p53 and Mouse Aging Models

Handbook of the Biology of Aging

Volumn , Issue , 2005, Pages 149-180

  Gatza, Catherine ^a   Hinkal, George ^a   Moore, Lynette ^a   Dumble, Melissa ^a   Donehower, Lawrence A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882537300     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088387-5/50009-1     Document Type: Chapter

References (192)

1. Alcorta D.A., Xiong Y., Phelps D., Hannon G., Beach D., Barrett J.C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proceedings of the National Academy of Sciences of the USA 1996, 93:13742-13747.
2. Andersen B., Pearse R.V., Jenne K., Sornson M., Lin S.C., Bartke A., Rosenfeld M.G. The Ames dwarf gene is required for Pit-1 gene activation. Developmental Biology 1995, 172:495-503.
3. Anisimov V.N. Aging and cancer in transgenic and mutant mice. Frontiers in Bioscience 2003, 8:s883-s902.
4. Appella E., Anderson C.W. Posttranslational modifications and activation of p53 by genotoxic stresses. European Journal of Biochemistry 2001, 268:2764-2772.
5. Arking R. The biology of aging 1998, 570. Sinauer Associates, Inc., Sunderland, MA.
6. Ashcroft M., Vousden K.H. Regulation of p53 stability. Oncogene 1999, 18:7637-7643.
7. Atadja P., Wong H., Garkavtsev I., Veillette C., Riabowol K. Increased activity of p53 in senescing fibroblasts. Proceedings of the National Academy of Sciences of the USA 1995, 92:8348-8352.
8. Baker D.J., Jeganathan K.B., Cameron J.D., Thompson M., Juneja S., Kopecka A., Kumar R., Jenkins R.B., de Groen P.C., Roche P., van Deursen J.M. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genetics 2004, 36:744-749.
9. Barger J.L., Walford R.L., Weindruch R. The retardation of aging by caloric restriction: its significance in the transgenic eral. Experimental Gerontology 2003, 38:1343-1351.
10. Barlow C., Hirotsune S., Paylor R., Liyanage M., Eckhaus M., Collins F., Shiloh Y., Crawley J.N., Ried T., Tagle D., Wynshaw-Boris A. Atmdeficient mice: a paradigm of ataxia telangiectasia. Cell 1996, 86:159-171.
11. Bartke A., Wright J.C., Mattison J.A., Ingram D.K., Miller R.A., Roth G.S. Extending the lifespan of long-lived mice. Nature 2001, 414:412.
12. Beausejour C.M., Krtolica A., Galimi F., Narita M., Lowe S.W., Yaswen P., Campisi J. Reversal of human cellular senescence: roles of the p53 and p16 pathways. Embo Journal 2003, 22:4212-4222.
13. Ben-Porath I., Weinberg R.A. When cells get stressed: an integrative view of cellular senescence. Journal of Clinical Investigation 2004, 113:8-13.
14. Bird J., Ostler E.L., Faragher R.G. Can we say that senescent cells cause ageing. Experimental Gerontology 2003, 38:1319-1326.
15. Bischoff F.Z., Yim S.O., Pathak S., Grant G., Siciliano M.J., Giovanella B.C., Strong L.C., Tainsky M.A. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Research 1990, 50:7979-7984.
16. Blander G., Guarente L. The Sir2 family of protein deacetylases. Annual Review of Biochemistry 2004, 73:417-435.
17. Bode A.M., Dong Z. Posttranslational modification of p53 in tumorigenesis. Nature Reviews Cancer 2004, 4:793-805.
18. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay I.W., Lichtsteiner S., Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
19. Bonafe M., Olivieri F., Mari D., Baggio G., Mattace R., Berardelli M., Sansoni P., De Benedictis G., De Luca M., Marchegiani F., Cavallone L., Cardelli M., Giovagnetti S., Ferrucci L., Amadio L., Lisa R., Tucci M.G., Troiano L., Pini G., Gueresi P., Morellini M., Sorbi S., Passeri G., Barbi C., Valensin S. p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. American Journal of Human Genetics 1999, 65:1782-1785.
20. Bringold F., Serrano M. Tumor suppressors and oncogenes in cellular senescence. Experimental Gerontology 2000, 35:317-329.
