-
1
-
-
0026336532
-
Gerontology as oncology: Research on aging as a key to the understanding of cancer
-
Miller, R. A. Gerontology as oncology: research on aging as a key to the understanding of cancer. Cancer 68, 2496-2501 (1991).
-
(1991)
Cancer
, vol.68
, pp. 2496-2501
-
-
Miller, R.A.1
-
2
-
-
0034626769
-
The age of cancer
-
DePinho, R. A. The age of cancer. Nature 408, 248-254 (2000).
-
(2000)
Nature
, vol.408
, pp. 248-254
-
-
DePinho, R.A.1
-
4
-
-
0030932869
-
Cancer susceptibility genes: Gatekeepers and caretakers
-
Kinzler, K. W. & Vogelstein, B. Cancer susceptibility genes: gatekeepers and caretakers. Nature 386, 761-763 (1997).
-
(1997)
Nature
, vol.386
, pp. 761-763
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
5
-
-
0035144176
-
Searching for human longevity genes: The future history of gerontology in the post-genomic era
-
Barzilai, N. & Shuldiner, A. R. Searching for human longevity genes: the future history of gerontology in the post-genomic era. J. Gerontol. 56, 83-87 (2001).
-
(2001)
J. Gerontol.
, vol.56
, pp. 83-87
-
-
Barzilai, N.1
Shuldiner, A.R.2
-
6
-
-
0025934488
-
Molecular genetics of the retinoblastoma tumor suppressor gene
-
Bookstein, R. & Lee, W. H. Molecular genetics of the retinoblastoma tumor suppressor gene. Crit. Rev. Oncol. 2, 211-227 (1991).
-
(1991)
Crit. Rev. Oncol.
, vol.2
, pp. 211-227
-
-
Bookstein, R.1
Lee, W.H.2
-
7
-
-
0025894713
-
p53 mutation in human cancer
-
Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C. C. p53 mutation in human cancer. Science 253, 49-53 (1991).
-
(1991)
Science
, vol.253
, pp. 49-53
-
-
Hollstein, M.1
Sidransky, D.2
Vogelstein, B.3
Harris, C.C.4
-
8
-
-
0029028701
-
Cancer: The rise of the genetic paradigm
-
Bishop, J. M. Cancer: the rise of the genetic paradigm. Genes Dev. 9, 1309-1315 (1995).
-
(1995)
Genes Dev.
, vol.9
, pp. 1309-1315
-
-
Bishop, J.M.1
-
9
-
-
0035500495
-
Mouse models for multistep tumorigenesis
-
Wu, X. & Pandolfi, P. Mouse models for multistep tumorigenesis. Trends Cell Biol. 11, 2-9 (2001).
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 2-9
-
-
Wu, X.1
Pandolfi, P.2
-
10
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
11
-
-
0034129118
-
Recent advances in research on multistage tumorigenesis
-
Compagni, A. & Christofori, G. Recent advances in research on multistage tumorigenesis. Br. J. Cancer. 83, 1-5 (2000).
-
(2000)
Br. J. Cancer
, vol.83
, pp. 1-5
-
-
Compagni, A.1
Christofori, G.2
-
12
-
-
0034002662
-
Tumor suppressor genes
-
Macleod, K. Tumor suppressor genes. Curr. Opin. Genet. Dev. 10, 81-93 (2000).
-
(2000)
Curr. Opin. Genet. Dev.
, vol.10
, pp. 81-93
-
-
Macleod, K.1
-
13
-
-
0030240944
-
How cancer arises
-
Weinberg, R. A. How cancer arises. Sci. Am. 275, 62-70 (1996).
-
(1996)
Sci. Am.
, vol.275
, pp. 62-70
-
-
Weinberg, R.A.1
-
14
-
-
0032427630
-
Mouse models in tumor suppression
-
Ghebranious, N. & Donehower, L. A. Mouse models in tumor suppression. Oncogene 17, 3385-3400 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 3385-3400
-
-
Ghebranious, N.1
Donehower, L.A.2
-
15
-
-
0034511179
-
Chasing the cancer demon
-
Knudson, A. G. Chasing the cancer demon. Annu. Rev. Genet. 34, 1-19 (2000).
-
(2000)
Annu. Rev. Genet.
, vol.34
, pp. 1-19
-
-
Knudson, A.G.1
-
16
-
-
0035679209
-
Animal models of tumor-suppressor genes
-
Hakem, R. & Mak, T. W. Animal models of tumor-suppressor genes. Annu. Rev. Genet. 35, 209-241 (2001).
-
(2001)
Annu. Rev. Genet.
, vol.35
, pp. 209-241
-
-
Hakem, R.1
Mak, T.W.2
-
17
-
-
0037470542
-
Aging and genome maintenance: Lessons from the mouse?
-
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Aging and genome maintenance: lessons from the mouse? Science 299, 1355-1359 (2003).
-
(2003)
Science
, vol.299
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
Van Steeg, H.4
Vijg, J.5
-
18
-
-
0037198009
-
Large genome rearrangements as a primary cause of aging
-
Vijg, J. & Dolle, M. E. Large genome rearrangements as a primary cause of aging. Mech. Ageing Dev. 123, 907-915 (2002).
-
(2002)
Mech. Ageing Dev.
