus 로고
    • Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice
    • Hughes, S.M., Chi, M.M., Lowry, O.H., and Gundersen, K. 1999. Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice. J. Cell Biol. 145:633-642.
    • (1999) J. Cell Biol. , vol.145 , pp. 633-642
    • Hughes, S.M.1    Chi, M.M.2    Lowry, O.H.3    Gundersen, K.4
  • 47
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant, O., Foufelle, F., Scotto, C., Dauca, M., and Wahli, W. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology. 137:354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 48
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARdelta
    • Wang, Y.X., et al. 2004. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2:e294.
    • (2004) PLoS Biol. , vol.2
    • Wang, Y.X.1
  • 49
    • 0642303113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability
    • Luquet, S., et al. 2003. Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB J. 17:2299-2301.
    • (2003) FASEB J. , vol.17 , pp. 2299-2301
    • Luquet, S.1
  • 50
    • 21344434775 scopus 로고    scopus 로고
    • Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells
    • Abbot, E.L., et al. 2005. Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. FEBS J. 272:3004-3014.
    • (2005) FEBS J. , vol.272 , pp. 3004-3014
    • Abbot, E.L.1
  • 51
    • 0142120289 scopus 로고    scopus 로고
    • Functional relationship between MyoD and peroxisome proliferator- activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription
    • Solanes, G., Pedraza, N., Iglesias, R., Giralt, M., and Villarroya, F. 2003. Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription. Mol. Endocrinol. 17:1944-1958.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1944-1958
    • Solanes, G.1    Pedraza, N.2    Iglesias, R.3    Giralt, M.4    Villarroya, F.5
  • 52
    • 0029157866 scopus 로고
    • Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans
    • Hickey, M.S., et al. 1995. Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am. J. Physiol. 268:E453-E457.
    • (1995) Am. J. Physiol. , vol.268
    • Hickey, M.S.1
  • 53
    • 0033043464 scopus 로고    scopus 로고
    • Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats
    • Higashiura, K., et al. 1999. Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats. Am. J. Hypertens. 12:596-602.
    • (1999) Am. J. Hypertens. , vol.12 , pp. 596-602
    • Higashiura, K.1
  • 54
    • 16044365000 scopus 로고    scopus 로고
    • Interrelationships between muscle morphology, insulin action, and adiposity
    • Kriketos, A.D., et al. 1996. Interrelationships between muscle morphology, insulin action, and adiposity. Am. J. Physiol. 270:R1332-R1339.
    • (1996) Am. J. Physiol. , vol.270
    • Kriketos, A.D.1
  • 55
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley, D.E., Goodpaster, B., Wing, R.R., and Simoneau, J.A. 1999. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. 277:E1130-E1141.
    • (1999) Am. J. Physiol. , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 56
    • 0033952722 scopus 로고    scopus 로고
    • Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides
    • Manco, M., et al. 2000. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism. 49:220-224.
    • (2000) Metabolism , vol.49 , pp. 220-224
    • Manco, M.1
  • 57
    • 20144387426 scopus 로고    scopus 로고
    • Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta
    • Kramer, D.K., et al. 2005. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 54:1157-1163.
    • (2005) Diabetes , vol.54 , pp. 1157-1163
    • Kramer, D.K.1
  • 58
    • 7244238303 scopus 로고    scopus 로고
    • Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes
    • Watt, M.J., Southgate, R.J., Holmes, A.G., and Febbraio, M.A. 2004. Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes. J. Mol. Endocrinol. 33:533-544.
    • (2004) J. Mol. Endocrinol. , vol.33 , pp. 533-544
    • Watt, M.J.1    Southgate, R.J.2    Holmes, A.G.3    Febbraio, M.A.4
  • 59
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney, D.J., Parise, G., Melov, S., Safdar, A., and Tarnopolsky, M.A. 2005. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J. 19:1498-1500.
    • (2005) FASEB J. , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 60
    • 0038460823 scopus 로고    scopus 로고
    • Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle
    • Holst, D., et al. 2003. Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. Biochim. Biophys. Acta. 1633:43-50.
    • (2003) Biochim. Biophys. Acta , vol.1633 , pp. 43-50
    • Holst, D.1
  • 61
    • 0034530972 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase a activators
    • Lazennec, G., Canaple, L., Saugy, D., and Wahli, W. 2000. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol. Endocrinol. 14:1962-1975.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1962-1975
    • Lazennec, G.1    Canaple, L.2    Saugy, D.3    Wahli, W.4
  • 62
    • 0035793577 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta (PPARdelta)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
    • Hansen, J.B., et al. 2001. Peroxisome proliferator-activated receptor delta (PPARdelta)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling. J. Biol. Chem. 276:3175-3182.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3175-3182
    • Hansen, J.B.1
  • 63
    • 15044354314 scopus 로고    scopus 로고
    • Kinase signaling cascades that modulate peroxisome proliferator-activated receptors
    • Gelman, L., Michalik, L., Desvergne, B., and Wahli, W. 2005. Kinase signaling cascades that modulate peroxisome proliferator-activated receptors. Curr. Opin. Cell Biol. 17:216-222.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 216-222
    • Gelman, L.1    Michalik, L.2    Desvergne, B.3    Wahli, W.4
  • 64
    • 2942746692 scopus 로고    scopus 로고
    • Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle
    • Long, Y.C., Widegren, U., and Zierath, J.R. 2004. Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc. Nutr. Soc. 63:227-232.
    • (2004) Proc. Nutr. Soc. , vol.63 , pp. 227-232
    • Long, Y.C.1    Widegren, U.2    Zierath, J.R.3
  • 65
    • 30744439347 scopus 로고    scopus 로고
    • Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
    • Coffey, V.G., et al. 2005. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J. 20:190-192.
    • (2005) FASEB J. , vol.20 , pp. 190-192
    • Coffey, V.G.1
  • 66
    • 23044495913 scopus 로고    scopus 로고
    • Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity
    • Chin, E.R. 2005. Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity. J. Appl. Physiol. 99:414-423.
    • (2005) J. Appl. Physiol. , vol.99 , pp. 414-423
    • Chin, E.R.1
  • 67
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley, W.C., Recchia, F.A., and Lopaschuk, G.D. 2005. Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 85:1093-1129.
    • (2005) Physiol. Rev. , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 68
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng, L., et al. 2004. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med. 10:1245-1250.
    • (2004) Nat. Med. , vol.10 , pp. 1245-1250
    • Cheng, L.1
  • 69
    • 0345735302 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
    • Cheng, L., et al. 2004. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem. Biophys. Res. Commun. 313:277-286.
    • (2004) Biochem. Biophys. Res. Commun. , vol.313 , pp. 277-286
    • Cheng, L.1
  • 70
    • 13844256366 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes
    • Planavila, A., et al. 2005. Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc. Res. 65:832-841.
    • (2005) Cardiovasc. Res. , vol.65 , pp. 832-841
    • Planavila, A.1
  • 71
    • 20444466460 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy
    • Planavila, A., Laguna, J.C., and Vazquez-Carrera, M. 2005. Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. J. Biol. Chem. 280:17464-17471.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17464-17471
    • Planavila, A.1    Laguna, J.C.2    Vazquez-Carrera, M.3
  • 72
    • 0942287345 scopus 로고    scopus 로고
    • Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response
    • Feingold, K., Kim, M.S., Shigenaga, J., Moser, A., and Grunfeld, C. 2004. Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response. Am. J. Physiol. Endocrinol. Metab. 286:E201-E207.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.286
    • Feingold, K.1    Kim, M.S.2    Shigenaga, J.3    Moser, D.4    Grunfeld, C.5
  • 73
    • 0035941270 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages
    • Vosper, H., et al. 2001. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages. J. Biol. Chem. 276:44258-44265.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44258-44265
    • Vosper, H.1
  • 74
    • 85047693466 scopus 로고    scopus 로고
    • Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
    • doi:10.1172/JCI200418730
    • Li, A.C., et al. 2004. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ. J. Clin. Invest. 114:1564-1576. doi:10.1172/JCI200418730.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1564-1576
    • Li, A.C.1
  • 75
    • 0038460253 scopus 로고    scopus 로고
    • PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    • Welch, J.S., Ricote, M., Akiyama, T.E., Gonzalez, F.J., and Glass, C.K. 2003. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc. Natl. Acad. Sci. U. S. A. 100:6712-6717.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 6712-6717
    • Welch, J.S.1    Ricote, M.2    Akiyama, T.E.3    Gonzalez, F.J.4    Glass, C.K.5
  • 76
    • 20444378931 scopus 로고    scopus 로고
    • The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice
    • Graham, T.L., et al. 2005. The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice. Atherosclerosis. 181:29-37.
    • (2005) Atherosclerosis , vol.181 , pp. 29-37
    • Graham, T.L.1
  • 77
    • 84985015106 scopus 로고    scopus 로고
    • PPAR delta is a potent insulin sensitizer
    • In press
    • Lee, C.H., et al. 2006. PPAR delta is a potent insulin sensitizer. Proc. Natl. Acad. Sci. U. S. A. In press.
    • (2006) Proc. Natl. Acad. Sci. U. S. A.
    • Lee, C.H.1
  • 78
    • 0033615352 scopus 로고    scopus 로고
    • PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He, T.C., Chan, T.A., Vogelstein, B., and Kinzler, K.W. 1999. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 99:335-345.
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 79
    • 10644231009 scopus 로고    scopus 로고
    • PPARdelta status and Apcmediated tumourigenesis in the mouse intestine
    • Reed, K.R., et al. 2004. PPARdelta status and Apcmediated tumourigenesis in the mouse intestine. Oncogene. 23:8992-8996.
    • (2004) Oncogene , vol.23 , pp. 8992-8996
    • Reed, K.R.1
  • 80
    • 2442708845 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis
    • Harman, F.S., et al. 2004. Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat. Med. 10:481-483.
    • (2004) Nat. Med. , vol.10 , pp. 481-483
    • Harman, F.S.1
  • 81
    • 1942470331 scopus 로고    scopus 로고
    • Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    • Gupta, R.A., et al. 2004. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med. 10:245-247.
    • (2004) Nat. Med. , vol.10 , pp. 245-247
    • Gupta, R.A.1
  • 82
    • 0035956850 scopus 로고    scopus 로고
    • Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells
    • Park, B.H., Vogelstein, B., and Kinzler, K.W. 2001. Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. Proc. Natl. Acad. Sci. U. S. A. 98:2598-2603.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 2598-2603
    • Park, B.H.1    Vogelstein, B.2    Kinzler, K.W.3
  • 83
    • 0031667938 scopus 로고    scopus 로고
    • Activators of the nuclear receptor PPARgamma enhance colon polyp formation
    • Saez, E., et al. 1998. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat. Med. 4:1058-1061.
    • (1998) Nat. Med. , vol.4 , pp. 1058-1061
    • Saez, E.1
  • 84
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    • Lefebvre, A.M., et al. 1998. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat. Med. 4:1053-1057.
    • (1998) Nat. Med. , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1
  • 85
    • 0035117591 scopus 로고    scopus 로고
    • The importance of clinical research: The role of thermogenesis in human obesity
    • Schoeller, D.A. 2001. The importance of clinical research: the role of thermogenesis in human obesity. Am. J. Clin. Nutr. 73:511-516.
    • (2001) Am. J. Clin. Nutr. , vol.73 , pp. 511-516
    • Schoeller, D.A.1
  • 86
    • 0042707908 scopus 로고    scopus 로고
    • Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
    • Lakka, T.A., et al. 2003. Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome. Med. Sci. Sports Exerc. 35:1279-1286.
    • (2003) Med. Sci. Sports Exerc. , vol.35 , pp. 1279-1286
    • Lakka, T.A.1
  • 87
    • 0033546190 scopus 로고    scopus 로고
    • Endothelial cell apoptosis induced by the peroxisome proliferator- activated receptor (PPAR) ligand 15-deoxy-Delta12,14-prostaglandin J2
    • Bishop-Bailey, D., and Hla, T. 1999. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12,14-prostaglandin J2. J. Biol. Chem. 274:17042-17048.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17042-17048
    • Bishop-Bailey, D.1    Hla, T.2
  • 88
    • 0037192764 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells
    • Zhang, J., et al. 2002. Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells. J. Biol. Chem. 277:11505-11512.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11505-11512
    • Zhang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.