Tumor suppressors and oncogenes in cellular senescence

Experimental Gerontology

Volumn 35, Issue 3, 2000, Pages 317-329

  Bringold, Frank ^a   Serrano, Manuel ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Cell cycle; Myc; Ras; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P16; PROTEIN P21; PROTEIN P27; PROTEIN P53;

APOPTOSIS; CELL AGING; CELL CYCLE; CELL IMMORTALIZATION; HUMAN; MITOSIS INHIBITION; NONHUMAN; ONCOGENE; ONCOGENE MYC; ONCOGENE RAS; PRIORITY JOURNAL; REVIEW; SENESCENCE; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL AGING; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; GENES, MYC; GENES, P53; GENES, RAS; GENES, RETINOBLASTOMA; GENES, TUMOR SUPPRESSOR; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; ONCOGENES; PHOSPHORIC MONOESTER HYDROLASES; PROTEINS; PTEN PHOSPHOHYDROLASE; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0034028836     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00083-8     Document Type: Review

References (69)

1. 1/S cell cycle mediators in cellular senescence. Exp Cell Res. 209:1993;231-237.
2. INK4a in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA. 93:1996;13742-13747.
3. Atadja P., Wong H., Garkavtsev I., Veillette C., Riabowol K. Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA. 92:1995;8348-8352.
4. ARF links the tumor suppressors Rb and p53. Nature. 395:1998;124-125.
5. Bond J., Haughton M., Blaydes J., Gire V., Wynford-Thomas D., Wyllie F. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. Oncogene. 13:1996;2097-2104.
6. Bos J.L. Ras oncogenes in human cancer A review. Cancer Res. 49:1989;4682-4689.
7. Bouchard C., Thieke K., Maier A., Saffrich R., Hanley-Hyde J., Ansorge W., Reed S., Sicinski P., Bartek J., Eilers M. Direct induction of cyclin D2 by myc contributes to cell cycle progression and sequestration of p27. EMBO J. 18:1999;5321-5333.
8. Brenner A.J., Stampfer M.R., Aldaz C.M. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene. 17:1998;199-205.
9. CIP1/WAF1 gene in normal diploid human fibroblasts. Science. 277:1997;831-834.
10. Cantley L.C., Neel B.G. New insights into tumor suppression PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA. 96:1999;4240-4245.
11. Chin L., Pomerantz J., Polsky D., Jacobson M., Cohen C., Cordon-Cardo C., Horner J.W. II, DePinho R.A. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 12:1998;2822-2834.
12. Cole M.D., McMahon S.B. The Myc oncoprotein A critical evaluation of transactivation and target gene regulation. Oncogene. 18:1999;2916-2924.
13. Dang C.V., Resar L.M., Emison E., Kim S., Li Q., Prescott J.E., Wonsey D., Zeller K. Function of the c-Myc oncogenic transcription factor. Exp Cell Res. 253:1999;63-77.
14. Donnellan R., Chetty R. Cyclin D1 and human neoplasia. Mol Pathol. 51:1998;1-7.
15. Eischen C.M., Weber J.D., Roussel M.F., Sherr C.J., Cleveland J.L. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13:1999;2658-2669.
16. Giaccia A.J., Kastan M.B. The complexity of p53 modulation Emerging patterns from divergent signals. Genes Dev. 12:1998;2973-2983.
17. Greene M.H. The genetics of hereditary melanoma and nevi 1998 update. Cancer. 86(S11:1999;2464-2477.
18. Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., Weinberg R.A. Creation of human tumor cells with defined genetic elements. Nature. 400:1999;464-468.
19. CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol. 16:1996;859-867.
20. 1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 12:1998;3675-3685.
21. INK4a and the control of cellular proliferative life span. Carcinogenesis. 20:1999;921-926.
22. Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A., van Lohuizen M. (1999). The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168.
23. Jacobs J.J., Scheijen B., Voncken J.W., Kieboom K., Berns A., van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-myc-induced apoptosis via INK4a/ARF. Genes Dev. 13:1999;2678-2690.
24. Jansen-Dürr P. How viral oncogenes make the cell cycle. Trends Genet. 12:1996;270-275.
25. Jiménez C., Jones D.R., Rodríguez-Viciana P., González-García A., Leonardo E., Wennstrom S., von Kobbe C., Toran J.L., R-Borlado L., Calvo V., Copin S.G., Albar J.P., Gaspar M.L., Díez E., Marcos M.A., Downward J., Martínez-A C., Mérida I., Carrera A.C. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J. 17:1998;743-753.
26. Kaelin W.G. Jr. Functions of the retinoblastoma protein. BioEssays. 21:1999;950-958.
27. ARF. Cell. 91:1997;649-659.
