The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

Cell

Volumn 85, Issue 7, 1996, Pages 1009-1023

  Hakem, Razqallah ^a   De La Pompa, José Luis ^a   Sirard, Christian ^a   Mo, Rong ^b   Woo, Minna ^a   Hakem, Anne ^a   Wakeham, Andrew ^a   Potter, Julia ^a   Reitmair, Armin ^a   Billia, Filio ^a   Firpo, Eduardo ^c   Hui, Chi Chung ^b   Roberts, Jim ^c   Rossant, Janet ^d   Mak, Tak W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c Fred Hutchinson Cancer Research Center   (United States)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; DNA; PROTEIN P21; PROTEIN P53; RNA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; BLASTOCYST; CELL GROWTH; CELL PROLIFERATION; EMBRYO; EMBRYO DEVELOPMENT; EXON; GENE MUTATION; GERM LAYER; INNER CELL MASS; MESODERM; MOUSE; MUTANT; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; TROPHOBLAST; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 15844371372     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81302-1     Document Type: Article

References (49)

1. Brady, G., Barbara, M., and Iscove, N.N. (1990). Representative in vitro cDNA amplification from individual hematopoietic cells and colonies. Meth. Mol. Cell. Biol. 2, 17-25.
2. Brugarolas, J., Chandrasekaran, C., Gordon, J.I., Beach, D., Jacks, T., and Hannon, G.J. (1995). Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552-557.
3. Castilla, L.H., Cough, F.J., Erdos, M.R., Hoskins, K.F., Calzone, K., Garber, J.E., Boyd, J., Lubin, M.B., Deshano, M.L., Brody, L.C., et al. (1994). Mutations in the BRCA1 gene families with early-onset breast and ovarian cancer. Nature Genet. 8, 387-391.
4. Chen, Y.M., Chen, C.F., Riley, D.J., Allred, D.C., Chen, P.L., Von Hoff, D., Osborne, C.K., and Lee, W.H. (1995). Aberrant subcellular-localization of BRCA1 in breast cancer. Science 270, 789-791.
5. Cornelis, R.S., Neuhausen, S.L., Johansson, O., Arason, A., Kelsell, D., Ponder, B.A.J., Tonin, P., Hamann, U., Lindblom, A., Lalle, P., et al. (1995). High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCA1-linked families. Genes Chrom. Cancer 13, 203-210.
6. Coucovanis, E., and Martin, G.R. (1995). Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 83, 279-287.
7. Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P. (1995). Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684.
8. Easton, D.F., Bishop, D.T., Ford, D., and Crockford, G.P. (1993). Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am. J. Hum. Genet. 52, 678-701.
9. El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, E., Kinzler, K.W., and Vogelstein, B. (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.
10. Englert, C., Hou, X., Maheswaran, S., Bennett, P., Ngwu, C., Re, G.G., Garvin, A.J., Rosner, M.R., and Haber, D.A. (1995). WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 14, 4662-4675.
11. Ford, D., Easton, D.F., Bishop, D.T., Narod, S.A., and Goldgar, D.E. (1994). Risks of cancer in BRCA1-mutation carriers. Breast cancer linkage consortium. Lancet 343, 692-695.
12. Friedman, L.S., Ostermeyer, E.A., Szabo, G.I., Dowd, P., Lynch, E.D., Rowell, S.E., and King, M.C. (1994). Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian-cancer in 10 families. Nature Genet. 8, 399-404.
13. Futreal, P.A., Liu, Q.Y., Shattuck Eidens, D., Cochran, C., Harshman, K., Tavtigian, G., Bennett, L.M., Haugenstrano, A., Swensen, J., Miki, Y.K.E., et al. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122.
14. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S.A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
15. Gowen, L.C., Johnson, B.L., Latour, A.M., Sulik, K.K., and Koller, B.H. (1996). BRCA1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12, 191-194.
16. Gu, Y., Turek, C.W., and Morgan, D.O. (1993). Inhibition of CDK2 activity in vivo by an associated 20k regulatory subunit. Nature 366, 707-710.
17. Guillemot, F., Nagy, A., Auerbach, A., Rossant, J., and Joyner-A, L. (1994). Essential role of Mash-2 in extraembryonic development. Nature 371, 333-336.
18. Hall, J., Lee, M.K., Newman, B., Morrow, J.E., Anderson, L.A., Huey, B., and King, M.C. (1990). Linkage of early on-set familial breast cancer to chromosome 17q21. Science 250, 1684-1689.
19. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., and Elledge, S.J. (1993). The p21-cdk interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
20. Hayashi, Y., Koike, M., Matsunami, M., and Hoshino, T. (1988). Effects of fixation timeand enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue. J. Histochem. Cytochem. 36, 511-514.
21. Holt, J.T., Thompson, M.E., Szabo, C., Robinsonbenion, C., Arteaga, C.L., King, M.C., and Jensen, R.A. (1996). Growth-retardation and tumor-inhibition by BRCA1. Nature Genet. 12, 298-302.
22. Hosking, L., Tronsdale, J., Nicolai, H., Solomon, E., Foulkes, W., Stamp, G., Signer, E., and Jeffreys, A. (1995). A somatic BRCA1 mutation in an ovarian tumor. Nature Genet. 9, 343-344.