, vol.123
, pp. 907-915
-
-
Vijg, J.1
Dolle, M.E.2
-
21
-
-
0024991930
-
Escherichia coli RecQ protein is a DNA helicase
-
Umezu, K., Nakayama, K. & Nakayama, H. Escherichia coli RecQ protein is a DNA helicase. Proc. Natl Acad. Sci. USA 87, 5363-5367 (1990).
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 5363-5367
-
-
Umezu, K.1
Nakayama, K.2
Nakayama, H.3
-
22
-
-
0028033989
-
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
-
Gangloff, S., McDonald, J. P., Bendixen, C., Arthur, L. & Rothstein, R. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14, 8391-8398 (1994).
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 8391-8398
-
-
Gangloff, S.1
McDonald, J.P.2
Bendixen, C.3
Arthur, L.4
Rothstein, R.5
-
23
-
-
0030994386
-
Rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
-
Stewart, E., Chapman, C. R., Al-Khodairy, F., Carr, A. M. & Enoch, T. Rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16, 2682-2692 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 2682-2692
-
-
Stewart, E.1
Chapman, C.R.2
Al-Khodairy, F.3
Carr, A.M.4
Enoch, T.5
-
24
-
-
0033841114
-
RecQ-like helicases: The DNA replication checkpoint connection
-
Frei, C. & Gasser, S. M. RecQ-like helicases: the DNA replication checkpoint connection. J. Cell Sci. 113, 2641-2646 (2000).
-
(2000)
J. Cell Sci.
, vol.113
, pp. 2641-2646
-
-
Frei, C.1
Gasser, S.M.2
-
25
-
-
0034578446
-
DNA helicases, genomic instability, and human genetic disease
-
van Brabant, A. J., Stan, R. & Ellis, N. A. DNA helicases, genomic instability, and human genetic disease. Annu. Rev. Genom Hum. Genet. 1, 409-459 (2000).
-
(2000)
Annu. Rev. Genom. Hum. Genet.
, vol.1
, pp. 409-459
-
-
Van Brabant, A.J.1
Stan, R.2
Ellis, N.A.3
-
26
-
-
0033119701
-
Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
-
Chakraverty, R. K. & Hickson, I. D. Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. Bioessays 21, 286-294 (1999).
-
(1999)
Bioessays
, vol.21
, pp. 286-294
-
-
Chakraverty, R.K.1
Hickson, I.D.2
-
27
-
-
0030691121
-
Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
-
Goto, M. Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech. Ageing Dev. 98, 239-254 (1997).
-
(1997)
Mech. Ageing Dev.
, vol.98
, pp. 239-254
-
-
Goto, M.1
-
28
-
-
0032825111
-
What genatricians should know about the Werner Syndrome
-
Martin, G. M., Oshima, J., Gray, M. D. & Poot, M. What genatricians should know about the Werner Syndrome. J. Am. Geriatr. Soc. 47, 1136-1144 (1999).
-
(1999)
J. Am. Geriatr. Soc.
, vol.47
, pp. 1136-1144
-
-
Martin, G.M.1
Oshima, J.2
Gray, M.D.3
Poot, M.4
-
29
-
-
0029814277
-
Molecular genetics of Bloom's syndrome
-
Ellis, N. A. & German, J. Molecular genetics of Bloom's syndrome. Hum. Mol. Genet. 5, 1457-1463 (1996).
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 1457-1463
-
-
Ellis, N.A.1
German, J.2
-
30
-
-
0028896957
-
Rothmund-Thomson syndrome
-
Vennos, E. M. & James, W. D. Rothmund-Thomson syndrome. Dermatol. Clin. 13, 143-150 (1995).
-
(1995)
Dermatol. Clin.
, vol.13
, pp. 143-150
-
-
Vennos, E.M.1
James, W.D.2
-
31
-
-
0035062128
-
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders
-
Mohaghegh, P. & Hickson, I. D. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders Hum. Mol. Genet. 10, 741-746 (2001).
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 741-746
-
-
Mohaghegh, P.1
Hickson, I.D.2
-
32
-
-
0028831333
-
Bloom's syndrome
-
German, J. Bloom's syndrome. Dermatol. Clin. 13, 7-18 (1995).
-
(1995)
Dermatol. Clin.
, vol.13
, pp. 7-18
-
-
German, J.1
-
33
-
-
0033771208
-
The Werner syndrome protein: An update
-
Oshima, J. The Werner syndrome protein: an update Bioessays 22, 894-901 (2000).
-
(2000)
Bioessays
, vol.22
, pp. 894-901
-
-
Oshima, J.1
-
34
-
-
0037364415
-
RecQ helicases: Caretakers of the genome
-
Hickson, I. D. RecQ helicases: caretakers of the genome Nature Rev. Cancer 3, 169-178 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 169-178
-
-
Hickson, I.D.1
-
36
-
-
0024465870
-
Mutator phenotype of Werner syndrome is characterized by extensive deletions
-
Fukuchi, K., Martin, G. M. & Monnat, R. J. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl Acad. Sci. USA 66, 5893-5897 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.66
, pp. 5893-5897
-
-
Fukuchi, K.1
Martin, G.M.2
Monnat, R.J.3
-
37
-
-
0036200960
-
Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue
-
Lebel, M. Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue. Carcinogenesis 23, 213-216 (2002).
