-
1
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
2
-
-
0030881590
-
Differential regulation of the p21/WAF-1 and MDM2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the MDM2 gene
-
Wu, L. and Levine, A. J. Differential regulation of the p21/WAF-1 and MDM2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the MDM2 gene. Mol. Med., 3: 441-451, 1997.
-
(1997)
Mol. Med.
, vol.3
, pp. 441-451
-
-
Wu, L.1
Levine, A.J.2
-
3
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden, K. H. and Lu, X. Live or let die: the cell's response to p53. Nat. Rev. Cancer, 2: 594-604, 2002.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
4
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara, M., Erster, S., Zaika, A., Petrenko, O., Chittenden, T., Pancoska, P., and Moll, U. M. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell, 11: 577-590, 2003.
-
(2003)
Mol. Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
5
-
-
0029913730
-
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
-
Chen, J., Wu, X., Lin, J., and Levine, A. J. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol., 16: 2445-2452, 1996.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2445-2452
-
-
Chen, J.1
Wu, X.2
Lin, J.3
Levine, A.J.4
-
6
-
-
0027498314
-
The MDM-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
-
Finlay, C. A. The MDM-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol., 13: 301-306, 1993.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 301-306
-
-
Finlay, C.A.1
-
7
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69: 1237-1245, 1992.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
8
-
-
0023339504
-
Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
-
Cahilly-Snyder, L., Yang-Feng, T., Francke, U., and George, D. L. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somatic Cell Mol. Genet., 13: 235-244, 1987.
-
(1987)
Somatic Cell Mol. Genet.
, vol.13
, pp. 235-244
-
-
Cahilly-Snyder, L.1
Yang-Feng, T.2
Francke, U.3
George, D.L.4
-
9
-
-
0028834902
-
Rescue of embryonic lethality in MDM2-deficient mice by absence of p53
-
Jones, S. N., Roe, A. E., Donehower, L. A., and Bradley, A. Rescue of embryonic lethality in MDM2-deficient mice by absence of p53. Nature, 378: 206-208, 1995.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
10
-
-
0028823020
-
Rescue of early embryonic lethality in MDM2-deficient mice by deletion of p53
-
Montes de Oca Luna, R., Wagner, D. S., and Lozano, G. Rescue of early embryonic lethality in MDM2-deficient mice by deletion of p53. Nature, 378: 203-206, 1995.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
11
-
-
0027459198
-
The MDM2 expression is induced by wild type p53 activity
-
Barak, Y., Juven, T., Haffner, R., and Oren, M. The MDM2 expression is induced by wild type p53 activity. EMBO J., 12: 461-468, 1993.
-
(1993)
EMBO J.
, vol.12
, pp. 461-468
-
-
Barak, Y.1
Juven, T.2
Haffner, R.3
Oren, M.4
-
12
-
-
0027222956
-
Mapping of the p53 and mdm-2 interaction domains
-
Chen, J., Marechal, V., and Levine, A. J. Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol., 13: 4107-4114, 1993.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4107-4114
-
-
Chen, J.1
Marechal, V.2
Levine, A.J.3
-
13
-
-
0027673764
-
The p53-MDM2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
-
Picksley, S. M. and Lane, D. P. The p53-MDM2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? BioEssays, 15: 689-690, 1993.
-
(1993)
BioEssays
, vol.15
, pp. 689-690
-
-
Picksley, S.M.1
Lane, D.P.2
-
14
-
-
0030905284
-
MDM2 promotes the rapid degradation of p53
-
Haupt, Y., Maya, R., Kazaz, A., and Oren, M. MDM2 promotes the rapid degradation of p53. Nature, 387: 296-299, 1997.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
15
-
-
0030965946
-
Regulation of p53 stability by MDM2
-
Kubbutat, M. H., Jones, S. N., and Vousden, K. H. Regulation of p53 stability by MDM2. Nature, 387: 299-303, 1997.
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
16
-
-
0032931517
-
The p53 pathway
-
Prives, C. and Hall, P. A. The p53 pathway. J. Pathol., 187: 112-126, 1999.
-
(1999)
J. Pathol.
, vol.187
, pp. 112-126
-
-
Prives, C.1
Hall, P.A.2
-
17
-
-
0031282325
-
Design of a synthetic MDM2-binding mini protein that activates the p53 response in vivo
-
Bottger, A., Bottger, V., Sparks, A., Liu, W. L., Howard, S. F., and Lane, D. P. Design of a synthetic MDM2-binding mini protein that activates the p53 response in vivo. Curr. Biol., 7: 860-869, 1997.
-
(1997)
Curr. Biol.
, vol.7
, pp. 860-869
-
-
Bottger, A.1
Bottger, V.2
Sparks, A.3
Liu, W.L.4
Howard, S.F.5
Lane, D.P.6
-
18
-
-
0031014946
-
Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability
-
Kubbutat, M. H. and Vousden, K. H. Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability. Mol. Cell. Biol., 17: 460-468, 1997.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 460-468
-
-
Kubbutat, M.H.1
Vousden, K.H.2
-
19
-
-
0033523015
-
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2
-
Maki, C. G. Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2. J. Biol. Chem., 274: 16531-16535, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16531-16535
-
-
Maki, C.G.1
-
20
-
-
0036517104
-
Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage
-
Shirangi, T. R., Zaika, A., and Moll, U. M. Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage. FASEB J., 16: 420-422, 2002.
