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Volumn 55, Issue 21, 2012, Pages 8979-8996

Microtubule stabilizing agents as potential treatment for alzheimers disease and related neurodegenerative tauopathies

Author keywords

[No Author keywords available]

Indexed keywords

CERATAMINE DERIVATIVE; CYCLOSTREPTIN; DAVUNETIDE; DICOUMAROL; DICTYOSTATIN; DISCODERMOLIDE; ELEUTHESIDE DERIVATIVE; EPOTHILONE DERIVATIVE; JATROPHANE DERIVATIVE; LAULIMALIDE; MICROTUBULE STABILIZING AGENT; NATURAL PRODUCT; PELORUSIDE; TACCALONOLIDE DERIVATIVE; TAU PROTEIN; TAXANE DERIVATIVE; TUBERCIDIN; UNCLASSIFIED DRUG; XANTHOPHYLL; ZAMPANOLIDE;

EID: 84868514765     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301079z     Document Type: Review
Times cited : (153)

References (237)
  • 2
    • 0021686169 scopus 로고
    • Dynamic instability of microtubule growth
    • Mitchison, T.; Kirschner, M. Dynamic instability of microtubule growth Nature 1984, 312, 237-242
    • (1984) Nature , vol.312 , pp. 237-242
    • Mitchison, T.1    Kirschner, M.2
  • 3
    • 14244261725 scopus 로고    scopus 로고
    • Axonal transport defects: A common theme in neurodegenerative diseases
    • Roy, S.; Zhang, B.; Lee, V. M.-Y.; Trojanowski, J. Q. Axonal transport defects: a common theme in neurodegenerative diseases Acta Neuropathol. 2005, 109, 5-13
    • (2005) Acta Neuropathol. , vol.109 , pp. 5-13
    • Roy, S.1    Zhang, B.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 6
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel, D. N.; Hyman, A. A.; Cobb, M. H.; Kirschner, M. W. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau Mol. Biol. Cell 1992, 3, 1141-1154
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 7
    • 0027338266 scopus 로고
    • Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
    • Biernat, J.; Gustke, N.; Drewes, G.; Mandelkow, E. M.; Mandelkow, E. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding Neuron 1993, 11, 153-163
    • (1993) Neuron , vol.11 , pp. 153-163
    • Biernat, J.1    Gustke, N.2    Drewes, G.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 8
    • 0033850407 scopus 로고    scopus 로고
    • Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
    • Buee, L.; Bussiere, T.; Buee-Scherrer, V.; Delacourte, A.; Hof, P. R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders Brain Res. Rev. 2000, 33, 95-130
    • (2000) Brain Res. Rev. , vol.33 , pp. 95-130
    • Buee, L.1    Bussiere, T.2    Buee-Scherrer, V.3    Delacourte, A.4    Hof, P.R.5
  • 11
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimers disease and related disorders
    • Ballatore, C.; Lee, V. M.-Y.; Trojanowski, J. Q. Tau-mediated neurodegeneration in Alzheimers disease and related disorders Nat. Rev. Neurosci. 2007, 8, 663-672
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 12
    • 0030240325 scopus 로고    scopus 로고
    • Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimers disease
    • Hempen, B.; Brion, J. P. Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimers disease J. Neuropathol. Exp. Neurol. 1996, 55, 964-972
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 964-972
    • Hempen, B.1    Brion, J.P.2
  • 13
    • 0027992814 scopus 로고
    • Microtubule stabilizing drugs for the treatment of Alzheimers disease
    • Lee, V. M.-Y.; Daughenbaugh, R.; Trojanowski, J. Q. Microtubule stabilizing drugs for the treatment of Alzheimers disease Neurobiol. Aging 1994, 15 (Suppl. 2) S87-S89
    • (1994) Neurobiol. Aging , vol.15 , Issue.SUPPL. 2
    • Lee, V.M.-Y.1    Daughenbaugh, R.2    Trojanowski, J.Q.3
  • 14
    • 19044378780 scopus 로고    scopus 로고
    • Microtubule-stabilizing drugs for therapy of Alzheimers disease and other neurodegenerative disorders with axonal transport impairments
    • Trojanowski, J. Q.; Smith, A. B.; Huryn, D.; Lee, V. M.-Y. Microtubule-stabilizing drugs for therapy of Alzheimers disease and other neurodegenerative disorders with axonal transport impairments Expert Opin. Pharmacother. 2005, 6, 683-686
    • (2005) Expert Opin. Pharmacother. , vol.6 , pp. 683-686
    • Trojanowski, J.Q.1    Smith, A.B.2    Huryn, D.3    Lee, V.M.-Y.4
  • 15
    • 0343247810 scopus 로고    scopus 로고
    • Bloo-brain barrier function of P-glycoprotein
    • Tsuji, A.; Tamai, I. Bloo-brain barrier function of P-glycoprotein Adv. Drug Delivery Rev. 1997, 25, 287-298
    • (1997) Adv. Drug Delivery Rev. , vol.25 , pp. 287-298
    • Tsuji, A.1    Tamai, I.2
  • 16
    • 12344273726 scopus 로고    scopus 로고
    • The bloo-brain barrier: Bottleneck in brain drug development
    • Pardridge, W. M. The bloo-brain barrier: bottleneck in brain drug development NeuroRx 2005, 2, 3-14
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 17
    • 0036007257 scopus 로고    scopus 로고
    • Why is the global CNS pharmaceutical market so under-penetrated?
    • Pardridge, W. M. Why is the global CNS pharmaceutical market so under-penetrated? Drug Discovery Today 2002, 7, 5-7
    • (2002) Drug Discovery Today , vol.7 , pp. 5-7
    • Pardridge, W.M.1
  • 18
    • 76849087811 scopus 로고    scopus 로고
    • Taxanes: Optimizing adjuvant chemotherapy for early-stage breast cancer
    • Bedard, P. L.; Di Leo, A.; Piccart-Gebhart, M. J. Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer Nat. Rev. Clin. Oncol. 2010, 7, 22-36
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 22-36
    • Bedard, P.L.1    Di Leo, A.2    Piccart-Gebhart, M.J.3
  • 19
    • 33645736326 scopus 로고    scopus 로고
    • Peripheral neuropathy induced by microtubule-stabilizing agents
    • Lee, J.; Swain, S. M. Peripheral neuropathy induced by microtubule-stabilizing agents J. Clin. Oncol. 2006, 24, 1633-1642
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1633-1642
    • Lee, J.1    Swain, S.M.2
  • 20
    • 79955952344 scopus 로고    scopus 로고
    • Rescue of neurons from undergoing hallmark tau-induced Alzheimers disease cell pathologies by the antimitotic drug paclitaxel
    • Shemesh, O. A.; Spira, M. E. Rescue of neurons from undergoing hallmark tau-induced Alzheimers disease cell pathologies by the antimitotic drug paclitaxel Neurobiol. Dis. 2011, 43, 163-175
    • (2011) Neurobiol. Dis. , vol.43 , pp. 163-175
    • Shemesh, O.A.1    Spira, M.E.2
  • 21
    • 84861906161 scopus 로고    scopus 로고
    • Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation
    • Das, V.; Miller, J. H. Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation Eur. J. Neurosci. 2012, 35, 1705-1717
    • (2012) Eur. J. Neurosci. , vol.35 , pp. 1705-1717
    • Das, V.1    Miller, J.H.2
  • 27
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • Zhang, B.; Carroll, J.; Trojanowski, J. Q.; Yao, Y.; Iba, M.; Potuzak, J. S.; Hogan, A. M.; Xie, S. X.; Ballatore, C.; Smith, A. B.; Lee, V. M.; Brunden, K. R. The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice J. Neurosci. 2012, 32, 3601-3611
    • (2012) J. Neurosci. , vol.32 , pp. 3601-3611
    • Zhang, B.1    Carroll, J.2    Trojanowski, J.Q.3    Yao, Y.4    Iba, M.5    Potuzak, J.S.6    Hogan, A.M.7    Xie, S.X.8    Ballatore, C.9    Smith, A.B.10    Lee, V.M.11    Brunden, K.R.12
  • 30
    • 84875005473 scopus 로고    scopus 로고
    • Study To Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects with Mild Alzheimer's Disease
    • Study To Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects with Mild Alzheimer's Disease. http://clinicaltrials.gov/ct2/show/NCT01492374?term=BMS-241027&rank=1.
