Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening

Kidney International

Volumn 63, Issue 6, 2003, Pages 2134-2143

  Melk, Anette ^a   Kittikowit, Wipawee ^b   Sandhu, Irwindeep ^b   Halloran, Kieran M ^b   Grimm, Paul ^b   Schmidt, Bernhard M W ^b   Halloran, Philip F ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NONE

Author keywords

Aging; Fischer 344; Lipofuscin; p16INK4a; Senescence; Senescence associated galactosidase; Telomere

Indexed keywords

BETA GALACTOSIDASE; DNA; LIPOFUSCIN; MESSENGER RNA; PROTEIN P16;

ADOLESCENT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL GROWTH; CELL NUCLEUS; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; EPITHELIUM CELL; GENE IDENTIFICATION; KIDNEY CELL; KIDNEY CORTEX; KIDNEY DEVELOPMENT; KIDNEY FUNCTION; LIFE EXPECTANCY; NEPHRON; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; RAT; SENESCENCE; SOMATIC CELL; STRUCTURE ANALYSIS; TELOMERE; TELOMERE SHORTENING;

EID: 0037850928     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00032.x     Document Type: Article

References (53)

1. LEVI M, ROWE JW: Aging and the kidney, chap. 88, in Diseases of the Kidney, 5 ed., edited by SCHRIER RW, GOTTSCHALK CW, Boston, MA, Little, Brown, and Company, 1993, pp 2405-2432
2. PANNU N, HALLORAN PF: The kidney in aging, chap. 57, in Primer on Kidney Diseases, 3 ed., edited by GREENBERG A, San Diego, CA, Academic Press, 2001, pp 377-381
3. EPSTEIN M: Aging and the kidney. J Am Soc Nephrol 7:1106-1122, 1996
4. LINDEMAN RD, GOLDMAN R: Anatomic and physiologic age changes in the kidney. Exp Geront 21:379-406, 1986
5. GOURTSOYIANNIS N, PRASSOPOULOS P, CAVOURAS D, PANTELIDIS N: The thickness of the renal parenchyma decreases with age. A CT study of 360 patients. Am J Roentgenol 155:541-544, 1990
6. FILSER D, ZEIER M, NOWACK R, RITZ E: Renal functional reserve in healthy elderly subjects. J Am Soc Nephrol 3:1371-1377, 1993
7. NYENGAARD JR, BENDTSEN TF: Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232:194-201, 1992
8. JOHNSON FB, SINCLAIR DA, GUARENTE L: Molecular biology of aging. Cell 96:291-302, 1999
9. FINCH CE, TANZI RE: Genetics of aging. Science 278:407-411, 1997
10. HAYFLICK L, MOORHEAD PS: The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621, 1961
11. WRIGHT WE, SHAY JW: Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat Med 6:849-851, 2000
12. BLASCO MA, LEE H-W, HANDE MP, et al: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34, 1997
13. LEE H-W, BLASCO MA, GOTTLIEB GJ, et al: Essential role of mouse telomerase in highly proliferative organs. Nature 392:569-574, 1998
14. TANG DG, TOKUMOTO YM, APPERLY JA, et al: Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 291:868-871, 2001
15. MATHON NF, MALCOLM DS, HARRISINGH MC, et al: Lack of replicative senescence in normal rodent glia. Science 291:872-875, 2001
16. SERRANO M, LEE H-W, CHIN L, et al: Role of the INK4a locus in tumor suppressor and cell mortality. Cell 85:27-37, 1996
17. INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15:203-211, 1997
18. Arf predisposes mice to tumorigenesis. Nature 413:86-91, 2001
19. Ink4a confers susceptibility to metastatic melanoma in mice. Nature 413:83-86, 2001
20. BAYLIS C, CORMAN B: The aging kidney: Insights from experimental studies. J Am Soc Nephrol 9:699-709, 1998
21. CORMAN B, PRATZ J, POUJEOL P: Changes in anatomy, glomerular filtration, and solute excretion in aging rat kidney. Am J Physiol 248:R282-R287, 1985
22. DODANE V, CHEVALIER J, BARIETY J, et al: Longitudinal study of solute excretion and glomerular ultrastructure in an experimental model of aging rats free of kidney disease. Lab Invest 64:377-391, 1991
23. BICH-THUY L, FAUCI AS: Recombinant interleukin-2 and gamma-interferon (IFN-γ) act synergistically on distinct steps of in vitro terminal human B cell maturation. J Clin Invest 77:1173-1179, 1986
