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Volumn 277, Issue 38, 2002, Pages 35105-35112

The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands

(7) Ashley Cowart, L a,b,c,d Wei, Shouzuo a,b,c,d Hsu, Mei Hui a,b,c,d Johnson, Eric F a,b,c,d Krishna, Murali U a,b,c,d Falck, John R a,b,c,d Capdevila, Jorge H a,b,c,d

a Department of Medicine ^* (United States)

b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

c SCRIPPS RESEARCH INSTITUTE (United States)

d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BLOOD; CARBON; CARBOXYLIC ACIDS; CATALYSIS; GENES; HYDROXYLATION; METABOLISM;

ISOFORMS;

BIOCHEMISTRY;

20 HYDROXYICOSATETRAENOIC ACID; 5,6 EPOXY 8,11,14 ICOSATRIENOIC ACID; ARACHIDONIC ACID; CARBOXYLIC ACID; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 4A; EPOXYICOSATRIENOIC ACID; ION CHANNEL; ISOENZYME; LAURIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; LIGAND BINDING; MALE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RAT; REACTION ANALYSIS; REGULATORY MECHANISM; STEREOCHEMISTRY; TRANSPORT KINETICS;

ALKANE 1-MONOOXYGENASE; ANIMALS; ARACHIDONIC ACIDS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; ISOENZYMES; LIGANDS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037144475 PISSN: 00219258 EISSN: None Source Type: Journal
DOI: 10.1074/jbc.M201575200 Document Type: Article

Times cited : (183)

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