  • 34
    • 13444269007 scopus 로고    scopus 로고
    • Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the bloo-brain barrier in vitro and in situ
    • Rice, A.; Liu, Y.; Michaelis, M. L.; Himes, R. H.; Georg, G. I.; Audus, K. L. Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the bloo-brain barrier in vitro and in situ J. Med. Chem. 2005, 48, 832-838
    • (2005) J. Med. Chem. , vol.48 , pp. 832-838
    • Rice, A.1    Liu, Y.2    Michaelis, M.L.3    Himes, R.H.4    Georg, G.I.5    Audus, K.L.6
  • 38
    • 51849114328 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo
    • OReilly, T.; Wartmann, M.; Brueggen, J.; Allegrini, P. R.; Floersheimer, A.; Maira, M.; McSheehy, P. M. Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo Cancer Chemother. Pharmacol 2008, 62, 1045-1054
    • (2008) Cancer Chemother. Pharmacol , vol.62 , pp. 1045-1054
    • Oreilly, T.1    Wartmann, M.2    Brueggen, J.3    Allegrini, P.R.4    Floersheimer, A.5    Maira, M.6    McSheehy, P.M.7
  • 40
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. the isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani, M. C.; Taylor, H. L.; Wall, M. E.; Coggon, P.; McPhail, A. T. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia J. Am. Chem. Soc. 1971, 93, 2325-2327
    • (1971) J. Am. Chem. Soc. , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 41
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by Taxol
    • Schiff, P. B.; Fant, J.; Horwitz, S. B. Promotion of microtubule assembly in vitro by Taxol Nature 1979, 277, 665-667
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 42
    • 0029063397 scopus 로고
    • Structure of tubulin at 6.5 Å and location of the Taxol-binding site
    • Nogales, E.; Wolf, S. G.; Khan, I. A.; Luduena, R. F.; Downing, K. H. Structure of tubulin at 6.5 Å and location of the Taxol-binding site Nature 1995, 375, 424-427
    • (1995) Nature , vol.375 , pp. 424-427
    • Nogales, E.1    Wolf, S.G.2    Khan, I.A.3    Luduena, R.F.4    Downing, K.H.5
  • 43
    • 0037424365 scopus 로고    scopus 로고
    • Fast kinetics of taxol binding to microtubules
    • Díaz, J. F.; Barasoain, I.; Andreu, J. M. Fast kinetics of taxol binding to microtubules J. Biol. Chem. 2003, 278, 8407 - 8419
    • (2003) J. Biol. Chem. , vol.278 , pp. 8407-8419
    • Díaz, J.F.1    Barasoain, I.2    Andreu, J.M.3
  • 45
    • 4344572092 scopus 로고    scopus 로고
    • Microtubule structure and its stabilisation
    • Amos, L. A. Microtubule structure and its stabilisation Org. Biomol. Chem. 2004, 2, 2153-2160
    • (2004) Org. Biomol. Chem. , vol.2 , pp. 2153-2160
    • Amos, L.A.1
  • 47
    • 0033102385 scopus 로고    scopus 로고
    • How Taxol stabilises microtubule structure
    • Amos, L. A.; Lowe, J. How Taxol stabilises microtubule structure Chem. Biol. 1999, 6, R65-R659
    • (1999) Chem. Biol. , vol.6
    • Amos, L.A.1    Lowe, J.2
  • 48
    • 0031973791 scopus 로고    scopus 로고
    • The taxoids: Comparative clinical pharmacology and therapeutic potential
    • Eisenhauer, E. A.; Vermorken, J. B. The taxoids: comparative clinical pharmacology and therapeutic potential Drugs 1998, 55, 5-30
    • (1998) Drugs , vol.55 , pp. 5-30
    • Eisenhauer, E.A.1    Vermorken, J.B.2
  • 49
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan, M. A.; Wilson, L. Microtubules as a target for anticancer drugs Nat. Rev. Cancer 2004, 4, 253-265
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 51
    • 0000052734 scopus 로고
    • Taxol and taxotere: Discovery, chemistry, and structure-activity relationships
    • Guenard, D.; Gueritte-Voegelein, F.; Potier, P. Taxol and taxotere: discovery, chemistry, and structure-activity relationships Acc. Chem. Res. 1993, 26, 160-167
    • (1993) Acc. Chem. Res. , vol.26 , pp. 160-167
    • Guenard, D.1    Gueritte-Voegelein, F.2    Potier, P.3
  • 53
    • 0000096261 scopus 로고
    • Recent advances in the.beta.-lactam synthon method
    • Ojima, I. Recent advances in the.beta.-lactam synthon method Acc. Chem. Res. 1995, 28, 383-389
    • (1995) Acc. Chem. Res. , vol.28 , pp. 383-389
    • Ojima, I.1
  • 54
    • 0026686518 scopus 로고
    • New and efficient approaches to the semisynthesis of Taxol and its C-13 side chain analogs by means of β-lactam synthon method
    • Ojima, I.; Habus, I.; Zhao, M.; Zucco, M.; Park, Y. H.; Sun, C. M.; Brigaud, T. New and efficient approaches to the semisynthesis of Taxol and its C-13 side chain analogs by means of β-lactam synthon method Tetrahedron 1992, 48, 6985-7012
    • (1992) Tetrahedron , vol.48 , pp. 6985-7012
    • Ojima, I.1    Habus, I.2    Zhao, M.3    Zucco, M.4    Park, Y.H.5    Sun, C.M.6    Brigaud, T.7
  • 55
    • 0026498769 scopus 로고
    • Synthesis of biologically active Taxol analogs with modified phenylisoserine side chains
    • Georg, G. I.; Cheruvallath, Z. S.; Himes, R. H.; Mejillano, M. R.; Burke, C. T. Synthesis of biologically active Taxol analogs with modified phenylisoserine side chains J. Med. Chem. 1992, 35, 4230-4237
    • (1992) J. Med. Chem. , vol.35 , pp. 4230-4237
    • Georg, G.I.1    Cheruvallath, Z.S.2    Himes, R.H.3    Mejillano, M.R.4    Burke, C.T.5
  • 60
    • 0030823912 scopus 로고    scopus 로고
    • P-Glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
    • Beaulieu, E.; Demeule, M.; Ghitescu, L.; Beliveau, R. P-Glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain Biochem. J. 1997, 326 (Part 2) 539-544
    • (1997) Biochem. J. , vol.326 , Issue.PART 2 , pp. 539-544
    • Beaulieu, E.1    Demeule, M.2    Ghitescu, L.3    Beliveau, R.4
  • 61
    • 79952198747 scopus 로고    scopus 로고
    • Cabazitaxel, a new taxane with favorable properties
    • Bouchet, B. P.; Galmarini, C. M. Cabazitaxel, a new taxane with favorable properties Drugs Today 2010, 46, 735-742
    • (2010) Drugs Today , vol.46 , pp. 735-742
    • Bouchet, B.P.1    Galmarini, C.M.2
  • 64
    • 1842843197 scopus 로고    scopus 로고
    • Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023
    • Minderman, H.; Brooks, T. A.; OLoughlin, K. L.; Ojima, I.; Bernacki, R. J.; Baer, M. R. Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023 Cancer Chemother. Pharmacol. 2004, 53, 363-369
    • (2004) Cancer Chemother. Pharmacol. , vol.53 , pp. 363-369
    • Minderman, H.1    Brooks, T.A.2    Oloughlin, K.L.3    Ojima, I.4    Bernacki, R.J.5    Baer, M.R.6
  • 65
    • 10144251769 scopus 로고    scopus 로고
    • Syntheses and structure-activity relationships of the second-generation antitumor taxoids: Exceptional activity against drug-resistant cancer cells
    • Ojima, I.; Slater, J. C.; Michaud, E.; Kuduk, S. D.; Bounaud, P. Y.; Vrignaud, P.; Bissery, M. C.; Veith, J. M.; Pera, P.; Bernacki, R. J. Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells J. Med. Chem. 1996, 39, 3889-3896
    • (1996) J. Med. Chem. , vol.39 , pp. 3889-3896
    • Ojima, I.1    Slater, J.C.2    Michaud, E.3    Kuduk, S.D.4    Bounaud, P.Y.5    Vrignaud, P.6    Bissery, M.C.7    Veith, J.M.8    Pera, P.9    Bernacki, R.J.10
  • 68
    • 0642309504 scopus 로고    scopus 로고
    • Overcoming the bloo-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors
    • Rice, A.; Michaelis, M.; Georg, G.; Liu, Y.; Turunen, B.; Audus, K. Overcoming the bloo-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors J. Mol. Neurosci. 2003, 20, 339-343
    • (2003) J. Mol. Neurosci. , vol.20 , pp. 339-343
    • Rice, A.1    Michaelis, M.2    Georg, G.3    Liu, Y.4    Turunen, B.5    Audus, K.6
  • 74
    • 84863131334 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and activity of GRN1005, a novel conjugate of angiopep-2, a peptide facilitating brain penetration, and paclitaxel, in patients with advanced solid tumors
    • Kurzrock, R.; Gabrail, N.; Chandhasin, C.; Moulder, S.; Smith, C.; Brenner, A.; Sankhala, K.; Mita, A.; Elian, K.; Bouchard, D.; Sarantopoulos, J. Safety, pharmacokinetics, and activity of GRN1005, a novel conjugate of angiopep-2, a peptide facilitating brain penetration, and paclitaxel, in patients with advanced solid tumors Mol. Cancer Ther. 2012, 11, 308-316
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 308-316
    • Kurzrock, R.1    Gabrail, N.2    Chandhasin, C.3    Moulder, S.4    Smith, C.5    Brenner, A.6    Sankhala, K.7    Mita, A.8    Elian, K.9    Bouchard, D.10    Sarantopoulos, J.11
  • 75
    • 84937419962 scopus 로고    scopus 로고
    • Epothilone, a Myxobacterial Metabolite with Promising Antitumor Activity
    • Cragg, G. M. Kingston, D. G. I. Newman, D. J. CRC Press: Boca Raton, FL
    • Hofle, G.; Reichenbach, H. Epothilone, a Myxobacterial Metabolite with Promising Antitumor Activity. In Anticancer Agents from Natural Products; Cragg, G. M.; Kingston, D. G. I.; Newman, D. J., Eds.; CRC Press: Boca Raton, FL, 2005; pp 413-450.
