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Volumn 285, Issue 5432, 1999, Pages 1390-1393

Gene expression profile of aging and its retardation by caloric restriction

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE; PROTEIN;

EID: 0033610079     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5432.1390     Document Type: Article
Times cited : (1300)

References (44)
  • 1
    • 0030016821 scopus 로고    scopus 로고
    • S. M. Jazwinski, Science 273, 54 (1996); G. M. Martin, S. N. Austad, T. E. Johnson, Nature Genet. 13, 25 (1996); F. B. Johnson, D. A. Sinclair, L. Cuarente, Cell 96, 291 (1996).
    • (1996) Science , vol.273 , pp. 54
    • Jazwinski, S.M.1
  • 2
    • 0029920370 scopus 로고    scopus 로고
    • S. M. Jazwinski, Science 273, 54 (1996); G. M. Martin, S. N. Austad, T. E. Johnson, Nature Genet. 13, 25 (1996); F. B. Johnson, D. A. Sinclair, L. Cuarente, Cell 96, 291 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 25
    • Martin, G.M.1    Austad, S.N.2    Johnson, T.E.3
  • 3
    • 0030016821 scopus 로고    scopus 로고
    • S. M. Jazwinski, Science 273, 54 (1996); G. M. Martin, S. N. Austad, T. E. Johnson, Nature Genet. 13, 25 (1996); F. B. Johnson, D. A. Sinclair, L. Cuarente, Cell 96, 291 (1996).
    • (1996) Cell , vol.96 , pp. 291
    • Johnson, F.B.1    Sinclair, D.A.2    Cuarente, L.3
  • 5
    • 0028220114 scopus 로고
    • W. C. Orr and R. S. Sohal, Science 263, 1128 (1994); T. L. Parkes et al., Nature Genet. 19, 171 (1998).
    • (1994) Science , vol.263 , pp. 1128
    • Orr, W.C.1    Sohal, R.S.2
  • 6
    • 0031864164 scopus 로고    scopus 로고
    • W. C. Orr and R. S. Sohal, Science 263, 1128 (1994); T. L. Parkes et al., Nature Genet. 19, 171 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 171
    • Parkes, T.L.1
  • 7
    • 0030659557 scopus 로고    scopus 로고
    • S. Ogg et al., Nature 389, 994 (1997); K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997); S. Paradis and G. Ruvkun, Genes Dev. 12, 2488 (1998); H. A. Tissenbaum and G. Ruvkun, Genetics 148, 703 (1998).
    • (1997) Nature , vol.389 , pp. 994
    • Ogg, S.1
  • 8
    • 0030657540 scopus 로고    scopus 로고
    • S. Ogg et al., Nature 389, 994 (1997); K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997); S. Paradis and G. Ruvkun, Genes Dev. 12, 2488 (1998); H. A. Tissenbaum and G. Ruvkun, Genetics 148, 703 (1998).
    • (1997) Science , vol.278 , pp. 1319
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 9
    • 0032529189 scopus 로고    scopus 로고
    • S. Ogg et al., Nature 389, 994 (1997); K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997); S. Paradis and G. Ruvkun, Genes Dev. 12, 2488 (1998); H. A. Tissenbaum and G. Ruvkun, Genetics 148, 703 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2488
    • Paradis, S.1    Ruvkun, G.2
  • 10
    • 0031935425 scopus 로고    scopus 로고
    • S. Ogg et al., Nature 389, 994 (1997); K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997); S. Paradis and G. Ruvkun, Genes Dev. 12, 2488 (1998); H. A. Tissenbaum and G. Ruvkun, Genetics 148, 703 (1998).
    • (1998) Genetics , vol.148 , pp. 703
    • Tissenbaum, H.A.1    Ruvkun, G.2
  • 11
    • 0025004091 scopus 로고
    • T. E. Johnson, Science 249, 908 (1990); S. Murakami and T. E. Johnson, Genetics 143, 1207 (1996); Y.-J. Lin, L. Seroude, S. Benzer, Science 282, 943 (1998).
    • (1990) Science , vol.249 , pp. 908
    • Johnson, T.E.1
  • 12
    • 0030014296 scopus 로고    scopus 로고
    • T. E. Johnson, Science 249, 908 (1990); S. Murakami and T. E. Johnson, Genetics 143, 1207 (1996); Y.-J. Lin, L. Seroude, S. Benzer, Science 282, 943 (1998).
    • (1996) Genetics , vol.143 , pp. 1207
    • Murakami, S.1    Johnson, T.E.2
  • 13
    • 0032582489 scopus 로고    scopus 로고
    • T. E. Johnson, Science 249, 908 (1990); S. Murakami and T. E. Johnson, Genetics 143, 1207 (1996); Y.-J. Lin, L. Seroude, S. Benzer, Science 282, 943 (1998).
    • (1998) Science , vol.282 , pp. 943
    • Lin, Y.-J.1    Seroude, L.2    Benzer, S.3
  • 14
    • 15844409553 scopus 로고    scopus 로고
    • C. E. Yu et al., Science 272, 258 (1996); L. Ye et al., Am. J. Med. Genet. 68, 494 (1997).
    • (1996) Science , vol.272 , pp. 258
    • Yu, C.E.1
  • 15
    • 17344379792 scopus 로고    scopus 로고
    • C. E. Yu et al., Science 272, 258 (1996); L. Ye et al., Am. J. Med. Genet. 68, 494 (1997).
    • (1997) Am. J. Med. Genet. , vol.68 , pp. 494
    • Ye, L.1
  • 19
    • 0345256844 scopus 로고    scopus 로고
    • Methods used to house and feed male C57BL/6 mice, a commonly used model in aging research with an average life-span of ∼30 months, were recently described [T. D. Pugh, T. D. Oberley, R. Weindruch, Cancer Res. 59, 642 (1999)].
    • (1999) Cancer Res. , vol.59 , pp. 642
