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Volumn 113, Issue 2, 2004, Pages 160-168

Telomeres, stem cells, senescence, and cancer

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

EID: 85047689866     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI20761     Document Type: Review
Times cited : (431)

References (123)
  • 1
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente, L., and Kenyon, C. 2000. Genetic pathways that regulate ageing in model organisms. Nature. 408:255-262.
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 2
    • 0035370372 scopus 로고    scopus 로고
    • Insulin/IGF signalling and ageing: Seeing the bigger picture
    • Gems, D., and Partridge, L. 2001. Insulin/IGF signalling and ageing: seeing the bigger picture. Curr. Opin. Genet. Dev. 11:287-292.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 287-292
    • Gems, D.1    Partridge, L.2
  • 3
    • 0037062496 scopus 로고    scopus 로고
    • Chromosome translocations and covert leukemic clones are generated during normal fetal development
    • Mori, H., et al. 2002. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc. Natl. Natl. Acad. Sci. U. S. A. 99:8242-8247.
    • (2002) Proc. Natl. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 8242-8247
    • Mori, H.1
  • 5
    • 0035989631 scopus 로고    scopus 로고
    • Historical claims and current interpretations of replicative aging
    • Wright, W.E., and Shay, J.W. 2002. Historical claims and current interpretations of replicative aging. Nat. Biotechnol. 20:682-688.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 682-688
    • Wright, W.E.1    Shay, J.W.2
  • 6
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi, J. 2001. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11:S27-S31.
    • (2001) Trends Cell Biol. , vol.11
    • Campisi, J.1
  • 7
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • Kamijo, T., et al. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 91:649-659.
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1
  • 8
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • Stein, G.H., Drullinger, L.F., Soulard, A., and Dulic, V. 1999. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 19:2109-2117.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 9
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D.A., et al. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 93:13742-13747.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1
  • 10
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage, J., Miller, A.L., Perez-Mancera, P.A., Wysocki, J.M., and Jacks, T. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 11
    • 0036884829 scopus 로고    scopus 로고
    • The retinoblastoma tumour suppressor in development and cancer
    • Classon, M., and Harlow, E. 2002. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer. 2:910-917.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 910-917
    • Classon, M.1    Harlow, E.2
  • 12
    • 0034703742 scopus 로고    scopus 로고
    • p53: Death star
    • Vousden, K.H. 2000. p53: death star. Cell. 103:691-694.
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 13
    • 0037067656 scopus 로고    scopus 로고
    • p53: Good cop/bad cop
    • Sharpless, N.E., and DePinho, R.A. 2002. p53: good cop/bad cop. Cell. 110:9-12.
    • (2002) Cell , vol.110 , pp. 9-12
    • Sharpless, N.E.1    DePinho, R.A.2
  • 14
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell. 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 15
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz, J., et al. 1998. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell. 92:713-723.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1
  • 16
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy, F., et al. 1998. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12:2424-2433.
    • (1998) Genes Dev. , vol.12 , pp. 2424-2433
    • Zindy, F.1
  • 17
    • 0032146795 scopus 로고    scopus 로고
    • E1A signaling to p53 involves the p19(ARF) tumor suppressor
    • de Stanchina, E., et al. 1998. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev. 12:2434-2442.
    • (1998) Genes Dev. , vol.12 , pp. 2434-2442
    • De Stanchina, E.1
  • 18
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Xiong, Y., and Yarbrough, W.G. 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 19
    • 0032169516 scopus 로고    scopus 로고
    • The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
    • Stott, F.J., et al. 1998. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J. 17:5001-5014.
    • (1998) EMBO J. , vol.17 , pp. 5001-5014
    • Stott, F.J.1
  • 20
    • 0032493350 scopus 로고    scopus 로고
    • Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
    • Kamijo, T., et al. 1998. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. U. S. A. 95:8292-8297.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8292-8297
    • Kamijo, T.1
  • 21
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu, J., Woods, D., McMahon, M., and Bishop, J.M. 1998. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12:2997-3007.
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 22
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D., and Lowe, S.W. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 23
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin, A.W., et al. 1998. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12:3008-3019.