    • (2005) Anticancer Agents from Natural Products , pp. 413-450
    • Hofle, G.1    Reichenbach, H.2
  • 78
    • 38149025356 scopus 로고    scopus 로고
    • Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution
    • Reese, M.; Sánchez-Pedregal, V. M.; Kubicek, K.; Meiler, J.; Blommers, M. J. J.; Griesinger, C.; Carlomagno, T. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution Angew. Chem. 2007, 119, 1896-1900
    • (2007) Angew. Chem. , vol.119 , pp. 1896-1900
    • Reese, M.1    Sánchez-Pedregal, V.M.2    Kubicek, K.3    Meiler, J.4    Blommers, M.J.J.5    Griesinger, C.6    Carlomagno, T.7
  • 79
    • 74849137129 scopus 로고    scopus 로고
    • Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones
    • Forli, S.; Manetti, F.; Altmann, K. H.; Botta, M. Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones ChemMedChem 2010, 5, 35-40
    • (2010) ChemMedChem , vol.5 , pp. 35-40
    • Forli, S.1    Manetti, F.2    Altmann, K.H.3    Botta, M.4
  • 80
    • 3843053396 scopus 로고    scopus 로고
    • The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography
    • Nettles, J. H.; Li, H.; Cornett, B.; Krahn, J. M.; Snyder, J. P.; Downing, K. H. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography Science 2004, 305, 866-869
    • (2004) Science , vol.305 , pp. 866-869
    • Nettles, J.H.1    Li, H.2    Cornett, B.3    Krahn, J.M.4    Snyder, J.P.5    Downing, K.H.6
  • 81
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
    • Giannakakou, P.; Sackett, D. L.; Kang, Y. K.; Zhan, Z.; Buters, J. T.; Fojo, T.; Poruchynsky, M. S. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization J. Biol. Chem. 1997, 272, 17118-17125
    • (1997) J. Biol. Chem. , vol.272 , pp. 17118-17125
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.K.3    Zhan, Z.4    Buters, J.T.5    Fojo, T.6    Poruchynsky, M.S.7
  • 82
    • 0034903353 scopus 로고    scopus 로고
    • New natural epothilones from Sorangium cellulosum, strains so ce90/B2 and so ce90/D13: Isolation, structure elucidation, and SAR studies
    • Hardt, I. H.; Steinmetz, H.; Gerth, K.; Sasse, F.; Reichenbach, H.; Höfle, G. New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies J. Nat. Prod. 2001, 64, 847-856
    • (2001) J. Nat. Prod. , vol.64 , pp. 847-856
    • Hardt, I.H.1    Steinmetz, H.2    Gerth, K.3    Sasse, F.4    Reichenbach, H.5    Höfle, G.6
  • 83
    • 4043177145 scopus 로고    scopus 로고
    • Epothilone D (Kosan/Roche)
    • Kolman, A. Epothilone D (Kosan/Roche) Curr. Opin. Invest. Drugs 2004, 5, 657-667
    • (2004) Curr. Opin. Invest. Drugs , vol.5 , pp. 657-667
    • Kolman, A.1
  • 84
  • 87
    • 0034814540 scopus 로고    scopus 로고
    • Insights into long-range structural effects on the stereochemistry of aldol condensations: A practical total synthesis of desoxyepothilone F
    • Lee, C. B.; Wu, Z.; Zhang, F.; Chappell, M. D.; Stachel, S. J.; Chou, T. C.; Guan, Y.; Danishefsky, S. J. Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F J. Am. Chem. Soc. 2001, 123, 5249-5259
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 5249-5259
    • Lee, C.B.1    Wu, Z.2    Zhang, F.3    Chappell, M.D.4    Stachel, S.J.5    Chou, T.C.6    Guan, Y.7    Danishefsky, S.J.8
  • 88
    • 4444339511 scopus 로고    scopus 로고
    • Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: On the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate
    • Rivkin, A.; Yoshimura, F.; Gabarda, A. E.; Cho, Y. S.; Chou, T. C.; Dong, H.; Danishefsky, S. J. Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13- desoxyepothilone B as a promising anticancer drug candidate J. Am. Chem. Soc. 2004, 126, 10913-10922
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 10913-10922
    • Rivkin, A.1    Yoshimura, F.2    Gabarda, A.E.3    Cho, Y.S.4    Chou, T.C.5    Dong, H.6    Danishefsky, S.J.7
  • 89
    • 0030627521 scopus 로고    scopus 로고
    • Tubulin synthesis and assembly in differentiating neurons
    • Laferriere, N.; MacRae, T.; Brown, D. Tubulin synthesis and assembly in differentiating neurons Biochem. Cell Biol. 1997, 75, 103-117
    • (1997) Biochem. Cell Biol. , vol.75 , pp. 103-117
    • Laferriere, N.1    MacRae, T.2    Brown, D.3
  • 90
    • 0024593690 scopus 로고
    • Dynamics of alpha-tubulin deacetylation in intact neurons
    • Black, M.; Baas, P.; Humphries, S. Dynamics of alpha-tubulin deacetylation in intact neurons J. Neurosci. 1989, 9, 358-368
    • (1989) J. Neurosci. , vol.9 , pp. 358-368
    • Black, M.1    Baas, P.2    Humphries, S.3
  • 96
    • 33845486692 scopus 로고    scopus 로고
    • Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development
    • Klar, U.; Buchmann, B.; Schwede, W.; Skuballa, W.; Hoffmann, J.; Lichtner, R. B. Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development Angew. Chem., Int. Ed. 2006, 45, 7942-7948
    • (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 7942-7948
    • Klar, U.1    Buchmann, B.2    Schwede, W.3    Skuballa, W.4    Hoffmann, J.5    Lichtner, R.B.6
  • 97
    • 54949105468 scopus 로고    scopus 로고
    • Sagopilone (ZK-EPO): From a natural product to a fully synthetic clinical development candidate
    • Klar, U.; Hoffmann, J.; Giurescu, M. Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate Expert Opin. Invest. Drugs 2008, 17, 1735-1748
    • (2008) Expert Opin. Invest. Drugs , vol.17 , pp. 1735-1748
    • Klar, U.1    Hoffmann, J.2    Giurescu, M.3
  • 98
    • 0025160288 scopus 로고
    • Discodermolide: A new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
    • Gunasekera, S. P.; Gunasekera, M.; Longley, R. E.; Schulte, G. K. Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta J. Org. Chem. 1990, 55, 4912-4915
    • (1990) J. Org. Chem. , vol.55 , pp. 4912-4915
    • Gunasekera, S.P.1    Gunasekera, M.2    Longley, R.E.3    Schulte, G.K.4
  • 99
    • 0025942924 scopus 로고
    • Discodermolide-a new, marine-derived immunosuppressive compound. I. in vitro studies
    • Longley, R. E.; Caddigan, D.; Harmody, D.; Gunasekera, M.; Gunasekera, S. P. Discodermolide-a new, marine-derived immunosuppressive compound. I. In vitro studies Transplantation 1991, 52, 650-656
    • (1991) Transplantation , vol.52 , pp. 650-656
    • Longley, R.E.1    Caddigan, D.2    Harmody, D.3    Gunasekera, M.4    Gunasekera, S.P.5
  • 100
    • 0025936629 scopus 로고
    • Discodermolide-a new, marine-derived immunosuppressive compound. II. in vivo studies
    • Longley, R. E.; Caddigan, D.; Harmody, D.; Gunasekera, M.; Gunasekera, S. P. Discodermolide-a new, marine-derived immunosuppressive compound. II. In vivo studies Transplantation 1991, 52, 656-661
    • (1991) Transplantation , vol.52 , pp. 656-661
    • Longley, R.E.1    Caddigan, D.2    Harmody, D.3    Gunasekera, M.4    Gunasekera, S.P.5
  • 102
    • 0030113284 scopus 로고    scopus 로고
    • (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks Taxol binding and results in mitotic arrest
    • Hung, D. T.; Chen, J.; Schreiber, S. L. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks Taxol binding and results in mitotic arrest Chem. Biol. 1996, 3, 287-293
    • (1996) Chem. Biol. , vol.3 , pp. 287-293
    • Hung, D.T.1    Chen, J.2    Schreiber, S.L.3
  • 103