-
(2002)
Carcinogenesis
, vol.23
, pp. 213-216
-
-
Lebel, M.1
-
38
-
-
0037081095
-
Lack of WRN results in extensive deletion at nonhomologous joining ends
-
Oshima, J., Huang, S., Pae, C., Campisi, J. & Schiestl, R. H. Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res. 62, 547-551 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 547-551
-
-
Oshima, J.1
Huang, S.2
Pae, C.3
Campisi, J.4
Schiestl, R.H.5
-
39
-
-
0035871341
-
Loss of Werner syndrome protein function promotes aberrant mitotic recombination
-
Prince, P.R., Emond, M. J. & Monnat, R. J. Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev. 15, 933-938 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 933-938
-
-
Prince, P.R.1
Emond, M.J.2
Monnat, R.J.3
-
40
-
-
0030070430
-
Somatic mutagenesis and antimutagenesis in aging research
-
Martin, G. M. Somatic mutagenesis and antimutagenesis in aging research. Mutat. Res. 350, 35-41 (1966).
-
(1966)
Mutat. Res.
, vol.350
, pp. 35-41
-
-
Martin, G.M.1
-
41
-
-
0028564949
-
Mismatch repair, genetic stability, and cancer
-
Modrich, P. Mismatch repair, genetic stability, and cancer. Science 266, 1959-1960 (1994).
-
(1994)
Science
, vol.266
, pp. 1959-1960
-
-
Modrich, P.1
-
42
-
-
0032739301
-
Cancer from the outside, aging from the inside: Mouse models to study the consequences of defective nucleotide excision repair
-
de Boer, J. & Hoeijmakers, J. Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair. Biochimie 81, 127-137 (1999).
-
(1999)
Biochimie
, vol.81
, pp. 127-137
-
-
De Boer, J.1
Hoeijmakers, J.2
-
43
-
-
0032209738
-
Pathological and physiological double-strand breaks: Roles in cancer, aging, and the immune system
-
Lieber, M. R. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system. Am. J. Pathol. 153, 1323-1332 (1998).
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 1323-1332
-
-
Lieber, M.R.1
-
44
-
-
0034981048
-
Homologous recombination: From model organisms to human disease
-
Modesti, M. & Kanaar, R. Homologous recombination: from model organisms to human disease. Genome Biol. 2, 1014 (2001).
-
(2001)
Genome Biol.
, vol.2
, pp. 1014
-
-
Modesti, M.1
Kanaar, R.2
-
45
-
-
0032786233
-
A phylogenomic study of DNA repair genes proteins, and processes
-
Eisen, J. A. & Hanawalt, P. C. A phylogenomic study of DNA repair genes, proteins, and processes. Mutat. Res. 435, 171-213 (1999).
-
(1999)
Mutat. Res.
, vol.435
, pp. 171-213
-
-
Eisen, J.A.1
Hanawalt, P.C.2
-
46
-
-
0034814670
-
Physiology and pathophysiology of poly(ADP-ribosyl)ation
-
Burkle, A. Physiology and pathophysiology of poly(ADP-ribosyl)ation Bioessays 23, 795-806 (2001).
-
(2001)
Bioessays
, vol.23
, pp. 795-806
-
-
Burkle, A.1
-
47
-
-
0035495386
-
How nucleotide excision repair protects against cancer
-
Friedberg, E. C. How nucleotide excision repair protects against cancer. Nature Rev. Cancer 1, 22-33 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 22-33
-
-
Friedberg, E.C.1
-
48
-
-
0035500805
-
Double-strand breaks and tumorigenesis
-
Pierce, A. et al. Double-strand breaks and tumorigenesis. Trends Cell Biol. 11, 52-59 (2001).
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 52-59
-
-
Pierce, A.1
-
49
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel, H., Lim, D. S., Karsenty, G., Finegold, M. & Hasty, P. Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl Acad. Sci. USA 96, 10770-10775 (1999). Describes the premature ageing phenotypes of mice that are deficient in a protein required for repairing double-strand breaks in DNA.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
50
-
-
0035234162
-
Xeroderma pigmentosum and related disorders: Defects in DNA repair and transcription
-
Berneburg, M. & Lehmann, A. R. Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription. Adv. Genet. 43, 71-102 (2001).
-
(2001)
Adv. Genet.
, vol.43
, pp. 71-102
-
-
Berneburg, M.1
Lehmann, A.R.2
-
51
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
de Boer, J. et al. Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276-1279 (2002). This paper describes the premature ageing phenotypes of mice deficient in a protein required for reparing damaged nucleotides in DNA.
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
De Boer, J.1
-
52
-
-
0037202608
-
Recombinational DNA repair and human disease
-
Thompson, L. H. & Schild, D. Recombinational DNA repair and human disease. Mutat. Res. 509, 49-78 (2002).
-
(2002)
Mutat. Res.
, vol.509
, pp. 49-78
-
-
Thompson, L.H.1
Schild, D.2
-
53
-
-
0037439071
-
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
-
Cao, L., Li, W., Kim, S., Brodie, S. G. & Deng, C. X. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev. 17, 201-213 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 201-213
-
-
Cao, L.1
Li, W.2
Kim, S.3
Brodie, S.G.4
Deng, C.X.5
-
54
-
-
0025932984
-
Apoptosis: Mechanisms and roles in pathology
-
Arends, M. J. & Wyllie, A. H. Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32, 223-254 (1991).