    • Pugh, T.D.1    Oberley, T.D.2    Weindruch, R.3
  • 20
    • 0344393998 scopus 로고    scopus 로고
    • note
    • +, 20 mM EDTA, and 0.01% Tween 20. The final concentration of fragmented cRNA was 0.05 μg/μl in the hybridization solutions. After hybridization, the hybridization solutions were removed and the gene chips were washed and stained with streptavidin-phycoerythrin. DNA chips were read at a resolution of 6 μm with a Hewlett-Packard GeneArray Scanner.
  • 21
    • 10544256600 scopus 로고    scopus 로고
    • Detailed protocols for data analysis of Affymetrix microarrays and extensive documentation of the sensitivity and quantitative aspects of the method have been described [D. J. Lockhart, Nature Biotechnol. 14, 1675 (1996)]. Briefly, each gene is represented by the use of ∼20 perfectly matched (PM) and mismatched (MM) control probes. The MM probes act as specificity controls that allow the direct subtraction of both background and cross-hybridization signals. The number of instances in which the PM hybridization signal is larger than the MM signal is computed along with the average of the logarithm of the PM:MM ratio (after background subtraction) for each probe set These values are used to make a matrix-based decision concerning the presence or absence of an RNA molecule. Positive average signal intensities after background subtraction were observed for over 4000 genes for all samples. To determine the quantitative RNA abundance, the average of the differences representing PM minus MM for each gene-specific probe family is calculated, after discarding the maximum, the minimum, and any outliers beyond 3 SDs. Averages of pairwise comparisons were made between animals with Affymetrix software. To determine the effect of age, each 5-month-old mouse (n = 3) was compared to each 30-month-old (n = 3) mouse, generating a total of nine pairwise comparisons. To determine the effect of diet, 30-month-old CR-fed (n = 3) and 30-month-old control-fed (n = 3) animals were similarly compared. Pearson correlation coeficients were calculated between individual animals in the same age/diet groups. No correlation coeficient between two animals in the same age/diet group was less than 0.98.
    • (1996) Nature Biotechnol. , vol.14 , pp. 1675
    • Lockhart, D.J.1
  • 26
    • 0030968886 scopus 로고    scopus 로고
    • L. Larsson, J. Gerontol. Biol. Sci. 50A, 96 (1995); J. Lexell, J. Nutr. 127, 1011S (1997).
    • (1997) J. Nutr. , vol.127
    • Lexell, J.1
  • 32
    • 0030715561 scopus 로고    scopus 로고
    • ATP synthase: W. Junge, H. Lill, S. Engelbrecht, Trends Biochem. Sci. 22, 420 (1997); NADP transhydrogenase: J. B. Hoek and J. Rydstrom, Biochem. J. 254, 1 (1988); LON protease: K. Luciakova, B. Sokolikova, M. Chloupkova, B. D. Nelson, FEBS Lett. 444, 186 (1999); ERV1: T. Lisowsky, Curr. Genet. 26, 15 (1994).
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 420
    • Junge, W.1    Lill, H.2    Engelbrecht, S.3
  • 33
    • 0023681148 scopus 로고
    • ATP synthase: W. Junge, H. Lill, S. Engelbrecht, Trends Biochem. Sci. 22, 420 (1997); NADP transhydrogenase: J. B. Hoek and J. Rydstrom, Biochem. J. 254, 1 (1988); LON protease: K. Luciakova, B. Sokolikova, M. Chloupkova, B. D. Nelson, FEBS Lett. 444, 186 (1999); ERV1: T. Lisowsky, Curr. Genet. 26, 15 (1994).
    • (1988) Biochem. J. , vol.254 , pp. 1
    • Hoek, J.B.1    Rydstrom, J.2
  • 34
    • 0033036242 scopus 로고    scopus 로고
    • ATP synthase: W. Junge, H. Lill, S. Engelbrecht, Trends Biochem. Sci. 22, 420 (1997); NADP transhydrogenase: J. B. Hoek and J. Rydstrom, Biochem. J. 254, 1 (1988); LON protease: K. Luciakova, B. Sokolikova, M. Chloupkova, B. D. Nelson, FEBS Lett. 444, 186 (1999); ERV1: T. Lisowsky, Curr. Genet. 26, 15 (1994).
    • (1999) FEBS Lett. , vol.444 , pp. 186
    • Luciakova, K.1    Sokolikova, B.2    Chloupkova, M.3    Nelson, B.D.4
  • 35
    • 0028318596 scopus 로고
    • ATP synthase: W. Junge, H. Lill, S. Engelbrecht, Trends Biochem. Sci. 22, 420 (1997); NADP transhydrogenase: J. B. Hoek and J. Rydstrom, Biochem. J. 254, 1 (1988); LON protease: K. Luciakova, B. Sokolikova, M. Chloupkova, B. D. Nelson, FEBS Lett. 444, 186 (1999); ERV1: T. Lisowsky, Curr. Genet. 26, 15 (1994).
    • (1994) Curr. Genet. , vol.26 , pp. 15
    • Lisowsky, T.1
  • 41
    • 0032518922 scopus 로고    scopus 로고
    • L. Wikstrom et al., EMBO J. 17, 455 (1998).
    • (1998) EMBO J. , vol.17 , pp. 455
    • Wikstrom, L.1
  • 44
    • 0344825565 scopus 로고    scopus 로고
    • note
    • Supported by NIH grants P01 AG11915 (R.W.) and RO1 CA78723 (T.A.P.). T.A.P. is a recipient of the Shaw Scientist (Milwaukee Foundation) and Burroughs Wellcome Young Investigator awards.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.