Health span and life span in transgenic mice with modulated DNA repair

Annals of the New York Academy of Sciences

Volumn 928, Issue , 2001, Pages 132-140

  Walter, Christi A ^a,b,c   Zhou, Zi Qiang ^a   Manguino, Diwi ^a   Ikeno, Yuji ^a   Reddick, Robert ^a   Nelson, James ^a   Intano, Gabriel ^a   Herbert, Damon C ^a   Alex McMahan, C ^a   Hanes, Martha ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c The University of Texas Health Science Center at San Antonio   (United States)

Author keywords

Aging; Alkylation damage; Hepatocellular carcinoma; MGMT; Transgenic mice

Indexed keywords

DNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TRANSFERRIN;

AGING; ALKYLATION; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE EXPRESSION; LIFESPAN; LIVER CELL CARCINOMA; MALE; MOUSE; MUTAGENESIS; NONHUMAN; PROMOTER REGION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0035035637     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb05643.x     Document Type: Conference Paper

References (33)

1. The aging process and carcinogensis
2. On the nature of the aging process
3. Role of free radicals in mutation, cancer, aging and maintenance of life
4. The role of DNA lesions in processes leading to aging in mice
5. Chromosomal aberrations in irradiated and nitrogen mustard treated mice
6. Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice
7. Increased chromosomal instability in lymphocytes from elderly humans
8. Acquired chromosome rearrangements in human lymphocytes: Effect of aging
9. G2 repair and aging: Influence of donor age on chromosomal aberrations in human lymphocytes
10. Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors: Related to donor's age
11. On the frequency of chromosome exchanges in a control population measured by chromosome painting
12. An investigation of mutation as a function of age in humans
13. Sex chromosome loss and aging: In situ hybridization studies on human interphase nuclei
14. Human lymphocytes resistant to 6-thioguanine increase with age
15. Mutation frequency in human lymphocytes increases with age
16. Somatic mutations are frequent and increase with age in human kidney epithelial cells
17. Frequency of 6-thioguanine T-cells is inversely related to the declining T-cell activities in aging mice
18. Effect of dietary restriction on in vivo somatic mutation in mice
19. Rates of chromosome abnormalities at different maternal ages
20. Spontaneous mutation in man
21. Comparative analysis of DNA mutations in lacI transgenic mice with age
22. Rapid accumulation of genome rearrangements in liver but not in brain of old mice
23. Mutation frequency declines during spermatogenesis in young mice but increases in old mice
24. Food restriction in rodents: An evaluation of its role in the study of aging
25. Protection of DNA damage by dietary restriction
26. Effect of age and caloric restriction on DNA oxidative damage in different tissue of C57BL/6 mice
27. No change in spontaneous mutation frequency or specificity in dietary restricted mice
28. Human transferrin: Expression and iron modulation of chimeric genes in transgenic mice
29. Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles
30. 6-methylguanine-DNA methyltransferase in transgenic mice
31. 6-methylguanine in DNA in inbred mice
32. 6-alkylguanine alkyl receptor protein activity in hepatocytes of C3H and C57BL mice during dimethylnitrosamine exposure