-
(2002)
FASEB J.
, vol.16
, pp. 420-422
-
-
Shirangi, T.R.1
Zaika, A.2
Moll, U.M.3
-
21
-
-
0034708458
-
MDM2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., and Weissman, A. M. MDM2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem., 275: 8945-8951, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
22
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda, R., Tanaka, H., and Yasuda, H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett., 420: 25-27, 1997.
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
23
-
-
0031702817
-
Regulation of MDM2-directed degradation by the C terminus of p53
-
Kubbutat, M. H., Ludwig, R. L., Ashcroft, M., and Vousden, K. H. Regulation of MDM2-directed degradation by the C terminus of p53. Mol. Cell. Biol., 18: 5690-5698, 1998.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5690-5698
-
-
Kubbutat, M.H.1
Ludwig, R.L.2
Ashcroft, M.3
Vousden, K.H.4
-
24
-
-
0035903157
-
Human MDM2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization
-
Lai, Z., Ferry, K. V., Diamond, M. A., Wee, K. E., Kim, Y. B., Ma, J., Yang, T., Benfield, P. A., Copeland, R. A., and Auger, K. R. Human MDM2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization. J. Biol. Chem., 276: 31357-31367, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 31357-31367
-
-
Lai, Z.1
Ferry, K.V.2
Diamond, M.A.3
Wee, K.E.4
Kim, Y.B.5
Ma, J.6
Yang, T.7
Benfield, P.A.8
Copeland, R.A.9
Auger, K.R.10
-
25
-
-
0037432773
-
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
-
Grossman, S. R., Deato, M. E., Brignone, C., Chan, H. M., Kung, A. L., Tagami, H., Nakatani, Y., and Livingston, D. M. Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science, 300: 342-344, 2003.
-
(2003)
Science
, vol.300
, pp. 342-344
-
-
Grossman, S.R.1
Deato, M.E.2
Brignone, C.3
Chan, H.M.4
Kung, A.L.5
Tagami, H.6
Nakatani, Y.7
Livingston, D.M.8
-
26
-
-
0032185124
-
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
-
Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z. X., Kumar, S., Howley, P. M., and Livingston, D. M. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell, 2: 405-415, 1998.
-
(1998)
Mol. Cell
, vol.2
, pp. 405-415
-
-
Grossman, S.R.1
Perez, M.2
Kung, A.L.3
Joseph, M.4
Mansur, C.5
Xiao, Z.X.6
Kumar, S.7
Howley, P.M.8
Livingston, D.M.9
-
27
-
-
0035868964
-
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
-
Ito, A., Lai, C. H., Zhao, X., Saito, S., Hamilton, M. H., Appella, E., and Yao, T. P. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J., 20: 1331-1340, 2001.
-
(2001)
EMBO J.
, vol.20
, pp. 1331-1340
-
-
Ito, A.1
Lai, C.H.2
Zhao, X.3
Saito, S.4
Hamilton, M.H.5
Appella, E.6
Yao, T.P.7
-
28
-
-
0033732303
-
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a temary complex with the two proteins
-
Kobet, E., Zeng, X., Zhu, Y., Keller, D., and Lu, H. MDM2 inhibits p300-mediated p53 acetylation and activation by forming a temary complex with the two proteins. Proc. Natl. Acad. Sci. USA, 97: 12547-12552, 2000.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12547-12552
-
-
Kobet, E.1
Zeng, X.2
Zhu, Y.3
Keller, D.4
Lu, H.5
-
29
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science, 274: 948-953, 1996.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
Elenbaas, B.4
Moreau, J.5
Levine, A.J.6
Pavletich, N.P.7
-
30
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., and Vogelstein, B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature, 362: 857-860, 1993.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
31
-
-
0031588025
-
Molecular characterization of the hdm2-p53 interaction
-
Bottger, A., Bottger, V., Garcia-Echeverria, C., Chene, P., Hochkeppel, H. K., Sampson, W., Ang, K., Howard, S. F., Picksley, S. M., and Lane, D. P. Molecular characterization of the hdm2-p53 interaction. J. Mol. Biol., 269: 744-756, 1997.
-
(1997)
J. Mol. Biol.
, vol.269
, pp. 744-756
-
-
Bottger, A.1
Bottger, V.2
Garcia-Echeverria, C.3
Chene, P.4
Hochkeppel, H.K.5
Sampson, W.6
Ang, K.7
Howard, S.F.8
Picksley, S.M.9
Lane, D.P.10
-
32
-
-
0029818380
-
Identification of novel MDM2 binding peptides by phage display
-
Bottger, V., Bottger, A., Howard, S. F., Picksley, S. M., Chene, P., Garcia-Echeverria, C., Hochkeppel, H. K., and Lane, D. P. Identification of novel MDM2 binding peptides by phage display. Oncogene, 13: 2141-2147, 1996.
-
(1996)
Oncogene
, vol.13
, pp. 2141-2147
-
-
Bottger, V.1
Bottger, A.2
Howard, S.F.3
Picksley, S.M.4
Chene, P.5
Garcia-Echeverria, C.6
Hochkeppel, H.K.7
Lane, D.P.8
-
33
-
-
0030981049
-
A genetic approach to mapping the p53 binding site in the MDM2 protein
-
Freedman, D. A., Epstein, C. B., Roth, J. C., and Levine, A. J. A genetic approach to mapping the p53 binding site in the MDM2 protein. Mol. Med., 3: 248-259, 1997.
-
(1997)
Mol. Med.
, vol.3
, pp. 248-259
-
-
Freedman, D.A.1
Epstein, C.B.2
Roth, J.C.3
Levine, A.J.4
-
34
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science, 274: 948-953, 1996.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
Elenbaas, B.4
Moreau, J.5
Levine, A.J.6
Pavletich, N.P.7
-
35
-
-
0036407644
-
Molecular mechanism of the interaction between MDM2 and p53
-
Schon, O., Friedler, A., Bycroft, M., Freund, S. M., and Fersht, A. R. Molecular mechanism of the interaction between MDM2 and p53. J. Mol. Biol., 323: 491-501, 2002.
-
(2002)
J. Mol. Biol.
, vol.323
, pp. 491-501
-
-
Schon, O.1
Friedler, A.2
Bycroft, M.3
Freund, S.M.4
Fersht, A.R.5
-
36
-
-
0034664684
-
Thermodynamics of p53 binding to hdm2(1-126): Effects of phosphorylation and p53 peptide length
-
Lai, Z., Auger, K. R., Manubay, C. M., and Copeland, R. A. Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length. Arch. Biochem. Biophys., 381: 278-284, 2000.
-
(2000)
Arch. Biochem. Biophys.
, vol.381
, pp. 278-284
-
-
Lai, Z.1
Auger, K.R.2
Manubay, C.M.3
Copeland, R.A.4
-
37
-
-
0034737438
-
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on MDM2 binding
-
Sakaguchi, K., Saito, S., Higashimoto, Y., Roy, S., Anderson, C. W., and Appella, E. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on MDM2 binding. J. Biol. Chem., 275: 9278-9283, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9278-9283
-
-
Sakaguchi, K.1
Saito, S.2
Higashimoto, Y.3
Roy, S.4
Anderson, C.W.5
Appella, E.6
-
38
-
-
0029952441
-
In vivo ubiquitination and proteasome-mediated degradation of p53 (1)
-
Maki, C. G., Huibregtse, J. M., and Howley, P. M. In vivo ubiquitination and proteasome-mediated degradation of p53 (1). Cancer Res., 56: 2649-2654, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 2649-2654
-
-
Maki, C.G.1
Huibregtse, J.M.2
Howley, P.M.3
-
39
-
-
0035201820
-
C-terminal ubiquitination of p53 contributes to nuclear export
-
Lohrum, M. A., Woods, D. B., Ludwig, R. L., Balint, E., and Vousden, K. H. C-terminal ubiquitination of p53 contributes to nuclear export. Mol. Cell. Biol., 21: 8521-8532, 2001.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8521-8532
-
-
Lohrum, M.A.1
Woods, D.B.2
Ludwig, R.L.3
Balint, E.4
Vousden, K.H.5
-
40
-
-
0037317840
-
Inhibiting the p53-MDM2 interaction: An important target for cancer therapy
-
Chene, P. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat. Rev. Cancer, 3: 102-109, 2003.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 102-109
-
-
Chene, P.1
-
41
-
-
0037370357
-
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding
-
Wang, W., Takimoto, R., Rastinejad, F., and El-Deiry, W. S. Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding. Mol. Cell. Biol., 23: 2171-2181, 2003.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2171-2181
-
-
Wang, W.1
Takimoto, R.2
Rastinejad, F.3
El-Deiry, W.S.4
-
42
-
-
0037423446
-
Binding of an inhibitor of the p53/MDM2 interaction to MDM2
-
Duncan, S. J., Cooper, M. A., and Williams, D. H. Binding of an inhibitor of the p53/MDM2 interaction to MDM2. Chem. Commun. (Camb.), 7: 316-317, 2003.
-
(2003)
Chem. Commun. (Camb.)
, vol.7
, pp. 316-317
-
-
Duncan, S.J.1
Cooper, M.A.2
Williams, D.H.3
-
43
-
-
85083843429
-
Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.
-
Duncan, S. J., Grushow, S., Williams, D. H., McNicholas, C., Purewal, R., Hajek, M., Gerlitz, M., Martin, S., Wrigley, S. K., and Moore, M. Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. J. Am. Chem. Soc., 124: 14503, 2002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 14503
-
-
Duncan, S.J.1
Grushow, S.2
Williams, D.H.3
McNicholas, C.4
Purewal, R.5
Hajek, M.6
Gerlitz, M.7
Martin, S.8
Wrigley, S.K.9
Moore, M.10
-
44
-
-
0035895350
-
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
-
Stoll, R., Renner, C., Hansen, S., Palme, S., Klein, C., Belling, A., Zeslawski, W., Kamionka, M., Rehm, T., Muhlhahn, P., Schumacher, R., Hesse, F., Kaluza, B., Voelter, W., Engh, R. A., and Holak, T. A. Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry, 40: 336-344, 2001.
-
(2001)
Biochemistry
, vol.40
, pp. 336-344
-
-
Stoll, R.1
Renner, C.2
Hansen, S.3
Palme, S.4
Klein, C.5
Belling, A.6
Zeslawski, W.7
Kamionka, M.8
Rehm, T.9
Muhlhahn, P.10
Schumacher, R.11
Hesse, F.12
Kaluza, B.13
Voelter, W.14
Engh, R.A.15
Holak, T.A.16
-
45
-
-
0031724593
-
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
-
Freedman, D. A. and Levine, A. J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol., 18: 7288-7293, 1998.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7288-7293
-
-
Freedman, D.A.1
Levine, A.J.2
-
46
-
-
0032518917
-
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
-
Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T., and Levine, A. J. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J., 17: 554-564, 1998.
