Identification of a fatty acid Δ6-desaturase deficiency in human skin fibroblasts

Journal of Lipid Research

Volumn 42, Issue 4, 2001, Pages 501-508

  Williard, D E ^a   Nwankwo, J O ^a   Kaduce, T L ^a   Harmon, S D ^a   Irons, M ^a   Moser, H W ^a   Raymond, G V ^a   Spector, A A ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

5 desaturase; linolenic acid; Arachidonic acid; Docosahexaenoic acid; Fatty acid desaturation; Gene expression; Genetic defect; Linoleic acid; Polyunsaturated fatty acids

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; LINOLEIC ACID; POLYUNSATURATED FATTY ACID;

ARTICLE; CASE REPORT; CELL CULTURE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME DEFICIENCY; FATTY ACID METABOLISM; FEMALE; GENE EXPRESSION; GENETIC DISORDER; HUMAN; HUMAN CELL; LIPID COMPOSITION; LIPID METABOLISM; PRIORITY JOURNAL; SCHOOL CHILD; SKIN FIBROBLAST;

CELLS, CULTURED; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY FATS; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; FEMALE; FIBROBLASTS; HUMANS; LINOLEOYL-COA DESATURASE; LIPID METABOLISM, INBORN ERRORS; RNA, MESSENGER; SKIN;

EID: 0035058781     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Reevaluation of the pathway for the biosynthesis of polyunsaturated fatty acids
2. The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase
3. Regulation of the biosynthesis of 4,7,10,13,16,19-docosahexaenoic acid
4. Regulation of the biosynthesis of 4,7,10,13, 16-docosapentaenoic acid
5. Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid
6. Cloning, expression, and nutritional regulation of the mammalian δ-6 desaturase
7. Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase
8. Cloning, expression, and fatty acid regulation of the human δ-5 desaturase
9. Studies to determine if rat liver contains chain-length-specific acyl-CoA 6-desaturases
10. 6-desaturase activities may exist
11. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty, acid desaturase family
12. Enzyme deletions and essential fatty acid metabolism in cultured cells
13. Fatty acid utilization by L1210 murine leukemia cells
14. Lipid nutrition and metabolism of cultured mammalian cells
15. Resistance to killing by tumor necrosis factor in an adipose cell line caused by a defect in arachidonic acid biosynthesis
16. Astrocytes, not neurons, produce docosahexaenoic acid (22:6ω-3) and arachidonic acid (20:4ω-6)
17. Alternative routes for the biosynthesis of polyunsaturated fatty acids
18. N-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines
19. Suspected faulty essential fatty acid metabolism in Sjogren-Larsson syndrome
20. Effects of polyunsaturated fatty acid diets on plasma lipids of patients with adrenomultineuronal degeneration, hepatosplenomegaly, and fatty acid derangement
21. Formation and release of a peroxisome-dependent arachidonic acid metabolite by human skin fibroblasts
22. Conversion of eicosapentaenoic acid to chain-shortened omega-3 fatty acid metabolites by peroxisomal oxidation
23. Conversion of epoxyeicosatrienoic acids (EETs) to chain-shortened epoxy fatty acids by human skin fibroblasts
24. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill
25. Retinoic acid receptors α, β, and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer
26. Characterization of γ-linolenic acid in Ribes seed
27. γ-Linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocyroma cells but not to "normal" rat astrocytes
28. Supply of n-3 polyunsaturated fatty acids and their significance in the central nervous system
29. Essential fatty acids: The importance of n-3 fatty acids in the retina and brain
30. Role of essential fatty acids in the function of the developing nervous system
31. Why is docosahexaenoic acid essential for nervous system function?
32. Developmental changes in rat brain membrane lipids and fatty acids: The preferential prenatal accumulation of docosahexaenoic acid
33. Essentiality of fatty acids
34. Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina
35. The enrichment of n-3 polyunsaturated fatty acids using aminopropyl solid phase extraction columns
36. Sjogren-Larsson syndrome. Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol NAD oxidoreductase in cultured fibroblasts
37. Sjogren-Larsson syndrome: Accumulation of free fatty alcohols in cultured fibroblasts and plasma