-
1
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf, D. J. et al. The nuclear receptor superfamily: the second decade. Cell 83, 835-839 (1995).
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
-
2
-
-
0006132932
-
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptor α and γ
-
Kliewer, S. A. et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptor α and γ. Proc. Natl Acad. Sci. USA 94, 4318-4323 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 4318-4323
-
-
Kliewer, S.A.1
-
3
-
-
0030952937
-
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome profilerator-activated receptor α and δ
-
Forman, B. M., Chen, J. & Evans, R. M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome profilerator-activated receptor α and δ. Proc. Natl Acad. Sci. USA 94, 4312-4317 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
4
-
-
0028321529
-
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
-
Kliewer, S. A. et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl Acad. Sci. USA 91, 7355-7359 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7355-7359
-
-
Kliewer, S.A.1
-
5
-
-
0028015713
-
Peroxisome proliferator-activated receptor γ: Adipose-predominant expression and induction early in adipocyte differentiation
-
Chawla, A., Schwartz, E. J., Dimaculangan, D. D. & Lazar, M. A. Peroxisome proliferator-activated receptor γ: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinol. 135, 798-800 (1994).
-
(1994)
Endocrinol.
, vol.135
, pp. 798-800
-
-
Chawla, A.1
Schwartz, E.J.2
Dimaculangan, D.D.3
Lazar, M.A.4
-
6
-
-
0030062325
-
The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones
-
Willson, T. M. et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39, 665-668 (1996).
-
(1996)
J. Med. Chem.
, vol.39
, pp. 665-668
-
-
Willson, T.M.1
-
7
-
-
0029905399
-
Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids
-
Wu, Z., Bucher, N. L. R. & Farmer, S. R. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol. Cell. Biol. 16, 4128-4136 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4128-4136
-
-
Wu, Z.1
Bucher, N.L.R.2
Farmer, S.R.3
-
8
-
-
0028180070
-
mPPARγ2: Tissue-specific regulator of an adipocyte enhancer
-
Tontonoz, P., Hu, E., Graves, R., Budavari, A. & Spiegelman, B. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8, 1224-1234 (1994).
-
(1994)
Genes Dev.
, vol.8
, pp. 1224-1234
-
-
Tontonoz, P.1
Hu, E.2
Graves, R.3
Budavari, A.4
Spiegelman, B.5
-
9
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor
-
Tontonoz, P., Hu, E., & Spiegelman, B. M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor. Cell 79, 1147-1156 (1994).
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
10
-
-
0031886864
-
The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation
-
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J. & Glass, C. K. The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation. Nature 391, 79-82 (1998).
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
11
-
-
0032540012
-
PPARγ promotes monocyte/ macrophage differentiation and uptake of oxidized LDL
-
Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomazy, V. A. & Evans, R. M. PPARγ promotes monocyte/ macrophage differentiation and uptake of oxidized LDL. Cell 93, 241-252 (1998).
-
(1998)
Cell
, vol.93
, pp. 241-252
-
-
Tontonoz, P.1
Nagy, L.2
Alvarez, J.G.A.3
Thomazy, V.A.4
Evans, R.M.5
-
12
-
-
0029981772
-
Differential activation of adipogenesis by multiple PPAR isoforms
-
Brun, R. P. et al. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 10, 974-984 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 974-984
-
-
Brun, R.P.1
-
13
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
-
Lehmann, J. M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
-
14
-
-
0001981607
-
The glitazone family of antidiabetic agents
-
Hulin, B., McCarthy, P. A. & Gibbs, E. M. The glitazone family of antidiabetic agents. Curr. Pharm. Des. 2, 85-102 (1996).
-
(1996)
Curr. Pharm. Des.
, vol.2
, pp. 85-102
-
-
Hulin, B.1
McCarthy, P.A.2
Gibbs, E.M.3
-
15
-
-
0023913120
-
The steroid and thyroid hormone receptor superfamily
-
Evans, R. M. The steroid and thyroid hormone receptor superfamily. Science 240, 889-895 (1988).
-
(1988)
Science
, vol.240
, pp. 889-895
-
-
Evans, R.M.1
-
16
-
-
0029012163
-
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
-
Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. & Moras, D. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375, 377-382 (1995).
-
(1995)
Nature
, vol.375
, pp. 377-382
-
-
Bourguet, W.1
Ruff, M.2
Chambon, P.3
Gronemeyer, H.4
Moras, D.5
-
17
-
-
0029643769
-
A structural role for hormone in the thyroid hormone receptor
-
Wagner, R. L. et al. A structural role for hormone in the thyroid hormone receptor. Nature 378, 690-697 (1995).