    • 0030761586 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
    • Kowalski, R. J.; Giannakakou, P.; Gunasekera, S. P.; Longley, R. E.; Day, B. W.; Hamel, E. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells Mol. Pharmacol. 1997, 52, 613-622
    • (1997) Mol. Pharmacol. , vol.52 , pp. 613-622
    • Kowalski, R.J.1    Giannakakou, P.2    Gunasekera, S.P.3    Longley, R.E.4    Day, B.W.5    Hamel, E.6
  • 104
    • 33749370142 scopus 로고    scopus 로고
    • A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin
    • Xia, S.; Kenesky, C. S.; Rucker, P. V.; Smith, A. B.; Orr, G. A.; Horwitz, S. B. A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin Biochemistry 2006, 45, 11762-11775
    • (2006) Biochemistry , vol.45 , pp. 11762-11775
    • Xia, S.1    Kenesky, C.S.2    Rucker, P.V.3    Smith, A.B.4    Orr, G.A.5    Horwitz, S.B.6
  • 105
    • 0034826406 scopus 로고    scopus 로고
    • The relationship between Taxol and (+)-discodermolide: Synthetic analogs and modeling studies
    • Martello, L. A.; LaMarche, M. J.; He, L.; Beauchamp, T. J.; Smith, A. B., 3rd; Horwitz, S. B. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies Chem. Biol. 2001, 8, 843-855
    • (2001) Chem. Biol. , vol.8 , pp. 843-855
    • Martello, L.A.1    Lamarche, M.J.2    He, L.3    Beauchamp, T.J.4    Smith III, A.B.5    Horwitz, S.B.6
  • 107
    • 3142723291 scopus 로고    scopus 로고
    • Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells
    • Honore, S.; Kamath, K.; Braguer, D.; Horwitz, S. B.; Wilson, L.; Briand, C.; Jordan, M. A. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells Cancer Res. 2004, 64, 4957-4964
    • (2004) Cancer Res. , vol.64 , pp. 4957-4964
    • Honore, S.1    Kamath, K.2    Braguer, D.3    Horwitz, S.B.4    Wilson, L.5    Briand, C.6    Jordan, M.A.7
  • 110
    • 0029860912 scopus 로고    scopus 로고
    • Syntheses of discodermolides useful for investigating microtubule binding and stabilization
    • Hung, D. T.; Nerenberg, J. B.; Schreiber, S. L. Syntheses of discodermolides useful for investigating microtubule binding and stabilization J. Am. Chem. Soc. 1996, 118, 11054-11080
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 11054-11080
    • Hung, D.T.1    Nerenberg, J.B.2    Schreiber, S.L.3
  • 111
    • 0027858856 scopus 로고
    • Total synthesis of the immunosuppressive agent (-)-discodermolide
    • Nerenberg, J. B.; Hung, D. T.; Somers, P. K.; Schreiber, S. L. Total synthesis of the immunosuppressive agent (-)-discodermolide J. Am. Chem. Soc. 1993, 115, 12621-12622
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 12621-12622
    • Nerenberg, J.B.1    Hung, D.T.2    Somers, P.K.3    Schreiber, S.L.4
  • 112
    • 36549038147 scopus 로고    scopus 로고
    • (+)-Discodermolide: Total synthesis, construction of novel analogues, and biological evaluation
    • Smith, A. B., III; Freeze, B. S. (+)-Discodermolide: total synthesis, construction of novel analogues, and biological evaluation Tetrahedron 2008, 64, 261-298
    • (2008) Tetrahedron , vol.64 , pp. 261-298
    • Iii, B.S.A.1    Freeze, B.S.2
  • 115
    • 0034677179 scopus 로고    scopus 로고
    • Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones
    • Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P. Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones Angew. Chem., Int. Ed. 2000, 39, 377-380
    • (2000) Angew. Chem., Int. Ed. , vol.39 , pp. 377-380
    • Paterson, I.1    Florence, G.J.2    Gerlach, K.3    Scott, J.P.4
  • 116
    • 31544473618 scopus 로고    scopus 로고
    • A phase i pharmacokinetic (PK) trial of XAA296A (discodermolide) administered every 3 wks to adult patients with advanced solid malignancies
    • (2004 ASCO Annual Meeting Proceedings
    • Mita, A.; Lockhart, A. C.; Chen, T. L.; Bochinski, K.; Curtright, J.; Cooper, W.; Hammond, L.; Rothenberg, M.; Rowinsky, E.; Sharma, S. A phase I pharmacokinetic (PK) trial of XAA296A (discodermolide) administered every 3 wks to adult patients with advanced solid malignancies J. Clin. Oncol. 2004, 14S, 2025 (2004 ASCO Annual Meeting Proceedings
    • (2004) J. Clin. Oncol. , vol.14 , pp. 2025
    • Mita, A.1    Lockhart, A.C.2    Chen, T.L.3    Bochinski, K.4    Curtright, J.5    Cooper, W.6    Hammond, L.7    Rothenberg, M.8    Rowinsky, E.9    Sharma, S.10
  • 117
    • 33845503870 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
    • Paterson, I.; Gardner, N. M. Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid Chem. Commun. (Cambridge, U. K.) 2007, 49-51
    • (2007) Chem. Commun. (Cambridge, U. K.) , pp. 49-51
    • Paterson, I.1    Gardner, N.M.2
  • 118
    • 80052808315 scopus 로고    scopus 로고
    • Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity
    • Smith, A. B.; Sugasawa, K.; Atasoylu, O.; Yang, C.-P. H.; Horwitz, S. B. Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity J. Med. Chem. 2011, 54, 6319-6327
    • (2011) J. Med. Chem. , vol.54 , pp. 6319-6327
    • Smith, A.B.1    Sugasawa, K.2    Atasoylu, O.3    Yang, C.-P.H.4    Horwitz, S.B.5
  • 125
    • 53849091740 scopus 로고    scopus 로고
    • The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin
    • Canales, A.; Matesanz, R.; Gardner, N. M.; Andreu, J. M.; Paterson, I.; Díaz, J. F.; Jiménez-Barbero, J. The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin Chem.-Eur. J. 2008, 14, 7557-7569
    • (2008) Chem.-Eur. J. , vol.14 , pp. 7557-7569
    • Canales, A.1    Matesanz, R.2    Gardner, N.M.3    Andreu, J.M.4    Paterson, I.5    Díaz, J.F.6    Jiménez-Barbero, J.7
  • 126
    • 33751204460 scopus 로고    scopus 로고
    • The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide
    • Sánchez-Pedregal, V. M.; Kubicek, K.; Meiler, J.; Lyothier, I.; Paterson, I.; Carlomagno, T. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide Angew. Chem., Int. Ed. 2006, 45, 7388-7394
    • (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 7388-7394
    • Sánchez-Pedregal, V.M.1    Kubicek, K.2    Meiler, J.3    Lyothier, I.4    Paterson, I.5    Carlomagno, T.6
  • 127
    • 5344236083 scopus 로고    scopus 로고
    • Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin
    • Paterson, I.; Britton, R.; Delgado, O.; Meyer, A.; Poullennec, K. G. Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin Angew. Chem., Int. Ed. 2004, 43, 4629-4633
    • (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 4629-4633
    • Paterson, I.1    Britton, R.2    Delgado, O.3    Meyer, A.4    Poullennec, K.G.5
  • 128
    • 5344247972 scopus 로고    scopus 로고
    • Total synthesis of (-)-dictyostatin: Confirmation of relative and absolute configurations
    • Shin, Y.; Fournier, J.-H.; Fukui, Y.; Bruckner, A. M.; Curran, D. P. Total synthesis of (-)-dictyostatin: confirmation of relative and absolute configurations Angew. Chem., Int. Ed. 2004, 43, 4634-4637
    • (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 4634-4637
    • Shin, Y.1    Fournier, J.-H.2    Fukui, Y.3    Bruckner, A.M.4    Curran, D.P.5
  • 129
    • 33846418752 scopus 로고    scopus 로고
    • Total synthesis of potential antitumor agent, (-)-dictyostatin
    • Ramachandran, P. V.; Srivastava, A.; Hazra, D. Total synthesis of potential antitumor agent, (-)-dictyostatin Org. Lett. 2006, 9, 157-160