-
(1991)
Int. Rev. Exp. Pathol.
, vol.32
, pp. 223-254
-
-
Arends, M.J.1
Wyllie, A.H.2
-
55
-
-
0025719085
-
Mechanisms and functions of cell death
-
Ellis, R. E., Yuan, J. Y. & Horvitz, H. R. Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7, 663-698 (1991).
-
(1991)
Annu. Rev. Cell Biol.
, vol.7
, pp. 663-698
-
-
Ellis, R.E.1
Yuan, J.Y.2
Horvitz, H.R.3
-
56
-
-
0033593572
-
Cell death in development
-
Vaux, D. L. & Korsmeyer, S. J. Cell death in development. Cell 96, 245-254 (1999).
-
(1999)
Cell
, vol.96
, pp. 245-254
-
-
Vaux, D.L.1
Korsmeyer, S.J.2
-
57
-
-
0033022705
-
Hormonal and genetic control of germ cell apoptosis in the testis
-
Sinha Hakim, A. P. & Swerdloff, R. S. Hormonal and genetic control of germ cell apoptosis in the testis. Rev. Reprod. 4, 38-47 (1999).
-
(1999)
Rev. Reprod.
, vol.4
, pp. 38-47
-
-
Sinha Hakim, A.P.1
Swerdloff, R.S.2
-
58
-
-
0035100306
-
Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis
-
Laun, P. et al. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol. Microbiol. 39, 1166-1173 (2001).
-
(2001)
Mol. Microbiol.
, vol.39
, pp. 1166-1173
-
-
Laun, P.1
-
59
-
-
0033026714
-
Mechanisms of apoptosis in avoidance of cancer
-
Reed, J. C. Mechanisms of apoptosis in avoidance of cancer. Curr. Opin. Oncol. 11, 68-75 (1999).
-
(1999)
Curr. Opin. Oncol.
, vol.11
, pp. 68-75
-
-
Reed, J.C.1
-
60
-
-
0036463405
-
A matter of life and death
-
Green, D. R. & Evan, G. I. A matter of life and death. Cancer Cell 1, 19-30 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
61
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11, 27-31 (2001).
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 27-31
-
-
Campisi, J.1
-
62
-
-
0037148342
-
Telomeres, aging and cancer: In search of a happy ending
-
Kim, S. H., Kaminker P. & Campisi, J. Telomeres, aging and cancer: in search of a happy ending. Oncogene 21, 503-511 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 503-511
-
-
Kim, S.H.1
Kaminker, P.2
Campisi, J.3
-
63
-
-
0031047426
-
Replicative senescence and cell immortality: The role of telomeres and telomerase
-
Chiu, C. P. & Harley, C. B. Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc. Soc. Exp. Biol. Med. 214, 99-106 (1997).
-
(1997)
Proc. Soc. Exp. Biol. Med.
, vol.214
, pp. 99-106
-
-
Chiu, C.P.1
Harley, C.B.2
-
64
-
-
0034069237
-
Cancer, aging and cellular senescence
-
Campisi, J. Cancer, aging and cellular senescence. In Vivo 14, 183-188 (2000).
-
(2000)
In Vivo
, vol.14
, pp. 183-188
-
-
Campisi, J.1
-
66
-
-
0004168813
-
-
(eds Schneider, E. & Rowe, J.) (Academic Press, New York)
-
Campisi, J., Dimri, G. P. & Hara, E. in Handbook of the Biology of Aging (eds Schneider, E. & Rowe, J.) 121-149 (Academic Press, New York, 1996).
-
(1996)
Handbook of the Biology of Aging
, pp. 121-149
-
-
Campisi, J.1
Dimri, G.P.2
Hara, E.3
-
67
-
-
0029164707
-
Cataloging altered gene expression in young and senescent cells using enhanced differential display
-
Linskens, M. H. K. et al. Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucl. Acids Res. 23, 3244-3251 (1995).
-
(1995)
Nucl. Acids Res.
, vol.23
, pp. 3244-3251
-
-
Linskens, M.H.K.1
-
68
-
-
0033539169
-
Microarray analysis of replicative senescence
-
Shelton, D. N., Chang, E., Whittier, P. S., Choi, D. & Funk, W. D. Microarray analysis of replicative senescence. Curr. Biol. 9, 939-945 (1999). This paper uses microarrays to compare the senescent phenotype of replicatively senescent human fibroblasts with human fibroblasts that are induced to 'prematurely' senesce owing to nontelomeric events.
-
(1999)
Curr. Biol.
, vol.9
, pp. 939-945
-
-
Shelton, D.N.1
Chang, E.2
Whittier, P.S.3
Choi, D.4
Funk, W.D.5
-
69
-
-
0035059672
-
From cells to organisms: Can we learn about aging from cells in culture?
-
Campisi, J. From cells to organisms: can we learn about aging from cells in culture? Exp. Gerontol. 36, 607-618 (2001).
-
(2001)
Exp. Gerontol.
, vol.36
, pp. 607-618
-
-
Campisi, J.1
-
70
-
-
0028892114
-
Identification and behavior of epithelial stem cells in the Drosophila ovary
-
Margolis, J. & Spradling, A. Identification and behavior of epithelial stem cells in the Drosophila ovary. Development 121, 3797-3807 (1995).
-
(1995)
Development
, vol.121
, pp. 3797-3807
-
-
Margolis, J.1
Spradling, A.2
-
71
-
-
0030016821
-
Longevity, Genes and Aging
-
Jazwinski, S. M. Longevity, Genes and Aging. Science 273, 54-59 (1996).
-
(1996)
Science
, vol.273
, pp. 54-59
-
-
Jazwinski, S.M.1
-
72
-
-
0026006294
-
Senescence as a mode of tumor suppression
-
Sager, R. Senescence as a mode of tumor suppression. Environ. Health Persp. 93, 59-62 (1991).
-
(1991)
Environ. Health Persp.
, vol.93
, pp. 59-62
-
-
Sager, R.1
-
73
-
-
0030038104
-
Replicative senescence: Implications for in vivo aging and tumor suppression
-
Smith, J. R. & Pereira-Smith, O. M. Replicative senescence: implications for in vivo aging and tumor suppression. Science 273, 63-67 (1996).
-
(1996)
Science
, vol.273
, pp. 63-67
-
-
Smith, J.R.1
Pereira-Smith, O.M.2
-
74
-
-
0035253719
-
Cellular senescence as a tumor-protection mechanism: The essential role of counting
-
Wright, W. E. & Shay, J. W. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr. Opin. Genet. Dev. 11, 98-103 (2001).
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 98-103
-
-
Wright, W.E.1
Shay, J.W.2
-
75
-
-
15444339879
-
Overcoming cellular senescence in human cancer pathogenesis
-
Yeager, T. R. et al. Overcoming cellular senescence in human cancer pathogenesis. Genes Dev. 12, 163-174 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 163-174
-
-
Yeager, T.R.1
-
76
-
-
0029993450
-
Role of the INK4A locus in tumor suppression and cell mortality
-
Serrano, M. et al. Role of the INK4A locus in tumor suppression and cell mortality. Cell 85, 27-37 (1996).
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
-
77
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumongenesis
-
Sharpless, N. E. et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumongenesis. Nature 413, 86-91 (2001).
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
-
78
-
-
0027179908
-
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
-
Harvey, M. et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467 (1993).
-
(1993)
Oncogene
, vol.8
, pp. 2457-2467
-
-
Harvey, M.1
-
79
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
-
Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356, 215-221 (1992).
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
-
80
-
-
0029670840
-
Regulation of p16/CDKN2 expression and its implications for cell immortalization and senescence
-
Hara, E. et al. Regulation of p16/CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell. Biol. 16, 859-867 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 859-867
-
-
Hara, E.1
-
81
-
-
0032510327
-
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
-
McConnell, B. B., Starborg, M., Brookes, S. & Peters, G. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr. Biol. 8, 351-354 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 351-354
-
-
McConnell, B.B.1
Starborg, M.2
Brookes, S.3
Peters, G.4
-
82
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997).
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
83
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta, D. A. et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl Acad. Sci. USA 93, 13742-13747 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
-
84
-
-
0033989829
-
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14/ARF tumor suppressor
-
Dimri, G. P. Itahana, K., Acosta, M. & Campisi, J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14/ARF tumor suppressor. Mol. Cell. Biol. 20, 273-285 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 273-285
-
-
Dimri, G.P.1
Itahana, K.2
Acosta, M.3
Campisi, J.4
-
85
-
-
0025150387
-
Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
-
Stein, G. H., Beeson, M. & Gordon, L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669 (1991).
-
(1991)
Science
, vol.249
, pp. 666-669
-
-
Stein, G.H.1
Beeson, M.2
Gordon, L.3
-
86
-
-
0025838080
-
Failure of senescent cells to phosphorylate the RB protein
-
Futreal, P. A. & Barrett, J. C. Failure of senescent cells to phosphorylate the RB protein. Oncogene 6, 1109-1113 (1991).
-
(1991)
Oncogene
, vol.6
, pp. 1109-1113
-
-
Futreal, P.A.1
Barrett, J.C.2
-
87
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
Atadja, P., Wong, H., Garkavstev, I., Veillette, C. & Riabowol, K. Increased activity of p53 in senescing fibroblasts. Proc. Natl Acad. Sci. USA 92, 8348-8352 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
Garkavstev, I.3
Veillette, C.4
Riabowol, K.5
-
88
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
-
DiLeonardo, A., Linke, S. P., Clarkin, K. & Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551 (1994).
-
(1994)
Genes Dev.
, vol.8
, pp. 2540-2551
-
-
DiLeonardo, A.1
Linke, S.P.2
Clarkin, K.3
Wahl, G.M.4
-
89
-
-
0032524563
-
2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G(1) arrest but not cell replication
-
2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G(1) arrest but not cell replication. Biochem. J. 332, 43-50 (1998).
-
(1998)
Biochem. J.
, vol.332
, pp. 43-50
-
-
Chen, Q.1
-
90
-
-
0026055983
-
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1
-
Hara, E., Tsuri, H., Shinozaki, S. & Oda, K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Comm. 179, 528-534 (1991).