    • (1998) Genes Dev. , vol.12 , pp. 3008-3019
    • Lin, A.W.1
  • 24
    • 0030612349 scopus 로고    scopus 로고
    • Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
    • Zindy, F., Quelle, D.E., Roussel, M.F., and Sherr, C.J. 1997. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene. 15:203-211.
    • (1997) Oncogene , vol.15 , pp. 203-211
    • Zindy, F.1    Quelle, D.E.2    Roussel, M.F.3    Sherr, C.J.4
  • 25
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: Roles of the p53 and p16 pathways
    • Beausejour, C.M., et al. 2003. Reversal of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J. 22:4212-4222.
    • (2003) EMBO J. , vol.22 , pp. 4212-4222
    • Beausejour, C.M.1
  • 26
    • 0037686707 scopus 로고    scopus 로고
    • Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
    • Dirac, A.M., and Bernards, R. 2003. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J. Biol. Chem. 278:11731-11734.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11731-11734
    • Dirac, A.M.1    Bernards, R.2
  • 27
    • 0031935827 scopus 로고    scopus 로고
    • Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
    • Gire, V., and Wynford-Thomas, D. 1998. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol. 18:1611-1621.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1611-1621
    • Gire, V.1    Wynford-Thomas, D.2
  • 29
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita, M., et al. 2003. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 113:703-716.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1
  • 30
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong, K.K., et al. 2003. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421:643-648.
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1
  • 31
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph, K.L., et al. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:701-712.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1
  • 32
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • Lee, H.W., et al. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:569-574.
    • (1998) Nature , vol.392 , pp. 569-574
    • Lee, H.W.1
  • 33
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S.W., Ruley, H.E., Jacks, T., and Housman, D.E. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 34
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach, E., et al. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature. 352:345-347.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1
  • 35
    • 0036527761 scopus 로고    scopus 로고
    • Dissecting p53 tumor suppressor functions in vivo
    • Schmitt, C.A., et al. 2002. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell. 1:289-298.
    • (2002) Cancer Cell , vol.1 , pp. 289-298
    • Schmitt, C.A.1
  • 36
    • 0034909856 scopus 로고    scopus 로고
    • Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability
    • Lu, X., et al. 2001. Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability. Mol. Cell. Biol. 21:6017-6030.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6017-6030
    • Lu, X.1
  • 37
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L., et al. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1
  • 38
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi, S.E., et al. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1
  • 39
    • 0035815695 scopus 로고    scopus 로고
    • The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
    • Ausserlechner, M.J., et al. 2001. The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels. J. Biol. Chem. 276:10984-10989.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10984-10989
    • Ausserlechner, M.J.1
  • 40
    • 0036499117 scopus 로고    scopus 로고
    • Transgenic expression of the p16(INK4a) cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8-immature thymocytes
    • Lagresle, C., et al. 2002. Transgenic expression of the p16(INK4a) cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8-immature thymocytes. J. Immunol. 168:2325-2331.
    • (2002) J. Immunol. , vol.168 , pp. 2325-2331
    • Lagresle, C.1
  • 41
    • 0034683576 scopus 로고    scopus 로고
    • A novel function for the tumor suppressor p16(INK4a): Induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor
    • Plath, T., et al. 2000. A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor. J. Cell Biol. 150:1467-1478.
    • (2000) J. Cell Biol. , vol.150 , pp. 1467-1478
    • Plath, T.1
  • 42
    • 0036021890 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo
    • Tamm, I., et al. 2002. Adenovirus-mediated gene transfer of P16INK4/ CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo. Cancer Gene Ther. 9:641-650.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 641-650
    • Tamm, I.1
  • 43
    • 0037178761 scopus 로고    scopus 로고
    • Connecting chromosomes, crisis, and cancer
    • Maser, R.S., and DePinho, R.A. 2002. Connecting chromosomes, crisis, and cancer. Science. 297:565-569.
    • (2002) Science , vol.297 , pp. 565-569
    • Maser, R.S.1    DePinho, R.A.2
  • 44
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange, T. 2002. Protection of mammalian telomeres. Oncogene. 21:532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 45
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., Smogorzewska, A., and de Lange, T. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 46
    • 0037382414 scopus 로고    scopus 로고
    • Erosion of the telomeric single-strand overhang at replicative senescence
    • Stewart, S.A., et al. 2003. Erosion of the telomeric single-strand overhang at replicative senescence. Nat. Genet. 33:492-496.
    • (2003) Nat. Genet. , vol.33 , pp. 492-496
    • Stewart, S.A.1
  • 47
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi, K., et al. 2003. Telomerase maintains telomere structure in normal human cells. Cell. 114:241-253.
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1
  • 48
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli, D., Young, J.W., and de Lange, T. 1995. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. U. S. A. 92:9082-9086.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9082-9086
    • Broccoli, D.1    Young, J.W.2    De Lange, T.3
  • 49
    • 0028938262 scopus 로고
    • Telomerase activity in normal leukocytes and in hematologic malignancies
    • Counter, C.M., Gupta, J., Harley, C.B., Leber, B., and Bacchetti, S. 1995. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood. 85:2315-2320.
    • (1995) Blood , vol.85 , pp. 2315-2320
    • Counter, C.M.1    Gupta, J.2    Harley, C.B.3    Leber, B.4    Bacchetti, S.5
  • 50
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright, W.E., Piatyszek, M.A., Rainey, W.E., Byrd, W., and Shay, J.W. 1996. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18:173-179.
    • (1996) Dev. Genet. , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 51
    • 0029894199 scopus 로고    scopus 로고
    • Regulated expression of telomerase activity in human T lymphocyte development and activation
    • Weng, N.P., Levine, B.L., June, C.H., and Hodes, R.J. 1996. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183:2471-2479.
    • (1996) J. Exp. Med. , vol.183 , pp. 2471-2479
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 52
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar, A.G., et al. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 53
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A., and de Lange, T. 2002. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21:4338-4348.
    • (2002) EMBO J. , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    De Lange, T.2
  • 54
    • 0000146723 scopus 로고    scopus 로고
    • Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
    • Greenberg, RA., et al. 1999. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 97:515-525.
    • (1999) Cell , vol.97 , pp. 515-525
    • Greenberg, R.A.1
  • 55
    • 0031899814 scopus 로고    scopus 로고
    • Inactivation of p16 in human mammary epithelial cells by CpG island methylation
    • Foster, S.A., Wong, D.J., Barrett, M.T., and Galloway, D.A. 1998. Inactivation of p16 in human mammary epithelial cells by CpG island methylation. Mol. Cell. Biol. 18:1793-1801.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1793-1801
    • Foster, S.A.1    Wong, D.J.2    Barrett, M.T.3    Galloway, D.A.4
  • 56
    • 0032528623 scopus 로고    scopus 로고
    • Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
    • Huschtscha, L.I., et al. 1998. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res. 58:3508-3512.
    • (1998) Cancer Res. , vol.58 , pp. 3508-3512
    • Huschtscha, L.I.1
  • 57
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono, T., et al. 1998. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature. 396:84-88.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1
  • 58
    • 0032589106 scopus 로고    scopus 로고
    • Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues
    • Nielsen, G.P., et al. 1999. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab. Invest. 79:1137-1143.
    • (1999) Lab. Invest. , vol.79 , pp. 1137-1143
    • Nielsen, G.P.1
  • 59
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C.M., et al. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1
  • 60
    • 0031586324 scopus 로고    scopus 로고
    • Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes
    • Coursen, J.D., Bennett, W.P., Gollahon, L., Shay, J.W., and Harris, C.C. 1997. Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes. Exp. Cell Res. 235:245-253.
    • (1997) Exp. Cell Res. , vol.235 , pp. 245-253
    • Coursen, J.D.1    Bennett, W.P.2    Gollahon, L.3    Shay, J.W.4    Harris, C.C.5
  • 61
    • 0028198679 scopus 로고
    • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
    • Counter, C.M., Botelho, F.M., Wang, P., Harley, C.B., and Bacchetti, S. 1994. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J. Virol. 68:3410-3414.
