Genetic mouse models of extended lifespan

Experimental Gerontology

Volumn 38, Issue 11-12, 2003, Pages 1353-1364

  Liang, Hanyu ^a   Masoro, Edward J ^a   Nelson, James F ^a   Strong, Randy ^a,b   McMahan, C Alex ^a   Richardson, Arlan ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Caloric restriction; Dwarf mice; Growth hormone receptor binding protein; Insulin like growth factor I; Insulin receptor

Indexed keywords

BINDING PROTEIN; GROWTH HORMONE RECEPTOR; SOMATOMEDIN RECEPTOR;

AGING; AGRICULTURE; DATA ANALYSIS; EVALUATION; GENE MUTATION; GENETIC ANALYSIS; HETEROZYGOSITY; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALIA; MAMMALIA;

EID: 0347416781     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2003.10.019     Document Type: Article

References (79)

1. Andersen B., Pearse R.V. 2nd, Jenne K., Sornson M., Lin S.C., Bartke A., Rosenfeld M.G. The Ames dwarf gene is required for Pit-1 gene activation. Dev. Biol. 172:1995;495-503.
2. Bartke A. Prolactin-deficient mice. Alexander N.J. Animal Models for Research on Contraception and Fertility. 1979;360-365 Harper & Row, Hagerstown.
3. Bartke A., Brown-Borg H.M., Bode A.M., Carlson J., Hunter W.S., Bronson R.T. Does growth hormone prevent or accelerate aging? Exp. Gerontol. 33:1998;675-687.
4. Bartke A., Wright J.C., Mattison J.A., Ingram D.K., Miller R.A., Roth G.S. Extending the lifespan of long-lived mice. Nature. 414:2001;412.
5. Bellush L.L., Doublier S., Holland A.N., Striker L.J., Striker G.E., Kopchick J.J. Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice. Endocrinology. 141:2000;163-168.
6. Bertrand H.A., Lynd F.T., Masoro E.J., Yu B.P. Changes in adipose tissue mass and cellularity through adult life of rats fed ad libitum or a life-prolonging restricted diet. J. Gerontol. 35:1980;827-835.
7. Blüher M., Michael M.D., Peroni O.D., Ueki K., Carter N., Kahn B.B., Kahn C.R. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell. 3:2002;25-38.
8. Blüher M., Kahn B.B., Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 299:2003;572-574.
9. Brown-Borg H.M., Rakoczy S.G. Catalase expression in delayed and premature aging mouse models. Exp. Gerontol. 35:2000;199-212.
10. Brown-Borg H.M., Borg K.E., Meliska C.J., Bartke A. Dwarf mice and the aging process. Nature. 384:1996;33.
11. Brown-Borg H.M., Bode A.M., Bartke A. Antioxidative mechanisms and plasma growth hormone levels. Endocrine. 11:1999;41-48.
12. Brown-Borg H.M., Johnson W.T., Rakoczy S., Romanick M. Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice. J. Am. Aging Assoc. 85:2001;85-100.
13. Chen H.W., Meier H., Heiniger H.J., Heubner R.J. Tumorigenesis in strain DW/J mice and induction by prolactin of the group-specific antigen of endogenous C-type RNA tumor virus. J. Natl Cancer Inst. 49:1972;1145-1154.
14. Cheng T.C., Beamer W.G., Phillip J.A., Bartke A., Mallonee R.L., Dowling C. Etiology of growth hormone deficiency in little, Ames and Snell dwarf mice. Endocrinology. 113:1983;1669-1678.
15. Coschigano K.T., Clemmons D., Bellush L.L., Kopchick J.J. Assessment of growth parameters and lifespan of GHR/BP gene-disrupted mice. Endocrinology. 141:2000;2608-2613.
16. Coschigano K.T., Holland A.N., Riders M.E., List E.O., Flyvbjerg A., Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology. 144:2003;3799-3810.
17. Cross R.J., Bryson J.S., Roszman T.L. Immunologic disparity in the hypopituitary dwarf mouse. J. Immunol. 148:1992;1347-1352.
18. D'Costa A.P., Lehham J.E., Ingram R.L., Sonntag W.E. Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats. Mech. Ageing Dev. 71:1993;59-71.
19. Dominici F.P., Hauck S., Argentino D.P., Bartke A., Turyn D. Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. J. Endocrinol. 173:2002;81-94.
20. Dominici F.P., Argentino D.P., Bartke A., Turyn D. The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver. Mech. Ageing Dev. 124:2003;819-827.
21. Dumont F., Robert F., Bischoff P. T and B lymphocytes in pituitary dwarf Snell-Bagg mice. Immunology. 38:1979;23-32.
22. Eicher E.M., Beamer W.G. New mouse dw allele: genetic location and effects on lifespan and growth hormone levels. J. Hered. 71:1980;187-190.
