-
1
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta, D. A., Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J. C. Barrett. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA 93:13742-13747.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
2
-
-
0031050261
-
Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex
-
Alkema, M. J., M. Bronk, E. Verhoeven, A. P. Otte, L. J. van't Veer, A. Berns, and M. van Lohuizen. 1997. Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex. Genes Dev. 11:226-240.
-
(1997)
Genes Dev.
, vol.11
, pp. 226-240
-
-
Alkema, M.J.1
Bronk, M.2
Verhoeven, E.3
Otte, A.P.4
Van't Veer, L.J.5
Berns, A.6
Van Lohuizen, M.7
-
3
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
Atadja, P., H. Wong, I. Garkavtsev, C. Veillette, and K. Riabowol. 1995. Increased activity of p53 in senescing fibroblasts. Proc. Natl. Acad. Sci. USA 92:8348-8352.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
Garkavtsev, I.3
Veillette, C.4
Riabowol, K.5
-
4
-
-
0021223916
-
Oxygen modulates growth of human cells at physiological partial pressures
-
Balin, A. K., A. J. Fisher, and D. M. Carter. 1984. Oxygen modulates growth of human cells at physiological partial pressures. J. Exp. Med. 160:152-166.
-
(1984)
J. Exp. Med.
, vol.160
, pp. 152-166
-
-
Balin, A.K.1
Fisher, A.J.2
Carter, D.M.3
-
5
-
-
0010045614
-
Extension of life span by introduction of telomerase into normal human cells
-
Bodnar, A. G., M. Ouellette, M. Frolkis, S. E. Holt, C. P. Chiu, G. B. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner, and W. E. Wright. 1998. Extension of life span by introduction of telomerase into normal human cells. Science 279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
6
-
-
0032912802
-
Control of replicative life span in human cells: Barriers to clonal expansion intermediate between M1 senescence and M2 crisis
-
Bond, J. A., M. F. Haughton, J. M. Rowson, P. J. Smith, V. Gire, D. Wynford-Thomas, and F. S. Wyllie. 1999. Control of replicative life span in human cells: Barriers to clonal expansion intermediate between M1 senescence and M2 crisis. Mol. Cell. Biol. 19:3103-3114.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3103-3114
-
-
Bond, J.A.1
Haughton, M.F.2
Rowson, J.M.3
Smith, P.J.4
Gire, V.5
Wynford-Thomas, D.6
Wyllie, F.S.7
-
7
-
-
0028261160
-
Escape from senescence in human diploid fibroblasts induced directly by mutant p53
-
Bond, J. A., F. S. Wyllie, and D. Wynford-Thomas. 1994. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9:1885-1889.
-
(1994)
Oncogene
, vol.9
, pp. 1885-1889
-
-
Bond, J.A.1
Wyllie, F.S.2
Wynford-Thomas, D.3
-
8
-
-
0030025660
-
Replicative senescence: An old lives' tale?
-
Campisi, J. 1996. Replicative senescence: An old lives' tale? Cell 84:497-500.
-
(1996)
Cell
, vol.84
, pp. 497-500
-
-
Campisi, J.1
-
9
-
-
0030964277
-
The biology of replicative senescence
-
Campisi, J. 1997. The biology of replicative senescence. Eur. J. Cancer 33:703-709.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 703-709
-
-
Campisi, J.1
-
10
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi, J. 2001. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11:27-31.
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 27-31
-
-
Campisi, J.1
-
11
-
-
0033913425
-
Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints
-
Chen, Q. M. 2000. Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Ann. N. Y. Acad. Sci. 908:111-125.