    • (1994) J. Virol. , vol.68 , pp. 3410-3414
    • Counter, C.M.1    Botelho, F.M.2    Wang, P.3    Harley, C.B.4    Bacchetti, S.5
  • 62
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, R.R. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:4240-4248.
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 63
    • 0030916582 scopus 로고    scopus 로고
    • The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
    • Bryan, T.M., Marusic, L., Bacchetti, S., Namba, M., and Reddel, R.R. 1997. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum. Mol. Genet. 6:921-926.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 921-926
    • Bryan, T.M.1    Marusic, L.2    Bacchetti, S.3    Namba, M.4    Reddel, R.R.5
  • 64
    • 0029072561 scopus 로고
    • Telomerase activity in small-cell and non-small-cell lung cancers
    • Hiyama, K., et al. 1995. Telomerase activity in small-cell and non-small-cell lung cancers. J. Natl. Cancer Inst. 87:895-902.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 895-902
    • Hiyama, K.1
  • 65
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim, N.W., et al. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1
  • 66
    • 84993876589 scopus 로고
    • Correlating telomerase activity levels with human neuroblastoma outcomes
    • Hiyama, E., et al. 1995. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat. Med. 1:249-255.
    • (1995) Nat. Med. , vol.1 , pp. 249-255
    • Hiyama, E.1
  • 67
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn, W.C., et al. 1999. Creation of human tumour cells with defined genetic elements. Nature. 400:464-468.
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 68
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • Gonzalez-Suarez, E., Samper, E., Flores, J.M., and Blasco, M.A. 2000. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 26:114-117.
    • (2000) Nat. Genet. , vol.26 , pp. 114-117
    • Gonzalez-Suarez, E.1    Samper, E.2    Flores, J.M.3    Blasco, M.A.4
  • 69
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph, K.L., Millard, M., Bosenberg, M.W., and DePinho, R.A. 2001. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28:155-159.
    • (2001) Nat. Genet. , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 70
    • 0036782884 scopus 로고    scopus 로고
    • Telomerase: A target for cancer therapeutics
    • Shay, J.W., and Wright, W.E. 2002. Telomerase: a target for cancer therapeutics. Cancer Cell. 2:257-265.
    • (2002) Cancer Cell , vol.2 , pp. 257-265
    • Shay, J.W.1    Wright, W.E.2
  • 71
    • 0035836727 scopus 로고    scopus 로고
    • Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells
    • Strampfer, M.R., et al. 2001. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 98:4498-4503.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 4498-4503
    • Strampfer, M.R.1
  • 72
    • 0037062454 scopus 로고    scopus 로고
    • Constitutive telomerase expression promotes mammary carcinomas in aging mice
    • Artandi, S.E., et al. 2002. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl. Acad. Sci. U. S. A. 99:8191-8196.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 8191-8196
    • Artandi, S.E.1
  • 73
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez, E., et al. 2001. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20:2619-2630.
    • (2001) EMBO J. , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1
  • 74
    • 0037224923 scopus 로고    scopus 로고
    • Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression
    • Chang, S., Khoo, C.M., Naylor, M.L., Maser, R.S., and DePinho, R.A. 2003. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev. 17:88-100.
    • (2003) Genes Dev. , vol.17 , pp. 88-100
    • Chang, S.1    Khoo, C.M.2    Naylor, M.L.3    Maser, R.S.4    DePinho, R.A.5
  • 75
    • 0029681361 scopus 로고    scopus 로고
    • Accelerated telomere shortening in ataxia telangiectasia
    • Metcalfe, J.A., et al. 1996. Accelerated telomere shortening in ataxia telangiectasia. Nat. Genet. 13:350-353.
    • (1996) Nat. Genet. , vol.13 , pp. 350-353
    • Metcalfe, J.A.1
  • 76
    • 0030565541 scopus 로고    scopus 로고
    • Reduced telomere length in ataxia-telangiectasia fibroblasts
    • Xia, S.J., Shammas, M.A., and Shmookler Reis, R.J. 1996. Reduced telomere length in ataxia-telangiectasia fibroblasts. Mutat. Res. 364:1-11.
