Large genome rearrangements as a primary cause of aging

Mechanisms of Ageing and Development

Volumn 123, Issue 8, 2002, Pages 907-915

  Vijg, Jan ^a,b   Dollé, Martijn E T ^a  

^a STCBM   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Genome rearrangements; LacZ reporter genes; Mutations; Nuclear architecture

Indexed keywords

GENOMIC DNA; RIBOSOME RNA;

AGING; BIOLOGICAL MODEL; CARCINOGENESIS; CELL DEATH; DNA REPAIR; DNA STRAND BREAKAGE; DOG; ESCHERICHIA COLI; GENE CONTROL; GENE DELETION; GENE LOSS; GENE MUTATION; GENE REARRANGEMENT; GENETIC MODEL; HISTORY; IN VIVO STUDY; PLASMID; PRIORITY JOURNAL; REVIEW; SENESCENCE; SOMATIC CELL;

AGING; ANIMALS; DNA REPAIR; GENE REARRANGEMENT; HUMANS; MODELS, GENETIC; MUTATION;

CANIS FAMILIARIS; ESCHERICHIA COLI;

EID: 0037198009     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(02)00028-3     Document Type: Article

References (39)

1. Insulators and boundaries: Versatile regulatory elements in the eukaryotic
2. The molecular basis of the evolution of sex
3. Plasmid-based transgenic mouse model for studying in vivo mutations
4. Fisher, medawar, hamilton and the evolution of aging
5. The modification by X-irradiation of the life span of haploids and diploids of the wasp, Habrobracon sp
6. Biological mechanisms underlying the aging process
7. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
8. Rapid accumulation of genome rearrangements in liver but not in brain of old mice
9. Background mutations and polymorphisms in lacZ-plasmid transgenic mice
10. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
11. Mutational fingerprints of aging
12. A phylogenomic study of DNA repair genes, proteins, and processes
13. Mutator phenotype of Werner syndrome is characterized by extensive deletions
14. Age-related mutation accumulation of a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice
15. Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
16. Does oxidative damage to DNA increase with age
17. Revisiting the rodent repairadox
18. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
19. Genome maintenance mechanisms for preventing cancer
20. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
21. Mutation frequency and type during ageing in mouse seminiferous tubules
22. A theory of ageing
23. Is ageing the result of dominant and co-dominant mutations
24. The contribution of exogenous and endogenous mutagens to in vivo mutations
25. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination
26. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting
27. Longevity, stress response, and cancer in aging telomerase-deficient mice
28. Genetic instability as the primary cause of human aging
29. Deletion mutation are the basic cause of aging: Historical perspectives
30. Aging alters the apoptotic response to genotoxic stress
31. On the nature of the aging process
32. Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis
33. Frequency of spontaneous chromosome aberrations in mice: Effects of age
34. Cockayne syndrome: Defective repair of transcription
35. Gene expression and protein degradation
36. Somatic mutations and aging: A re-evaluation
37. Deletion of Ku86 causes early onset of senescence in mice
38. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases