Telomere biology in human aging and aging syndromes

Mechanisms of Ageing and Development

Volumn 122, Issue 7, 2001, Pages 695-712

  Klapper, W ^a   Parwaresch, R ^a   Krupp, G ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Arteriosclerosis; Ataxia telangiectasia; Bloom syndrome; Diabetes; Down syndrome; Dyskeratosis congenita; End replication problem; Hutchinson Gilford progeria; Osteoporosis; Premature aging; Senescence; Telomerase; Telosome; Werner syndrome

Indexed keywords

TELOMERASE;

AGING; ATAXIA TELANGIECTASIA; BLOOM SYNDROME; CELL AGING; CELL DIVISION; CELL IMMORTALIZATION; CELL PROLIFERATION; CHROMOSOME; DOWN SYNDROME; DYSKERATOSIS CONGENITA; HUMAN; IN VITRO STUDY; MALIGNANT LENTIGO; NONHUMAN; PRIORITY JOURNAL; REVIEW; TELOMERE; WERNER SYNDROME;

AGING; ANIMALS; CELL AGING; DISEASE; HUMANS; MODELS, BIOLOGICAL; SYNDROME; TELOMERASE; TELOMERE;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0035978931     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00223-8     Document Type: Review

References (94)

1. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
2. Telomere reduction in human liver tissues with age and chronic inflammation
3. Telomere length predicts replicative capacity of human fibroblasts
4. Telomere shortening is associated with cell division in vitro and in vivo
5. Mice without telomerase: What can they teach us about human cancer?
6. Chromosome ends in Drosophila without telomeric DNA sequences
7. Addition of telomere-associated HeT DNA sequences heal broken chromosome ends in Drosophila
8. The Werner syndrome protein contributes to induction of p53 by DNA damage
9. Functional characterization and developmental regulation of mouse telomerase RNA
10. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
11. Extension of life-span by introduction of telomerase into normal human cells
12. Genetic diseases of premature aging as models of senescence
13. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
14. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
15. Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization
16. Mammalian telomeres and telomerase
17. Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
18. Telomere length and replicative aging in human vascular tissues
19. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
20. Olovnikov's clock: Telomeres and vascular biology
21. Shorter telomeres in dystrophic muscle consistent with extensive regeneration in young children
22. Telomeres, telomerase and cancer: An up-date
23. Normal telomere lengths in young mothers of children with Down's syndrome
24. The rate of telomere sequence loss in human leukocytes varies with age
25. Anti-apoptotic role of telomerase in pheochromocytoma cells
26. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function
27. Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model
28. The Werner syndrome protein is a DNA helicase
29. Mammalian telomeres end in a large duplex loop
30. Molecular model for telomeric heterochromatin in yeast
31. Inhibition of telomerase limits the growth of human cancer cells
32. Creation of human tumour cells with defined genetic elements
33. Telomerase activity is sufficient to allow transformed cells to escape from crisis
34. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro
35. Elongated telomeres in scid mice
36. Telomeres shorten during ageing of human fibroblasts
37. Telomere loss: Mitotic clock or genetic time bomb?
38. Telomere reduction in human colorectal carcinoma and with ageing
39. WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts
40. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
41. Immortalized mouse mammary cells in vivo do not exhibit increased telomerase activity
42. Molecular biology of aging
43. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
44. Specific association of human telomerase activity with immortal cells and cancer
45. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
46. DNA damage and repair in telomeres: Relation to aging
47. Cell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation
48. Essential role of mouse telomerase in highly proliferative organs
49. Gene expression profile of aging and its retardation by caloric restriction
50. Studies of the molecular mechanisms in the regulation of telomerase activity
51. Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans
52. The terminal DNA structure of mammalian chromosomes
53. Applications of telomerase research in the fight against cancer
54. Telomere shortening in kidneys with age
55. Accelerated telomere shortening in ataxia telangiectasia
56. Moyzis, conservation of the human telomere sequence (TTAGGG)n among vertebrates
57. A telomerase component is defective in the human disease dyskeratosis congenita
58. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
59. WRN helicase expression in Werner syndrome cell lines
60. Helicases and aging
61. Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex
62. The telomerase reverse transcriptase: Components and regulation
63. Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A
64. Telomere attrition of the human abdominal aorta: Relationships with age and atherosclerosis
65. Telomeres, telomerase, and aging: Origin of the theory
66. Telomeres and telomerase: More than the end of the line
67. Developmental and tissue-specific regulation of mouse telomerase and telomere length
68. Mitochondria, oxygen free radicals, disease and ageing
69. Telomerase activity concentrates in the mitotically active segments of human hair follicles
70. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
71. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
72. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
73. Transplantation of normal and DMD myoblasts expressing the telomerase gene in SCID mice
74. A role for both RB and p53 in the regulation of human cellular senescence
75. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts
76. Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p
77. Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment
78. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
79. Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase
80. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
81. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
82. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
83. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
84. Risky immortalization by telomerase
85. Human naive and memory T lymphocytes differ in telomeric length and replicative potential
86. Telomere lengthening and telomerase activation during human B cell differentiation
87. Telomeric repeats (TTAGGC)n are sufficient for chromosome capping function in Caenorhabditis elegans
88. Saccharomyces telomeres assume a non-nucleosomal chromatin structure
89. Normal human chromosomes have long G-rich telomeric overhangs at one end
90. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology
91. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
92. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
93. Human endothelial cell life extension by telomerase expression
94. Nuclear structure in normal and Bloom syndrome cells