23. j mutation contains an intragenic deletion of the Gli3 gene. Nature Genet. 3, 241-246.
24. Jensen, R.A., Thompson, M.E., Jetton, T.L., Szabo, C.I., Vandermeer, R., Helou, B., Tronick, S.R., Page, D.L., King, M.C., and Holt, J.T. (1996). BRCA1 is secreted and exhibits properties of a granin. Nature Genet. 12, 303-308.
25. Jones, S.N., Roe, A.E., Donehower, L.A., and Bradley, A. (1995). Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378, 206-208.
26. Kispert, A., and Herrmann, B.G. (1993). The brachyury gene encodes a novel DNA binding protein. EMBO J. 12, 3211-3220.
27. Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J.W., Elledge, S., Nishimoto, T., Morgan, D.O., Franza, R., and Roberts, J.M. (1992). Formation and activation of cyclin E/CDK2 complex during the G1 phase of the human cell cycle. Science 257, 1689-1694.
28. Lane, T.F., Deng, C.X., Elson, A., Lyu, M.S., Kozak, C.A., and Leder, P. (1995). Expression of BRCA1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 9, 2712-2722.
29. Marquis, ST., Rajan, J.V., Wynshaw-Boris, A., Xu, T.J., Yin, G.Y., Abel, K.J., Weber, B.L., and Chodosh, L.A. (1995). The developmental pattern of BRCA1 expression implies a role in differentiation of the breast and other tissues. Nature Genet. 11, 17-26.
30. Merajver, S.D., Pham, T.M., Caduff, R.F., Chen, M., Poy, E.L., Cooney, K.A., Weber, B.L., Collins, F.S., Johnston, C., and Frank, T.S. (1995a). Somatic mutations in the BRCA1 gene in sporadic ovarian-tumor. Nature Genet. 9, 439-443.
31. Merajver, S.D., Frank, T.S., Xu, J.Z., Pham, T.M., Calzone, K.A., Bennettbaker, P., Chamberlain, J., Boyd, J., Garber, J.E., Collins, F.S., and Weber, B.L. (1995b). Germline BRCA1 mutations and loss of the wildtype allele in tumors from families with early-onset breast and ovarian -cancer. Clin. Cancer Res. 1, 539-544.
32. Miki, Y., Swensen, J., Shattuckeidens, D., Futreal, P.A., Harshman, K., Tavtigian, S., Liu, Q.Y., Cochran, C., Bennett, L.M., Ding, W., et al. (1994). A strong candidate for the breast and ovarian-cancer susceptibility gene. Science 266, 66-71.
33. Mishina, Y., Suzuki, A., Veno, N., and Behringer, R.R. (1995). BMPR encodes a type I bone morphogenetic protein-receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9, 3027-3037.
34. Momand, J., Zambetti, G.P., Olson, D.C., George, D., and Levine, A.J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation. Cell 69, 1237-1245.
35. Montes de Oca Luna, R., Wagner, D.S., and Lozano, G. (1995). Rescue of early embryonic lethality in MDM2-deficient mice by deletion of p53. Nature 378, 203-206.
36. Moser, A.R., Shoemaker, A.R., Connelly, C.S., Clipson, L., Gould, K.A., Luongo, C., Dove, W.F., Siggers, P.M., and Gardner, R.L. (1995). Homozygosity for the min allele of APC results indisruption of mouse development prior to gastrulation. Dev. Dyn. 203, 422-433.
37. Nagy. A., and Rossant, J. (1993). Production of completely ES cell-derived fetuses. In Gene Targeting: A Practical Approach, A.L. Joyner, ed. (Oxford: IRL Press), pp.147-179.
38. Ohtsubo, M., and Roberts, J.M. (1993). Cyclin dependent regulation of G1 in mammalian fibroblasts. Science 59, 1908-1912.
39. Ohtsubo, M., Theodoras, A.M., Schumacher, J., Roberts, J.M., and Pagano, M. (1995). Human cyclin E, a nuclear protein essential for the G1 to S phase transition. Mol. Cell. Biol 15, 2612-2624.
40. Power, M.-A., and Tam, P.P.L. (1993). Onset of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth. Anat. Embryol. 187, 493-504.
41. Rao, V.N., Shao, N.S., Ahmad, M., and Reddy, E.S.P. (1996). Antisense RNA to the putative tumor-suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene 12, 523-528.
42. Snow, M.H.L. (1977). Gastrulation in the mouse: growth and regionalization of the epiblast. J. Embryol. Exp. Morph. 42, 293-303.
43. Tavtigian, S.V., Simard, J., Rommens, J., Couch, F., Shattuckeidens, D., Neuhausen, S., Merajver, S., Thorlacius, S., Offit, K., Stoppalyonnet, D., et al. (1996). The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12, 333-337.
44. Trumpp, A., Blundell, P.A., de la Pompa, J.L., and Zeller, R. (1992). The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis. Genes Dev. 6, 14-28.
45. Varmuza, S., Prideaux, V., Kothary, R., and Rossant, J. (1988). Polytene chromosomes in mouse trophoblast giant cells. Development 102, 127-134.
46. Wooster, R., Neuhausen, S.L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., et al. (1994). Localization of a breast-cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 265, 2088-2090.
47. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., Micklem, G., et al. (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792.
48. Wu, H., Wade, M., Krall, L., Grisham, J., Xiong, Y., and Van Dyke, T. (1996). Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development, and regeneration. Genes Dev. 10, 245-260.
49. Zhang, H., Hannon, G.J., and Beach, D. (1994). p21-containing cyclin kinases exists in both active and inactive states. Genes Dev. 8, 1750-1758.