    • (1996) Mutat. Res. , vol.364 , pp. 1-11
    • Xia, S.J.1    Shammas, M.A.2    Shmookler Reis, R.J.3
  • 77
    • 12944328742 scopus 로고    scopus 로고
    • Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
    • Borghesani, P.R., et al. 2000. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc. Natl. Acad. Sci. U. S. A. 97:3336-3341.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 3336-3341
    • Borghesani, P.R.1
  • 78
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow, C., et al. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. 86:159-171.
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1
  • 79
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu, Y., et al. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:2411-2422.
    • (1996) Genes Dev. , vol.10 , pp. 2411-2422
    • Xu, Y.1
  • 80
    • 0029848286 scopus 로고    scopus 로고
    • Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
    • Elson, A., et al. 1996. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 93:13084-13089.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 13084-13089
    • Elson, A.1
  • 81
    • 0033563099 scopus 로고    scopus 로고
    • Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
    • Liao, M.J., and Van Dyke, T. 1999. Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev. 13:1246-1250.
    • (1999) Genes Dev. , vol.13 , pp. 1246-1250
    • Liao, M.J.1    Van Dyke, T.2
  • 82
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy, T., et al. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature. 413:432-435.
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1
  • 84
    • 0031054261 scopus 로고    scopus 로고
    • Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
    • Miura, N., et al. 1997. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet. Cytogenet. 93:56-62.
    • (1997) Cancer Genet. Cytogenet. , vol.93 , pp. 56-62
    • Miura, N.1
  • 85
    • 10544224540 scopus 로고    scopus 로고
    • Telomere length in human liver diseases
    • Urabe, Y., et al. 1996. Telomere length in human liver diseases. Liver. 16:293-297.
    • (1996) Liver , vol.16 , pp. 293-297
    • Urabe, Y.1
  • 86
    • 18444374159 scopus 로고    scopus 로고
    • Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
    • Wiemann, S.U., et al. 2002. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J. 16:935-942.
    • (2002) FASEB J. , vol.16 , pp. 935-942
    • Wiemann, S.U.1
  • 88
    • 0344990162 scopus 로고    scopus 로고
    • Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders
    • Obana, N., et al. 2003. Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders. Intern. Med. 42:150-153.
    • (2003) Intern. Med. , vol.42 , pp. 150-153
    • Obana, N.1
  • 89
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon, R.M., Smith, K.R., O'Brien, E., Sivatchenko, A., and Kerber, R.A. 2003. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 361:393-395.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 90
    • 0034003333 scopus 로고    scopus 로고
    • A critical role for telomeres in suppressing and facilitating carcinogenesis
    • Artandi, S.E., and DePinho, R.A. 2000. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr. Opin. Genet. Dev. 10:39-46.
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 39-46
    • Artandi, S.E.1    DePinho, R.A.2
  • 91
    • 0000839280 scopus 로고    scopus 로고
    • Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    • O'Hagan, R.C., et al. 2002. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell. 2:149-155.
    • (2002) Cancer Cell , vol.2 , pp. 149-155
    • O'Hagan, R.C.1
  • 92
    • 0032980789 scopus 로고    scopus 로고
    • Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways
    • Buerger, H., et al. 1999. Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. J. Pathol. 187:396-402.
    • (1999) J. Pathol. , vol.187 , pp. 396-402
    • Buerger, H.1
  • 93
    • 0034673232 scopus 로고    scopus 로고
    • Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences
    • Waldman, F.M., et al. 2000. Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. J. Natl. Cancer Inst. 92:313-320.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 313-320
    • Waldman, F.M.1
  • 94
    • 0033016778 scopus 로고    scopus 로고
    • Wide-spread chromosomal abnormalities in high-grade ductal carcinoma in situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS
    • Moore, E., Magee, H., Coyne, J., Gorey, T., and Dervan, P.A. 1999. Wide-spread chromosomal abnormalities in high-grade ductal carcinoma in situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS. J. Pathol. 187:403-409.