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.908
, pp. 111-125
-
-
Chen, Q.M.1
-
12
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin, L., S. E. Artandi, Q. Shen, A. Tam, S. L. Lee, G. J. Gottlieb, C. W. Greider, and R. A. DePinho. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97:527-538.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
Greider, C.W.7
DePinho, R.A.8
-
13
-
-
0029791451
-
Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity
-
Cohen, K. J., J. S. Hanna, J. E. Prescott, and C. V. Dang. 1996. Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol. Cell. Biol. 16:5527-5535.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5527-5535
-
-
Cohen, K.J.1
Hanna, J.S.2
Prescott, J.E.3
Dang, C.V.4
-
14
-
-
0035843952
-
Telomere capping - One strand fits all
-
de Lange, T. 2001. Telomere capping - One strand fits all. Science 292:1075-1076.
-
(2001)
Science
, vol.292
, pp. 1075-1076
-
-
De Lange, T.1
-
15
-
-
0028361374
-
Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
-
Dimri, G. P., E. Hara, and J. Campisi. 1994. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269:16180-16186.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16180-16186
-
-
Dimri, G.P.1
Hara, E.2
Campisi, J.3
-
16
-
-
0033989829
-
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
-
Dimri, G. P., K. Itahana, M. Acosta, and J. Campisi. 2000. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol. Cell. Biol. 20:273-285.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 273-285
-
-
Dimri, G.P.1
Itahana, K.2
Acosta, M.3
Campisi, J.4
-
18
-
-
0037102196
-
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells
-
Dimri, G. P., J. L. Martinez, J. J. Jacobs, P. Keblusek, K. Itahana, M. von Lohuizen, J. Campisi, D. E. Wazer, and V. Band. 2002. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 62:4736-4745.
-
(2002)
Cancer Res.
, vol.62
, pp. 4736-4745
-
-
Dimri, G.P.1
Martinez, J.L.2
Jacobs, J.J.3
Keblusek, P.4
Itahana, K.5
Von Lohuizen, M.6
Campisi, J.7
Wazer, D.E.8
Band, V.9
-
19
-
-
0029047362
-
A novel biomarker identifies senescent human cells in culture and in aging skin in vivo
-
Dimri, G. P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj, O. M. Pereira-Smith, M. Peacocke, and J. Campisi. 1995. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.M.10
Peacocke, M.11
Campisi, J.12
-
20
-
-
0033816629
-
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
-
Dulic, V., G. E. Beney, G. Frebourg, L. F. Drullinger, and G. H. Stein. 2000. Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol. Cell. Biol. 20:6741-6754.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6741-6754
-
-
Dulic, V.1
Beney, G.E.2
Frebourg, G.3
Drullinger, L.F.4
Stein, G.H.5
-
21
-
-
0026055983
-
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts
-
Hara, E., H. Tsurui, A. Shinozaki, S. Nakada, and K. Oda. 1991. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 179:528-534.
-
(1991)
TIG-1. Biochem. Biophys. Res. Commun.
, vol.179
, pp. 528-534
-
-
Hara, E.1
Tsurui, H.2
Shinozaki, A.3
Nakada, S.4
Oda, K.5
-
22
-
-
0029670840
-
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
-
Hara, E., R. Smith, D. Parry, H. Tahara, S. Stone, and G. Peters. 1996. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell. Biol. 16:859-867.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 859-867
-
-
Hara, E.1
Smith, R.2
Parry, D.3
Tahara, H.4
Stone, S.5
Peters, G.6
-
23
-
-
0027976669
-
Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
-
Hara, E., T. Yamaguchi, H. Nojima, T. Ide, J. Campisi, H. Okayama, and K. Oda. 1994. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269:2139-2145.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2139-2145
-
-
Hara, E.1
Yamaguchi, T.2
Nojima, H.3
Ide, T.4
Campisi, J.5
Okayama, H.6
Oda, K.7
-
24
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
25
-
-
0025727771
-
Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice
-
Haupt, Y., W. S. Alexander, G. Barri, S. P. Klinken, and J. M. Adams. 1991. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 65:753-763.
-
(1991)
Cell
, vol.65
, pp. 753-763
-
-
Haupt, Y.1
Alexander, W.S.2
Barri, G.3
Klinken, S.P.4
Adams, J.M.5
-
26
-
-
0034832956
-
Regulation of cellular senescence by p53
-
Itahana, K., G. Dimri, and J. Campisi. 2001. Regulation of cellular senescence by p53. Eur. J. Biochem. 268:2784-2791.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2784-2791
-
-
Itahana, K.1
Dimri, G.2
Campisi, J.3
-
27
-
-
0037124024
-
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells
-
Itahana, K., G. P. Dimri, E. Hara, Y. Itahana, Y. Zou, P. Y. Desprez, and J. Campisi. 2002. A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J. Biol. Chem. 277:18206-18214.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18206-18214
-
-
Itahana, K.1
Dimri, G.P.2
Hara, E.3
Itahana, Y.4
Zou, Y.5
Desprez, P.Y.6
Campisi, J.7
-
28
-
-
0033552813
-
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the INK4a locus
-
Jacobs, J. J., K. Kieboom, S. Marino, R. A. DePinho, and M. van Lohuizen. 1999. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the INK4a locus. Nature 397:164-168.
-
(1999)
Nature
, vol.397
, pp. 164-168
-
-
Jacobs, J.J.1
Kieboom, K.2
Marino, S.3
DePinho, R.A.4
Van Lohuizen, M.5
-
29
-
-
0035929591
-
TANK2, a new TRF1-associated poly (ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression
-
Kaminker, P. G., S. H. Kim, R. D. Taylor, Y. Zebarjadian, W. D. Funk, G. B. Morin, P. Yaswen, and J. Campisi. 2001. TANK2, a new TRF1-associated poly (ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J. Biol. Chem. 276:35891-35899.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35891-35899
-
-
Kaminker, P.G.1
Kim, S.H.2
Taylor, R.D.3
Zebarjadian, Y.4
Funk, W.D.5
Morin, G.B.6
Yaswen, P.7
Campisi, J.8
-
30
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
Karlseder, J., A. Smogorzewska, and T. de Lange. 2002. Senescence induced by altered telomere state, not telomere loss. Science 295:2446-2449.
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
De Lange, T.3
-
31
-
-
0032496373
-
Features of replicative senescence induced by addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts
-
Kato, D., K. Miyazawa, M. Ruas, M. Starborg, I. Wada, T. Oka, T. Sakai, G. Peters, and E. Hara. 1998. Features of replicative senescence induced by addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts. FEBS Lett. 427:203-208.
-
(1998)
FEBS Lett.
, vol.427
, pp. 203-208
-
-
Kato, D.1
Miyazawa, K.2
Ruas, M.3
Starborg, M.4
Wada, I.5
Oka, T.6
Sakai, T.7
Peters, G.8
Hara, E.9
-
32
-
-
0034626686
-
Adenovirus-mediated p16INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner
-
Kawabe, S., J. A. Roth, D. R. Wilson, and R. E. Meyn. 2000. Adenovirus-mediated p16INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner. Oncogene 19:5359-5366.
-
(2000)
Oncogene
, vol.19
, pp. 5359-5366
-
-
Kawabe, S.1
Roth, J.A.2
Wilson, D.R.3
Meyn, R.E.4
-
33
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich, and J. W. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
34
-
-
0037148342
-
Telomeres, aging and cancer: In search of a happy ending
-
Kim, S. H., P. Kaminker, and J. Campisi. 2002. Telomeres, aging and cancer: In search of a happy ending. Oncogene 21:503-511.
-
(2002)
Oncogene
, vol.21
, pp. 503-511
-
-
Kim, S.H.1
Kaminker, P.2
Campisi, J.3
-
35
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono, T., S. A. Foster, J. I. Koop, J. K. McDougall, D. A. Galloway, and A. J. Klingelhutz. 1998. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
36
-
-
0035817687
-
Loss of p16INK4a confers susceptibility to metastatic melanoma in mice
-
Krimpenfort, P., K. C. Quon, W. J. Mooi, A. Loonstra, and A. Berns. 2001. Loss of p16INK4a confers susceptibility to metastatic melanoma in mice. Nature 413:83-86.