-
(1998)
EMBO J.
, vol.17
, pp. 554-564
-
-
Roth, J.1
Dobbelstein, M.2
Freedman, D.A.3
Shenk, T.4
Levine, A.J.5
-
47
-
-
0032980646
-
Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
-
Tao, W. and Levine, A. J. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc. Natl. Acad. Sci. USA, 96: 3077-3080, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3077-3080
-
-
Tao, W.1
Levine, A.J.2
-
48
-
-
0033559256
-
A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
-
Stommel, J. M., Marchenko, N. D., Jimenez, G. S., Moll, U. M., Hope, T. J., and Wahl, G. M. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J., 18: 1660-1672, 1999.
-
(1999)
EMBO J.
, vol.18
, pp. 1660-1672
-
-
Stommel, J.M.1
Marchenko, N.D.2
Jimenez, G.S.3
Moll, U.M.4
Hope, T.J.5
Wahl, G.M.6
-
49
-
-
0035827335
-
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
-
Zhang, Y. and Xiong, Y. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science, 292: 1910-1915, 2001.
-
(2001)
Science
, vol.292
, pp. 1910-1915
-
-
Zhang, Y.1
Xiong, Y.2
-
50
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd, S. D., Tsai, K. Y., and Jacks, T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat. Cell Biol., 2: 563-568, 2000.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacks, T.3
-
51
-
-
0034282220
-
The MDM2 RING-finger domain is required to promote p53 nuclear export
-
Geyer, R. K., Yu, Z. K., and Maki, C. G. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat. Cell Biol., 2: 569-573, 2000.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 569-573
-
-
Geyer, R.K.1
Yu, Z.K.2
Maki, C.G.3
-
52
-
-
0038298110
-
An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to UIA-positive nuclear bodies associated with the PODs
-
Lain, S., Midgley, C., Sparks, A., Lane, E. B., and Lane, D. P. An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to UIA-positive nuclear bodies associated with the PODs. Exp. Cell Res., 248: 457-472, 1999.
-
(1999)
Exp. Cell Res.
, vol.248
, pp. 457-472
-
-
Lain, S.1
Midgley, C.2
Sparks, A.3
Lane, E.B.4
Lane, D.P.5
-
53
-
-
0343044332
-
Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B
-
Smart, P., Lane, E. B., Lane, D. P., Midgley, C., Vojtesek, B., and Lain, S. Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene, 18: 7378-7386, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 7378-7386
-
-
Smart, P.1
Lane, E.B.2
Lane, D.P.3
Midgley, C.4
Vojtesek, B.5
Lain, S.6
-
54
-
-
0034652143
-
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
-
Brooks, P., Fuertes, G., Murray, R. Z., Bose, S., Knecht, E., Rechsteiner, M. C., Hendil, K. B., Tanaka, K., Dyson, J., and Rivett, J. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. Biochem. J., 346 (Pt. 1): 155-161, 2000.1
-
(2000)
Biochem. J.
, vol.346
, Issue.PART 1
, pp. 155-161
-
-
Brooks, P.1
Fuertes, G.2
Murray, R.Z.3
Bose, S.4
Knecht, E.5
Rechsteiner, M.C.6
Hendil, K.B.7
Tanaka, K.8
Dyson, J.9
Rivett, J.10
-
55
-
-
0030010769
-
Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol
-
Palmer, A., Rivett, A. J., Thomson, S., Hendil, K. B., Butcher, G. W., Fuertes, G., and Knecht, E. Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol. Biochem. J., 316 (Pt. 2): 401-407, 1996.
-
(1996)
Biochem. J.
, vol.316
, Issue.PART 2
, pp. 401-407
-
-
Palmer, A.1
Rivett, A.J.2
Thomson, S.3
Hendil, K.B.4
Butcher, G.W.5
Fuertes, G.6
Knecht, E.7
-
56
-
-
0028238846
-
Changes in proteasome localization during the cell cycle
-
Palmer, A., Mason, G. G., Paramio, J. M., Knecht, E., and Rivett, A. J. Changes in proteasome localization during the cell cycle. Eur. J. Cell Biol., 64: 163-175, 1994.
-
(1994)
Eur. J. Cell Biol.
, vol.64
, pp. 163-175
-
-
Palmer, A.1
Mason, G.G.2
Paramio, J.M.3
Knecht, E.4
Rivett, A.J.5
-
57
-
-
0030703686
-
Dynamics of proteasome distribution in living cells
-
Reits, E. A., Benham, A. M., Plougastel, B., Neefjes, J., and Trowsdale, J. Dynamics of proteasome distribution in living cells. EMBO J., 16: 6087-6094, 1997.
-
(1997)
EMBO J.
