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Volumn 20, Issue 8, 2000, Pages 2803-2808

Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; PROTEIN P53;

EID: 0034114544     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.8.2803-2808.2000     Document Type: Article
Times cited : (161)

References (59)
  • 2
    • 0029114679 scopus 로고
    • Telomeres and telomerase in human cancer
    • Bacchetti, S., and C. M. Counter. 1995. Telomeres and telomerase in human cancer. Int. J. Oncol. 7:423-432.
    • (1995) Int. J. Oncol. , vol.7 , pp. 423-432
    • Bacchetti, S.1    Counter, C.M.2
  • 3
    • 0032572792 scopus 로고    scopus 로고
    • DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site
    • Blaydes, J. P., and T. Hupp. 1998. DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site. Oncogene 17:1045-1052.
    • (1998) Oncogene , vol.17 , pp. 1045-1052
    • Blaydes, J.P.1    Hupp, T.2
  • 5
    • 0028261160 scopus 로고
    • Escape from senescence in human diploid fibroblasts induced directly by mutant p53
    • Bond, J. A., F. S. Wyllie, and D. Wynford-Thomas. 1994. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9:1885-1889.
    • (1994) Oncogene , vol.9 , pp. 1885-1889
    • Bond, J.A.1    Wyllie, F.S.2    Wynford-Thomas, D.3
  • 7
    • 0029841549 scopus 로고    scopus 로고
    • Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
    • Bond, J. A., M. Haughton, J. Blaydes, V. Gire, D. Wynford-Thomas, and F. Wyllie. 1996. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. Oncogene 13:2097-2104.
    • (1996) Oncogene , vol.13 , pp. 2097-2104
    • Bond, J.A.1    Haughton, M.2    Blaydes, J.3    Gire, V.4    Wynford-Thomas, D.5    Wyllie, F.6
  • 8
    • 0033600158 scopus 로고    scopus 로고
    • p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts
    • Bond, J. A., K. Webley, F. S. Wyllie, C. J. Jones, A. Craig, T. Hupp, and D. Wynford-Thomas. 1999. p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts. Oncogene 18:3788-3792.
    • (1999) Oncogene , vol.18 , pp. 3788-3792
    • Bond, J.A.1    Webley, K.2    Wyllie, F.S.3    Jones, C.J.4    Craig, A.5    Hupp, T.6    Wynford-Thomas, D.7
  • 11
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • Campisi, J. 1997. The biology of replicative senescence. Eur. J. Cancer 33:703-709.
    • (1997) Eur. J. Cancer , vol.33 , pp. 703-709
    • Campisi, J.1
  • 12
    • 0028171182 scopus 로고
    • The p53-dependent G1 cell cycle checkpoint pathway and ataxiatelangiectasia
    • Canman, C. E., A. C. Wolff, C. Y. Chen, A. J. Fornace, Jr., and M. B. Kastan. 1994. The p53-dependent G1 cell cycle checkpoint pathway and ataxiatelangiectasia. Cancer Res. 54:5054-5058.
    • (1994) Cancer Res. , vol.54 , pp. 5054-5058
    • Canman, C.E.1    Wolff, A.C.2    Chen, C.Y.3    Fornace A.J., Jr.4    Kastan, M.B.5
  • 13
    • 0033523777 scopus 로고    scopus 로고
    • Dephosphorylation of human p53 at serine20 following cellular exposure to low levels of non-ionizing radiation
    • Craig, A., J. Blaydes, L. Burch, A. Thompson, and T. Hupp. 1999. Dephosphorylation of human p53 at serine20 following cellular exposure to low levels of non-ionizing radiation. Oncogene 18:6305-6312.
    • (1999) Oncogene , vol.18 , pp. 6305-6312
    • Craig, A.1    Blaydes, J.2    Burch, L.3    Thompson, A.4    Hupp, T.5
  • 14
    • 0033567340 scopus 로고    scopus 로고
    • Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
    • Craig, A. L., L. Burch, B. Vojtesek, J. Mikutowska, A. Thompson, and T. R. Hupp. 1999. Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers. Biochem. J. 342:133-141.
    • (1999) Biochem. J. , vol.342 , pp. 133-141
    • Craig, A.L.1    Burch, L.2    Vojtesek, B.3    Mikutowska, J.4    Thompson, A.5    Hupp, T.R.6
  • 15
    • 0343504749 scopus 로고
    • Telomere dynamics and genome instability in human cancer
    • de Lange, T. 1995. Telomere dynamics and genome instability in human cancer. Cold Spring Harbor Monogr. Ser. 10:1-27.
    • (1995) Cold Spring Harbor Monogr. Ser. , vol.10 , pp. 1-27
    • De Lange, T.1
  • 16
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo, A., S. P. Linke, K. Clarkin, and G. M. Wahl. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:2540-2551.
    • (1994) Genes Dev. , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 17
    • 0030900592 scopus 로고    scopus 로고
    • Extension of the replicative lifespan of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor
    • Garkavtsev, I., and K. Riabowol. 1997. Extension of the replicative lifespan of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. Mol. Cell. Biol. 17:2014-2019.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2014-2019
    • Garkavtsev, I.1    Riabowol, K.2
  • 19
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A. J., and M. B. Kastan. 1998. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12:2973-2983.
    • (1998) Genes Dev. , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 20
    • 0031935827 scopus 로고    scopus 로고
    • Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
    • Gire, V., and D. Wynford-Thomas. 1998. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol. 18:1611-1621.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1611-1621
    • Gire, V.1    Wynford-Thomas, D.2
  • 21
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu, W., and R. G. Roeder. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 22
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 23
    • 0028673142 scopus 로고
    • Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases
    • Hupp, T. R., and D. P. Lane. 1994. Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. Cold Spring Harbor Symp. Quant. Biol. 59:195-206.
    • (1994) Cold Spring Harbor Symp. Quant. Biol. , vol.59 , pp. 195-206
    • Hupp, T.R.1    Lane, D.P.2
  • 24
    • 0028519273 scopus 로고
    • Allosteric activation of latent p53 tetramers
    • Hupp, T. R., and D. P. Lane. 1994. Allosteric activation of latent p53 tetramers. Curr. Biol. 4:865-875.
    • (1994) Curr. Biol. , vol.4 , pp. 865-875
    • Hupp, T.R.1    Lane, D.P.2
  • 25
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • Hupp, T. R., A. Sparks, and D. P. Lane. 1995. Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83:237-245.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 27
    • 0032539816 scopus 로고    scopus 로고
    • Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation
    • Kapoor, M., and G. Lozano. 1998. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation. Proc. Natl. Acad. Sci. USA 95:2834-2837.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2834-2837
    • Kapoor, M.1    Lozano, G.2
  • 29
    • 0028924516 scopus 로고
    • Increased p53 protein associated with aging in human diploid fibroblasts
    • Kulju, K. S., and J. M. Lehman. 1995. Increased p53 protein associated with aging in human diploid fibroblasts. Exp. Cell Res. 217:336-345.
    • (1995) Exp. Cell Res. , vol.217 , pp. 336-345
    • Kulju, K.S.1    Lehman, J.M.2
  • 30
    • 0033536164 scopus 로고    scopus 로고
    • The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
    • Lakin, N., B. Hann, and S. Jackson. 1999. The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene 18:3989-3995.
    • (1999) Oncogene , vol.18 , pp. 3989-3995
    • Lakin, N.1    Hann, B.2    Jackson, S.3
  • 31
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D. P. 1992. p53, guardian of the genome. Nature 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 32
    • 0029062595 scopus 로고
    • Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants
    • Lin, J., A. K. Teresky, and A. J. Levine. 1995. Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants. Oncogene 10:2387-2390.
    • (1995) Oncogene , vol.10 , pp. 2387-2390
    • Lin, J.1    Teresky, A.K.2    Levine, A.J.3
  • 33
    • 0030938259 scopus 로고    scopus 로고
    • p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation
    • Linke, S. P., K. C. Clarkin, and G. M. Wahl. 1997. p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation. Cancer Res. 57:1171-1179.
    • (1997) Cancer Res. , vol.57 , pp. 1171-1179
    • Linke, S.P.1    Clarkin, K.C.2    Wahl, G.M.3
  • 35
    • 0032568633 scopus 로고    scopus 로고
    • Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
    • Lu, H., Y. Taya, M. Ikeda, and A. J. Levine. 1998. Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389. Proc. Natl. Acad. Sci. USA 95:6399-6402.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6399-6402
    • Lu, H.1    Taya, Y.2    Ikeda, M.3    Levine, A.J.4
  • 36
    • 0025221676 scopus 로고
    • Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein
    • Milner, J., and J. V. Watson. 1990. Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein. Oncogene 5:1683-1690.
    • (1990) Oncogene , vol.5 , pp. 1683-1690
    • Milner, J.1    Watson, J.V.2
  • 37
    • 0030816303 scopus 로고    scopus 로고
    • Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential
    • Mundt, M., T. Hupp, M. Fritsche, C. Merkle, S. Hansen, D. Lane, and B. Groner. 1997. Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential. Oncogene 15:237-244.
    • (1997) Oncogene , vol.15 , pp. 237-244
    • Mundt, M.1    Hupp, T.2    Fritsche, M.3    Merkle, C.4    Hansen, S.5    Lane, D.6    Groner, B.7
  • 38
    • 0031010341 scopus 로고    scopus 로고
    • The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: The role of telomerase reactivation
    • Parkinson, E. K., R. F. Newbold, and W. N. Keith. 1997. The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: the role of telomerase reactivation. Eur. J. Cancer 33:727-734.
    • (1997) Eur. J. Cancer , vol.33 , pp. 727-734
    • Parkinson, E.K.1    Newbold, R.F.2    Keith, W.N.3
  • 39
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives, C. 1998. Signaling to p53: breaking the MDM2-p53 circuit. Cell 95:5-8.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 40
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives, C., and P. Hall. 1999. The p53 pathway. J. Pathol. 187:112-126.