24. MATHER MW: Base composition-independent hybridization in dried agarose gels: Screening and recovery for cloning of genomic DNA fragments. Biotechniqaes 6:444-447, 1988
25. HARLEY CB, FUTCHER AB, GREIḊER CW: Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460, 1990
26. CHIRGWIN JM, PRYZYBYLA AE, MACDONALD RJ, RUTTER WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
27. HEID CA, STEVENS J, LIVAK KJ, WILLIAMS PM: Real time quantitative PCR. Genome Res 6:986-994, 1996
28. DIMRI GP, LEE X, BASILE G, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367, 1995
29. CHKHOTUA A, SHAPIRA Z, TOVAR A, et al: Cellular senescence: A new marker of kidney function recovery after ischemic injury in rats. Transplant Proc 33:2910-2915, 2001
30. COLEMAN GL, BARTHOLD W, OSBALDISTON GW, et al: Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol 32:258-278, 1977
31. MAEDA H, GLEISER CA, MASORO EJ, et al: Nutritional influences on aging of Fischer 344 rats. II. Pathol J Gerontol 40:671-688, 1985
32. YU BP, MASORO EJ, MCMAHAN CA: Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J Gerontol 40:657-670, 1985
33. MASORO EJ: Mortality and growth characteristics of rat strains commonly used in aging research. Exp Aging Res 6:219-233, 1980
34. RACUSEN LC, SOLEZ K, COLVIN RB, et al: The Banff 97 working classification of renal allograft pathology. Kidney Int 55:713-723, 1999
35. STARLING JA, MAULE J, HASTIE ND, ALLSHIRE RC: Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res 18:6881-6888, 1990
36. MELK A, RAMASSAR V, HELMS LM, et al: Telomere shortening in kidneys with age. J Am Soc Nephrol 11:444-453, 2000
37. BODNAR AG, OULLLETTE M, FROLKIS M, et al: Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352, 1998
38. SIGAL SH, RAJVANSHI P, GORLA GR, et al: Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events. Am J Physiol 276:G1260-G1272, 1999
39. DING G, FRANKI N, KAPASI AA, et al: Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats. Exp Mol Pathol 70:43-53, 2001
40. TERMAN A, BRUNK UT: Lipofuscin: Mechanisms of formation and increase with age. APMIS 106:265-276, 1998
41. INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. Oncogene 15:495-503, 1997
42. SHERR CJ, DEPINHO RA: Cellular senescence: mitotic clock or culture shock? Cell 102:407-410, 2000
43. ARF. Cell 91:649-659, 1997
44. HARVEY M, SANDS AT, WEISS RS, et al: In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8:2457-2467, 1993
45. HARVEY DM, LEVINE AJ: p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev 5:2375-2385, 1991
46. KRISHNA DR, SPERKER B, FRITZ P, KLOTZ U: Does pH 6 beta-galactosidase activity indicate cell senescence? Mech Ageing Dev 109:113-123, 1999
47. KURZ DJ, DECARY S, HONG Y, ERUSALIMSKY JD: Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113 (Pt 20):3613-3622, 2000
48. ROBBINS E, LEVlNE EM, EAGLE H: Morpholigic changes accompanying senescence of cultured human diploid cells. J Exp Med 131:1211-1222, 1970
49. YU BP, MASORO EJ, MURATA I, et al: Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J Gerontol 37:130-141, 1982
50. VAN LIEW JB, DAVIS FB, DAVIS PJ, et al: Calorie restriction decreases microalbuminuria associated with aging in barrier-raised Fischer 344 rats. Am J Physiol 263:F554-F561, 1992
51. BENGELE HH, MATHIAS RS, PERKINS JH, ALEXANDER EA: Urinary concentrating defect in the aged rat. Am J Physiol 240:F147-F150, 1981
52. KREGEL KC, JOHNSON DG, TIPTON CM, SEALS DR: Cardiovascular-sympathetic adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats. J Appl Physiol 69:2043-2049, 1990
53. HERLIHY JT, KIM S-W: Modulation of the aging cardiovascular system by dietary restriction, chap. 3, in Modulation of Aging Processes by Dietary Restriction, edited by YU BP, Boca Raton, CRC Press, 2002, pp 57-87