    • (2006) Org. Lett. , vol.9 , pp. 157-160
    • Ramachandran, P.V.1    Srivastava, A.2    Hazra, D.3
  • 130
    • 33646453676 scopus 로고    scopus 로고
    • Total synthesis of (-)-dictyostatin
    • ONei, G. W.; Phillips, A. J. Total synthesis of (-)-dictyostatin J. Am. Chem. Soc. 2006, 128, 5340-5341
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 5340-5341
    • Onei, G.W.1    Phillips, A.J.2
  • 131
    • 77955653152 scopus 로고    scopus 로고
    • Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin
    • Paterson, I.; Britton, R.; Delgado, O.; Gardner, N. M.; Meyer, A.; Naylor, G. J.; Poullennec, K. G. Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin Tetrahedron 2010, 66, 6534-6545
    • (2010) Tetrahedron , vol.66 , pp. 6534-6545
    • Paterson, I.1    Britton, R.2    Delgado, O.3    Gardner, N.M.4    Meyer, A.5    Naylor, G.J.6    Poullennec, K.G.7
  • 134
    • 84928704587 scopus 로고
    • Sarcodictyin A and sarcodictyin B, novel diterpenoidic alcohols esterified by (E)- N (1)-methylurocanic acid. Isolation from the mediterranean stolonifer Sarcodictyon roseum
    • DAmbrosio, M.; Guerriero, A.; Pietra, F. Sarcodictyin A and sarcodictyin B, novel diterpenoidic alcohols esterified by (E)- N (1)-methylurocanic acid. Isolation from the mediterranean stolonifer Sarcodictyon roseum Helv. Chim. Acta 1987, 70, 2019-2027
    • (1987) Helv. Chim. Acta , vol.70 , pp. 2019-2027
    • Dambrosio, M.1    Guerriero, A.2    Pietra, F.3
  • 135
    • 84986348031 scopus 로고
    • Isolation from the Mediterranean Stolonifern coral Sarcodictyon roseum of sarcodictyin C, D, E, and F, novel diterpenodic alcohols esterified by (E)- or (Z)- N (1)-methylurocanic acid. Failure of the carbon-skeleton type as a classification criterion
    • (Abstract 30)
    • DAnbrosio, M.; Guerriero, A.; Pietra, F. Isolation from the Mediterranean Stolonifern coral Sarcodictyon roseum of sarcodictyin C, D, E, and F, novel diterpenodic alcohols esterified by (E)- or (Z)- N (1)-methylurocanic acid. Failure of the carbon-skeleton type as a classification criterion Helv. Chim. Acta 1988, 71, 964-976 (Abstract 30)
    • (1988) Helv. Chim. Acta , vol.71 , pp. 964-976
    • Danbrosio, M.1    Guerriero, A.2    Pietra, F.3
  • 137
    • 0033609037 scopus 로고    scopus 로고
    • The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site
    • Hamel, E.; Sackett, D. L.; Vourloumis, D.; Nicolaou, K. C. The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site Biochemistry 1999, 38, 5490-5498
    • (1999) Biochemistry , vol.38 , pp. 5490-5498
    • Hamel, E.1    Sackett, D.L.2    Vourloumis, D.3    Nicolaou, K.C.4
  • 139
    • 0030723674 scopus 로고    scopus 로고
    • Synthesis of the tricyclic core of eleutherobin and sarcodictyins and total synthesis of sarcodictyin A
    • Nicolaou, K. C.; Xu, J. Y.; Kim, S.; Ohshima, T.; Hosokawa, S.; Pfefferkorn, J. Synthesis of the tricyclic core of eleutherobin and sarcodictyins and total synthesis of sarcodictyin A J. Am. Chem. Soc. 1997, 119, 11353-11354
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 11353-11354
    • Nicolaou, K.C.1    Xu, J.Y.2    Kim, S.3    Ohshima, T.4    Hosokawa, S.5    Pfefferkorn, J.6
  • 146
    • 0023710155 scopus 로고
    • Laulimalide. New potent cytotoxic macrolides from a marine sponge and a nudibranch predator
    • Corley, D. G.; Herb, R.; Moore, R. E.; Scheuer, P. J.; Paul, V. J. Laulimalide. New potent cytotoxic macrolides from a marine sponge and a nudibranch predator J. Org. Chem. 1988, 53, 3644-3646
    • (1988) J. Org. Chem. , vol.53 , pp. 3644-3646
    • Corley, D.G.1    Herb, R.2    Moore, R.E.3    Scheuer, P.J.4    Paul, V.J.5
  • 147
    • 33845278737 scopus 로고
    • Fijianolides, polyketide heterocyclics from amarine sponge
    • Quinoa, E.; Kakou, Y.; Crews, P. Fijianolides, polyketide heterocyclics from amarine sponge J. Org. Chem. 1988, 53, 3642-3644
    • (1988) J. Org. Chem. , vol.53 , pp. 3642-3644
    • Quinoa, E.1    Kakou, Y.2    Crews, P.3
  • 148
    • 0030068561 scopus 로고    scopus 로고
    • Structures and absolute configurations of the marine toxins, latrunculin A and laulimalide
    • Jefford, C. W.; Bernardinelli, G.; Tanaka, J.-i.; Higa, T. Structures and absolute configurations of the marine toxins, latrunculin A and laulimalide Tetrahedron Lett. 1996, 37, 159-162
    • (1996) Tetrahedron Lett. , vol.37 , pp. 159-162
    • Jefford, C.W.1    Bernardinelli, G.2    Tanaka, J.-I.3    Higa, T.4
  • 149
    • 0033083045 scopus 로고    scopus 로고
    • Laulimalide and isolaulimalide, new paclitaxel-like microtubule- stabilizing agents
    • Mooberry, S. L.; Tien, G.; Hernandez, A. H.; Plubrukarn, A.; Davidson, B. S. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents Cancer Res. 1999, 59, 653-660
    • (1999) Cancer Res. , vol.59 , pp. 653-660
    • Mooberry, S.L.1    Tien, G.2    Hernandez, A.H.3    Plubrukarn, A.4    Davidson, B.S.5
  • 150
    • 18444400213 scopus 로고    scopus 로고
    • The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity
    • Pryor, D. E.; OBrate, A.; Bilcer, G.; Diaz, J. F.; Wang, Y.; Kabaki, M.; Jung, M. K.; Andreu, J. M.; Ghosh, A. K. The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity Biochemistry 2002, 41, 9109-9115
    • (2002) Biochemistry , vol.41 , pp. 9109-9115
    • Pryor, D.E.1    Obrate, A.2    Bilcer, G.3    Diaz, J.F.4    Wang, Y.5    Kabaki, M.6    Jung, M.K.7    Andreu, J.M.8    Ghosh, A.K.9
  • 153
    • 77955453358 scopus 로고    scopus 로고
    • Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping
    • Bennett, M. J.; Barakat, K.; Huzil, J. T.; Tuszynski, J.; Schriemer, D. C. Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping Chem. Biol. 2010, 17, 725-734
    • (2010) Chem. Biol. , vol.17 , pp. 725-734
    • Bennett, M.J.1    Barakat, K.2    Huzil, J.T.3    Tuszynski, J.4    Schriemer, D.C.5
  • 154
    • 0034623543 scopus 로고    scopus 로고
    • Total synthesis of (-)-laulimalide
    • Ghosh, A. K.; Wang, Y. Total synthesis of (-)-laulimalide J. Am. Chem. Soc. 2000, 122, 11027-11028
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 11027-11028
    • Ghosh, A.K.1    Wang, Y.2
  • 155
    • 0141508044 scopus 로고    scopus 로고
    • Microtubule-stabilizing marine metabolite laulimalide and its derivatives: Synthetic approaches and antitumor activity
    • Mulzer, J.; Ohler, E. Microtubule-stabilizing marine metabolite laulimalide and its derivatives: synthetic approaches and antitumor activity Chem. Rev. 2003, 103, 3753-3786
    • (2003) Chem. Rev. , vol.103 , pp. 3753-3786
    • Mulzer, J.1    Ohler, E.2
  • 159
    • 0034723214 scopus 로고    scopus 로고
    • Peloruside A: A potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp
    • West, L. M.; Northcote, P. T.; Battershill, C. N. Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp J. Org. Chem. 2000, 65, 445-449
    • (2000) J. Org. Chem. , vol.65 , pp. 445-449
    • West, L.M.1    Northcote, P.T.2    Battershill, C.N.3
  • 160
    • 0035727024 scopus 로고    scopus 로고
    • The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C
    • Hood, K. A.; Bäckström, B. T.; West, L. M.; Northcote, P. T.; Berridge, M. V.; Miller, J. H. The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C Anti-Cancer Drug Des. 2001, 16, 155-166