    • (1999) J. Pathol. , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.2
  • 41
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles, S. J., and G. R. Adami. 1998. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16:1113-1123.
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 43
    • 0030071548 scopus 로고    scopus 로고
    • Regulation of specific DNA binding by p53: Evidence for a role for O-glycosylation and charged residues at the carboxy-terminus
    • Shaw, P., J. Freeman, R. Bovey, and R. Iggo. 1996. Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. Oncogene 12:921-930.
    • (1996) Oncogene , vol.12 , pp. 921-930
    • Shaw, P.1    Freeman, J.2    Bovey, R.3    Iggo, R.4
  • 44
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh, S. Y., M. Ikeda, Y. Taya, and C. Prives. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 46
    • 0028915250 scopus 로고
    • Characterisation of epitopes on human p53 using phage-displayed peptide libraries: Insights into antibody-peptide interactions
    • Stephen, C. W., P. Helminen, and D. P. Lane. 1995. Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions. J. Mol. Biol. 248:58-78.
    • (1995) J. Mol. Biol. , vol.248 , pp. 58-78
    • Stephen, C.W.1    Helminen, P.2    Lane, D.P.3
  • 47
    • 0028966935 scopus 로고
    • Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
    • Takenaka, I., F. Morin, B. R. Seizinger, and N. Kley. 1995. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases. J. Biol. Chem. 270:5405-5411.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5405-5411
    • Takenaka, I.1    Morin, F.2    Seizinger, B.R.3    Kley, N.4
  • 49
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 50
    • 0030761351 scopus 로고    scopus 로고
    • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase
    • Vaziri, H., M. D. West, R. C. Allsopp, T. S. Davison, Y.-S. Wu, C. H. Arrowsmith, G. G. Poirier, and S. Benchimol. 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase. EMBO J. 16:6018-6033.
    • (1997) EMBO J. , vol.16 , pp. 6018-6033
    • Vaziri, H.1    West, M.D.2    Allsopp, R.C.3    Davison, T.S.4    Wu, Y.-S.5    Arrowsmith, C.H.6    Poirier, G.G.7    Benchimol, S.8
  • 51
    • 0026769713 scopus 로고
    • An immunochemical analysis of the human nuclear phosphoprotein p53
    • Vojtesek, B., J. Bartek, C. A. Midgley, and D. P. Lane. 1992. An immunochemical analysis of the human nuclear phosphoprotein p53. J. Immunol. Methods 151:237-244.
    • (1992) J. Immunol. Methods , vol.151 , pp. 237-244
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3    Lane, D.P.4
  • 53
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman, M. J., E. S. Stavridi, J. L. Waterman, and T. D. Halazonetis. 1998. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19:175-178.
    • (1998) Nat. Genet. , vol.19 , pp. 175-178
    • Waterman, M.J.1    Stavridi, E.S.2    Waterman, J.L.3    Halazonetis, T.D.4
  • 54
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo, R. A., K. G. McLure, S. P. Lees-Miller, D. E. Rancourt, and P. W. K. Lee. 1998. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394:700-704.
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.K.5
  • 55
    • 0028981143 scopus 로고
    • Time, telomeres and tumours: Is cellular senescence more than an anticancer mechanism?
    • Wright, W. E., and J. W. Shay. 1995. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism? Trends Cell Biol. 5:293-297.
    • (1995) Trends Cell Biol. , vol.5 , pp. 293-297
    • Wright, W.E.1    Shay, J.W.2
  • 56
    • 0029916635 scopus 로고    scopus 로고
    • S phase cell-cycle arrest following DNA damage is independent of the p53/p21 WAF1 signalling pathway
    • Wyllie, F. S., M. F. Haughton, J. A. Bond, J. M. Rowson, C. J. Jones, and D. Wynford-Thomas. 1996. S phase cell-cycle arrest following DNA damage is independent of the p53/p21 WAF1 signalling pathway. Oncogene 12:1077-1082.
    • (1996) Oncogene , vol.12 , pp. 1077-1082
    • Wyllie, F.S.1    Haughton, M.F.2    Bond, J.A.3    Rowson, J.M.4    Jones, C.J.5    Wynford-Thomas, D.6
  • 58
    • 0028910530 scopus 로고
    • Does telomere shortening drive selection for p53 mutation in human cancer?
    • Wynford-Thomas, D., J. A. Bond, F. S. Wyllie, and C. J. Jones. 1995. Does telomere shortening drive selection for p53 mutation in human cancer? Mol. Carcinog. 12:119-123.
    • (1995) Mol. Carcinog. , vol.12 , pp. 119-123
    • Wynford-Thomas, D.1    Bond, J.A.2    Wyllie, F.S.3    Jones, C.J.4
  • 59
    • 0030917098 scopus 로고    scopus 로고
    • Proliferative lifespan checkpoints: Cell-type specificity and influence on tumour biology
    • Wynford-Thomas, D. 1997. Proliferative lifespan checkpoints: cell-type specificity and influence on tumour biology. Eur. J. Cancer 33:716-726.
    • (1997) Eur. J. Cancer , vol.33 , pp. 716-726
    • Wynford-Thomas, D.1


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