23. Flurkey K.F., Harrison D.E. Use of genetic models to investigate the hypophyseal regulation of senescence. Harrison D.E. Genetic Effects on Aging II. 1990;435-456 The Telford Press, Caldwell, NJ.
24. Flurkey K., Papaconstantinou J., Miller R.A., Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA. 98:2001;6736-6741.
25. Flurkey K., Papaconstantinou J., Harrison D.E. The Snell dwarf mutation Pit1(dw) can increase lifespan in mice. Mech. Ageing Dev. 123:2002;121-130.
26. Godfrey P., Rahal J.O., Beamer W.G., Copeland N.G., Jenkins N.A., Mayo K.E. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat. Genet. 4:1993;227-232.
27. Grüneberg H. The Genetics of the Mouse. 1952;Martinus Nijhoff, The Hague. pp. 122-129.
28. Guarente L., Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 408:2000;255-262.
29. Harrison D.E., Archer J.R., Astole C.M. Effects of food restriction on aging: separation of food intake and adiposity. Proc. Natl Acad. Sci. USA. 81:1984;1835-1838.
30. Hauck S.J., Bartke A. Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase. Free Radic. Biol. Med. 28:2001;970-978.
31. Hauck S.J., Aaron J.M., Wright C., Kopchick J.J., Bartke A. Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice. Horm. Metab. Res. 34:2002;481-486.
32. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 421:2003;182-187.
33. Hsieh C.C., DeFord J.H., Flurkey K., Harrison D.E., Papaconstantinou J. Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm. Mech. Ageing Dev. 123:2002;1229-1244.
34. Hunter W.S., Croson W.B., Bartke A., Gentry M.V., Meliska C.J. Low body temperature in long-lived Ames dwarf mice at rest and during stress. Physiol. Behav. 67:1999;433-437.
35. Ikeno Y., Bronson R.T., Hubbard G.B., Lee S., Bartke A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 58:2003;291-296.
36. Iwasaki K., Gleiser C.A., Masoro E.J., McMahan C.A., Seo E.J., Yu B.P. The influences of dietary protein source on longevity and age-related disease processes of Fischer rats. J. Gerontol. 43:1988;B5-B12.
37. Johnson T.E. A personal retrospective on the genetics of aging. Biogerontology. 3:2002;7-12.
38. Johnson T.E., de Castro E., Hegi de Castro S., Cypser J., Henderson S., Tedesco P. Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans. Exp. Gerontol. 36:2001;1609-1617.
39. Johnson T.E., Henderson S., Murakami S., de Castro E., de Castro S.H., Cypser J., Rikke B., Tedesco P., Link C. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. J. Inherit. Metab. Dis. 25:2002;197-206.
40. Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 366:1993;461-464.
41. Kinney B.A., Meliska C.J., Steger R.W., Bartke A. Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 39:2001;277-284.
42. Kinney B.A., Coschigano K.T., Kopchick J.J., Steger R.W., Bartke A. Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol. Behav. 72:2001;653-660.
43. Li S., Crenshaw B.E. III, Rawson E.J., Simmons D.M., Swanson L.W., Rosenfeld M.G. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature. 347:1990;528-533.
44. Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 418:2002;344-348.
45. Lithgow G.J. Invertebrate gerontology: the age mutations of Caenorhabditis elegans. BioEssays. 18:1996;809-815.
46. Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75:1993;59-72.
47. Maeda H., Gleiser C.A., Masoro E.J., McMahan C.A., Seo E.-J., Yu B.P. Nutritional influences in aging of Fischer 344 rats. II. Pathology. J. Gerontol. 40:1985;671-688.
48. Martin G.M., Austad S.N., Johnson T.E. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat. Genet. 13:1996;25-34.
49. Masoro E.J. Food restriction in rodents: an evaluation of its role in the study of aging. J. Gerontol. 43:1988;B59-B64.
50. Masoro E.J. Dietary restriction and aging. J. Am. Geriatr. Soc. 41:1993;994-999.
51. Masoro E.J. Diet and the aging processes. Clin. J. Sport Med. 4:1994;262-267.
52. Masoro E.J. Caloric restriction and aging: an update. Exp. Gerontol. 35:2000;299-305.
53. Masoro E.J. Caloric Restriction: A Key to Understanding and Modulating Aging. 2002;Elsevier Science, Amsterdam.