-
(1991)
Biochem. Biophys. Res. Comm.
, vol.179
, pp. 528-534
-
-
Hara, E.1
Tsuri, H.2
Shinozaki, S.3
Oda, K.4
-
91
-
-
0026054961
-
A role for both Rb and p53 in the regulation of human cellular senescence
-
Shay, J. W., Pereira-Smith, O. M. & Wright, W. E. A role for both Rb and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196, 33-39 (1991).
-
(1991)
Exp. Cell Res.
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
92
-
-
0031935827
-
Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
-
Gire, V. & Wynford-Thomas, D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol. 18, 1611-1621 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1611-1621
-
-
Gire, V.1
Wynford-Thomas, D.2
-
93
-
-
0033695080
-
Genes involved in senescence and immortalization
-
Lundberg, A. S., Hahn, W. C., Gupta, P. & Weinberg, R. A. Genes involved in senescence and immortalization. Curr. Opin. Cell Biol. 12, 705-709 (2000).
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 705-709
-
-
Lundberg, A.S.1
Hahn, W.C.2
Gupta, P.3
Weinberg, R.A.4
-
94
-
-
0034028836
-
Tumor suppressors and oncogenes in cellular senescence
-
Bringold, F. & Serrano, M. Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol. 35, 317-329 (2000).
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 317-329
-
-
Bringold, F.1
Serrano, M.2
-
95
-
-
0034832956
-
Regulation of cellular senescence by p53
-
Itahana, K., Dimri, G. & Campisi, J. Regulation of cellular senescence by p53. Eur. J. Biochem. 268, 2784-2791 (2001).
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2784-2791
-
-
Itahana, K.1
Dimri, G.2
Campisi, J.3
-
97
-
-
0034704848
-
p16 INK4a can initiate an autonomous senescence program
-
Dai, C. Y. & Enders, G. H. p16 INK4a can initiate an autonomous senescence program. Oncogene 19, 1613-1622 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 1613-1622
-
-
Dai, C.Y.1
Enders, G.H.2
-
98
-
-
0030886015
-
Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
-
Sugrue, M. M., Shin, D. Y., Lee, S. W. & Aaronson, S. A. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl Acad. Sci. USA 94, 9648-9653 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9648-9653
-
-
Sugrue, M.M.1
Shin, D.Y.2
Lee, S.W.3
Aaronson, S.A.4
-
99
-
-
9844232032
-
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
-
Xu, H. J. et al. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 15, 2589-2596 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 2589-2596
-
-
Xu, H.J.1
-
100
-
-
0032411599
-
Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress
-
Amundson, S. A. Myers, T. G. & Fornace, A. J. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 17, 3287-3299 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 3287-3299
-
-
Amundson, S.A.1
Myers, T.G.2
Fornace, A.J.3
-
101
-
-
0032931517
-
The p53 pathway
-
Prives, C. & Hall, P. A. The p53 pathway. J. Pathol. 187, 112-126 (1999).
-
(1999)
J. Pathol.
, vol.187
, pp. 112-126
-
-
Prives, C.1
Hall, P.A.2
-
102
-
-
0036145018
-
Multiple roles of the tumor suppressor p53
-
Bargonetti, J. & Manfredi, J. J. Multiple roles of the tumor suppressor p53. Curr. Opin. Oncol. 14, 86-91 (2002).
-
(2002)
Curr. Opin. Oncol.
, vol.14
, pp. 86-91
-
-
Bargonetti, J.1
Manfredi, J.J.2
-
103
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
-
Wahl, G. M. & Carr, A. M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biol. 3, 277-286 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 277-286
-
-
Wahl, G.M.1
Carr, A.M.2
-
104
-
-
0032433854
-
Iin-35 and Iin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbbAp48
-
Lu, X. & Horvitz, H. R. Iin-35 and Iin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbbAp48. Cell 95, 981-991 (1998).
-
(1998)
Cell
, vol.95
, pp. 981-991
-
-
Lu, X.1
Horvitz, H.R.2
-
105
-
-
0029894254
-
RBF a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila
-
Du, W., Vidal, M., Xie, J. E. & Dyson, N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10, 1206-1218 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 1206-1218
-
-
Du, W.1
Vidal, M.2
Xie, J.E.3
Dyson, N.4
-
106
-
-
0035913975
-
Caenorhabditis elegans p53: Role in apoptosis, meiosis, and stress resistance
-
Derry, W. B., Putzke, A. P. & Rothman, J. H. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance Science 294, 591-595 (2001).
-
(2001)
Science
, vol.294
, pp. 591-595
-
-
Derry, W.B.1
Putzke, A.P.2
Rothman, J.H.3
-
107
-
-
0035975986
-
The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis
-
Schumacher, B., Hoffman, K., Boulton, S. & Gartner, A. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr. Biol. 11, 1722-1727 (2001).
-
(2001)
Curr. Biol.
, vol.11
, pp. 1722-1727
-
-
Schumacher, B.1
Hoffman, K.2
Boulton, S.3
Gartner, A.4
-
108
-
-
0034737292
-
Drosophila p53 binds a damage response element at the reaper locus
-
Brodsky, M. H. et al. Drosophila p53 binds a damage response element at the reaper locus. Cell 101, 103-113 (2000).