-
(1995)
Nature
, vol.378
, pp. 690-697
-
-
Wagner, R.L.1
-
18
-
-
0029643780
-
Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
-
Renaud, J.-P. et al. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature 378, 681-689 (1995).
-
(1995)
Nature
, vol.378
, pp. 681-689
-
-
Renaud, J.-P.1
-
19
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski, A. M. et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389, 753-758 (1997).
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
-
20
-
-
0029740105
-
Nuclear receptor coactivators and corepressors
-
Horwitz, K. B. et al. Nuclear receptor coactivators and corepressors. Mol. Endocrinol. 10, 1167-1177 (1996).
-
(1996)
Mol. Endocrinol.
, vol.10
, pp. 1167-1177
-
-
Horwitz, K.B.1
-
21
-
-
0030937411
-
Nuclear receptor coactivators
-
Glass, C. K., Rose, D. W. & Rosenfeld, M. G. Nuclear receptor coactivators. Curr. Opin. Cell Biol. 9, 222-232 (1997).
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 222-232
-
-
Glass, C.K.1
Rose, D.W.2
Rosenfeld, M.G.3
-
22
-
-
0028233763
-
Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor
-
Barettino, D., Vivanco Ruìz, M. M. & Stunnenberg, H. G. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J. 13, 3039-3049 (1994).
-
(1994)
EMBO J.
, vol.13
, pp. 3039-3049
-
-
Barettino, D.1
Vivanco Ruìz, M.M.2
Stunnenberg, H.G.3
-
23
-
-
0026600841
-
Identification of a conserved region required for hormone-dependent transcriptional activation by steroid hormone receptors
-
Danielian, P. S., White, R., Lees, J. A. & Parker, M. G. Identification of a conserved region required for hormone-dependent transcriptional activation by steroid hormone receptors. EMBO J. 11, 1025-1033 (1992).
-
(1992)
EMBO J.
, vol.11
, pp. 1025-1033
-
-
Danielian, P.S.1
White, R.2
Lees, J.A.3
Parker, M.G.4
-
24
-
-
0027941792
-
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor; presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity
-
Durand, B. et al. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor; presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13, 5370-5382 (1994).
-
(1994)
EMBO J.
, vol.13
, pp. 5370-5382
-
-
Durand, B.1
-
25
-
-
0027996382
-
Functional analysis of a transactivation domain in the thyroid hormone beta receptor
-
Tone, Y., Collingwood, T. N., Adams, M. & Chatterjee, V. K. Functional analysis of a transactivation domain in the thyroid hormone beta receptor. J. Biol. Chem. 269, 31157-31161 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 31157-31161
-
-
Tone, Y.1
Collingwood, T.N.2
Adams, M.3
Chatterjee, V.K.4
-
26
-
-
0029954339
-
TIF2, a 160 kD a transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
-
Voegel, J. J., Heine, M. J. S., Zechel, C., Chambon, P. & Gronemeyer, H. TIF2, a 160 kD a transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15, 3667-3675 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 3667-3675
-
-
Voegel, J.J.1
Heine, M.J.S.2
Zechel, C.3
Chambon, P.4
Gronemeyer, H.5
-
27
-
-
0030912539
-
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
-
Torchia, J. et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-684 (1997).
-
(1997)
Nature
, vol.387
, pp. 677-684
-
-
Torchia, J.1
-
28
-
-
0030341454
-
Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor γ
-
Zhu, Y., Qi, C., Calandra, C., Rao, M. S. & Reddy, J. K. Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor γ. Gene Expr. 6, 185-195 (1996).
-
(1996)
Gene Expr.
, vol.6
, pp. 185-195
-
-
Zhu, Y.1
Qi, C.2
Calandra, C.3
Rao, M.S.4
Reddy, J.K.5
-
29
-
-
0030949836
-
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
-
Hong, H., Kohli, K., Garabedian, M. J. & Stallcup, M. R. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol. 17, 2735-2744 (1997).
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 2735-2744
-
-
Hong, H.1
Kohli, K.2
Garabedian, M.J.3
Stallcup, M.R.4
-
30
-
-
0030797902
-
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
-
Anzick, S. L. et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965-968 (1997).
-
(1997)
Science
, vol.277
, pp. 965-968
-
-
Anzick, S.L.1
-
31
-
-
0030740253
-
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
-
Chen, H. et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580 (1997).
-
(1997)
Cell
, vol.90
, pp. 569-580
-
-
Chen, H.1
-
32
-
-
0242587820
-
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
-
Kamei, Y. et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414 (1996).
-
(1996)
Cell
, vol.85
, pp. 403-414
-
-
Kamei, Y.1
-
33
-
-
0032518944
-
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
-
Voegel, J. J. et al. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 17, 507-519 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 507-519
-
-
Voegel, J.J.1
-
34
-
-
0030986236
-
A signature motif in transcriptional coactivators mediates binding to nuclear receptors
-
Heery, D. M., Kalkhoven, E., Hoare, S. & Parker, M. G. A signature motif in transcriptional coactivators mediates binding to nuclear receptors. Nature 387, 733-736 (1997).
