Regulation of the activity of the pyruvate dehydrogenase complex

Advances in Enzyme Regulation

Volumn 42, Issue , 2002, Pages 249-259

  Harris, Robert A ^a   Bowker Kinley, Melissa M ^a   Huang, Boli ^a   Wu, Pengfei ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; CARBON; FAT; FATTY ACID; GLUCOCORTICOID; GLUCOSE; INORGANIC COMPOUND; INSULIN; ISOENZYME; ISOPROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE KINASE 2; PYRUVATE DEHYDROGENASE KINASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA CHAIN; ANIMAL; BIOLOGICAL MODEL; CATALYSIS; CONFERENCE PAPER; COVALENT BOND; DIABETES MELLITUS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME REGULATION; ENZYME STRUCTURE; FAT INTAKE; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HUMAN; METABOLISM; NONHUMAN; NUTRITION; PHOSPHORYLATION; PROTEIN EXPRESSION; RAT; STARVATION;

ANIMALS; CARBON; CATALYSIS; DIETARY FATS; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN; MODELS, BIOLOGICAL; PROTEIN ISOFORMS; PYRUVATE DEHYDROGENASE COMPLEX; RATS;

ANIMALIA;

EID: 0036377351     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(01)00061-9     Document Type: Conference Paper

References (44)

1. Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal
2. Regulation of the pyruvate dehydrogenase multienzyme complex
3. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
4. 2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase
5. Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?
6. The hormonal regulation of pyruvate dehydrogenase complex
7. Accelerated loss of lean body mass in fasting rats due to activation of pyruvate dehydrogenase by dichloroacetate
8. Diversity of the pyruvate dehydrogenase kinase gene family in humans
9. Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex
10. Targeted up-regulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding
11. Pyruvate dehydrogenase kinase 4 mRNA is increased in the hypertrophied ventricles of carnitine-deficient juvenile visceral steatosis (JVS) mice
12. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation
13. Regulation of pyruvate dehydrogenase kinase expression by PPARα ligands, glucocorticoids, and insulin
14. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers
15. Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C
16. Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase
17. Binding of the pyruvate dehydrogenase kinase to recombinant constructs containing the inner lipoyl domain of the dihydrolipoyl acetyltransferase component
18. Structure of rat BCKD kinase. Nucleotide-induced domain communication in a mitochondrial protein kinase
19. Component X of mammalian pyruvate dehydrogenase complex: Structural and functional relationship to the lipoate acetyltransferase (E2) component
20. Molecular biology and biochemistry of pyruvate dehydrogenase complexes
21. Swinging arms and swinging domains in multifunctional enzymes: Catalytic machines for multiple reactions
22. Muscle fiber type comparison of pyruvate dehydrogenase kinase activity and isoform expression in fed and fasted rats
23. Human skeletal muscle PDH kinase activity and isoform expression during three days of a high-fat/low-carbohydrate diet
24. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases
25. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases
26. Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases
27. Fuel selection in animals
28. Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
29. Hypoxia in vivo decreases peroxisome proliferator-activated receptor α-regulated gene expression in rat heart
30. A trail of research from lipoic acid to α-keto acid dehydrogenase complexes
31. Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle
32. Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase
33. Role of peroxisome proliferator-activated receptor α in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding
34. Substrate interactions in the short- and long-term regulation of renal glucose oxidation
35. Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression
36. The pyruvate dehydrogenase complex: Nutrient control and pathogenesis of insulin resistance
37. An essential role of Glu-243 and His-239 in the phosphotransfer reaction catalyzed by pyruvate dehydrogenase kinase
38. Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney. Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion
39. Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues
40. Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes
41. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor α
42. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
43. Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase
44. The 2-oxo acid dehydrogenase complexes: Recent advances