Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway

Biochemical Journal

Volumn 354, Issue 1, 2001, Pages 189-197

  Louet, J F ^a   Chatelain, F ^a   Decaux, J F ^a   Park, E A ^a   Kohl, C ^a   Pineau, T ^a   Girard, J ^a   Pegorier, J P ^a  

^a CNRS   (France)

Author keywords

Cultured hepatocyte; Long chain fatty acyl CoA; PPAR null mice; Transient transfection

Indexed keywords

ACYL COENZYME A; CARNITINE PALMITOYLTRANSFERASE; LONG CHAIN FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FAT INTAKE; FATTY ACID TRANSPORT; FEMALE; GENE EXPRESSION SYSTEM; GENETIC TRANSFECTION; LIVER CELL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CARNITINE O-PALMITOYLTRANSFERASE; CELLS, CULTURED; CLOFIBRATE; DNA PRIMERS; ENZYME INHIBITORS; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROMOTER REGIONS (GENETICS); RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA; EUKARYOTA;

EID: 0035865496     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540189     Document Type: Article

References (54)

1. Fatty acid regulation of gene expression. Its role in fuel partitioning and insulin resistance
2. Regulation of gene expression by fatty acids
3. Molecular and biochemical analyses of fatty acid transport, metabolism and gene regulation in Escherichia coli
4. Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae
5. Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by free acid rather than the acyl-CoA derivative
6. A new look at fatty acids as signal-transducing molecules
7. Peroxisome proliferator activated receptors: Transcriptional regulators of adipogenesis, lipid metabolism and more
8. Perox some proliferators and peroxisome proliferator activated receptors (PPARs) as regulator of lipid metabolism
9. Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I transcription in cultured fetal rat hepatocytes
10. Glucose administration induces the premature expression of liver glucokinase gene in newborn rats. Relation with DNase I-hypersensitive sites
11. Initial expression or glucokinase gene in cultured hepatocytes from suckling rats is linked to the synthesis of an insulin-dependent protein
12. Peroxisome proliferator-activated receptor α isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
13. Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase 1 (L-CPT1) gene
14. PPAR-RXR heterodimer activates a peroxysome proloferator response element upstream of the bifunctional enzyme gene
15. Reporter constructs with low background activity utilizing the cat gene
16. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
17. Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells
18. Widespread long-term gene transfer to mouse skeletal muscles and heart
19. A simple phase-extraction assay for chloramphenicol acetyltransferase activity
20. Inhibition of long-chain acyl-CoA synthetase by the peroxisome proliferator perfluorodecanoic acid in rat hepatocytes
21. Troglitazone inhibits fatty acid oxidation and esterilication and gluconeogenesis in isolated hepatocytes from starved rats
22. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
23. Dominant role of glucagon in the initial induction of phosphoenolpyruvate carboxykinase (PEPCK) mRNA in cultured hepatocytes from fetal rats
24. Expression of liver carnitine palmitoyltransferase I and II genes during development of the rat
25. Developmental changes in mitochondrial 3-hydroxy-3-methyl-glutaryl-CoA synthase gene express on in rat liver, intestine and kidney
26. Identification of a DNA clone to phosphoenolpyruvate carboxykinase (GTP) from rat cytosol
27. The nucleotide sequence of a rat 18 S ribosomal ribonucleic acid gene and a proposal for the secondary structure of 18 S ribosomal ribonucleic acid
28. Guanosine 5′-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1,4,5-triphosphate
29. Regulation of fatty acid oxidation in isolated hepatocytes and liver mitochondria from newborn rabbits
30. Acyl-CoA synthetase in rat liver peroxisomes. Computer-assisted analysis of cell fractionation experiments
31. Protein measurement with the folin phenol reagent
32. Probability tables for individual comparisons by ranking methods
33. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
34. Reduced hepatic fatty acid oxidation in fasting PPARα null mice is due to impaired mitochondrial hydroxymethyl-glutaryl-CoA synthase gene expression
35. Up-regulation of the expression of the gene for liver fatty-acid binding protein by long-chain fatty acids
36. Peroxisome proliferator-activated receptor agonists
37. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator activated receptors α and δ
38. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and δ
39. Fatty acids, eicosanoids and hypolipidemic agents identified as ligand of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
40. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha
41. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor α-deficient mice
42. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
43. Peroxisomal and mitochondrial fatty acid β-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor α and peroxisomal fatty acyl-CoA oxidase
44. Peroxisome proliferator-activated receptor α mediates the adaptative response to fasting
45. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα -null mouse as a model of fatty acid oxidation disorders
46. Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator of polyunsaturated fatty acid supression of hepatic L-pyruvate kinase gene transcription
47. Mitochondrial 3-hydroxy-3methylglutaryl-CoA synthase: A control enzyme in ketogenesis
48. Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription
49. The mouse peroxisome proliferator activated receptor recognizes a response element in 5′ flanking sequence of the rat acyl CoA oxidase
50. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase 1β gene promoters by fatty acid enzyme substrate
51. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
52. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α
53. Peroxisome proliferator-activated receptor-α inhibits hepatic S14 gene transcription. Evidence against the peroxisome proliferator-activated recepfor-α as the mediator of polyunsaturated fatty acid regulation of S14 gene transcription
54. Localization of polyunsaturated fatty acid response region in stearoyl-CoA desaturase gene