    • (2001) Anti-Cancer Drug Des. , vol.16 , pp. 155-166
    • Hood, K.A.1    Bäckström, B.T.2    West, L.M.3    Northcote, P.T.4    Berridge, M.V.5    Miller, J.H.6
  • 161
    • 3442894416 scopus 로고    scopus 로고
    • Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines
    • Gaitanos, T. N.; Buey, R. M.; Diaz, J. F.; Northcote, P. T.; Teesdale-Spittle, P.; Andreu, J. M.; Miller, J. H. Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines Cancer Res. 2004, 64, 5063-5067
    • (2004) Cancer Res. , vol.64 , pp. 5063-5067
    • Gaitanos, T.N.1    Buey, R.M.2    Diaz, J.F.3    Northcote, P.T.4    Teesdale-Spittle, P.5    Andreu, J.M.6    Miller, J.H.7
  • 163
    • 79959597439 scopus 로고    scopus 로고
    • Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells
    • Wilmes, A.; OSullivan, D.; Chan, A.; Chandrahasen, C.; Paterson, I.; Northcote, P. T.; La Flamme, A. C.; Miller, J. H. Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells Cancer Chemother. Pharmacol. 2011, 68, 117-126
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 117-126
    • Wilmes, A.1    Osullivan, D.2    Chan, A.3    Chandrahasen, C.4    Paterson, I.5    Northcote, P.T.6    La Flamme, A.C.7    Miller, J.H.8
  • 164
    • 0037432898 scopus 로고    scopus 로고
    • Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A
    • Liao, X.; Wu, Y.; De Brabander, J. K. Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A Angew. Chem., Int. Ed. Engl. 2003, 42, 1648-1652
    • (2003) Angew. Chem., Int. Ed. Engl. , vol.42 , pp. 1648-1652
    • Liao, X.1    Wu, Y.2    De Brabander, J.K.3
  • 165
    • 17444403596 scopus 로고    scopus 로고
    • Total synthesis of (+)-peloruside A
    • Jin, M.; Taylor, R. E. Total synthesis of (+)-peloruside A Org. Lett. 2005, 7, 1303-1305
    • (2005) Org. Lett. , vol.7 , pp. 1303-1305
    • Jin, M.1    Taylor, R.E.2
  • 166
    • 43549088617 scopus 로고    scopus 로고
    • Enantioselective total synthesis of peloruside A: A potent microtubule stabilizer
    • Ghosh, A. K.; Xu, X.; Kim, J.-H.; Xu, C.-X. Enantioselective total synthesis of peloruside A: a potent microtubule stabilizer Org. Lett. 2008, 10, 1001-1004
    • (2008) Org. Lett. , vol.10 , pp. 1001-1004
    • Ghosh, A.K.1    Xu, X.2    Kim, J.-H.3    Xu, C.-X.4
  • 167
    • 67849095752 scopus 로고    scopus 로고
    • An aldol-based synthesis of (+)-peloruside a, a potent microtubule stabilizing agent
    • Evans, D. A.; Welch, D. S.; Speed, A. W.; Moniz, G. A.; Reichelt, A.; Ho, S. An aldol-based synthesis of (+)-peloruside a, a potent microtubule stabilizing agent J. Am. Chem. Soc. 2009, 131, 3840-3841
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 3840-3841
    • Evans, D.A.1    Welch, D.S.2    Speed, A.W.3    Moniz, G.A.4    Reichelt, A.5    Ho, S.6
  • 170
    • 77956041046 scopus 로고    scopus 로고
    • Total synthesis of peloruside a through kinetic lactonization and relay ring-closing metathesis cyclization reactions
    • Hoye, T. R.; Jeon, J.; Kopel, L. C.; Ryba, T. D.; Tennakoon, M. A.; Wang, Y. Total synthesis of peloruside a through kinetic lactonization and relay ring-closing metathesis cyclization reactions Angew. Chem., Int. Ed. 2010, 49, 6151-6155
    • (2010) Angew. Chem., Int. Ed. , vol.49 , pp. 6151-6155
    • Hoye, T.R.1    Jeon, J.2    Kopel, L.C.3    Ryba, T.D.4    Tennakoon, M.A.5    Wang, Y.6
  • 171
    • 78650080777 scopus 로고    scopus 로고
    • Synthesis of polyketide natural products and analogs as promising anticancer agents
    • Dalby, S. M.; Paterson, I. Synthesis of polyketide natural products and analogs as promising anticancer agents Curr. Opin. Drug Discovery Dev. 2010, 13, 777-794
    • (2010) Curr. Opin. Drug Discovery Dev. , vol.13 , pp. 777-794
    • Dalby, S.M.1    Paterson, I.2
  • 172
    • 73449093833 scopus 로고    scopus 로고
    • Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: Isolation, structure, total synthesis, and bioactivity
    • Singh, A. J.; Xu, C.-X.; Xu, X.; West, L. M.; Wilmes, A.; Chan, A.; Hamel, E.; Miller, J. H.; Northcote, P. T.; Ghosh, A. K. Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity J. Org. Chem. 2009, 75, 2-10
    • (2009) J. Org. Chem. , vol.75 , pp. 2-10
    • Singh, A.J.1    Xu, C.-X.2    Xu, X.3    West, L.M.4    Wilmes, A.5    Chan, A.6    Hamel, E.7    Miller, J.H.8    Northcote, P.T.9    Ghosh, A.K.10
  • 174
    • 0034009228 scopus 로고    scopus 로고
    • A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
    • Sato, B.; Muramatsu, H.; Miyauchi, M.; Hori, Y.; Takase, S.; Hino, M.; Hashimoto, S.; Terano, H. A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities J. Antibiot. (Tokyo) 2000, 53, 123-130
    • (2000) J. Antibiot. (Tokyo) , vol.53 , pp. 123-130
    • Sato, B.1    Muramatsu, H.2    Miyauchi, M.3    Hori, Y.4    Takase, S.5    Hino, M.6    Hashimoto, S.7    Terano, H.8
  • 177
    • 4243852929 scopus 로고    scopus 로고
    • (errata)
    • (J. Antibiot. 2002, 55, C-1 (errata))
    • (2002) J. Antibiot. , vol.55 , pp. 1
  • 178
    • 0037846481 scopus 로고    scopus 로고
    • An enantioselective synthesis of FR182877 provides a chemical rationalization of its structure and affords multigram quantities of its direct precursor
    • Vanderwal, C. D.; Vosburg, D. A.; Weiler, S.; Sorensen, E. J. An enantioselective synthesis of FR182877 provides a chemical rationalization of its structure and affords multigram quantities of its direct precursor J. Am. Chem. Soc. 2003, 125, 5393-5407
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 5393-5407
    • Vanderwal, C.D.1    Vosburg, D.A.2    Weiler, S.3    Sorensen, E.J.4
  • 179
    • 0036570208 scopus 로고    scopus 로고
    • A synthesis of (+)-FR182877, featuring tandem transannular Diels-Alder reactions inspired by a postulated biogenesis
    • Vosburg, D. A.; Vanderwal, C. D.; Sorensen, E. J. A synthesis of (+)-FR182877, featuring tandem transannular Diels-Alder reactions inspired by a postulated biogenesis J. Am. Chem. Soc. 2002, 124, 4552-4553
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 4552-4553
    • Vosburg, D.A.1    Vanderwal, C.D.2    Sorensen, E.J.3
  • 180
    • 0036260285 scopus 로고    scopus 로고
    • A cascade cycloaddition strategy leading to the total synthesis of (-)-FR182877
    • Evans, D. A.; Starr, J. T. A cascade cycloaddition strategy leading to the total synthesis of (-)-FR182877 Angew. Chem., Int. Ed. 2002, 41, 1787-1790
    • (2002) Angew. Chem., Int. Ed. , vol.41 , pp. 1787-1790
    • Evans, D.A.1    Starr, J.T.2
  • 181
    • 23944524786 scopus 로고    scopus 로고
    • Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site
    • Edler, M. C.; Buey, R. M.; Gussio, R.; Marcus, A. I.; Vanderwal, C. D.; Sorensen, E. J.; Diaz, J. F.; Giannakakou, P.; Hamel, E. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Biochemistry 2005, 44, 11525-11538
    • (2005) Biochemistry , vol.44 , pp. 11525-11538
    • Edler, M.C.1    Buey, R.M.2    Gussio, R.3    Marcus, A.I.4    Vanderwal, C.D.5    Sorensen, E.J.6    Diaz, J.F.7    Giannakakou, P.8    Hamel, E.9
  • 183
    • 75649117065 scopus 로고    scopus 로고
    • Cyclostreptin and microtubules: Is a low-affinity binding site required?
    • Prussia, A. J.; Yang, Y.; Geballe, M. T.; Snyder, J. P. Cyclostreptin and microtubules: is a low-affinity binding site required? ChemBioChem 2010, 11, 101-109
    • (2010) ChemBioChem , vol.11 , pp. 101-109
    • Prussia, A.J.1    Yang, Y.2    Geballe, M.T.3    Snyder, J.P.4
  • 185
  • 186
    • 0001544042 scopus 로고
    • Steroidal bitter principles from Tacca plantaginea structures of taccalonolide A and B
    • Chen, Z.; Wang, B.; Chen, M. Steroidal bitter principles from Tacca plantaginea structures of taccalonolide A and B Tetrahedron Lett. 1987, 28, 1673-1675
    • (1987) Tetrahedron Lett. , vol.28 , pp. 1673-1675
    • Chen, Z.1    Wang, B.2    Chen, M.3
  • 187
    • 0000786909 scopus 로고
    • Taccalonolide C and D, two pentacyclic steroids of Tacca plantaginea
    • Chen, Z.-L.; Wang, B.-d.; Shen, J.-H. Taccalonolide C and D, two pentacyclic steroids of Tacca plantaginea Phytochemistry 1988, 27, 2999-3001
    • (1988) Phytochemistry , vol.27 , pp. 2999-3001
    • Chen, Z.-L.1    Wang, B.-D.2    Shen, J.-H.3
  • 190
    • 81855199852 scopus 로고    scopus 로고
    • Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers
    • Li, J.; Risinger, A. L.; Peng, J.; Chen, Z.; Hu, L.; Mooberry, S. L. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers J. Am. Chem. Soc. 2011, 133, 19064-19067
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 19064-19067
    • Li, J.1    Risinger, A.L.2    Peng, J.3    Chen, Z.4    Hu, L.5    Mooberry, S.L.6
  • 193
    • 28844499921 scopus 로고    scopus 로고
    • Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity
    • Buey, R. M.; Barasoain, I.; Jackson, E.; Meyer, A.; Giannakakou, P.; Paterson, I.; Mooberry, S.; Andreu, J. M.; DÌaz, J. F. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity Chem. Biol. 2005, 12, 1269-1279
    • (2005) Chem. Biol. , vol.12 , pp. 1269-1279
    • Buey, R.M.1    Barasoain, I.2    Jackson, E.3    Meyer, A.4    Giannakakou, P.5    Paterson, I.6    Mooberry, S.7    Andreu, J.M.8    Dìaz, J.F.9
  • 194
    • 79960017904 scopus 로고    scopus 로고
    • Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel
    • Risinger, A. L.; Mooberry, S. L. Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel Cell Cycle 2011, 10, 2162-2171
    • (2011) Cell Cycle , vol.10 , pp. 2162-2171
    • Risinger, A.L.1    Mooberry, S.L.2
  • 195
    • 0030605887 scopus 로고    scopus 로고
    • Zampanolide, a new cytotoxic marcrolide from a marine sponge
    • Tanaka, J.-i.; Higa, T. Zampanolide, a new cytotoxic marcrolide from a marine sponge Tetrahedron Lett. 1996, 37, 5535-5538
    • (1996) Tetrahedron Lett. , vol.37 , pp. 5535-5538
    • Tanaka, J.-I.1    Higa, T.2
  • 198
    • 0037130667 scopus 로고    scopus 로고
    • Total syntheses of (+)-zampanolide and (+)-dactylolide exploiting a unified strategy
    • Smith, A. B.; Safonov, I. G.; Corbett, R. M. Total syntheses of (+)-zampanolide and (+)-dactylolide exploiting a unified strategy J. Am. Chem. Soc. 2002, 124, 11102-11113
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 11102-11113
    • Smith, A.B.1    Safonov, I.G.2    Corbett, R.M.3
  • 199
    • 0043127291 scopus 로고    scopus 로고
    • Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: A total synthesis of (-)-dactylolide [and zampanolide]
    • Hoye, T. R.; Hu, M. Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: a total synthesis of (-)-dactylolide [and zampanolide] J. Am. Chem. Soc. 2003, 125, 9576-9577
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 9576-9577
    • Hoye, T.R.1    Hu, M.2
  • 200
    • 68149139558 scopus 로고    scopus 로고
    • Total Synthesis of (-)-zampanolide and questionable existence of (-)-dactylolide as the elusive biosynthetic precursor of (-)-zampanolide in an Okinawan sponge
    • Uenishi, J. i.; Iwamoto, T.; Tanaka, J. Total Synthesis of (-)-zampanolide and questionable existence of (-)-dactylolide as the elusive biosynthetic precursor of (-)-zampanolide in an Okinawan sponge Org. Lett. 2009, 11, 3262-3265
    • (2009) Org. Lett. , vol.11 , pp. 3262-3265
    • J, I.U.1    Iwamoto, T.2    Tanaka, J.3
  • 201
    • 84864228337 scopus 로고    scopus 로고
    • Total synthesis of potent antitumor macrolide (-)-zampanolide: An oxidative intramolecular cyclization-based strategy
    • Ghosh, A. K.; Cheng, X.; Bai, R.; Hamel, E. Total synthesis of potent antitumor macrolide (-)-zampanolide: an oxidative intramolecular cyclization-based strategy Eur. J. Org. Chem. 2012, 4130-4139
    • (2012) Eur. J. Org. Chem. , pp. 4130-4139
    • Ghosh, A.K.1    Cheng, X.2    Bai, R.3    Hamel, E.4
  • 202
    • 0037149007 scopus 로고    scopus 로고
    • Total synthesis of (+)-dactylolide
    • Smith, A. B.; Safonov, I. G. Total synthesis of (+)-dactylolide Org. Lett. 2002, 4, 635-637
    • (2002) Org. Lett. , vol.4 , pp. 635-637
    • Smith, A.B.1    Safonov, I.G.2
  • 203
    • 20444390663 scopus 로고    scopus 로고
    • Total synthesis of (+)-dactylolide through an efficient sequential peterson olefination and prins cyclization reaction
    • Aubele, D. L.; Wan, S.; Floreancig, P. E. Total synthesis of (+)-dactylolide through an efficient sequential peterson olefination and prins cyclization reaction Angew. Chem., Int. Ed. 2005, 44, 3485-3488
    • (2005) Angew. Chem., Int. Ed. , vol.44 , pp. 3485-3488
    • Aubele, D.L.1    Wan, S.2    Floreancig, P.E.3
  • 204
    • 22244485705 scopus 로고    scopus 로고
    • Total synthesis of (+)-dactylolide
    • Sanchez, C. C.; Keck, G. E. Total synthesis of (+)-dactylolide Org. Lett. 2005, 7, 3053-3056
    • (2005) Org. Lett. , vol.7 , pp. 3053-3056
    • Sanchez, C.C.1    Keck, G.E.2
  • 205
    • 48249085734 scopus 로고    scopus 로고
    • Total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide via target oriented β- C -glycoside formation
    • Ding, F.; Jennings, M. P. Total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide via target oriented β- C -glycoside formation J. Org. Chem. 2008, 73, 5965-5976
    • (2008) J. Org. Chem. , vol.73 , pp. 5965-5976
    • Ding, F.1    Jennings, M.P.2
  • 207
    • 70949095549 scopus 로고    scopus 로고
    • Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the tongan marine sponge Cacospongia mycofijiensis
    • Field, J. J.; Singh, A. J.; Kanakkanthara, A.; Halafihi, T. i.; Northcote, P. T.; Miller, J. H. Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the tongan marine sponge Cacospongia mycofijiensis J. Med. Chem. 2009, 52, 7328-7332
    • (2009) J. Med. Chem. , vol.52 , pp. 7328-7332
    • Field, J.J.1    Singh, A.J.2    Kanakkanthara, A.3    T, I.H.4    Northcote, P.T.5    Miller, J.H.6
  • 208
    • 77952335930 scopus 로고    scopus 로고
    • Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin
    • Zurwerra, D.; Gertsch, J. r.; Altmann, K.-H. Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin Org. Lett. 2010, 12, 2302-2305
    • (2010) Org. Lett. , vol.12 , pp. 2302-2305
    • Zurwerra, D.1    J, R.G.2    Altmann, K.-H.3
  • 209
    • 0347411077 scopus 로고    scopus 로고
    • Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea
    • Manzo, E.; van Soest, R.; Matainaho, L.; Roberge, M.; Andersen, R. J. Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea Org. Lett. 2003, 5, 4591-4594
    • (2003) Org. Lett. , vol.5 , pp. 4591-4594
    • Manzo, E.1    Van Soest, R.2    Matainaho, L.3    Roberge, M.4    Andersen, R.J.5
  • 210
    • 17144385513 scopus 로고    scopus 로고
    • Ceratamines, structurally simple microtubule-stabilizing antimitotic agents with unusual cellular effects
    • Karjala, G.; Chan, Q.; Manzo, E.; Andersen, R. J.; Roberge, M. Ceratamines, structurally simple microtubule-stabilizing antimitotic agents with unusual cellular effects Cancer Res. 2005, 65, 3040-3043
    • (2005) Cancer Res. , vol.65 , pp. 3040-3043
    • Karjala, G.1    Chan, Q.2    Manzo, E.3    Andersen, R.J.4    Roberge, M.5
  • 211
    • 66149148661 scopus 로고    scopus 로고
    • A direct and efficient total synthesis of the tubulin-binding agents ceratamine A and B; Use of IBX for a remarkable heterocycle dehydrogenation
    • Coleman, R. S.; Campbell, E. L.; Carper, D. J. A direct and efficient total synthesis of the tubulin-binding agents ceratamine A and B; use of IBX for a remarkable heterocycle dehydrogenation Org. Lett. 2009, 11, 2133-2136
    • (2009) Org. Lett. , vol.11 , pp. 2133-2136