    • (1999) J. Pathol. , vol.187 , pp. 403-409
    • Moore, E.1    Magee, H.2    Coyne, J.3    Gorey, T.4    Dervan, P.A.5
  • 95
    • 0033899382 scopus 로고    scopus 로고
    • Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence
    • Walch, A.K., et al. 2000. Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence. Am. J. Pathol. 156:555-566.
    • (2000) Am. J. Pathol. , vol.156 , pp. 555-566
    • Walch, A.K.1
  • 96
    • 0032980212 scopus 로고    scopus 로고
    • Clonal analysis of a case of multifocal oesophageal (Barrett's) adenocarcinoma by comparative genomic hybridization
    • van Dekken, H., Vissers, C.J., Tilanus, H.W., Tanke, H.J., and Rosenberg, C. 1999. Clonal analysis of a case of multifocal oesophageal (Barrett's) adenocarcinoma by comparative genomic hybridization. J. Pathol. 188:263-266.
    • (1999) J. Pathol. , vol.188 , pp. 263-266
    • Van Dekken, H.1    Vissers, C.J.2    Tilanus, H.W.3    Tanke, H.J.4    Rosenberg, C.5
  • 97
    • 0034146097 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence
    • Lord, R.V., et al. 2000. Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence. J. Gastrointest. Surg. 4:135-142.
    • (2000) J. Gastrointest. Surg. , vol.4 , pp. 135-142
    • Lord, R.V.1
  • 98
    • 0029013631 scopus 로고
    • Telomerase activity associated with acquisition of malignancy in human colorectal cancer
    • Chadeneau, C., Hay, K., Hirte, H.W., Gallinger, S., and Bacchetti, S. 1995. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res. 55:2533-2536.
    • (1995) Cancer Res. , vol.55 , pp. 2533-2536
    • Chadeneau, C.1    Hay, K.2    Hirte, H.W.3    Gallinger, S.4    Bacchetti, S.5
  • 99
    • 0030706072 scopus 로고    scopus 로고
    • Telomerase and telomere length in the development and progression of pre-malignant lesions to colorectal cancer
    • Engelhardt, M., Drullinsky, P., Guillem, J., and Moore, M.A. 1997. Telomerase and telomere length in the development and progression of pre-malignant lesions to colorectal cancer. Clin. Cancer Res. 3:1931-1941.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1931-1941
    • Engelhardt, M.1    Drullinsky, P.2    Guillem, J.3    Moore, M.A.4
  • 101
    • 0032531003 scopus 로고    scopus 로고
    • Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis
    • Tang, R., Cheng, A.J., Wang, J.Y., and Wang, T.C. 1998. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis. Cancer Res. 58:4052-4054.
    • (1998) Cancer Res. , vol.58 , pp. 4052-4054
    • Tang, R.1    Cheng, A.J.2    Wang, J.Y.3    Wang, T.C.4
  • 102
    • 0031931107 scopus 로고    scopus 로고
    • Telomerase activity in human proliferative breast lesions
    • Poremba, C., et al. 1998. Telomerase activity in human proliferative breast lesions. Int. J. Oncol. 12:641-648.
    • (1998) Int. J. Oncol. , vol.12 , pp. 641-648
    • Poremba, C.1
  • 103
    • 0030917358 scopus 로고    scopus 로고
    • Telomerase activity in normal and neoplastic breast
    • Tsao, J., et al. 1997. Telomerase activity in normal and neoplastic breast. Clin. Cancer Res. 3:627-631.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 627-631
    • Tsao, J.1
  • 104
    • 0042140590 scopus 로고    scopus 로고
    • Telomere dysfunction: A potential cancer predisposition factor
    • Wu, X., et al. 2003. Telomere dysfunction: a potential cancer predisposition factor. J. Natl. Cancer Inst. 95:1211-1218.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 1211-1218
    • Wu, X.1
  • 105
    • 0042913370 scopus 로고    scopus 로고
    • Walking the telomere plank into cancer
    • Wong, K.K., and DePinho, R.A. 2003. Walking the telomere plank into cancer. J. Natl. Cancer Inst. 95:1184-1186.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 1184-1186
    • Wong, K.K.1    DePinho, R.A.2
  • 106
    • 0033521960 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation
    • Greenberg, R.A., et al. 1999. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 18:1219-1226.