21. Brooks C.L., Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Current Opinion in Cell Biology 2003, 15:164-171.
22. Brown-Borg H.M., Borg K.E., Meliska C.J., Bartke A. Dwarf mice and the ageing process. Nature 1996, 384:33.
23. Campsisi J. From cells to organisms: can we learn about aging from cells in culture?. Experimental Gerontology 2001, 36:607-618.
24. Campisi J. Cancer and ageing: rival demons?. Nature Reviews Cancer 2003, 3:339-349.
25. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Experimental Gerontology 2003, 38:5-11.
26. Campisi J., Kim S.H., Lim C.S., Rubio M. Cellular senescence, cancer and aging: the telomere connection. Experimental Gerontology 2001, 36:1619-1637.
27. Canman C.E., Lim D.S., Cimprich K.A., Taya Y., Tamai K., Sakaguchi K., Appella E., Kastan M.B., Siliciano J.D. Activation of the Atm kinase by ionizing radiation and phosphorylation of p53. Science 1998, 281:1677-1679.
28. Cao L., Li W., Kim S., Brodie S.G., Deng C.X. Senescence aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform. Genes & Development 2003, 17:201-213.
29. Chan G.K., Yen T.J. The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. Progress in Cell Cycle Research 2003, 5:431-439.
30. Chang S., Multani A.S., Cabrera N.G., Naylor M.L., Laud P., Lombard D., Pathak S., Guarente L., DePinho R.A. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics 2004, 36:877-882.
31. Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., Chua K.F. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proceedings of the National Academy of Sciences of the USA 2003, 100:10794-10799.
32. Choi J., Donehower L.A. p53 in embryonic development: maintaining a fine balance. Cell and Molecular Life Sciences 1999, 55:38-47.
33. Choi J., Shendrik I., Peacocke M., Peehl D., Buttyan R., Ikeguchi E.F., Katz A.E., Benson M.C. Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. Urology 2000, 56:160-166.
34. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacety lase. Science 2004, 305:390-392.
35. de Boer J., Andressoo J.O., de Wit J., Huijmans J., Beems R.B., van Steeg H., Weeda G., van der Horst G.T., van Leeuwen W., Themmen A.P., Meradji M., Hoeijmakers J.H. Premature aging in mice deficient in DNA repair and transcription. Science 2002, 296:1276-1279.
36. de Magalhaes J.P., Cabral J., Magalhaes D. The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics 2005, 169:265-274.
37. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., Linskens M., Rubelj I., Pereira-Smith O., Peacocke M., Campisi J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proceedings of the National Academy of Sciences of the USA 1995, 92:9363-9367.
38. Dirac A.M., Bernards R. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. Journal of Biological Chemistry 2003, 278:11731-11734.
39. Dohoney K.M., Guillerm C., Whiteford C., Elbi C., Lambert P.F., Hager G.L., Brady J.N. Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage. Oncogene 2004, 23:49-57.
40. Dolle M.E., Snyder W.K., Dunson D.B., Vijg J. Mutational fingerprints of aging. Nucleic Acids Research 2002, 30:545-549.
41. Dolle M.E., Snyder W.K., Gossen J.A., Lohman P.H., Vijg J. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proceedings of the National Academy of Sciences of the USA 2000, 97:8403-8408.
42. Donehower L.A. The p53-deficient mouse: a model for basic and applied cancer studies. Seminars in Cancer Biology 1996, 7:269-278.
43. Donehower L.A. Does p53 affect organismal aging. Journal of Cellular Physiology 2002, 192:23-33.
44. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A., Butel J.S., Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992, 356:215-221.
45. Du X., Shen J., Kugan N., Furth E.E., Lombard D.B., Cheung C., Pak S., Luo G., Pignolo R.J., DePinho R.A., Guarente L., Johnson F.B. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Molecular and Cellular Biology 2004, 24:8437-8446.
46. Dumont P., Leu J.I., Della Pietra A.C., George D.L., Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nature Genetics 2003, 33:357-365.
47. el-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 1993, 75:817-825.
48. Elson A., Wang Y., Daugherty C.J., Morton C.C., Zhou F., Campos-Torres J., Leder P. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proceedings of the National Academy of Sciences of the USA 1996, 93:13084-13089.
49. Erster S., Mihara M., Kim R.H., Petrenko O., Moll U.M. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Molecular and Cellular Biology 2004, 24:6728-6741.
