Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin

Biochemical Journal

Volumn 364, Issue 2, 2002, Pages 361-368

  Sugden, Mary C ^a   Bulmer, Karen ^a   Gibbons, Geoffrey F ^a   Knight, Brian L ^a   Holness, Mark J ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Glycogen; Lipogenesis; Pyruvate dehydrogenase kinase; Sterol regulatory element binding protein; Triacylglycerol

Indexed keywords

CARBOHYDRATES; INSULIN; LIPIDS; METABOLISM; PROTEINS; RNA;

GLYCOGENESIS;

BIOCHEMISTRY;

FATTY ACID; GLYCOGEN; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PYRUVATE DEHYDROGENASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CATABOLISM; CONTROLLED STUDY; DIET RESTRICTION; ENZYME REGULATION; GLYCOGEN LIVER LEVEL; HOMEOSTASIS; INSULIN BLOOD LEVEL; KNOCKOUT MOUSE; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID OXIDATION; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REFEEDING;

ANIMALS; ANTIGENS, CD95; BASE SEQUENCE; CARBOHYDRATE METABOLISM; CCAAT-ENHANCER-BINDING PROTEINS; DNA PRIMERS; DNA-BINDING PROTEINS; FATTY ACIDS, NONESTERIFIED; INSULIN; LIPID METABOLISM; LIPIDS; LIVER; MICE; MICE, KNOCKOUT; PROTEIN KINASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STARVATION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

ANIMALIA;

EID: 0036606670     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20011699     Document Type: Article

References (52)

1. Insulin sensitivity, muscle fibre types, and membrane lipids
2. Peroxisome proliferator-activated receptor (PPAR)-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: Comparison with PPAR-γ activation
3. Triglycerides, fatty acids and insulin resistance - Hyperinsulinemia
4. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
5. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
6. Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes
7. Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding
8. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
9. Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: Potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects
10. The pyruvate dehydrogenase complex: Nutrient control and the pathogenesis of insulin resistance
11. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat
12. Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans
13. Regulation of lipid and lipoprotein metabolism by PPAR activators
14. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
15. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
16. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
17. Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice
18. Evidence for existence of tissue-specific reguration of the mammalian pyruvate dehydrogenase complex
19. Peroxisome proliferator-activated receptor-α regulates ripid homeostasis, but is not associated with obesity: Studies with congenic mouse lines
20. Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rats in vivo: Evidence for the possible involvement of insulin
21. Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle
22. Diurnal variations of lipogenic enzymes, their substrate and effector levels, and lipogenesis from tritiated water in rat liver
23. A simple method for the isolation and purification of total lipids from animal tissues
24. Regulation of hepatic fatty acid oxidation and ketone body production
25. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: A control enzyme in ketogenesis
26. Reduced hepatic fatty acid oxidation in fasting PPARα null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression
27. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
28. Regulation of hepatic de novo lipogenesis in humans
29. Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues
30. Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes
31. Short-term regulation of glucokinase
32. The short-term regulation of hepatic acetyl-CoA carboxylase during starvation and refeeding in the rat
33. Regulation of genes for enzymes involved in fatty acid synthesis
34. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis
35. Direction of carbon flux in starvation and after refeeding: In vitro and in vivo effects of 3-mercaptopicolinate
36. Efficient hepatic grycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway
37. The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition
38. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
39. Fuel selection and carbon flux during the starved-to-fed transition
40. Variations in hepatic carbon flux during unrestricted feeding
41. Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals
42. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
43. Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
44. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
45. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
46. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
47. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
48. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
49. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
50. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
51. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes