-
1
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N.W., et al. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
-
2
-
-
0030697342
-
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
-
Bryan, T.M., Englezou, A., Dalla-Pozza, L., Dunham, M.A., and Reddel, R.R. 1997. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 3:1271-1274.
-
(1997)
Nat. Med.
, vol.3
, pp. 1271-1274
-
-
Bryan, T.M.1
Englezou, A.2
Dalla-Pozza, L.3
Dunham, M.A.4
Reddel, R.R.5
-
3
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar, A.G., et al. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
-
4
-
-
0032567967
-
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
-
Vaziri, H., and Benchimol, S. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:279-282.
-
(1998)
Curr. Biol.
, vol.8
, pp. 279-282
-
-
Vaziri, H.1
Benchimol, S.2
-
5
-
-
0033614998
-
Creation of human tumor cells with defined genetic elements
-
Hahn, W.C., et al. 1999. Creation of human tumor cells with defined genetic elements. Nature. 400:464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
-
6
-
-
0032080191
-
Telomerase activity in candidate stem cells from fetal liver and adult bone marrow
-
Yui, J., Chiu, C.P., and Lansdorp, P.M. 1998. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood. 91:3255-3262.
-
(1998)
Blood
, vol.91
, pp. 3255-3262
-
-
Yui, J.1
Chiu, C.P.2
Lansdorp, P.M.3
-
7
-
-
0037071386
-
Replicative senescence of hematopoietic stem cells during serial transplantation: Does telomere shortening play a role?
-
Allsopp, R.C., and Weissman, I.L. 2002. Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? Oncogene. 21:3270-3273.
-
(2002)
Oncogene
, vol.21
, pp. 3270-3273
-
-
Allsopp, R.C.1
Weissman, I.L.2
-
8
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph, K.L., et al. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
-
9
-
-
0033593814
-
Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
-
Hande, M.P., Samper, E., Lansdorp, P., and Blasco, M.A. 1999. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:589-601.
-
(1999)
J. Cell Biol.
, vol.144
, pp. 589-601
-
-
Hande, M.P.1
Samper, E.2
Lansdorp, P.3
Blasco, M.A.4
-
10
-
-
0031810555
-
Severe growth defect in mouse cells lacking the telomerase RNA component
-
Niida, H., et al. 1998. Severe growth defect in mouse cells lacking the telomerase RNA component. Nat. Genet. 19:203-206.
-
(1998)
Nat. Genet.
, vol.19
, pp. 203-206
-
-
Niida, H.1
-
11
-
-
1542781659
-
When cells get stressed: An integrative view of cellular senescence
-
doi:10.1172/JC1200420663
-
Ben-Porath, I., and Weinberg, R.A. 2004. When cells get stressed: an integrative view of cellular senescence. J. Clin. Invest. 113:8-13. doi:10.1172/JC1200420663.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 8-13
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
12
-
-
85047689866
-
Telomeres, stem cells, senescence, and cancer
-
In press
-
Sharpless, N.E., and DePinho, R.A. 2004. Telomeres, stem cells, senescence, and cancer. J. Clin. Invest. In press.
-
(2004)
J. Clin. Invest.
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
13
-
-
1342289563
-
Bmi-I, stem cells, and senescence regulation
-
In press
-
Park, I.-K., Morrison, S.J., and Clarke, M.F. 2004. Bmi-I, stem cells, and senescence regulation. J. Clin. Invest. In press.
-
(2004)
J. Clin. Invest.
-
-
Park, I.-K.1
Morrison, S.J.2
Clarke, M.F.3
-
14
-
-
85047694328
-
Cellular senescence in cancer treatment: Friend or foe?
-
In press
-
Kahlem, P., Dötken, B., and Schmitt, C.A. 2004. Cellular senescence in cancer treatment: friend or foe? J. Clin. Invest. In press.
-
(2004)
J. Clin. Invest.
-
-
Kahlem, P.1
Dötken, B.2
Schmitt, C.A.3
-
15
-
-
0035793381
-
Lack of replicative senescence in normal rodent glia
-
Mathon, N.F., Malcolm, D.S., Harrisingh, M.C., Cheng, L., and Lloyd, A.C. 2001. Lack of replicative senescence in normal rodent glia. Science. 291:872-875.
-
(2001)
Science
, vol.291
, pp. 872-875
-
-
Mathon, N.F.1
Malcolm, D.S.2
Harrisingh, M.C.3
Cheng, L.4
Lloyd, A.C.5
-
16
-
-
0035793380
-
Lack of replicative senescence in cultured rat oligodendrocyte precursor cells
-
Tang, D.G., Tokumoto, Y.M., Apperly, J.A., Lloyd, A.C. and Raff, M.C. 2001. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science. 291:868-871.
-
(2001)
Science
, vol.291
, pp. 868-871
-
-
Tang, D.G.1
Tokumoto, Y.M.2
Apperly, J.A.3
Lloyd, A.C.4
Raff, M.C.5
-
17
-
-
0035114576
-
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
-
Ramirez, R.D., et al. 2001. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15:398-403.
-
(2001)
Genes Dev.
, vol.15
, pp. 398-403
-
-
Ramirez, R.D.1
-
18
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello, S., et al. 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 5:741-747.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
-
19
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin, L., et al. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:527-538.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
-
20
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
Arrandi, S.E., et al. 2002. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:641-645.
-
(2002)
Nature
, vol.406
, pp. 641-645
-
-
Arrandi, S.E.1
-
21
-
-
0032980789
-
Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways
-
Buerger, H., et al. 1999. Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. J. Pathol. 187:396-402.
-
(1999)
J. Pathol.
, vol.187
, pp. 396-402
-
-
Buerger, H.1
-
22
-
-
0035355340
-
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
-
Gonzalez-Suarez, E., et al. 2001. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20:2619-2630.
-
(2001)
EMBO J.
, vol.20
, pp. 2619-2630
-
-
Gonzalez-Suarez, E.1
-
23
-
-
0343228751
-
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
-
Gonzalez-Suarez, E., Samper, E., Flores, J.M., and Blasco, M.A. 2000. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 26:114-117.
-
(2000)
Nat. Genet.
, vol.26
, pp. 114-117
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Flores, J.M.3
Blasco, M.A.4
-
24
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi, K., et al. 2003. Telomerase maintains telomere structure in normal human cells. Cell. 114:241-253.
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
-
25
-
-
0141483064
-
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
-
Passegue, E., Jamieson, C.H., Ailles, L.E., and Weissman, I.L. 2003. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc. Natl. Acad. Sci. U. S. A. 100(Suppl 1):11842-11849.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, Issue.SUPPL. 1
, pp. 11842-11849
-
-
Passegue, E.1
Jamieson, C.H.2
Ailles, L.E.3
Weissman, I.L.4
-
26
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J., and Clarke, M.F. 2003. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 100:3983-3988.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
27
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park, I.K., et al. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 423:302-305.
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
-
28
-
-
0242667922
-
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
-
Molofsky, A.V., et al. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 425:962-967.
-
(2003)
Nature
, vol.425
, pp. 962-967
-
-
Molofsky, A.V.1
-
29
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt, C.A., et al. 2002. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 109:335-346.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
-
30
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele, R.H., Okorokov, A.L., Jardine, L., Cummings, J., and Joel, S.P. 2002. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62:1876-1883.
-
(2002)
Cancer Res.
, vol.62
, pp. 1876-1883
-
-
Te Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
31
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner, S.D., et al. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature. 415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
-
32
-
-
0037112844
-
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao, I., et al. 2002. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21:6225-6235.
-
(2002)
EMBO J.
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
-
34
-
-
0037421896
-
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
-
Wong, K.K., et al. 2003. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421:643-648
-
(2003)
Nature
, vol.421
, pp. 643-648
-
-
Wong, K.K.1
-
35
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Migliaccio, E., et al. 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 402:309-313.
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
-
36
-
-
85047695800
-
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
-
Trinei, M., et al. 2002. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 21:3872-3878.
-
(2002)
Oncogene
, vol.21
, pp. 3872-3878
-
-
Trinei, M.1
|