50. Fabrizio P., Longo V.D. The chronological life span of Saccharomyces cerevisiae. Aging Cell 2003, 2:73-81.
51. Ferbeyre G. PML a target of translocations in APL is a regulator of cellular senescence. Leukemia 2002, 16:1918-1926.
52. Ferbeyre G., Lowe S.W. The price of tumour suppression?. Nature 2002, 415:26-27.
53. Ferbeyre G., de Stanchina E., Lin A.W., Querido E., McCurrach M.E., Hannon G.J., Lowe S.W. Oncogenic ras and p53 cooperate to induce cellular senescence. Molecular and Cellular Biology 2002, 22:3497-3508.
54. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
55. Fridman J.S., Lowe S.W. Control of apotosis by p53. Oncogene 2003, 22:9030-9040.
56. Fuchs S.Y., Adler V., Buschmann T., Wu X., Ronai Z. Mdm2 association with p53 targets its ubiquitination. Oncogene 1998, 17:2543-2547.
57. Garcia-Cao I., Garcia-Cao M., Martin-Caballero J., Criado L.M., Klatt P., Flores J.M., Weill J.C., Blasco M.A., Serrano M. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. Embo Journal 2002, 21:6225-6235.
58. Giaccia A.J., Kastan M.B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes & Development 1998, 12:2973-2983.
59. Gire V., Wynford-Thomas D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Molecular and Cellular Biology 1998, 18:1611-1621.
60. Goldstein S. Replicative senescence: the human fibroblast comes of age. Science 1990, 249:1129-1133.
61. Gowen L.C., Johnson B.L., Latour A.M., Sulik K.K., Koller B.H. Brcal deficiency results in early embryonic lethality characterized by neuroepithelial abnorm alities. Nature Genetics 1996, 12:191-194.
62. Gu W., Luo J., Brooks C.L., Nikolaev A.Y., Li M. Dynamics of the p53 acetylation pathway. Novartis Foundation Symposium 2004, 259:197-205. discussion 205-207, 223-225.
63. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes & Development 2000, 14:1021-1026.
64. Guarente L., Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000, 408:255-262.
65. Hakem R., de la Pompa J.L., Sirard C., Mo R., Woo M., Hakem A., Wakeham A., Potter J., Reitmair A., Billia F., Firpo E., Hui C.C., Roberts J., Rossant J., Mak T.W. The tumor suppressor gene Brcal is required for embryonic cellular proliferation in the mouse. Cell 1996, 85:1009-1023.
66. Harley C.B., Kim N.W., Prowse K.R., Weinrich S.L., Hirsch K.S., West M.D., Bacchetti S., Hirte H.W., Counter C.M., Greider C.W., Piatyszek M.A., Wright W.E., Shay J.W. Telomerase, cell immortality, and cancer. Cold Spring Harbor Symposium of Quantitative Biology 1994, 59:307-315.
67. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip 1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
68. Harrison D.E. Animal models showing "accelerated aging" are more likely to be useful for pathology than for mechanisms of aging. Growth, Development, and Aging 1997, 61:167-168.
69. Harvey M., McArthur M.J., Montgomery C.A., Butel J.S., Bradley A., Donehower L.A. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nature Genetics 1993, 5:225-229.
70. Harvey M., Sands A.T., Weiss R.S., Hegi M.E., Wiseman R.W., Patazis P., Giovanella B.C., Tainsky M.A., Bradley A., Donehower L.A. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 1993, 8:2457-2467.
71. Hasty P., Vijg J. Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 2004, 3:55-65.
72. Hasty P., Vijg J. Rebuttal to Miller: 'accelerated aging': a primrose path to insight?. Aging Cell 2004, 3:67-69.
73. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 2003, 299:1355-1359.
74. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research 1965, 37:614-636.
75. Hekimi S., Guarente L. Genetics and the specificity of the aging process. Science 2003, 299:1351-1354.
76. Helfand S.L., Rogina B. Genetics of aging in the fruit fly, Drosophila melanogaster. Annual Review of Genetics 2003, 37:329-348.
77. Herbig U., Jobling W.A., Chen B.P., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving Atm, p53, and p21(CIP1), but not p16(INK4a). Molecular Cell 2004, 14:501-513.
78. Hill K.A., Buettner V.L., Halangoda A., Kunishige M., Moore S.R., Longmate J., Scaringe W.A., Sommer S.S. Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types. Environmental Molecular Mutagenesis 2004, 43:110-120.
79. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003, 421:182-187.
80. Horiuchi S., Finch C.E., Mesle F., Vallin J. Differential patterns of age-related mortality increase in middle age and old age. Journals of Gerontology Series A: Biological and Medical Sciences 2003, 58:495-507.
81. Itahana K., Campisi J., Dimri G.P. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004, 5:1-10.
82. Itahana K., Dimri G., Campisi J. Regulation of cellular senesence by p53. European Journal of Biochemistry 2001, 268:2784-2791.
83. Itahana K., Zou Y., Itahana Y., Martinez J.L., Beausejour C., Jacobs J.J., Van Lohuizen M., Band V., Campisi J., Dimri G.P. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Molecular and Cellular Biology 2003, 23:389-401.
84. Ito K., Hirao A., Arai F., Matsuoka S., Takubo K., Hamaguchi I., Nomiyama K., Hosokawa K., Sakurada K., Nakagata N., Ikeda Y., Mak T.W., Suda T. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004, 431:997-1002.
85. Jacobs H.T. The mitochondrial theory of aging: dead or alive?. Aging Cell 2003, 2:11-17.
86. Jayaraman J., Prives C. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 1995, 81:1021-1029.
87. Juan L.J., Shia W.J., Chen M.H., Yang W.M., Seto E., Lin Y.S., Wu C.W. Histone deacetylases specifically downregulate p53-dependent gene activation. Journal of Biology Chemistry 2000, 275:20436-20443.
88. Khaidakov M., Heflich R.H., Manjanatha M.G., Myers M.B., Aidoo A. Accumulation of point mutations in mitochondrial DNA of aging mice. Mutation Research 2003, 526:1-7.
89. Kim Sh S.H., Kaminker P., Campisi J. Telomeres aging and cancer: in search of a happy ending. Oncogene 2002, 21:503-511.
90. Kipling D., Wynford-Thomas D., Jones C.J., Akbar A., Aspinall R., Bacchetti S., Blasco M.A., Broccoli D., DePinho R.A., Edwards D.R., Effros R.B., Harley C.B., Landsdorp P.M., Linskens M.H., Prowse K.R., Newbold R.F., Olovnikov A.M., Parkinson E.K., Pawelec G., Ponten J., Shall S., Zijlmans M., Faragher R.G. Telomere-dependent senescence. Nature Biotechnology 1999, 17:313-314.
91. Kirkwood T.B., Rose M.R. Evolution of senescence: late survival sacrificed for reproduction. Philosophical Transactions of the Royal Society of London: B Biological Sciences 1991, 332:15-24.
92. Klapper W., Parwaresch R., Krupp G. Telomere biology in human aging and aging syndromes. Mechanisms of Ageing and Development 2001, 122:695-712.
93. Klatt P., Serrano M. Engineering cancer resistance in mice. Carcinogenesis 2003, 24:817-826.
94. Koubova J., Guarente L. How does calorie restriction work?. Genes & Development 2003, 17:313-321.
95. Krishnamurthy J., Torrice C., Ramsey M.R., Kovalev G.I., Al-Regaiey K., Su L., Sharpless N.E. Ink4a/Arf expression is a biomarker of aging. Journal of Clinical Investigation 2004, 114:1299-1307.
96. Krtolica A., Parrinello S., Lockett S., Desprez P.Y., Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proceedings of the National Academy of Sciences of the USA 2001, 98:12072-12077.
97. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., Nabeshima Y.I. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
98. Lane D.P. Cancer. p53, guardian of the genome. Nature 1992, 358:15-16.
99. Lane D.P., Crawford L.V. T antigen is bound to a host protein in SV 40-transformed cells. Nature 1979, 278:261-263.
100. Langley E., Pearson M., Faretta M., Bauer U.M., Frye R.A., Minucci S., Pelicci P.G., Kouzarides T. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. Embo Journal 2002, 21:2383-2396.
101. Lebel M., Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proceedings of the National Academy of Sciences of the USA 1998, 95:13097-13102.
102. Lee C.K., Klopp R.G., Weindruch R., Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction. Science 1999, 285:1390-1393.
