-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.6
-
2
-
-
0027459878
-
Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
-
Hotamisligil, G.S., N.S. Shargill, and B.M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science. 259:87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
3
-
-
0028031569
-
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α
-
Hotamisligil, G.S., A. Budavari, D. Murray, and B.M. Spiegelman. 1994. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α. J. Clin. Invest. 94:1543-1549.
-
(1994)
J. Clin. Invest.
, vol.94
, pp. 1543-1549
-
-
Hotamisligil, G.S.1
Budavari, A.2
Murray, D.3
Spiegelman, B.M.4
-
4
-
-
0029859045
-
Regulation of gene expression by insulin
-
O'Brien, R.M., and D.K. Granner. 1996. Regulation of gene expression by insulin. Physiol. Rev. 76:1109-1161.
-
(1996)
Physiol. Rev.
, vol.76
, pp. 1109-1161
-
-
O'Brien, R.M.1
Granner, D.K.2
-
5
-
-
0030446644
-
Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: A review of the potential cellular and molecular regulation
-
Foufelle, F., J. Girard, and P. Ferre. 1996. Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: a review of the potential cellular and molecular regulation. Adv. Enzyme Regul. 36:199-226.
-
(1996)
Adv. Enzyme Regul.
, vol.36
, pp. 199-226
-
-
Foufelle, F.1
Girard, J.2
Ferre, P.3
-
6
-
-
0027648820
-
ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
-
Tontonoz, P., J.B. Kim, R.A. Graves, and B.M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13:4753-1759.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4753-11759
-
-
Tontonoz, P.1
Kim, J.B.2
Graves, R.A.3
Spiegelman, B.M.4
-
7
-
-
0030007427
-
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
-
Kim, J.B., and B.M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10:1096-1107.
-
(1996)
Genes Dev.
, vol.10
, pp. 1096-1107
-
-
Kim, J.B.1
Spiegelman, B.M.2
-
8
-
-
2642619603
-
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
-
Shimano, H., J.D. Horton, R.E. Hammer, I. Shimomura, M.S. Brown, and J.L. Goldstein. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 99:846-854.
-
(1996)
J. Clin. Invest.
, vol.99
, pp. 846-854
-
-
Shimano, H.1
Horton, J.D.2
Hammer, R.E.3
Shimomura, I.4
Brown, M.S.5
Goldstein, J.L.6
-
9
-
-
0030904931
-
Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory clement-binding protein-responsive gene
-
Ericsson, J., S.M. Jackson, J.B. Kim, B.M. Spiegelman, and P.A. Edwards. 1997. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1-and sterol regulatory clement-binding protein-responsive gene. J. Biol. Chem. 272:7298-7305.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7298-7305
-
-
Ericsson, J.1
Jackson, S.M.2
Kim, J.B.3
Spiegelman, B.M.4
Edwards, P.A.5
-
10
-
-
0028875426
-
Sterol regulation of fatty acid synthase promoter
-
Bennett, M.K., J.M. Lopez, H.B. Sanchez, and T.F. Osborne. 1995. Sterol regulation of fatty acid synthase promoter. J. Biol. Chem. 270:20078-20083.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20078-20083
-
-
Bennett, M.K.1
Lopez, J.M.2
Sanchez, H.B.3
Osborne, T.F.4
-
11
-
-
0023926825
-
Cloning and expression of mouse fatty acid synthase and other specific mRNAs
-
Paulauskis, J.D., and H.S. Sul. 1988. Cloning and expression of mouse fatty acid synthase and other specific mRNAs. J. Biol. Chem. 263:7049-7054.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 7049-7054
-
-
Paulauskis, J.D.1
Sul, H.S.2
-
12
-
-
0015454954
-
Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine
-
Lakshmanan, M.R., C.M. Nepokroeff, and J.W. Porter. 1972. Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine. Proc. Natl. Acad. Sci. USA. 69:3516-3519.
-
(1972)
Proc. Natl. Acad. Sci. USA
, vol.69
, pp. 3516-3519
-
-
Lakshmanan, M.R.1
Nepokroeff, C.M.2
Porter, J.W.3
-
13
-
-
0027490174
-
SREBP-1. A basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
-
Yokoyama, C., X. Wang, M.R. Briggs, A. Admon, J. Wu, X. Hua, J.L. Goldstein, and M.S. Brown. 1993. SREBP-1. a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 75:187-197.
-
(1993)
Cell
, vol.75
, pp. 187-197
-
-
Yokoyama, C.1
Wang, X.2
Briggs, M.R.3
Admon, A.4
Wu, J.5
Hua, X.6
Goldstein, J.L.7
Brown, M.S.8
-
14
-
-
0027139362
-
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
-
Hua, X., C. Yokoyama, J. Wu, M.R. Briggs, M.S. Brown, J.L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA. 90:11603-11607.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 11603-11607
-
-
Hua, X.1
Yokoyama, C.2
Wu, J.3
Briggs, M.R.4
Brown, M.S.5
Goldstein, J.L.6
Wang, X.7
-
15
-
-
0028225462
-
SREBP1, a membrane-bound transcription factor released by sterol-regulated proteolysis
-
Wang, X., R. Sato, M.S. Brown, X. Hua, and J.L. Goldstein. 1994. SREBP1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77:53-62.
-
(1994)
Cell
, vol.77
, pp. 53-62
-
-
Wang, X.1
Sato, R.2
Brown, M.S.3
Hua, X.4
Goldstein, J.L.5
-
16
-
-
0030604717
-
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
-
Sakai, J., E.A. Duncan, R.B. Rawaon, X. Hua, M.S. Brown, and J.L. Goldstein. 1996. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 85: 1037-1046.
-
(1996)
Cell
, vol.85
, pp. 1037-1046
-
-
Sakai, J.1
Duncan, E.A.2
Rawaon, R.B.3
Hua, X.4
Brown, M.S.5
Goldstein, J.L.6
-
17
-
-
0028839010
-
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
-
Sheng, Z., H. Otani, M.S. Brown, and J.L. Goldstein. 1995. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92:935-938.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 935-938
-
-
Sheng, Z.1
Otani, H.2
Brown, M.S.3
Goldstein, J.L.4
-
18
-
-
0030892083
-
Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene
-
Guan, G., P.H. Dai, T.F. Osborne, J.B. Kim, and I. Shechter. 1997. Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. J. Biol. Chem. 272:10296-10302.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10296-10302
-
-
Guan, G.1
Dai, P.H.2
Osborne, T.F.3
Kim, J.B.4
Shechter, I.5
-
19
-
-
0028963743
-
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
-
Kim, J.B., G.D. Spotts, Y.D. Halvorsen, H.M. Shih, T. Ellenberger, H.C. Towle, and B.M. Spiegelman. 1995. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol. 15:2582-2588.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2582-2588
-
-
Kim, J.B.1
Spotts, G.D.2
Halvorsen, Y.D.3
Shih, H.M.4
Ellenberger, T.5
Towle, H.C.6
Spiegelman, B.M.7
-
20
-
-
0024554495
-
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
-
Murre, C., P.S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell. 56:777-783.
-
(1989)
Cell
, vol.56
, pp. 777-783
-
-
Murre, C.1
McCaw, P.S.2
Baltimore, D.3
-
21
-
-
0027190308
-
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence
-
Briggs, M.R., C. Yokoyama, X. Wang, M.S. Brown, and J.L. Goldstein. 1993. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J. Biol. Chem. 268:14490-14496.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14490-14496
-
-
Briggs, M.R.1
Yokoyama, C.2
Wang, X.3
Brown, M.S.4
Goldstein, J.L.5
-
22
-
-
0027167918
-
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization
-
Wang, X., M.R. Briggs, X. Hua, C. Yokoyama, J.L. Goldstein, and M.S. Brown. 1993. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. J. Biol. Chem. 268:14497-14504.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14497-14504
-
-
Wang, X.1
Briggs, M.R.2
Hua, X.3
Yokoyama, C.4
Goldstein, J.L.5
Brown, M.S.6
-
23
-
-
0027936018
-
Identification of an insulin response element in the fatty acid synthase promoter
-
Moustaid, N., R.S. Beyer, and H.S. Sul. 1994. Identification of an insulin response element in the fatty acid synthase promoter. J. Biol. Chem. 269:5629-5634.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5629-5634
-
-
Moustaid, N.1
Beyer, R.S.2
Sul, H.S.3
-
24
-
-
0026511284
-
Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes
-
Lin, F.T., and M.D. Lane. 1992. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes Dev. 6:533-544.
-
(1992)
Genes Dev.
, vol.6
, pp. 533-544
-
-
Lin, F.T.1
Lane, M.D.2
-
25
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
-
Hu, E., J.B. Kim, P. Sarraf, and B.M. Spiegelman. 1996. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science. 274:2100-2103.
-
(1996)
Science
, vol.274
, pp. 2100-2103
-
-
Hu, E.1
Kim, J.B.2
Sarraf, P.3
Spiegelman, B.M.4
-
26
-
-
0024529257
-
Hormonal regulation of mouse fatty acid synthase gene transcription in liver
-
Paulauskis, J.D., and H.S. Sul. 1989. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. J. Biol. Chem. 264:574-577.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 574-577
-
-
Paulauskis, J.D.1
Sul, H.S.2
-
27
-
-
0029157428
-
Transient increase in obese gene expression after food intake or insulin administration
-
Saladin, R., P. De Vos, M. Guerre-Millo, A. Leturque, J. Girard, B. Staels, and J. Auwerx. 1995. Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:527-529.
-
(1995)
Nature
, vol.377
, pp. 527-529
-
-
Saladin, R.1
De Vos, P.2
Guerre-Millo, M.3
Leturque, A.4
Girard, J.5
Staels, B.6
Auwerx, J.7
-
28
-
-
0029131574
-
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
-
Frederieh, R.C., B. Lollmann, A. Hamann, A. Napolitano-Rosen, B.B. Kahn, B.B. Lowell, and J.S. Flier. 1995. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest. 96:1658-1663.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 1658-1663
-
-
Frederieh, R.C.1
Lollmann, B.2
Hamann, A.3
Napolitano-Rosen, A.4
Kahn, B.B.5
Lowell, B.B.6
Flier, J.S.7
-
29
-
-
0018276872
-
Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells
-
Rubin, C.S., A. Hirsch, C. Fung, and O.M. Rosen. 1978. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J. Biol. Chem. 253:7570-7578.