-
(2000)
Cell
, vol.101
, pp. 103-113
-
-
Brodsky, M.H.1
-
109
-
-
20244385424
-
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
-
Ollmann, M. et al. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 101, 91-101 (2000).
-
(2000)
Cell
, vol.101
, pp. 91-101
-
-
Ollmann, M.1
-
110
-
-
12944269061
-
Identification and characterization of a p53 homologue in Drosophila melanogaster
-
Jin, S. et al. Identification and characterization of a p53 homologue in Drosophila melanogaster. Proc. Natl Acad. Sci. USA 97, 7301-7306 (2000). References 106-110 describe the conserved sequence and functions of invertebrate (C. elegans and D. melanogaster) p53.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7301-7306
-
-
Jin, S.1
-
112
-
-
0000055057
-
Pleiotropy, natural selection, and the evolution of senescence
-
Williams, G. C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398-411 (1957).
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
113
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462 (1995).
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
114
-
-
0033616140
-
Apoptosis in human disease: A new skin for an old ceremony?
-
Fadeel, B., Orrenius, S. & Zhivotovsky, B. Apoptosis in human disease: a new skin for an old ceremony? Biochem. Biophys. Res. Comm. 266, 699-717 (1999).
-
(1999)
Biochem. Biophys. Res. Comm.
, vol.266
, pp. 699-717
-
-
Fadeel, B.1
Orrenius, S.2
Zhivotovsky, B.3
-
115
-
-
0035348408
-
Neuronal cell death in nervous system development, disease, and injury
-
Martin, L. J. Neuronal cell death in nervous system development, disease, and injury. Int. J. Mol. Med. 7, 455-478 (2001).
-
(2001)
Int. J. Mol. Med.
, vol.7
, pp. 455-478
-
-
Martin, L.J.1
-
116
-
-
0035271888
-
Adult stem cell plasticity and methods of detection
-
Almeida-Porada, G., Porada, C. & Zanjani, E. D. Adult stem cell plasticity and methods of detection. Rev. Clin. Exp. Hematol 5, 26-41 (2001).
-
(2001)
Rev. Clin. Exp. Hematol
, vol.5
, pp. 26-41
-
-
Almeida-Porada, G.1
Porada, C.2
Zanjani, E.D.3
-
117
-
-
0035182533
-
Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
-
Weissman, I. L., Anderson, D. J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403 (2001).
-
(2001)
Annu. Rev. Cell Dev. Biol.
, vol.17
, pp. 387-403
-
-
Weissman, I.L.1
Anderson, D.J.2
Gage, F.3
-
118
-
-
0036123095
-
The reserve capacity hypothesis: Evolutionary origins and modern implications between tumor suppression and tissue repair
-
Weinstein, B. S. & Ciszek, D. The reserve capacity hypothesis: evolutionary origins and modern implications between tumor suppression and tissue repair. Exp. Gerontol. 37, 615-627 (2002).
-
(2002)
Exp. Gerontol.
, vol.37
, pp. 615-627
-
-
Weinstein, B.S.1
Ciszek, D.2
-
119
-
-
0036260527
-
Does p53 affect organismal aging?
-
Donehower, L. A Does p53 affect organismal aging? J. Cell Physiol. 192, 23-33 (2002).
-
(2002)
J. Cell Physiol.
, vol.192
, pp. 23-33
-
-
Donehower, L.A.1
-
120
-
-
0036829090
-
Cancer and aging: A model for the cancer promoting effects of the aging stroma
-
Krtolica, A. & Campisi, J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int. J. Biochem. Cell Biol. 34, 1401-1414 (2002).
-
(2002)
Int. J. Biochem. Cell Biol.
, vol.34
, pp. 1401-1414
-
-
Krtolica, A.1
Campisi, J.2
-
121
-
-
0029047362
-
A novel biomarker identifies senescent human cells in culture and in aging skin in vivo
-
Dimri, G. P. et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
-
122
-
-
0034051249
-
Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia
-
Choi, J. et al. Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. Urology 56, 160-166 (2000).
-
(2000)
Urology
, vol.56
, pp. 160-166
-
-
Choi, J.1
-
123
-
-
0035079864
-
Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
-
Paradis, V. et al. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum. Pathol. 32, 327-332 (2001).
-
(2001)
Hum. Pathol.
, vol.32
, pp. 327-332
-
-
Paradis, V.1
-
124
-
-
0035130153
-
Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: Evidence for senescent endothelial cells in vivo at sites of atherosclerosis
-
Vasile, E., Tomita, Y., Brown, L. F., Kocher, O. & Dvorak, H. F. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 15, 458-466 (2001). References 121-124 describe some of the evidence that senescent cells exist, accumulate with age and contribute to age-related pathology in vivo.
-
(2001)
FASEB J.
, vol.15
, pp. 458-466
-
-
Vasile, E.1
Tomita, Y.2
Brown, L.F.3
Kocher, O.4
Dvorak, H.F.5
-
125
-
-
0031728635
-
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes
-
Fusenig, N. E. & Boukamp, P. Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes. Mol. Carcinog. 23, 144-158 (1998).