-
(2001)
Nature
, vol.413
, pp. 83-86
-
-
Krimpenfort, P.1
Quon, K.C.2
Mooi, W.J.3
Loonstra, A.4
Berns, A.5
-
37
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
38
-
-
0026735646
-
Telomere end-replication problem and cell aging
-
Levy, M. Z., R. C. Allsopp, A. B. Futcher, C. W. Greider, and C. B. Harley. 1992. Telomere end-replication problem and cell aging. J. Mol. Biol. 225:951-960.
-
(1992)
J. Mol. Biol.
, vol.225
, pp. 951-960
-
-
Levy, M.Z.1
Allsopp, R.C.2
Futcher, A.B.3
Greider, C.W.4
Harley, C.B.5
-
39
-
-
0035884738
-
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection
-
Lorenz, M., G. Saretzki, N. Sitte, S. Metzkow, and T. von Zglinicki. 2001. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic. Biol. Med. 31:824-831.
-
(2001)
Free Radic. Biol. Med.
, vol.31
, pp. 824-831
-
-
Lorenz, M.1
Saretzki, G.2
Sitte, N.3
Metzkow, S.4
Von Zglinicki, T.5
-
40
-
-
0032924343
-
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
-
Morales, C. P., S. E. Holt, M. Ouellette, K. J. Kaur, Y. Yan, K. S. Wilson, M. A. White, W. E. Wright, and J. W. Shay. 1999. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet. 21:115-118.
-
(1999)
Nat. Genet.
, vol.21
, pp. 115-118
-
-
Morales, C.P.1
Holt, S.E.2
Ouellette, M.3
Kaur, K.J.4
Yan, Y.5
Wilson, K.S.6
White, M.A.7
Wright, W.E.8
Shay, J.W.9
-
41
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90-98.
-
(1994)
Exp. Cell Res.
, vol.211
, pp. 90-98
-
-
Noda, A.1
Ning, Y.2
Venable, S.F.3
Pereira-Smith, O.M.4
Smith, J.R.5
-
42
-
-
0035931859
-
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
-
Ohtani, N., Z. Zebedee, T. J. Huot, J. A. Stinson, M. Sugimoto, Y. Ohashi, A. D. Sharrocks, G. Peters, and E. Hara. 2001. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409:1067-1070.
-
(2001)
Nature
, vol.409
, pp. 1067-1070
-
-
Ohtani, N.1
Zebedee, Z.2
Huot, T.J.3
Stinson, J.A.4
Sugimoto, M.5
Ohashi, Y.6
Sharrocks, A.D.7
Peters, G.8
Hara, E.9
-
43
-
-
0017405185
-
2 concentration extends the life span of cultured human diploid cells
-
2 concentration extends the life span of cultured human diploid cells. Nature 267:423-425.
-
(1977)
Nature
, vol.267
, pp. 423-425
-
-
Packer, L.1
Fuehr, K.2
-
44
-
-
0032076718
-
Polycombing the genome: PcG, trxG, and chromatin silencing
-
Pirrotta, V. 1998. Polycombing the genome: PcG, trxG, and chromatin silencing. Cell 93:333-336.
-
(1998)
Cell
, vol.93
, pp. 333-336
-
-
Pirrotta, V.1
-
45
-
-
0035114576
-
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
-
Ramirez, R. D., C. P. Morales, B. S. Herbert, J. M. Rohde, C. Passons, J. W. Shay, and W. E. Wright. 2001. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15:398-403.
-
(2001)
Genes Dev.