, vol.16
, pp. 6087-6094
-
-
Reits, E.A.1
Benham, A.M.2
Plougastel, B.3
Neefjes, J.4
Trowsdale, J.5
-
58
-
-
0034735904
-
MDM2-dependent ubiquitination of nuclear and cytoplasmic P53
-
Yu, Z. K., Geyer, R. K., and Maki, C. G. MDM2-dependent ubiquitination of nuclear and cytoplasmic P53. Oncogene, 19: 5892-5897, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 5892-5897
-
-
Yu, Z.K.1
Geyer, R.K.2
Maki, C.G.3
-
59
-
-
0042415612
-
Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during downregulation of the p53 response after multiple types of DNA damage
-
Joseph, T. W., Zaika, A., and Moll, U. M. Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during downregulation of the p53 response after multiple types of DNA damage. FASEB J., 17: 1622-1630, 2003.
-
(2003)
FASEB J.
, vol.17
, pp. 1622-1630
-
-
Joseph, T.W.1
Zaika, A.2
Moll, U.M.3
-
60
-
-
0033552640
-
Mechanisms of switching on p53: A role for covalent modification?
-
Meek, D. W. Mechanisms of switching on p53: a role for covalent modification? Oncogene, 18: 7666-7675, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 7666-7675
-
-
Meek, D.W.1
-
61
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science, 281: 1677-1679, 1998.
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
62
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab, N. H., Malikzay, A., Appel, M., and Halazonetis, T. D. Chk2/ hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev., 14: 278-288, 2000.
-
(2000)
Genes Dev.
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
63
-
-
0033592868
-
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
-
Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., and Shkedy, D. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl. Acad. Sci. USA, 96: 14973-14977, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14973-14977
-
-
Khosravi, R.1
Maya, R.2
Gottlieb, T.3
Oren, M.4
Shiloh, Y.5
Shkedy, D.6
-
64
-
-
0034664684
-
Thermodynamics of p53 binding to hdm2(1-126): Effects of phosphorylation and p53 peptide length
-
Lai, Z., Auger, K. R., Manubay, C. M., and Copeland, R. A. Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length. Arch. Biochem. Biophys., 381: 278-284, 2000.
-
(2000)
Arch. Biochem. Biophys.
, vol.381
, pp. 278-284
-
-
Lai, Z.1
Auger, K.R.2
Manubay, C.M.3
Copeland, R.A.4
-
65
-
-
0033572417
-
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
-
Alarcon, R., Koumenis, C., Geyer, R. K., Maki, C. G., and Giaccia, A. J. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res., 59: 6046-6051, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 6046-6051
-
-
Alarcon, R.1
Koumenis, C.2
Geyer, R.K.3
Maki, C.G.4
Giaccia, A.J.5
-
66
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu, X., Bayle, J. H., Olson, D., and Levine, A. J., The p53-mdm-2 autoregulatory feedback loop. Genes Dev., 7: 1126-1132, 1993.
-
(1993)
Genes Dev.
, vol.7
, pp. 1126-1132
-
-
Wu, X.1
Bayle, J.H.2
Olson, D.3
Levine, A.J.4
-
67
-
-
0033571214
-
SUMO-1 modification activates the transcriptional response of p53
-
Rodriguez, M. S., Desterro, J. M., Lain, S., Midgley, C. A., Lane, D. P., and Hay, R. T. SUMO-1 modification activates the transcriptional response of p53. EMBO J., 18: 6455-6461, 1999.
-
(1999)
EMBO J.
, vol.18
, pp. 6455-6461
-
-
Rodriguez, M.S.1
Desterro, J.M.2
Lain, S.3
Midgley, C.A.4
Lane, D.P.5
Hay, R.T.6
-
68
-
-
0033020147
-
Regulation of p53 function and stability by phosphorylation
-
Ashcroft, M., Kubbutat, M. H., and Vousden, K. H. Regulation of p53 function and stability by phosphorylation. Mol. Cell. Biol., 19: 1751-1758, 1999.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1751-1758
-
-
Ashcroft, M.1
Kubbutat, M.H.2
Vousden, K.H.3
-
69
-
-
0033522143
-
DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation
-
Blattner, C., Tobiasch, E., Litfen, M., Rahmsdorf, H. J., and Herrlich, P., DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation. Oncogene, 18: 1723-1732, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 1723-1732
-
-
Blattner, C.1
Tobiasch, E.2
Litfen, M.3
Rahmsdorf, H.J.4
Herrlich, P.5
-
70
-
-
0032146795
-
E1A signaling to p53 involves the p19(ARF) tumor suppressor
-
de Stanchina, E., McCurrach, M. E., Zindy, F., Shieh, S. Y., Ferbeyre, G., Samuelson, A. V., Prives, C., Roussel, M. F., Sherr, C. J., and Lowe, S. W. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev., 12: 2434-2442, 1998.
-
(1998)
Genes Dev.
, vol.12
, pp. 2434-2442
-
-
De Stanchina, E.1
McCurrach, M.E.2
Zindy, F.3
Shieh, S.Y.4
Ferbeyre, G.5
Samuelson, A.V.6
Prives, C.7
Roussel, M.F.8
Sherr, C.J.9
Lowe, S.W.10
-
71
-
-
0034726060
-
Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains
-
Hay, T. J. and Meek, D. W. Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains. FEBS Lett., 478: 183-186, 2000.
-
(2000)
FEBS Lett.
, vol.478
, pp. 183-186
-
-
Hay, T.J.1
Meek, D.W.2
-
72
-
-
0033572746
-
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
-
Dumaz, N. and Meek, D. W. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J., 18: 7002-7010, 1999.