    • Coleman, R.S.1    Campbell, E.L.2    Carper, D.J.3
  • 212
    • 78149238232 scopus 로고    scopus 로고
    • Synthetic analogues of the microtubule-stabilizing sponge alkaloid ceratamine A are more active than the natural product
    • Nodwell, M.; Zimmerman, C.; Roberge, M.; Andersen, R. J. Synthetic analogues of the microtubule-stabilizing sponge alkaloid ceratamine A are more active than the natural product J. Med. Chem. 2010, 53, 7843-7851
    • (2010) J. Med. Chem. , vol.53 , pp. 7843-7851
    • Nodwell, M.1    Zimmerman, C.2    Roberge, M.3    Andersen, R.J.4
  • 213
    • 45549107292 scopus 로고    scopus 로고
    • Synthesis of antimitotic analogs of the microtubule stabilizing sponge alkaloid ceratamine A
    • Nodwell, M.; Riffell, J. L.; Roberge, M.; Andersen, R. J. Synthesis of antimitotic analogs of the microtubule stabilizing sponge alkaloid ceratamine A Org. Lett. 2008, 10, 1051-1054
    • (2008) Org. Lett. , vol.10 , pp. 1051-1054
    • Nodwell, M.1    Riffell, J.L.2    Roberge, M.3    Andersen, R.J.4
  • 214
    • 0037444278 scopus 로고    scopus 로고
    • Dicoumarol: A unique microtubule stabilizing natural product that is synergistic with Taxol
    • Madari, H.; Panda, D.; Wilson, L.; Jacobs, R. S. Dicoumarol: a unique microtubule stabilizing natural product that is synergistic with Taxol Cancer Res. 2003, 63, 1214-1220
    • (2003) Cancer Res. , vol.63 , pp. 1214-1220
    • Madari, H.1    Panda, D.2    Wilson, L.3    Jacobs, R.S.4
  • 215
    • 0037217727 scopus 로고    scopus 로고
    • Biological properties of jatrophane polyesters, new microtubule- interacting agents
    • Miglietta, A.; Gabriel, L.; Appendino, G.; Bocca, C. Biological properties of jatrophane polyesters, new microtubule-interacting agents Cancer Chemother. Pharmacol. 2003, 51, 67-74
    • (2003) Cancer Chemother. Pharmacol. , vol.51 , pp. 67-74
    • Miglietta, A.1    Gabriel, L.2    Appendino, G.3    Bocca, C.4
  • 216
    • 0029150213 scopus 로고
    • Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a Taxol-like effect
    • Mooberry, S. L.; Stratman, K.; Moore, R. E. Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a Taxol-like effect Cancer Lett. 1995, 96, 261-266
    • (1995) Cancer Lett. , vol.96 , pp. 261-266
    • Mooberry, S.L.1    Stratman, K.2    Moore, R.E.3
  • 217
    • 0034908061 scopus 로고    scopus 로고
    • Tubulins in the primate retina: Evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site
    • Crabtree, D. V.; Ojima, I.; Geng, X.; Adler, A. J. Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site Bioorg. Med. Chem. 2001, 9, 1967-1976
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 1967-1976
    • Crabtree, D.V.1    Ojima, I.2    Geng, X.3    Adler, A.J.4
  • 219
    • 80055108264 scopus 로고    scopus 로고
    • Microtubules (tau) as an emerging therapeutic target: NAP (davunetide)
    • Gozes, I. Microtubules (tau) as an emerging therapeutic target: NAP (davunetide) Curr. Pharm. Des. 2011, 17, 3413-3417
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 3413-3417
    • Gozes, I.1
  • 221
    • 84868568057 scopus 로고    scopus 로고
    • Davunetide (AL-108): Targeting tangles
    • Gozes, I. Davunetide (AL-108): targeting tangles Alzheimer's Dementia 2009, 5, P74-P74
    • (2009) Alzheimer's Dementia , vol.5
    • Gozes, I.1
  • 222
    • 3142582005 scopus 로고    scopus 로고
    • A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication
    • Divinski, I.; Mittelman, L.; Gozes, I. A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication J. Biol. Chem. 2004, 279, 28531-28538
    • (2004) J. Biol. Chem. , vol.279 , pp. 28531-28538
    • Divinski, I.1    Mittelman, L.2    Gozes, I.3
  • 224
    • 77950352070 scopus 로고    scopus 로고
    • The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules
    • Yenjerla, M.; LaPointe, N. E.; Lopus, M.; Cox, C.; Jordan, M. A.; Feinstein, S. C.; Wilson, L. The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules J. Alzheimer's Dis. 2010, 19, 1377-1386
    • (2010) J. Alzheimer's Dis. , vol.19 , pp. 1377-1386
    • Yenjerla, M.1    Lapointe, N.E.2    Lopus, M.3    Cox, C.4    Jordan, M.A.5    Feinstein, S.C.6    Wilson, L.7
  • 225
    • 0030801564 scopus 로고    scopus 로고
    • GS-164, a small synthetic compound, stimulates tubulin polymerization by a similar mechanism to that of Taxol
    • Shintani, Y.; Tanaka, T.; Nozaki, Y. GS-164, a small synthetic compound, stimulates tubulin polymerization by a similar mechanism to that of Taxol Cancer Chemother. Pharmacol. 1997, 40, 513-520
    • (1997) Cancer Chemother. Pharmacol. , vol.40 , pp. 513-520
    • Shintani, Y.1    Tanaka, T.2    Nozaki, Y.3
  • 226
    • 0033918981 scopus 로고    scopus 로고
    • Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability
    • Wang, Z.; Yang, D.; Mohanakrishnan, A. K.; Fanwick, P. E.; Nampoothiri, P.; Hamel, E.; Cushman, M. Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability J. Med. Chem. 2000, 43, 2419-2429
    • (2000) J. Med. Chem. , vol.43 , pp. 2419-2429
    • Wang, Z.1    Yang, D.2    Mohanakrishnan, A.K.3    Fanwick, P.E.4    Nampoothiri, P.5    Hamel, E.6    Cushman, M.7
  • 228
    • 33846424286 scopus 로고    scopus 로고
    • Synthesis and SAR of [1,2,4]triazolo[1,5- a ]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition
    • Zhang, N.; Ayral-Kaloustian, S.; Nguyen, T.; Afragola, J.; Hernandez, R.; Lucas, J.; Gibbons, J.; Beyer, C. Synthesis and SAR of [1,2,4]triazolo[1,5- a ]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition J. Med. Chem. 2007, 50, 319-327
    • (2007) J. Med. Chem. , vol.50 , pp. 319-327
    • Zhang, N.1    Ayral-Kaloustian, S.2    Nguyen, T.3    Afragola, J.4    Hernandez, R.5    Lucas, J.6    Gibbons, J.7    Beyer, C.8
  • 229
    • 57649219784 scopus 로고    scopus 로고
    • Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5- (substituted)phenylpyrimidines as anti-cancer agents
    • Zhang, N.; Ayral-Kaloustian, S.; Nguyen, T.; Hernandez, R.; Lucas, J.; Discafani, C.; Beyer, C. Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2- heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents Bioorg. Med. Chem. 2009, 17, 111-118
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 111-118
    • Zhang, N.1    Ayral-Kaloustian, S.2    Nguyen, T.3    Hernandez, R.4    Lucas, J.5    Discafani, C.6    Beyer, C.7
  • 231
    • 77950367752 scopus 로고    scopus 로고
    • Niementowski-type synthesis of pyrido[3,2- e ][1,2,4]triazines: Potent aza -analogs of pyrido[2,3- b ]pyrazine fungicides
    • Crowley, P. J.; Lamberth, C.; Müller, U.; Wendeborn, S.; Sageot, O.-A.; Williams, J.; Bartovič, A. Niementowski-type synthesis of pyrido[3,2- e ][1,2,4]triazines: potent aza -analogs of pyrido[2,3- b ]pyrazine fungicides Tetrahedron Lett. 2010, 51, 2652-2654
    • (2010) Tetrahedron Lett. , vol.51 , pp. 2652-2654
    • Crowley, P.J.1    Lamberth, C.2    Müller, U.3    Wendeborn, S.4    Sageot, O.-A.5    Williams, J.6    Bartovič, A.7
  • 235
    • 71749098742 scopus 로고    scopus 로고
    • Cevipabulin (TTI-237): Preclinical and clinical results for a novel antimicrotubule agent
    • Ayral-Kaloustian, S.; Zhang, N.; Beyer, C. Cevipabulin (TTI-237): preclinical and clinical results for a novel antimicrotubule agent Methods Find. Exp. Clin. Pharmacol. 2009, 31, 443-447
    • (2009) Methods Find. Exp. Clin. Pharmacol. , vol.31 , pp. 443-447
    • Ayral-Kaloustian, S.1    Zhang, N.2    Beyer, C.3
  • 236
    • 84863867694 scopus 로고    scopus 로고
    • Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets
    • Lee, V. M.-Y.; Brunden, K. R.; Hutton, M.; Trojanowski, J. Q. Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Cold Spring Harbor Perspect. Med. 2011, 1, a006437
    • (2011) Cold Spring Harbor Perspect. Med. , vol.1 , pp. 006437
    • Lee, V.M.-Y.1    Brunden, K.R.2    Hutton, M.3    Trojanowski, J.Q.4
  • 237
    • 70349638299 scopus 로고    scopus 로고
    • Advances in tau-focused drug discovery for Alzheimers disease and related tauopathies
    • Brunden, K. R.; Trojanowski, J. Q.; Lee, V. M.-Y. Advances in tau-focused drug discovery for Alzheimers disease and related tauopathies Nat. Rev. Drug Discovery 2009, 8, 783-793
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3


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