-
(1978)
J. Biol. Chem.
, vol.253
, pp. 7570-7578
-
-
Rubin, C.S.1
Hirsch, A.2
Fung, C.3
Rosen, O.M.4
-
30
-
-
0030961960
-
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
-
Shimomura, I., H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown. 1997. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99:838-845.
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 838-845
-
-
Shimomura, I.1
Shimano, H.2
Horton, J.D.3
Goldstein, J.L.4
Brown, M.S.5
-
31
-
-
0028849084
-
The mouse obese gene, genomic organization, promoter activity, and CCAAT/enhancer binding protein α
-
He, Y., H. Chen. M.J. Quon, and M. Reitman. 1995. The mouse obese gene, genomic organization, promoter activity, and CCAAT/enhancer binding protein α. J. Biol. Chem. 270:28887-28891.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 28887-28891
-
-
He, Y.1
Chen, H.2
Quon, M.J.3
Reitman, M.4
-
32
-
-
0030031780
-
Transcriptional activation of mouse obese (ob) gene by CCAAT/enhancer binding protein α
-
Hwang, C.S., S. Mandrup, O. MacDougald, D. Geiman, and M.D. Lane. 1996. Transcriptional activation of mouse obese (ob) gene by CCAAT/enhancer binding protein α. Proc. Natl. Acad. Sci. USA. 93:873-878.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 873-878
-
-
Hwang, C.S.1
Mandrup, S.2
MacDougald, O.3
Geiman, D.4
Lane, M.D.5
-
33
-
-
0023712739
-
Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
-
Yamamoto, K.K., G.A. Gonzalez, W.H. Biggs, and M.R. Montminy. 1988. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature. 334:494-498.
-
(1988)
Nature
, vol.334
, pp. 494-498
-
-
Yamamoto, K.K.1
Gonzalez, G.A.2
Biggs, W.H.3
Montminy, M.R.4
-
34
-
-
0021087686
-
Sequence-specific binding of the glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region
-
Payvar, F., D. DeFranco, G.L. Firestone, B. Edgar, O. Wrange, S. Okiet, J. Gustafsson, and K.R. Yamamoto. 1983. Sequence-specific binding of the glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell. 35:381-392.
-
(1983)
Cell
, vol.35
, pp. 381-392
-
-
Payvar, F.1
Defranco, D.2
Firestone, G.L.3
Edgar, B.4
Wrange, O.5
Okiet, S.6
Gustafsson, J.7
Yamamoto, K.R.8
-
35
-
-
0020568696
-
The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumor virus
-
Scheidereit, C., S. Geisse, H.M. Westphal, and M. Beato. 1983. The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumor virus. Nature. 304:749-752.
-
(1983)
Nature
, vol.304
, pp. 749-752
-
-
Scheidereit, C.1
Geisse, S.2
Westphal, H.M.3
Beato, M.4
-
36
-
-
0030907175
-
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
-
Shimano, H., J.D. Horton, I. Shimomura, R.E. Hammer, M.S. Brown, and J.L. Goldstein. 1997. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99:846-854.
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 846-854
-
-
Shimano, H.1
Horton, J.D.2
Shimomura, I.3
Hammer, R.E.4
Brown, M.S.5
Goldstein, J.L.6
-
37
-
-
0029965098
-
SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-1
-
Streicher, R., J. Kotzka, D. Muller-Wieland, G. Siemeister, M. Munck, H. Avci, and W. Krone. 1996. SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-1. J. Biol. Chem. 271:7128-7133.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7128-7133
-
-
Streicher, R.1
Kotzka, J.2
Muller-Wieland, D.3
Siemeister, G.4
Munck, M.5
Avci, H.6
Krone, W.7
-
38
-
-
0028851735
-
Upstream stimulatory factors bind to insulin response sequence of the fatty acid synthase promoter
-
Wang, D., and H.S. Sul. 1996. Upstream stimulatory factors bind to insulin response sequence of the fatty acid synthase promoter. J. Biol. Chem. 270: 28716-28722.
-
(1996)
J. Biol. Chem.
, vol.270
, pp. 28716-28722
-
-
Wang, D.1
Sul, H.S.2
-
39
-
-
12644314084
-
Two tandem binding sites for sterol regulatory clement binding proteins are required for sterol regulation of fatty-acid synthase promoter
-
Magana, M.M., and T.F. Osborne. 1996. Two tandem binding sites for sterol regulatory clement binding proteins are required for sterol regulation of fatty-acid synthase promoter. J. Biol. Chem. 271:32689-32694.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32689-32694
-
-
Magana, M.M.1
Osborne, T.F.2
-
40
-
-
0030941803
-
The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown, M.S., and J.L. Goldstein. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89:331-340.
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
|