    • (1999) Oncogene , vol.18 , pp. 1219-1226
    • Greenberg, R.A.1
  • 108
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous rumours
    • Donehower, L.A., et al. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous rumours. Nature. 356:215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 109
    • 0035817688 scopus 로고    scopus 로고
    • Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
    • Sharpless, N.E., et al. 2001. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413:86-91.
    • (2001) Nature , vol.413 , pp. 86-91
    • Sharpless, N.E.1
  • 110
    • 0035817687 scopus 로고    scopus 로고
    • Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
    • Krimpenfort, P., Quon, K.C., Mooi, W.J., Loonstra, A., and Berns, A. 2001. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature. 413:83-86.
    • (2001) Nature , vol.413 , pp. 83-86
    • Krimpenfort, P.1    Quon, K.C.2    Mooi, W.J.3    Loonstra, A.4    Berns, A.5
  • 111
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco, M.A., et al. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1
  • 112
    • 0037011958 scopus 로고    scopus 로고
    • p53 mutant mice that display early ageing-associated phenotypes
    • Tyner, S.D., et al. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature. 415:45-53.
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1
  • 113
    • 0037112844 scopus 로고    scopus 로고
    • "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    • Garcia-Cao, I., et al. 2002. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21:6225-6235.
    • (2002) EMBO J. , vol.21 , pp. 6225-6235
    • Garcia-Cao, I.1
  • 114
    • 0028201870 scopus 로고
    • Aged T cells are hyporesponsive to costimulation mediated by CD28
    • Engwerda, C.R., Handwerger, B.S., and Fox, B.S. 1994. Aged T cells are hyporesponsive to costimulation mediated by CD28. J. Immunol. 152:3740-3747.
    • (1994) J. Immunol. , vol.152 , pp. 3740-3747
    • Engwerda, C.R.1    Handwerger, B.S.2    Fox, B.S.3
  • 115
    • 0025143252 scopus 로고
    • Telomere reduction in human colorectal carcinoma and with ageing
    • Hastie, N.D., et al. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:866-868.
    • (1990) Nature. , vol.346 , pp. 866-868
    • Hastie, N.D.1
  • 116
    • 0026460896 scopus 로고
    • Telomere length predicts replicative capacity of human fibroblasts
    • Allsopp, R.C., et al. 1992. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89:10114-10118.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 10114-10118
    • Allsopp, R.C.1
  • 118
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann, M.T., Strong, M.A., Hao, L.Y., and Greider, C.W. 2001. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 107:67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 119
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park, LK., et al. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 423:302-305.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, L.K.1
  • 120
    • 0035353201 scopus 로고    scopus 로고
    • The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells
    • Lewis, J.L., et al. 2001. The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells. Blood. 97:2604-2610.
    • (2001) Blood , vol.97 , pp. 2604-2610
    • Lewis, J.L.1
  • 121
    • 0034636481 scopus 로고    scopus 로고
    • The effect of longevity on spending for acute and long-term care
    • Spillman, B.C., and Lubitz, J. 2000. The effect of longevity on spending for acute and long-term care. N. Engl. J. Med. 342:1409-1415.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1409-1415
    • Spillman, B.C.1    Lubitz, J.2
  • 122
    • 0042763546 scopus 로고    scopus 로고
    • Health, life expectancy, and health care spending among the elderly
    • Lubitz, J., Cai, L., Kramarow, E., and Lentzner, H. 2003. Health, life expectancy, and health care spending among the elderly. N. Engl. J. Med. 349:1048-1055.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1048-1055
    • Lubitz, J.1    Cai, L.2    Kramarow, E.3    Lentzner, H.4
  • 123
    • 0041886502 scopus 로고    scopus 로고
    • Disability and the future of Medicare
    • Cutler, D.M. 2003. Disability and the future of Medicare. N. Engl. J. Med. 349:1084-1085.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1084-1085
    • Cutler, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.