'Accelerated aging': A primrose path to insight?

Aging Cell

Volumn 3, Issue 2, 2004, Pages 47-51

  Miller, Richard A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Longevity; Mouse models; Mutants; Pathology; Segmental aging; Skepticism

Indexed keywords

ACHIEVEMENT; AGING; ARTICLE; DIETARY INTAKE; DOG; EXPERIMENTAL MODEL; FLY; GENE MUTATION; GENETIC ANALYSIS; GENETIC PROCEDURES; HUMAN; IMMUNE SYSTEM; LIFESPAN; MEDICAL RESEARCH; METABOLISM; MOLECULAR MIMICRY; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; THEORY; TIME; WORM; AGED; ANIMAL; ANIMAL MODEL; GENETICS; LIFESTYLE; LONGEVITY; PREMATURE AGING; REVIEW;

AGED; AGING, PREMATURE; ANIMALS; HUMANS; LIFE STYLE; LONGEVITY; MICE; MODELS, ANIMAL;

EID: 4444327055     PISSN: 14749718     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-9728.2004.00081.x     Document Type: Article

References (26)

1. Austad SN, Fischer KE (1991) Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials. J. Gerontol.: Biol. Sci. 46, B47-B53.
2. Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS (2001) Extending the lifespan of long-lived mice. Nature 414 412.
3. Bluher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574.
4. Brown WT (1991) Genetic diseases of premature aging as models of senescence. Annu. Rev. Gerontol. Geriatrics 10, 23-42.
5. Chaffey A (2003) Double dactyls. http://www.stinky.com/dactyl/dactyl.html#description. 28 November 2003.
6. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA 98, 6736-6741.
7. Gershon D (1979) Current status of age altered enzymes: alternative mechanisms. Mechanisms Ageing Dev. 9, 189-196.
8. Harrison DE (1994) Potential misinterpretations using models of accelerated aging. J. Gerontol.: Biol. Sci. 49, B245-B000.
9. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (2003) Aging and genome maintenance: lessons from the mouse? Science 299, 1355-1359.
10. Herrera E, Samper E, Martin-Caballero J, Flores JM, Lee HW, Blasco MA (1999) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960.
11. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P and Le Bouc Y. (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187.
12. Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A (2003) Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J. Gerontol. Series. A.-Biol. Sci. Med. Sci. 58, 291-296.
13. Kinney BA, Coschigano KT, Kopchick JJ, Steger RW, Bartke A (2001a) Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R.-KO (Laron) mice. Physiol. Behav. 72, 653-660.
14. Kinney BA, Meliska CJ, Steger RW, Bartke A (2001b) Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 39 277-284.
15. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Lida A, Shiraki-Iida T, Nishikawa S, Nagai R and Nabeshima YI. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390, 45-51.
16. Li Y, Huang TT, Carlson EJ, et al. (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11, 376-381.
17. Miller RA (2001) Genetics of increased longevity and retarded aging in mice. In Handbook of the Biology of Aging (Masoro EJ, Austad SN, eds). San Diego, CA: Academic Press, pp. 369-395.
18. Miller RA, Austad SN (1999) Large animals in the fast lane. Science 285, 199
19. Miller RA, Harper JM, Dysko RC, Durkee SJ, Austad SN (2002) Longer life spans and delayed maturation in wild-derived mice. Exp. Biol. Med. 227, 500 508.
20. Olshansky SJ, Carnes BA, Cassel C (1990) In search of Methuselah: estimating the upper limits to human longevity. Science 250, 634 640.
21. Silberberg R (1972) Articular aging and osteoarthritis in dwarf mice Path. Microbiol. 38, 417 430.
22. Smith GS, Walford RL (1977) Influence of the main histocompatibility complex on aging in mice. Nature 270, 727 729.
23. Takeshita S, Hosokawa M, Irino M, et al. (1982) Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM). Mechanisms Ageing Dev. 20, 13-23.
24. Tyner SD, Venkatachalam S, Choi J, et al. (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45 53.
25. Umezawa M, Hosokawa M, Kohno A, Ishikawa S, Kitagawa K, Takeda T (1993) Dietary soybean protein compared with casein retards senescence in the senescence accelerated mouse. J. Nutr. 123, 1905 1912.
26. Zimmerman JA, Malloy V, Krajcik R, Orentreich N (2003) Nutritional control of aging. Exp. Gerontol. 38, 47 52.