-
(1999)
EMBO J.
, vol.18
, pp. 7002-7010
-
-
Dumaz, N.1
Meek, D.W.2
-
73
-
-
0030667702
-
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
-
Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91: 325-334, 1997.
-
(1997)
Cell
, vol.91
, pp. 325-334
-
-
Shieh, S.Y.1
Ikeda, M.2
Taya, Y.3
Prives, C.4
-
74
-
-
0035339357
-
ATM-dependent phosphorylation of MDM2 on serine 395: Role in p53 activation by DNA damage
-
Maya, R., Balass, M., Kim, S. T., Shkedy, D., Leal, J. F., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., Kastan, M. B., Katzir, E., and Oren, M. ATM-dependent phosphorylation of MDM2 on serine 395: role in p53 activation by DNA damage. Genes Dev., 15: 1067-1077, 2001.
-
(2001)
Genes Dev.
, vol.15
, pp. 1067-1077
-
-
Maya, R.1
Balass, M.2
Kim, S.T.3
Shkedy, D.4
Leal, J.F.5
Shifman, O.6
Moas, M.7
Buschmann, T.8
Ronai, Z.9
Shiloh, Y.10
Kastan, M.B.11
Katzir, E.12
Oren, M.13
-
75
-
-
18644378985
-
SUMO-1 modification of MDM2 prevents its self-ubiquitination and increases MDM2 ability to ubiquitinate p53
-
Fuchs, S. Y., Lee, C. G., Pan, Z. Q., and Ronai, Z. SUMO-1 modification of MDM2 prevents its self-ubiquitination and increases MDM2 ability to ubiquitinate p53. Cell, 110: 531, 2002.
-
(2002)
Cell
, vol.110
, pp. 531
-
-
Fuchs, S.Y.1
Lee, C.G.2
Pan, Z.Q.3
Ronai, Z.4
-
76
-
-
17444370101
-
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells
-
Araki, R., Fukumura, R., Fujimori, A., Taya, Y., Shiloh, Y., Kurimasa, A., Burma, S., Li, G. C., Chen, D. J., Sato, K., Hoki, Y., Tatsumi, K., and Abe, M. Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. Cancer Res., 59: 3543-3546, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 3543-3546
-
-
Araki, R.1
Fukumura, R.2
Fujimori, A.3
Taya, Y.4
Shiloh, Y.5
Kurimasa, A.6
Burma, S.7
Li, G.C.8
Chen, D.J.9
Sato, K.10
Hoki, Y.11
Tatsumi, K.12
Abe, M.13
-
77
-
-
0030665146
-
MDM-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
-
Mayo, L. D., Turchi, J. J., and Berberich, S. J. MDM-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res., 57: 5013-5016, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 5013-5016
-
-
Mayo, L.D.1
Turchi, J.J.2
Berberich, S.J.3
-
78
-
-
0035839460
-
Cyclin a-CDK phosphorylation regulates MDM2 protein interactions
-
Zhang, T. and Prives, C. Cyclin a-CDK phosphorylation regulates MDM2 protein interactions. J. Biol. Chem., 276: 29702-29710, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29702-29710
-
-
Zhang, T.1
Prives, C.2
-
79
-
-
0037151032
-
p38 mitogen-activated protein kinase mediates hypoxic regulation of MDM2 and p53 in neurons
-
Zhu, Y., Mao, X. O., Sun, Y., Xia, Z., and Greenberg, D. A. p38 Mitogen-activated protein kinase mediates hypoxic regulation of MDM2 and p53 in neurons. J. Biol. Chem., 277: 22909-22914, 2002.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22909-22914
-
-
Zhu, Y.1
Mao, X.O.2
Sun, Y.3
Xia, Z.4
Greenberg, D.A.5
-
80
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of MDM2 from the cytoplasm to the nucleus
-
Mayo, L. D. and Donner, D. B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of MDM2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA, 98: 11598-11603, 2001.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
81
-
-
0037085271
-
PTEN protects p53 from MDM2 and sensitizes cancer cells to chemotherapy
-
Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., and Donner, D. B. PTEN protects p53 from MDM2 and sensitizes cancer cells to chemotherapy. J. Biol. Chem., 277: 5484-5489, 2002.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5484-5489
-
-
Mayo, L.D.1
Dixon, J.E.2
Durden, D.L.3
Tonks, N.K.4
Donner, D.B.5
-
82
-
-
85047699328
-
Cross-talk between Akt, p53 and MDM2: Possible implications for the regulation of apoptosis
-
Gottlieb, T. M., Leal, J. F., Seger, R., Taya, Y., and Oren, M. Cross-talk between Akt, p53 and MDM2: possible implications for the regulation of apoptosis. Oncogene, 21: 1299-1303, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 1299-1303
-
-
Gottlieb, T.M.1
Leal, J.F.2
Seger, R.3
Taya, Y.4
Oren, M.5
-
83
-
-
0035736487
-
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
-
Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M. C. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol., 3: 973-982, 2001.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 973-982
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Zou, Y.4
Spohn, B.5
Hung, M.C.6
-
84
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
-
Freeman, D. J., Li, A. G., Wei, G., Li, H. H., Kertesz, N., Lesche, R., Whale, A. D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R. D., Liu, X., and Wu, H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell, 3: 117-130, 2003.