-
(1998)
Mol. Carcinog.
, vol.23
, pp. 144-158
-
-
Fusenig, N.E.1
Boukamp, P.2
-
126
-
-
0033215242
-
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
-
Olumi, A. F. et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002-5011 (1999). Shows that fibroblasts, if appropriately stimulated, can facilitate the neoplastic progression of epithelial cells.
-
(1999)
Cancer Res.
, vol.59
, pp. 5002-5011
-
-
Olumi, A.F.1
-
127
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. & Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072-12077 (2001). Shows that senescent human fibroblasts can promote the neoplastic progression of preneoplastic epithelial cells.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.4
Campisi, J.5
-
128
-
-
0037011958
-
p53 mutant mice that display early aging-associated phenotypes
-
Tyner, S. D et al. p53 mutant mice that display early aging-associated phenotypes. Nature 415, 45-53 (2002). Shows that increased p53 activity suppresses the development of cancer in mice, but also promotes the premature development of ageing phenotypes.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
-
129
-
-
0037112844
-
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao, I. et al. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21, 6225-6235 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
-
130
-
-
0142175192
-
Tumor-free but not in the clear
-
SAGE-KE
-
Davenport, J. Tumor-free but not in the clear. Science. SAGE-KE, 2002.
-
(2002)
Science
-
-
Davenport, J.1
-
131
-
-
0034016185
-
Genome changes and gene expression in human solid tumors
-
Gray, J. W. & Collins, C. Genome changes and gene expression in human solid tumors Carcinog. 21, 443-452 (2000).
-
(2000)
Carcinog.
, vol.21
, pp. 443-452
-
-
Gray, J.W.1
Collins, C.2
-
132
-
-
0030459428
-
Frequent clones of p53-mutated keratinocytes in normal human skin
-
Jonason, A. S. et al. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc. Natl Acad. Sci. USA 93, 14025-14029 (1996). Shows that potentially oncogenic cells - in this case, harbouring TP53 mutations - are present in apparently normal young human tissue.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14025-14029
-
-
Jonason, A.S.1
-
133
-
-
0033991193
-
Extensive ductal carcinoma in situ with small foci of invasive ductal carcinoma: Evidence of genetic resemblance by CGH
-
Aubele, M. et al. Extensive ductal carcinoma in situ with small foci of invasive ductal carcinoma: evidence of genetic resemblance by CGH. Int. J. Cancer 85, 82-86 (2000).
-
(2000)
Int. J. Cancer
, vol.85
, pp. 82-86
-
-
Aubele, M.1
-
134
-
-
0030461224
-
Loss of heterozygosity in normal tissue adjacent to breast carcinomas
-
Deng, G., Lu, Y., Zlotnikov, G., Thor, A. D. & Smith, H. S. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274, 2057-2059 (1996). Shows that apparently normal human tissue harbours potentially oncogenic mutations.
-
(1996)
Science
, vol.274
, pp. 2057-2059
-
-
Deng, G.1
Lu, Y.2
Zlotnikov, G.3
Thor, A.D.4
Smith, H.S.5
-
135
-
-
0036132034
-
Comparative genomic hybridization detects genetic alterations during early stages of cervical cancer progression
-
Umayahara, K. et al. Comparative genomic hybridization detects genetic alterations during early stages of cervical cancer progression. Genes Chromosom. Cancer 33, 98-102 (2002).
-
(2002)
Genes Chromosom. Cancer
, vol.33
, pp. 98-102
-
-
Umayahara, K.1
-
136
-
-
0018244681
-
Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice
-
Ilmensee, K. Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice. Basic Life Sci. 12, 3-25 (1978). Shows that potentially malignant cells can fail to express their neoplastic properties when placed in a normal tissue microenvironment.
-
(1978)
Basic Life Sci.
, vol.12
, pp. 3-25
-
-
Ilmensee, K.1
-
137
-
-
0035902141
-
The microenvironment of the tumour-host interface
-
Liotta, L. A. & Kohn, E. C. The microenvironment of the tumour-host interface. Nature 411, 375-379 (2001).
-
(2001)
Nature
, vol.411
, pp. 375-379
-
-
Liotta, L.A.1
Kohn, E.C.2
-
138
-
-
0034254445
-
The influence of the microenvironment on the malignant phenotype
-
Park, C. C., Bissell, M. J. & Barcellos-Hoff, M. H. The influence of the microenvironment on the malignant phenotype. Molec. Med. Today 6, 324-329 (2000).
-
(2000)
Molec. Med. Today
, vol.6
, pp. 324-329
-
-
Park, C.C.1
Bissell, M.J.2
Barcellos-Hoff, M.H.3
-
139
-
-
0033552627
-
Mdm2: A bridge over the two tumour suppressors, p53 and Rb
-
Yap, D. B., Hsieh, J. K., Chan, F. S. & Lu, X. Mdm2: a bridge over the two tumour suppressors, p53 and Rb. Oncogene 18, 7681-7689 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7681-7689
-
-
Yap, D.B.1
Hsieh, J.K.2
Chan, F.S.3
Lu, X.4
-
140
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr, C. J. & Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
141
-
-
0032146274
-
The regulation of E2F by pRB-family proteins
-
Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 2245-2262
-
-
Dyson, N.1
|