28. Lee A.C., Fenster B.E., Ito H., Takeda K., Bae N.S., Hirai T., Yu Z.X., Ferrans V.J., Howard B.H., Finkel T. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem. 274:1999;7936-7940.
29. 1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci USA. 95:1998;15406-15411.
30. Lin A.W., Barradas M., Stone J.C., van Aelst L., Serrano M., Lowe S.W. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12:1998;3008-3019.
31. Lloyd A.C. Ras versus cyclin-dependent kinase inhibitors. Curr Opin Genet Dev. 8:1998;43-48.
32. kip1 A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol. 154:1999;313-323.
33. INK4A with human head and neck keratinocyte replicative senescence Relationship of dysfunction to immortality and neoplasia. Oncogene. 13:1996;561-568.
34. Malumbres M., Pellicer A. Ras pathways to cell cycle control and cell transformation. Front Biosci. 6:1998;887-912.
35. Mateyak M.K., Obaya A.J., Sedivy J.M. c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol. 19:1999;4672-4683.
36. shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 402:1999;309-313.
37. Momand J., Jung D., Wilczynski S., Niland J. The MDM2 gene amplification database. Nucleic Acids Res. 26:1998;3453-3459.
38. Montagnoli A., Fiore F., Eytan E., Carrano A.C., Draetta G.F., Hershko A., Pagano M. Ubiquitination of p27 is regulated by CDK-dependent phosphorylation and trimeric complex formation. Genes Dev. 13:1999;1181-1189.
39. INK4A upon immortalization. Cancer Res. 59:1999;2516-2521.
40. Nesbit C.E., Tersak J.M., Prochownik E.V. MYC oncogenes and human neoplastic disease. Oncogene. 18:1999;3004-3016.
41. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res. 211:1994;90-98.
42. INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. Oncogene. 15:1997;495-503.
43. ARF links the tumour suppressor p53 to Ras. Nature. 395:1998;125-126.
44. Pantoja C., Serrano M. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene. 18:1999;4974-4982.
45. Kip1 and p21. EMBO J. 18:1999;5310-5320.
46. Prendergast G.C. Mechanisms of apoptosis by c-Myc. Oncogene. 18:1999;2967-2987.
47. Rittling S.R., Brooks K.M., Cristofalo V.J., Baserga R. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts. Proc Natl Acad Sci USA. 83:1986;3316-3320.
48. INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta. 14:1998;115-177.
49. Schmitt C.A., McCurrach M.E., de Stanchina E., Wallace-Brodeur R.R., Lowe S.W. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev. 13:1999;2670-2677.
50. Serrano M., Lee H.-W., Chin L., Cordon-Cardo C., Beach D., DePinho R.A. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 85:1996;27-37.
51. INK4a. Exp Cell Res. 237:1997;7-13.
52. INK4a. Cell. 88:1997;593-602.
53. Cip1. Mol Cell Biol. 17:1997;5588-5597.
54. Shayesteh L., Lu Y., Kuo W.L., Baldocchi R., Godfrey T., Collins C., Pinkel D., Powell B., Mills G.B., Gray J.W. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 21:1999;99-102.
55. Sherr C.J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12:1998;2984-2991.
56. 1-phase progression. Genes Dev. 13:1999;1501-1512.
57. Sun H., Lesche R., Li D.M., Liliental J., Zhang H., Gao J., Gavrilova N., Mueller B., Liu X., Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA. 96:1999;6199-6204.
58. sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene. 10:1995;835-840.
59. Kip1 is instigated by Jab1. Nature. 398:1999;160-165.
60. Tresini M., Mawal-Dewan M., Cristofalo V.J., Sell C. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. Cancer Res. 58:1998;1-4.
61. Tsihlias J., Kapusta L., Slingerland J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu Rev Med. 50:1999;401-423.
62. Wang J., Xie L.Y., Allan S., Beach D., Hannon G.J. Myc activates telomerase. Genes Dev. 12:1998;1769-1774.
63. Watanabe Y., Lee S.W., Detmar M., Ajioka I., Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene. 14:1997;2025-2032.
64. Cip1. Mol Cell Biol. 17:1997;5598-5611.
65. Wu K.J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., Dalla-Favera R. Direct activation of TERT transcription by c-MYC. Nat Genet. 21:1999;220-224.
66. Yeager T.R., Reddel R. Constructing immortalized human cell lines. Curr Opin Biotech. 10:1999;465-469.
67. Zhu J., Woods D., McMahon M., Bishop J.M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12:1998;2997-3007.
68. INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene. 15:1997;203-211.
69. Zindy F., Eischen C.M., Randle D.H., Kamijo T., Cleveland J.L., Sherr C.J., Roussel M.F. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12:1998;2424-2433.