54. Masoro E.J., Iwasaki K., Gleiser C.A., McMahan C.A., Seo E.J., Yu B.P. Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein. Am. J. Clin. Nutr. 49:1989;1217-1227.
55. Masoro E.J., Katz M.S., McMahan C.A. Evidence for the glycation hypothesis of aging from the food-restricted rodent model. J. Gerontol. 44:1989;B20-B22.
56. Masoro E.J., Shimokawa I., Yu B.P. Retardation of the aging processes in rats by food restriction. Ann. N Y Acad. Sci. 621:1991;337-352.
57. Masoro E.J., McCarter R.J.M., Katz M.S., McMahan C.A. Dietary restriction alters characteristics of glucose fule use. J. Gerontol. 47:1992;B2202-B2208.
58. McCay C.M., Crowell M.F., Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 10:1935;63-79.
59. Migliaccio E., Mele S., Salcini A.E., Pelicci G., Lai K.M., Superti-Furga G., Pawson T., Di Fiore P.P., Lanfrancone L., Pelicci P.G. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J. 16:1997;706-716.
60. Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., Lanfrancone L., Pelicci P.G. The p66shc adaptor protein controls oxidative stress response and lifespan in mammals. Nature. 402:1999;309-313.
61. Miller R.A. Kleemeier award lecture: are there genes for aging? J. Gerontol. 54:1999;B297-B307.
62. Murakami S., Salmon A., Miller R.A. Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J. 17:2003;1565-1566.
63. Napoli C., Martin-Padura I., de Nigris F., Giorgio M., Mansueto G., Somma P., Condorelli M., Sica G., De Rosa G., Pelicci P. Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc. Natl Acad. Sci. USA. 100:2003;2112-2116.
64. Nemoto S., Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science. 295:2002;2450-2452.
65. Orr W.C., Mockett R.J., Benes J.J., Sohal R.S. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. J. Biol. Chem. 278:2003;26418-26422.
66. Partridge L., Gems D. Mechanisms of ageing: public or private? Nat. Genet. 3:2002;165-178.
67. Schaible R., Gowen J.W. A new dwarf mouse. Genetics. 46:1961;896.
68. Shimokawa I., Yu B.P., Higami Y., Ikeda T., Masoro E.J. DR retards onset but not progression of leukemia in male F344 rats. J. Gerontol. 48:1993;B68-B73.
69. Smith G.S., Walford R.L., Mickey M.R. Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J. Natl Cancer Inst. 50:1973;1195-1213.
70. Snell G.D. Dwarf, a new Mendelian recessive character of the house mouse. Proc. Natl Acad. Sci. USA. 15:1929;733-734.
71. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 273:1996;59-63.
72. Sonntag W.E., Lynch C.D., Cefalu W.T., Ingram R.L., Bennett S.A., Thornton P.L., Kahn A.S. Pleitropic effects of growth hormone and insulin-like growth factor (IGF)-I on biological aging: inferences from moderate caloric-restricted animals. J. Gerontol. 54A:1999;B521-B538.
73. Storer J.B. Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21:1966;404-409.
74. Trinei M., Giorgio M., Cicalese A., Barozzi S., Ventura A., Migliaccio E., Milia E., Padura I.M., Raker V.A., Maccarana M., Petronilli V., Minucci S., Bernardi P., Lanfrancone L., Pelicci P.G. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 21:2002;3872-3878.
75. Van Remmen H., Ikeno Y., Hamilton M., Pahlavani M., Wolf N., Thorpe S.R., Alderson N.L., Baynes J.W., Epstein C.J., Huang T.-T., Nelson J., Strong R., Richardson A. Lifelong reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics. 2003;. in press.
76. Weindruch R., Walford R.L. The retardation of aging and disease by dietary restriction. 1988;Thomas, Springfield, IL.
77. Yu B.P., Masoro E.J., Murata I., Bertrand H.A., Lynd F.T. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass, and disease. J. Gerontol. 37:1982;130-141.
78. Yu B.P., Masoro E.J., McMahan C.A. Nutritional influences on aging of Fischer 344 rats. I. Physical, metabolic, and longevity characteristics. J. Gerontol. 40:1985;657-670.
79. Zhou Y., Xu B.C., Maheshwari H.G., He L., Reed M., Lozykowski M., Okada S., Cataldo L., Coschigamo K., Wagner T.E., Baumann G., Kopchick J.J. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc. Natl Acad. Sci. USA. 94:1997;13215-13220.