103. Lee D.W., Yu B.P. Modulation of free radicals and superoxide dismutases by age and dietary restriction. Aging (Milano) 1990, 2:357-362.
104. Lehmann A. Ageing: repair and transcription keep us from premature ageing. Current Biology 2002, 12:R550-R551.
105. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell 1997, 88:323-331.
106. Levine A.J., Finlay C.A., Hinds P.W. P53 is a tumor suppressor gene. Cell 2004, 116:S67-S69. 1 p following S69.
107. Li S., Crenshaw E.B., Rawson E.J., Simmons D.M., Swanson L.W., Rosenfeld M.G. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 1990, 347:528-533.
108. Liang H., Masoro E.J., Nelson J.F., Strong R., McMahan C.A., Richardson A. Genetic mouse models of extended lifespan. Experimental Gerontology 2003, 38:1353-1364.
109. Lieber M.R., Ma Y., Pannicke U., Schwarz K. Mechanism and regulation of human non-homologous DNA end-joining. Nature Reviews Molecular and Cellular Biology 2003, 4:712-720.
110. Lim D.S., Vogel H., Willerford D.M., Sands A.T., Platt K.A., Hasty P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Molecular and Cellular Biology 2000, 20:3772-3780.
111. Lin S.J., Defossez P.A., Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000, 289:2126-2128.
112. Linzer D.I., Levine A.J. Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 1979, 17:43-52.
113. Ljungman M. Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia 2000, 2:208-225.
114. Longo V.D., Finch C.E. Evolutionary medicine: from dwarf model systems to healthy centenarians?. Science 2003, 299:1342-1346.
115. Lozano G., Elledge S.J. p53 sends nucleotides to repair DNA. Nature 2000, 404:24-25.
116. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001, 107:137-148.
117. Maier B., Gluba W., Bernier B., Turner T., Mohammad K., Guise T., Sutherland A., Thorner M., Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes & Development 2004, 18:306-319.
118. Malkin D., Li F.P., Strong L.C., Fraumeni J.F., Nelson C.E., Kim D.H., Kassel J., Gryka M.A., Bischoff F.Z., Tainsky M.A. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990, 250:1233-1238.
119. Masoro E.J. Caloric restriction and aging: an update. Experimental Gerontology 2000, 35:299-305.
120. Matakidou A., Eisen T., Houlston R.S. TP53 polymorphisms and lung cancer risk: a systematic review and metaanalysis. Mutagenesis 2003, 18:377-385.
121. Mathieu N., Pirzio L., Freulet-Marriere M.A., Desmaze C., Sabatier L. Telomeres and chromosomal instability. Cellular and Molecular Life Sciences 2004, 61:641-656.
122. McBurney M.W., Yang X., Jardine K., Hixon M., Boekelheide K., Webb J.R., Lansdorp P.M., Lemieux M. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Molecular and Cellular Biology 2003, 23:38-54.
123. McCay C.M., Crowell M.F., Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition 1989, 5:155-171. discussion, 172.
124. Melk A., Kittikowit W., Sandhu I., Halloran K.M., Grimm P., Schmidt B.M., Halloran P.F. Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney International 2003, 63:2134-2143.
125. Metcalfe J.A., Parkhill J., Campbell L., Stacey M., Biggs P., Byrd P.J., Taylor A.M. Accelerated telomere shortening in ataxia telangiectasia. Nature Genetics 1996, 13:350-353.
126. Shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999, 402:309-313.
127. Shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. Embo Journal 1997, 16:706-716.
128. Miller R.A. 'Accelerated aging': a primrose path to insight?. Aging Cell 2004, 3:47-51.
129. Miller R.A. Rebuttal to Hasty and Vijg: 'Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity'. Aging Cell 2004, 3:53-54.
130. Misra R.P., Duncan S.A. Gene targeting in the mouse: advances in introduction of transgenes into the genome by homologous recombination. Endocrine 2002, 19:229-238.
131. Mohr U., Dungworth D.L., Capen C.C., Carlton W.W., Sundberg J.P., Ward J.M. Pathobiology of the aging mouse 1996, 1032. ILSI Press, Washington, D.C.
132. Moll U.M., Petrenko O. The MDM2-p53 interaction. Molecular Cancer Research 2003, 1:1001-1008.
133. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004, 116:551-563.
134. Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., Li H., Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003, 424:277-283.
135. Nabeshima Y. Klotho: a fundamental regulator of aging. Ageing Research Reviews 2002, 1:627-638.
136. Nagai T., Yamada K., Kim H.C., Kim Y.S., Noda Y., Imura A., Nabeshima Y., Nabeshima T. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. Faseb Journal 2003, 17:50-52.
137. Shc-dependent signaling pathway. Science 2002, 295:2450-2452.
138. Nemoto S., Fergusson M.M., Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 2004, 306:2105-2108.
139. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Experimental Cell Research 1994, 211:90-98.
140. Oren M. Decision making by p53: life, death and cancer. Cell Death and Differentiation 2003, 10:431-442.
141. Pandita T.K. ATM function and telomere stability. Oncogene 2002, 21:611-618.
142. Paradis V., Youssef N., Dargere D., Ba N., Bonvoust F., Deschatrette J., Bedossa P. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Human Pathology 2001, 32:327-332.
143. Parrinello S., Samper E., Krtolica A., Goldstein J., Melov S., Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biology 2003, 5:741-747.
144. Pearson M., Carbone R., Sebastiani C., Cioce M., Fagioli M., Saito S., Higashimoto Y., Appella E., Minucci S., Pandolfi P.P., Pelicci P.G. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 2000, 406:207-210.
145. Pelicci P.G. Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?. Journal of Clinical Investigation 2004, 113:4-7.
146. Perlman S., Becker-Catania S., Gatti R.A. Ataxia-telangiectasia: diagnosis and treatment. Seminars in Pediatric Neurology 2003, 10:173-182.
147. Pletcher S.D., Khazaeli A.A., Curtsinger J.W. Why do life spans differ? Partitioning mean longevity differences in terms of age-specific mortality parameters. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2000, 55:B381-B389.
148. Richter C., Park J.W., Ames B.N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proceedings of the National Academy of Sciences of the USA 1988, 85:6465-6467.
149. Rockwood L.D., Nussenzweig A., Janz S. Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair. Mutation Research 2003, 529:51-58.
150. Rudolph K.L., Chang S., Lee H.W., Blasco M., Gottlieb G.J., Greider C., DePinho R.A. Longevity, stress response, and cancer in aging telomerasedeficient mice. Cell 1999, 96:701-712.
151. Selivanova G., Iotsova V., Okan I., Fritsche M., Strom M., Groner B., Grafstrom R.C., Wiman K.G. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nature Medicine 1997, 3:632-638.
152. Selivanova G., Ryabchenko L., Jansson E., Iotsova V., Wiman K.G. Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain. Molecular and Cellular Biology 1999, 19:3395-3402.
153. Seluanov A., Gorbunova V., Falcovitz A., Sigal A., Milyavsky M., Zurer I., Shohat G., Goldfinger N., Rotter V. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Molecular and Cellular Biology 2001, 21:1552-1564.
154. Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602.
155. Sharpless N.E., DePinho R.A. Telomeres, stem cells, senescence, and cancer. Journal of Clinical Investigation 2004, 113:160-168.
156. Sherr C.J., DePinho R.A. Cellular senescence: mitotic clock or culture shock?. Cell 2000, 102:407-410.
157. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nature Reviews Cancer 2003, 3:155-168.
158. Sinclair D.A. Paradigms and pitfalls of yeast longevity research. Mechanisms of Ageing and Development 2002, 123:857-867.
159. Smith D.W. Cancer mortality at very old ages. Cancer 1996, 77:1367-1372.
160. Smogorzewska A., de Lange T. Regulation of telomerase by telomeric proteins. Annual Review of Biochemistry 2004, 73:177-208.
161. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273:59-63.
162. Tahara H., Sato E., Noda A., Ide T. Increase in expression level of p2Isdil/cip1/wafl with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene 1995, 10:835-840.
163. Takeda T. Senescence-accelerated mouse (SAM): a biogerontological resource in aging research. Neurobiology of Aging 1999, 20:105-110.
164. Tanhauser S.M., Laipis P.J. Multiple deletions are detectable in mitochondrial DNA of aging mice. Journal of Biological Chemistry 1995, 270:24769-24775.
165. Tatar M., Bartke A., Antebi A. The endocrine regulation of aging by insulin-like signals. Science 2003, 299:1346-1351.