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
Whale, A.D.7
Martinez-Diaz, H.8
Rozengurt, N.9
Cardiff, R.D.10
Liu, X.11
Wu, H.12
-
85
-
-
0033600759
-
Cytoplasmically "sequestered" wild type p53 protein is resistant to MDM2-mediated degradation
-
Zaika, A., Marchenko, N., and Moll, U. M. Cytoplasmically "sequestered" wild type p53 protein is resistant to MDM2-mediated degradation. J. Biol. Chem., 274: 27474-27480, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27474-27480
-
-
Zaika, A.1
Marchenko, N.2
Moll, U.M.3
-
86
-
-
0037428078
-
Parc: A cytoplasmic anchor for p53
-
Nikolaev, A. Y., Li, M., Puskas, N., Qin, J., and Gu, W. Parc: a cytoplasmic anchor for p53. Cell, 112: 29-40, 2003.
-
(2003)
Cell
, vol.112
, pp. 29-40
-
-
Nikolaev, A.Y.1
Li, M.2
Puskas, N.3
Qin, J.4
Gu, W.5
-
87
-
-
0033521621
-
Association of p19(ARF) with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53
-
Honda, R. and Yasuda, H. Association of p19(ARF) with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53. EMBO J., 18: 22-27, 1999.
-
(1999)
EMBO J.
, vol.18
, pp. 22-27
-
-
Honda, R.1
Yasuda, H.2
-
88
-
-
0033536063
-
P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of MDM2
-
Tao, W. and Levine, A. J. P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of MDM2. Proc. Natl. Acad. Sci. USA, 96: 6937-6941, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6937-6941
-
-
Tao, W.1
Levine, A.J.2
-
89
-
-
0033130010
-
Nucleolar Arf sequesters MDM2 and activates p53
-
Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., and Bar-Sagi, D. Nucleolar Arf sequesters MDM2 and activates p53. Nat. Cell Biol., 1: 20-26, 1999.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 20-26
-
-
Weber, J.D.1
Taylor, L.J.2
Roussel, M.F.3
Sherr, C.J.4
Bar-Sagi, D.5
-
90
-
-
0033771948
-
Identification of a cryptic nucleolar-localization signal in MDM2
-
Lohrum, M. A., Ashcroft, M., Kubbutat, M. H., and Vousden, K. H. Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol., 2: 179-181, 2000.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 179-181
-
-
Lohrum, M.A.1
Ashcroft, M.2
Kubbutat, M.H.3
Vousden, K.H.4
-
91
-
-
0034744224
-
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
-
Llanos, S., Clark, P. A., Rowe, J., and Peters, G., Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat. Cell Biol., 3: 445-452, 2001.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 445-452
-
-
Llanos, S.1
Clark, P.A.2
Rowe, J.3
Peters, G.4
-
93
-
-
0035487104
-
The INK4a/ARF network in tumour suppression
-
Sherr, C. J. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol., 2: 731-737, 2001.
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 731-737
-
-
Sherr, C.J.1
-
94
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., and Sherr, C. J. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell, 91: 649-659, 1997.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
95
-
-
0036237039
-
Oncogenic ras and p53 cooperate to induce cellular senescence
-
Ferbeyre, G., de Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J., and Lowe, S. W. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol., 22: 3497-3508, 2002.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3497-3508
-
-
Ferbeyre, G.1
De Stanchina, E.2
Lin, A.W.3
Querido, E.4
McCurrach, M.E.5
Hannon, G.J.6
Lowe, S.W.7
-
96
-
-
0034644506
-
Opposing effects of Ras on p53: Transcriptional activation of MDM2 and induction of p19ARF
-
Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., and McCormick, F. Opposing effects of Ras on p53: transcriptional activation of MDM2 and induction of p19ARF. Cell, 103: 321-330, 2000.
-
(2000)
Cell
, vol.103
, pp. 321-330
-
-
Ries, S.1
Biederer, C.2
Woods, D.3
Shifman, O.4
Shirasawa, S.5
Sasazuki, T.6
McMahon, M.7
Oren, M.8
McCormick, F.9
-
97
-
-
0032815930
-
The E7 oneoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF)
-
Seavey, S. E., Holubar, M., Saucedo, L. J., and Peny, M. E. The E7 oneoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF). J. Virol., 73: 7590-7598, 1999.
-
(1999)
J. Virol.
, vol.73
, pp. 7590-7598
-
-
Seavey, S.E.1
Holubar, M.2
Saucedo, L.J.3
Peny, M.E.4
-
98
-
-
0036133649
-
p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
-
Tolbert, D., Lu, X., Yin, C. Tantama, M., and Van Dyke, T. p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo. Mol. Cell. Biol., 22: 370-377, 2002.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 370-377
-
-
Tolbert, D.1
Lu, X.2
Yin, C.3
Tantama, M.4
Van Dyke, T.5
-
99
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., and Jochemsen, A. G. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J., 15: 5349-5357, 1996.
-
(1996)
EMBO J.