, vol.15
, pp. 398-403
-
-
Ramirez, R.D.1
Morales, C.P.2
Herbert, B.S.3
Rohde, J.M.4
Passons, C.5
Shay, J.W.6
Wright, W.E.7
-
46
-
-
0036288508
-
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
-
Rheinwald, J. G., W. C. Hahn, M. R. Ramsey, J. Y. Yu, Z. Guo, H. Tsao, M. De Luca, C. Catricala, and K. M. O'Toole. 2002. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell Biol. 22:5157-5172.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 5157-5172
-
-
Rheinwald, J.G.1
Hahn, W.C.2
Ramsey, M.R.3
Yu, J.Y.4
Guo, Z.5
Tsao, H.6
De Luca, M.7
Catricala, C.8
O'Toole, K.M.9
-
47
-
-
0032485213
-
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
-
Robles, S. J., and G. R. Adami. 1998. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16:1113-1123.
-
(1998)
Oncogene
, vol.16
, pp. 1113-1123
-
-
Robles, S.J.1
Adami, G.R.2
-
48
-
-
0028915601
-
2 tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives
-
2 tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives. Exp. Cell Res. 217:272-279.
-
(1995)
Exp. Cell Res.
, vol.217
, pp. 272-279
-
-
Saito, H.1
Hammond, A.T.2
Moses, R.E.3
-
49
-
-
0033575958
-
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
-
Saretzki, G., N. Sitte, U. Merkel, R. E. Wurm, and T. von Zglinicki. 1999. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene 18:5148-5158.
-
(1999)
Oncogene
, vol.18
, pp. 5148-5158
-
-
Saretzki, G.1
Sitte, N.2
Merkel, U.3
Wurm, R.E.4
Von Zglinicki, T.5
-
50
-
-
0032927872
-
RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity
-
Satijn, D. P., and A. P. Otte. 1999. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. Mol. Cell. Biol. 19:57-68.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 57-68
-
-
Satijn, D.P.1
Otte, A.P.2
-
51
-
-
0027361196
-
The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins
-
Schluter, C., M. Duchrow, C. Wohlenberg, M. H. Becker, G. Key, H. D. Flad, and J. Gerdes. 1993. The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123:513-522.
-
(1993)
J. Cell Biol.
, vol.123
, pp. 513-522
-
-
Schluter, C.1
Duchrow, M.2
Wohlenberg, C.3
Becker, M.H.4
Key, G.5
Flad, H.D.6
Gerdes, J.7
-
52
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt, C. A., J. S. Fridman, M. Yang, S. Lee, E. Baranov, R. M. Hoffman, and S. W. Lowe. 2002. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109:335-346.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
Lee, S.4
Baranov, E.5
Hoffman, R.M.6
Lowe, S.W.7
-
53
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., A. W. Lin, M. E. McCurrach, D. Beach, and S. W. Lowe. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
54
-
-
0027319950
-
Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene
-
Seshadri, T., J. A. Uzman, J. Oshima, and J. Campisi. 1993. Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. J. Biol. Chem. 268:18474-18480.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18474-18480
-
-
Seshadri, T.1
Uzman, J.A.2
Oshima, J.3
Campisi, J.4
-
56
-
-
0035817688
-
Loss of p16INK4a with retention of p19Arf predisposes mice to tumorigenesis
-
Sharpless, N. E., N. Bardeesy, K. H. Lee, D. Carrasco, D. H. Castrillon, A. J. Aguirre, E. A. Wu, J. W. Horner, and R. A. DePinho. 2001. Loss of p16INK4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413:86-91.
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
Carrasco, D.4
Castrillon, D.H.5
Aguirre, A.J.6
Wu, E.A.7
Horner, J.W.8
DePinho, R.A.9
-
57
-
-
0026054961
-
A role for both RB and p53 in the regulation of human cellular senescence
-
Shay, J. W., O. M. Pereira-Smith, and W. E. Wright. 1991. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196:33-39.
-
(1991)
Exp. Cell Res.
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
58
-
-
0033539169
-
Microarray analysis of replicative senescence
-
Shelton, D. N., E. Chang, P. S. Whittier, D. Choi, and W. D. Funk. 1999. Microarray analysis of replicative senescence. Curr. Biol. 9:939-945.
-
(1999)
Curr. Biol.