166. Thomas M., Kalita A., Labrecque S., Pim D., Banks L., Matlashewski G. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Molecular and Cellular Biology 1999, 19:1092-1100.
167. Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly Y.M., Gidlof S., Oldfors A., Wibom R., Tornell J., Jacobs H.T., Larsson N.G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004, 429:417-423.
168. Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene 2002, 21:3872-3878.
169. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., Hee Park S., Thompson T., Karsenty G., Bradley A., Donehower L.A. p53 mutant mice that display early ageingassociated phenotypes. Nature 2002, 415:45-53.
170. Um J.H., Kim S.J., Kim D.W., Ha M.Y., Jang J.H., Chung B.S., Kang C.D., Kim S.H. Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction. Mechanisms of Ageing and Development 2003, 124:967-975.
171. Van Heemst D., Mooijaart S.P., Beekman M., Schreuder J., de Craen A.J.M., Brandt B.W., Slagboom P.E., Westendorp R.G.J. Variation in the human TP53 gene affects old age survival and cancer mortality. Experimental Gerontology 2005, 40:11-15. Long Life Study Group.
172. Van Zant G., Liang Y. The role of stem cells in aging. Experimental Hematology 2003, 31:659-672.
173. Vasile E., Tomita Y., Brown L.F., Kocher O., Dvorak H.F. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. Faseb Journal 2001, 15:458-466.
174. Vaziri H., Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Current Biology 1998, 8:279-282.
175. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001, 107:149-159.
176. Vaziri H., West M.D., Allsopp R.C., Davison T.S., Wu Y.S., Arrowsmith C.H., Poirier G.G., Benchimol S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase. Embo Journal 1997, 16:6018-6033.
177. Venkitaraman A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002, 108:171-182.
178. Vijg J., Dolle M.E. Large genome rearrangements as a primary cause of aging. Mechanisms of Ageing and Development 2002, 123:907-915.
179. Vogel H., Lim D.S., Karsenty G., Finegold M., Hasty P. Deletion of Ku86 causes early onset of senescence in mice. Proceedings of the National Academy of Sciences of the USA 1999, 96:10770-10775.
180. Vousden K.H. Activation of the p53 tumor suppressor protein. Biochimica et Biophysica Acta 2002, 1602:47-59.
181. Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nature Reviews Cancer 2002, 2:594-604.
182. Walter C.A., Zhou Z.Q., Manguino D., Ikeno Y., Reddick R., Nelson J., Intano G., Herbert D.C., McMahan C.A., Hanes M. Health span and life span in transgenic mice with modulated DNA repair. Annals of the New York Academy of Sciences 2001, 928:132-140.
183. Warner H.R., Sierra F. Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology. Mechanisms of Ageing and Development 2003, 124:581-587.
184. Webley K., Bond J.A., Jones C.J., Blaydes J.P., Craig A., Hupp T., Wynford-Thomas D. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Molecular and Cellular Biology 2000, 20:2803-2808.
185. Weston A., Godbold J.H. Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis. Environmental Health Perspectives 1997, 105(Supplement 4):919-926.
186. Wong K.K., Maser R.S., Bachoo R.M., Menon J., Carrasco D.R., Gu Y., Alt F.W., DePinho R.A. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003, 421:643-648.
187. Wright W.E., Shay J.W. Historical claims and current interpretations of replicative aging. Nature Biotechnology 2002, 20:682-688.
188. Xu X., Qiao W., Linke S.P., Cao L., Li W.M., Furth P.A., Harris C.C., Deng C.X. Genetic interactions between tumor suppressors Brcal and p53 in apoptosis, cell cycle and tumorigenesis. Nature Genetics 2001, 28:266-271.
189. Xu Y. Regulation of p53 responses by post-translational modifications. Cell Death and Differentiation 2003, 10:400-403.
190. Xu Y., Ashley T., Brainerd E.E., Bronson R.T., Meyn M.S., Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes and Development 1996, 10:2411-2422.
191. Yakes F.M., Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proceedings of the National Academy of Sciences of the USA 1997, 94:514-519.
192. Zhu J., Woods D., McMahon M., Bishop J.M. Senescence of human fibroblasts induced by oncogenic Raf. Genes & Development 1998, 12:2997-3007.