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
Van Laar, T.4
Dekker, P.5
Bazuine, M.6
Van Ham, R.C.7
Van Der Houven Van Oordt, W.8
Hateboer, G.9
Van Der Eb, A.J.10
Jochemsen, A.G.11
-
100
-
-
0036606416
-
mdmx is a negative regulator of p53 activity in vivo
-
Finch, R. A., Donoviel, D. B., Potter, D., Shi, M., Fan, A., Freed, D. D., Wang, C. Y., Zambrowicz, B. P., Ramirez-Solis, R., Sands, A. T., and Zhang, N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res., 62: 3221-3225, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
Wang, C.Y.7
Zambrowicz, B.P.8
Ramirez-Solis, R.9
Sands, A.T.10
Zhang, N.11
-
101
-
-
0037205454
-
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
-
Gu, J., Kawai, H., Nie, L., Kitao, H., Wiederschain, D., Jochemsen, A. G., Parant, J., Lozano, G., and Yuan, Z. M. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J. Biol. Chem., 277: 19251-19254, 2002.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
Kitao, H.4
Wiederschain, D.5
Jochemsen, A.G.6
Parant, J.7
Lozano, G.8
Yuan, Z.M.9
-
102
-
-
0141866880
-
Hdmx protein stability is regulated by the ubiquitin ligase activity of MDM2
-
de Graaf P., Little, N. A., Ramos, Y. F., Meulmeester, E., Letteboer, S. J., Jochemsen, A. G. Hdmx protein stability is regulated by the ubiquitin ligase activity of MDM2. J. Biol. Chem., 278: 38315-38324, 2003.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38315-38324
-
-
De Graaf, P.1
Little, N.A.2
Ramos, Y.F.3
Meulmeester, E.4
Letteboer, S.J.5
Jochemsen, A.G.6
-
103
-
-
0042592947
-
MDM2 promotes ubiquitination and degradation of MDMX
-
Pan, Y. and Chen, J. MDM2 promotes ubiquitination and degradation of MDMX. Mol. Cell. Biol., 23: 5113-5121, 2003.1
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5113-5121
-
-
Pan, Y.1
Chen, J.2
-
104
-
-
0034863683
-
Rescue of embryonic lethality in MDM4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant, J., Chavez-Reyes, A., Little, N. A., Yan, W., Reinke, V., Jochemsen, A. G., and Lozano, G. Rescue of embryonic lethality in MDM4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat. Genet., 29: 92-95, 2001.
-
(2001)
Nat. Genet.
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
105
-
-
0036311067
-
MDM4 (MDMx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., and Marine, J. C. MDM4 (MDMx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol., 22: 5527-5538, 2002.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Denchi, E.L.2
Danovi, D.3
Jochemsen, A.4
Capillo, M.5
Gobbi, A.6
Helin, K.7
Pelicci, P.G.8
Marine, J.C.9
-
106
-
-
0035266128
-
Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53
-
Ramos, Y. F., Stad, R., Attema, J., Peltenburg, L. T., van der Eb, A. J., and Jochemsen, A. G. Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. Cancer Res., 61: 1839-1842, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 1839-1842
-
-
Ramos, Y.F.1
Stad, R.2
Attema, J.3
Peltenburg, L.T.4
Van Der Eb, A.J.5
Jochemsen, A.G.6
-
107
-
-
0038724615
-
Regulation of HDM2 activity by the ribosomal protein L11
-
Lohrum, M. A., Ludwig, R. L., Kubbutat, M. H., Hanlon, M., and Vousden, K. H. Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell, 3: 577-587, 2003.
-
(2003)
Cancer Cell
, vol.3
, pp. 577-587
-
-
Lohrum, M.A.1
Ludwig, R.L.2
Kubbutat, M.H.3
Hanlon, M.4
Vousden, K.H.5
-
108
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
Leng, R. P., Lin, Y., Ma, W., Wu, H., Lemmers, B., Chung, S., Parant, J. M., Lozano, G., Hakem, R., and Benchimol, S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell, 112: 779-791, 2003.
-
(2003)
Cell
, vol.112
, pp. 779-791
-
-
Leng, R.P.1
Lin, Y.2
Ma, W.3
Wu, H.4
Lemmers, B.5
Chung, S.6
Parant, J.M.7
Lozano, G.8
Hakem, R.9
Benchimol, S.10
-
109
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., and Gu, W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature, 416: 648-653, 2002.
-
(2002)
Nature
, vol.416
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
Luo, J.4
Nikolaev, A.Y.5
Qin, J.6
Gu, W.7
-
110
-
-
0034745050
-
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
-
Buschmann, T., Potapova, O., Bar-Shira, A., Ivanov, V. N., Fuchs, S. Y., Henderson, S., Fried, V. A., Minamoto, T., Alarcon-Vargas, D., Pincus, M. R., Gaarde, W. A., Holbrook, N. J., Shiloh, Y., and Ronai, Z. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell. Biol., 21: 2743-2754, 2001.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2743-2754
-
-
Buschmann, T.1
Potapova, O.2
Bar-Shira, A.3
Ivanov, V.N.4
Fuchs, S.Y.5
Henderson, S.6
Fried, V.A.7
Minamoto, T.8
Alarcon-Vargas, D.9
Pincus, M.R.10
Gaarde, W.A.11
Holbrook, N.J.12
Shiloh, Y.13
Ronai, Z.14
-
111
-
-
0035801388
-
Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
-
Damalas, A., Kahan, S., Shtutman, M., Ben-Ze'ev, A., and Oren, M. Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J., 20: 4912-4922, 2001.
-
(2001)
EMBO J.
, vol.20
, pp. 4912-4922
-
-
Damalas, A.1
Kahan, S.2
Shtutman, M.3
Ben-Ze'ev, A.4
Oren, M.5
|