, vol.9
, pp. 939-945
-
-
Shelton, D.N.1
Chang, E.2
Whittier, P.S.3
Choi, D.4
Funk, W.D.5
-
59
-
-
0034682721
-
Cellular senescence: Mitotic clock or culture shock?
-
Sherr, C. J., and R. A. DePinho. 2000. Cellular senescence: Mitotic clock or culture shock? Cell 102:407-410.
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
60
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein, G. H., L. F. Drullinger, A. Soulard, and V. Dulic. 1999. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 19:2109-2117.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
61
-
-
0028201742
-
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
-
van der Lugt, N. M., J. Domen, K. Linders, M. van Roon, E. Robanus-Maandag, H. te Riele, M. van der Valk, J. Deschamps, M. Sofroniew, M. van Lohuizen, and A. Berns. 1994. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8:757-769.
-
(1994)
Genes Dev.
, vol.8
, pp. 757-769
-
-
Van der Lugt, N.M.1
Domen, J.2
Linders, K.3
Van Roon, M.4
Robanus-Maandag, E.5
Te Riele, H.6
Van der Valk, M.7
Deschamps, J.8
Sofroniew, M.9
Van Lohuizen, M.10
Berns, A.11
-
62
-
-
0025863346
-
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
-
van Lohuizen, M., S. Verbeek, B. Scheijen, E. Wientjens, H. van der Gulden, and A. Berns. 1991. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65:737-752.
-
(1991)
Cell
, vol.65
, pp. 737-752
-
-
Van Lohuizen, M.1
Verbeek, S.2
Scheijen, B.3
Wientjens, E.4
Van der Gulden, H.5
Berns, A.6
-
63
-
-
0033013985
-
1 checkpoint in telomerase-induced extended-life-span human fibroblasts
-
1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol. Cell. Biol. 19:2373-2379.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2373-2379
-
-
Vaziri, H.1
Squire, J.A.2
Pandita, T.K.3
Bradley, G.4
Kuba, R.M.5
Zhang, H.6
Gulyas, S.7
Hill, R.P.8
Nolan, G.P.9
Benchimol, S.10
-
64
-
-
0030761351
-
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
-
Vaziri, H., M. D. West, R. C. Allsopp, T. S. Davison, Y. S. Wu, C. H. Arrowsmith, G. G. Poirier, and S. Benchimol. 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16:6018-6033.
-
(1997)
EMBO J.
, vol.16
, pp. 6018-6033
-
-
Vaziri, H.1
West, M.D.2
Allsopp, R.C.3
Davison, T.S.4
Wu, Y.S.5
Arrowsmith, C.H.6
Poirier, G.G.7
Benchimol, S.8
-
65
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
von Zglinicki, T., G. Saretzki, W. Docke, and C. Lotze. 1995. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence? Exp. Cell Res. 220:186-193.
-
(1995)
Exp. Cell Res.
, vol.220
, pp. 186-193
-
-
Von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
Lotze, C.4
-
66
-
-
0024366596
-
Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
-
Wright, W. E., O. M. Pereira-Smith, and J. W. Shay. 1989. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts. Mol. Cell. Biol. 9:3088-3092.
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 3088-3092
-
-
Wright, W.E.1
Pereira-Smith, O.M.2
Shay, J.W.3
-
67
-
-
0033834247
-
Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology
-
Wright, W. E., and J. W. Shay. 2000. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat. Med. 6:849-851.
-
(2000)
Nat. Med.
, vol.6
, pp. 849-851
-
-
Wright, W.E.1
Shay, J.W.2
-
68
-
-
0032192153
-
Senescence of human fibroblast induced by oncogenic Raf
-
Zhu, J., D. Woods, M. McMahon, and J. M. Bishop. 1998. Senescence of human fibroblast induced by oncogenic Raf. Genes Dev. 12:2997-3007.
-
(1998)
Genes Dev.
, vol.12
, pp. 2997-3007
-
-
Zhu, J.1
Woods, D.2
McMahon, M.3
Bishop, J.M.4
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