-
(1997)
Nature
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, E.2
Hoare, S.3
Parker, M.G.4
-
35
-
-
0028067872
-
Insulin resistance and the prevention of diabetes mellitus
-
Keen, H. Insulin resistance and the prevention of diabetes mellitus. New. Eng. J. Med. 331, 1226-1227 (1994).
-
(1994)
New. Eng. J. Med.
, vol.331
, pp. 1226-1227
-
-
Keen, H.1
-
36
-
-
0001294801
-
Non-thazolidinedione antihyperglycemic agents. 2: α-Carbon substituted β-phenylpropanoic acids
-
Buckle, D. R. et al. Non-thazolidinedione antihyperglycemic agents. 2: α-Carbon substituted β-phenylpropanoic acids. Bioorg. Med. Chem. Lett. 6, 2127-2130 (1996).
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 2127-2130
-
-
Buckle, D.R.1
-
37
-
-
0032505066
-
Interactions controlling complexes of nuclear-receptor heterodimers and coactivators
-
Westin, S. et al. Interactions controlling complexes of nuclear-receptor heterodimers and coactivators. Nature 395, 199-202 (1998).
-
(1998)
Nature
, vol.395
, pp. 199-202
-
-
Westin, S.1
-
38
-
-
0031033980
-
Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids
-
Feng, X. et al. Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. Genes Dev. 11, 59-71 (1997).
-
(1997)
Genes Dev.
, vol.11
, pp. 59-71
-
-
Feng, X.1
-
39
-
-
0027941792
-
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: Presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity
-
Durand, B. et al. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13, 5370-5382 (1994).
-
(1994)
EMBO J.
, vol.13
, pp. 5370-5382
-
-
Durand, B.1
-
40
-
-
0030950531
-
AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors
-
Henttu, P. M. A., Kalkhoven, E. & Parker, M. G. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Mol. Cell. Biol. 17, 1832-1839 (1997).
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1832-1839
-
-
Henttu, P.M.A.1
Kalkhoven, E.2
Parker, M.G.3
-
41
-
-
0028122988
-
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
-
Kurokawa, R. et al. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371, 528-531 (1994).
-
(1994)
Nature
, vol.371
, pp. 528-531
-
-
Kurokawa, R.1
-
42
-
-
0029002298
-
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
-
Forman, B. M., Umesono, K., Chen, J. & Evans, R. M. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81, 541-550 (1995).
-
(1995)
Cell
, vol.81
, pp. 541-550
-
-
Forman, B.M.1
Umesono, K.2
Chen, J.3
Evans, R.M.4
-
43
-
-
0002452464
-
-
(ed. Sawyer, L.) SERC Caresbury Lab., Daresbury
-
Otwinowski, Z., Isaacs, N. & Burley, S. in Proc. CCP4 Study Weekend (ed. Sawyer, L.) 56-62 (SERC Caresbury Lab., Daresbury, 1993).
-
(1993)
Proc. CCP4 Study Weekend
, pp. 56-62
-
-
Otwinowski, Z.1
Isaacs, N.2
Burley, S.3
-
44
-
-
85058199339
-
-
(eds Carter, C. & Sweet, R.) Academic, Orlando
-
Furey, W. S. & Swaminathin, S. in Methods in Enzymology: Macromolecular Crystallography Part B Vol. 277 (eds Carter, C. & Sweet, R.) 590-620 (Academic, Orlando, 1997).
-
(1997)
Methods in Enzymology: Macromolecular Crystallography Part B Vol. 277
, vol.277
, pp. 590-620
-
-
Furey, W.S.1
Swaminathin, S.2
-
45
-
-
0002583957
-
"DM": An automated procedure for phase improvement by density modification
-
Cowtan, K. "DM": an automated procedure for phase improvement by density modification. Joint CCP4 ESF-EACBM Newsletter Protein Crystallogr. 31, 34-38 (1994).
-
(1994)
Joint CCP4 ESF-EACBM Newsletter Protein Crystallogr.
, vol.31
, pp. 34-38
-
-
Cowtan, K.1
-
46
-
-
0028103275
-
The CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project Number 4. The CCP4 suite: programs for protein crystallography. Acta Cryst. D 50, 760-776 (1994).
-
(1994)
Acta Cryst. D
, vol.50
, pp. 760-776
-
-
-
48
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Cryst. A 47, 110-119 (1991).
-
(1991)
Acta Cryst. A
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.Y.2
Cowan, S.W.3
Kjeldgaard, M.4
|