Oncogenic ras and p53 cooperate to induce cellular senescence

Molecular and Cellular Biology

Volumn 22, Issue 10, 2002, Pages 3497-3508

  Ferbeyre, Gerardo ^a   De Stanchina, Elisa ^a   Lin, Athena W ^a   Querido, Emmanuelle ^a   McCurrach, Mila E ^a   Hannon, Gregory J ^a   Lowe, Scott W ^a  

^a Watson School of Biological Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P19; PROTEIN P53;

ALLELE; ANIMAL CELL; ARTICLE; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; MITOSIS INHIBITION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL AGING; CELL CYCLE; CELL FRACTIONATION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EMBRYO; ENZYME ACTIVATION; FIBROBLASTS; GENES, P53; GENES, RAS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RAS PROTEINS; TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 0036237039     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.10.3497-3508.2002     Document Type: Article

References (67)

1. 1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
2. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
3. A p53-dependent mouse spindle checkpoint
4. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
5. E1A signaling to p53 involves the p19(ARF) tumor suppressor
6. 1 arrest and long-term induction of Cip1 in normal human fibroblasts
7. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
8. PML is induced by oncogenic ras and promotes premature senescence
9. Regulation of p53 activity in nuclear bodies by a specific PML isoform
10. Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport
11. The complexity of p53 modulation: Emerging patterns from divergent signals
12. Wild-type p53 can down-modulate the activity of various promoters
13. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-I
14. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
15. 1-phase checkpoint by low-oxygen conditions is independent of p53 status
16. The function of PML in p53-dependent apoptosis
17. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
18. MARX: An approach to genetics in mammalian cells
19. Mediation of c-Myc-induced apoptosis by p53
20. Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination
21. A transactivation-deficient mouse model provides insights into Trp53 regulation and function
22. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation
23. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia
24. Identification of p53 as a sequence-specific DNA-binding protein
25. Phosphorylation of p53 serine 15 increases interaction with CBP
26. Functional interplay between p53 and E2F through co-activator p300
27. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
28. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
29. 1 arrest
30. 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
31. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 EIA and accompanies apoptosis
32. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
33. Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
34. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
35. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
36. Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines
37. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
38. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
39. DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
40. Cellular adhesion regulates p53 protein levels in primary human keratinocytes
41. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
42. ARF links the tumour suppressor p53 to Ras
43. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
44. Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
45. Role of cysteinc residues in regulation of p53 function
46. Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
47. SUMO-1 modification activates the transcriptional response of p53
48. The puzzling multiple lives of PML and its role in the genesis of cancer
49. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
50. Cellular senescence: Mitotic clock or culture shock?
51. The ARF/p53 pathway
52. The cellular response to p53: The decision between life and death
53. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
54. Cooperation of the tumour suppressors IRF-I and p53 in response to DNA damage
55. P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2
56. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
57. Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs
58. Nucleolar Arf sequesters Mdm2 and activates p53
59. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
60. The p53-mdm-2 autoregulatory feedback loop
61. p53 and E2F-1 cooperate to mediate apoptosis
62. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
63. Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene
64. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
65. Analysis of p53-regulated gene expression patterns with oligonucleotide arrays
66. Senescence of human fibroblasts induced by oncogenic Raf
67. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization