Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Nature

Volumn 423, Issue 6941, 2003, Pages 762-769

  Yamauchi, Toshimasa ^a   Kamon, Junji ^a,b   Ito, Yusuke ^a   Tsuchida, Atsushi ^a   Yokomizo, Takehiko ^c   Kita, Shunbun ^a   Sugiyama, Takuya ^c   Miyagishi, Makoto ^d,e   Hara, Kazuo ^a   Tsunoda, Masaki ^f   Murakami, Koji ^f   Ohteki, Toshiaki ^g   Uchida, Shoko ^a   Takekawa, Sato ^a   Waki, Hironori ^a   Tsuno, Nelson H ^a   Shibata, Yoichi ^a   Terauchi, Yasuo ^a   Froguel, Philippe ^h   Tobe, Kazuyuki ^a   Koyasu, Shigeo ^g   Taira, Kazunari ^d,e   Kitamura, Toshio ^c   Shimizu, Takao ^c   Nagai, Ryozo ^a   Kadowaki, Takashi ^a   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^f Central Research Laboratories   (Japan)

^g KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CLONING; FATTY ACIDS; INSULIN; METABOLISM; OXIDATION; RNA;

OBESITY;

PROTEINS;

ADENYLATE KINASE; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; DNA; G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RNA; UNCLASSIFIED DRUG;

CLONE; MEDICINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FATTY ACID OXIDATION; HORMONE ACTION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; MOLECULAR CLONING; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKELETAL MUSCLE; TISSUE DISTRIBUTION;

ADIPONECTIN; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CLONING, MOLECULAR; DIABETES MELLITUS; ENDOTHELIUM, VASCULAR; FATTY ACIDS; GLUCOSE; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; MUSCLE CELLS; OXIDATION-REDUCTION; PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037494960     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01705     Document Type: Article

References (27)

1. Scherer, P. E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H. F. A novel serum protein similar to Clq, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746-26749 (1995).
2. Hu, E., Liang, P. & Spiegelman, B. M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697-10703 (1996).
3. Maeda, K. et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. 221, 286-296 (1996).
4. Nakano, Y., Tobe, T., Choi-Miura, N. H., Mazda, T. & Tomita, M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J. Biochem. (Tokyo) 120, 802-812 (1996).
5. Fruebis, J. et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl Acad. Sci. USA 98, 2005-2010 (2001).
6. Yamauchi, T. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med. 7, 941-946 (2001).
7. Berg, A. H., Combs, T. P., Du, X., Brownlee, M. & Scherer, P. E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Med. 7, 947-953 (2001).
8. Kubota, N. et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 277, 25863-25866 (2002).
9. Maeda, N. et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature Med. 8, 731-737 (2002).
10. Yamauchi, T. et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Med. 8, 1288-1295 (2002).
11. Tomas, E. et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc. Natl Acad. Sci. USA 99, 16309-16313 (2002).
12. Yamauchi, T. et al. Globular adiponectin protected ob/ob mice from diabetes and apoE deficient mice from atherosclerosis. J. Biol. Chem. 278, 2461-2468 (2003).
13. Ouchi, N. et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103, 1057-1063 (2001).
14. Kitamura, T. et al. Efficient screening of retroviral cDNA expression libraries. Proc. Natl Acad. Sci. USA 92, 9146-9150 (1995).
15. Waterston, R. H. et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (2002).
16. Okazaki, Y. et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420, 563-573 (2002).
17. Wess, J. G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB. J. 11, 346-354 (1997).
18. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y. & Shimizu, T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-624 (1997).
19. Scheer, A., Fanelli, F., Costa, T., De Benedetti, P. G. & Cotecchia, S. Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO. J. 15, 3566-3578 (1996).
20. Miyagishi, M. & Taira, K. U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nature Biotechnol. 20, 497-500 (2002).
21. Karpichev, I. V., Cornivelli, L. & Small, G. M. Multiple regulatory roles of a novel Saccharomyces cerevisiae protein, encoded by YOL002c, in lipid and phosphate metabolism. J. Biol. Chem. 277, 19609-19617 (2002).
22. Barger, P. M., Browning, A. C., Garner, A. N. & Kelly, D. P. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J. Biol. Chem. 276, 44495-44501 (2001).
23. Puigserver, P. et al. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1. Mol. Cell 8, 971-982 (2001).
24. Michael, L. F. et al. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc. Natl Acad. Sci. USA 98, 3820-3825 (2001).
25. Morita, S., Kojima, T. & Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066 (2000).
26. Niwa, H., Yamamura, K. & Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-200 (1991).
27. Kyte, J. & Doolittle, R. F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132 (1982).